In the transition towards a hydrogen-based energy system, the strategic use of pipelines is crucial for efficient hydrogen distribution. Leveraging existing natural gas pipelines to carry a mix of hydrogen and natural gas offers a cost-effective alternative to building new infrastructure. This study explores the development of a leak detection system compatible with existing pipelines, specifically tailored for the blended hydrogen and natural gas mix. Given the scarcity of leak data for blended hydrogen-natural gas pipelines, the study introduces a Real-Time Transient Model (RTTM) for blended gases, simulating leak dynamics to generate necessary data. Additionally, a leak detection system (LDS) is developed using a fusion of Convolutional Neural Network (CNN) and Explainable Artificial Intelligence (XAI) through Adaptive Neuro-Fuzzy Inference Systems (ANFIS). This LDS framework overcomes the “black box” issue common in AI-driven systems, enabling reliable detection. The integration of Explainable and traditional AI techniques holds promising implications for blended hydrogen pipelines by enhancing the safety and efficiency of hydrogen transportation, thereby mitigating economic and environmental impacts, and addressing public concerns.