Medical Imaging Detection Research Articles

Retraction Note: Application of optical medical equipment imaging detection and fire needle therapy for intestinal mucosal barrier function in patients with intestinal diseases

Retraction Note: Application of optical medical equipment imaging detection and fire needle therapy for intestinal mucosal barrier function in patients with intestinal diseases

Breast tumor segmentation using neural cellular automata and shape guided segmentation in mammography images.

Using computer-aided design (CAD) systems, this research endeavors to enhance breast cancer segmentation by addressing data insufficiency and data complexity during model training. As perceived by computer vision models, the inherent symmetry and complexity of mammography images make segmentation difficult. The objective is to optimize the precision and effectiveness of medical imaging. The study introduces a hybrid strategy combining shape-guided segmentation (SGS) and M3D-neural cellular automata (M3D-NCA), resulting in improved computational efficiency and performance. The implementation of Shape-guided segmentation (SGS) during the initialization phase, coupled with the elimination of convolutional layers, enables the model to effectively reduce computation time. The research proposes a novel loss function that combines segmentation losses from both components for effective training. The robust technique provided aims to improve the accuracy and consistency of breast tumor segmentation, leading to significant improvements in medical imaging and breast cancer detection and treatment. This study enhances breast cancer segmentation in medical imaging using CAD systems. Combining shape-guided segmentation (SGS) and M3D-neural cellular automata (M3D-NCA) is a hybrid approach that improves performance and computational efficiency by dealing with complex data and not having enough training data. The approach also reduces computing time and improves training efficiency. The study aims to improve breast cancer detection and treatment methods in medical imaging technology.

Leukocyte detection based on convolutional neural network fusion with color Fourier ptychographic microscopy

Abstract In the field of optical microscopic imaging, color Fourier Ptychographic Microscopy (FPM) technology has attracted much attention due to its advantages of large field of view, high resolution, and quantitative phase imaging. In this paper, a color FPM fusion algorithm based on deep learning is proposed in combination with Convolutional Neural Networks (CNN) and applied to leukocyte detection. Firstly, this paper introduces a fusion model of a convolutional neural network based on the traditional color FPM imaging method and fuses low-resolution color images and high-resolution grayscale images through a multilayer convolutional network. This method improves the quality of reconstructed images while reducing the reconstruction time. Secondly, this paper constructs a leukocyte detection dataset by using an improved color FPM reconstruction algorithm and builds a leukocyte detection system based on the YOLOv7 architecture. This paper shows that combining convolutional neural networks with color FPM technology can provide higher-quality reconstructed images in medical imaging and cell detection, which provides strong technical support for digital pathology and medical diagnosis.

Computer-aided diagnosis of pituitary microadenoma on dynamic contrast-enhanced MRI based on spatio-temporal features

Computer-aided diagnosis (CAD) of pituitary microadenoma (PM) can assist doctors in decision-making, leading to improved lesion detection rates and diagnostic accuracy. However, the performance of existing CAD methods for PM detection has been hindered by the difficulty in obtaining high-quality segmentation results. This is primarily due to the small size of PM lesions and the relatively low resolution of Magnetic Resonance Imaging (MRI) images. To address these challenges, this paper proposes a new medical image detection and segmentation model based on spatio-temporal information. The proposed model aims to addresses the disease classification of PM by designing a network module based on multi-scale feature fusion. This module ensures comprehensive extraction of target semantic information while retaining clear spatial information, achieving classification from dynamic contrast-enhanced MRI(DCE-MRI) to identify positive PM samples. For the lesion segmentation of PM, after ROI Align alignment, the model further adds a semantic segmentation module named Dual-path Semantic Segmentation Module (DSSM) behind the mask head and classification head. This module captures more precise spatio-temporal semantic information, reducing accuracy loss and achieving pituitary segmentation. Finally, leveraging the results of pituitary detection, a feature pyramid network (FPN) layer is redesigned named Reuse Underlying Information Module (RUIM) to reuse low-level information, enhancing the detection capability for PM and thus achieving precise object detection and segmentation. The proposed model achieves an accuracy of 97.10% for PM, mAP of 50.24%, which is superior to multiple representative deep models for medical data. The code is available at https://github.com/BUCT-IUSRC/Research__PM-CAD.

Evaluating the Applicability of NaI(Tl) Detectors for Medical Imaging and Radiation Therapy

Evaluating the Applicability of NaI(Tl) Detectors for Medical Imaging and Radiation Therapy

Discrepancy-based diffusion models for lesion detection in brain MRI

Diffusion probabilistic models (DPMs) have exhibited significant effectiveness in computer vision tasks, particularly in image generation. However, their notable performance heavily relies on labelled datasets, which limits their application in medical images due to the associated high-cost annotations. Current DPM-related methods for lesion detection in medical imaging, which can be categorized into two distinct approaches, primarily rely on image-level annotations. The first approach, based on anomaly detection, involves learning reference healthy brain representations and identifying anomalies based on the difference in inference results. In contrast, the second approach, resembling a segmentation task, employs only the original brain multi-modalities as prior information for generating pixel-level annotations. In this paper, our proposed model – discrepancy distribution medical diffusion (DDMD) – for lesion detection in brain MRI introduces a novel framework by incorporating distinctive discrepancy features, deviating from the conventional direct reliance on image-level annotations or the original brain modalities. In our method, the inconsistency in image-level annotations is translated into distribution discrepancies among heterogeneous samples while preserving information within homogeneous samples. This property retains pixel-wise uncertainty and facilitates an implicit ensemble of segmentation, ultimately enhancing the overall detection performance. Thorough experiments conducted on the BRATS2020 benchmark dataset containing multimodal MRI scans for brain tumour detection demonstrate the great performance of our approach in comparison to state-of-the-art methods.

Brain tumor detection using a MobileNetV2-SSD model with modified feature pyramid network levels

Brain tumors, a subset of these malignancies, demand accurate and efficient diagnosis. Traditional methods use non-invasive medical imaging like magnetic resonance imaging (MRI) and computed tomography (CT). Although necessary for diagnosis, manual brain MRI picture segmentation is tedious and time-consuming. Using deep learning is a promising solution. This study proposes an innovative approach for brain tumor detection, focusing on meningioma tumors. Utilizing threshold-based segmentation, the MobileNetV2 architecture, a modified feature pyramid network (FPN), and single shot MultiBox detector (SSD), our model achieves precise localization and object detection. Pre-processing techniques such as grayscale conversion, histogram equalization, and Gaussian filtering enhance the MRI image quality. Morphological operations and thresholding facilitate tumor segmentation. Data augmentation and a meticulous dataset division aid in model generalization. The architecture combines MobileNetV2 as a feature extractor, SSD for object detection, and FPN for detecting small objects. Modifications, including lowering the minimum FPN level, enhance small object detection accuracy. The proposed model achieved a recall value of around 98% and a precision value of around 89%. Additionally, the proposed model achieved approximately 93% on both the dice similarity coefficient (DSC) value and the index of similarity. Based on the promising results, our research holds significant advancements for the field of medical imaging and tumor detection.

Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images-Nevus and Melanoma.

Automated region of interest detection in histopathological image analysis is a challenging and important topic with tremendous potential impact on clinical practice. The deep learning methods used in computational pathology may help us to reduce costs and increase the speed and accuracy of cancer diagnosis. We started with the UNC Melanocytic Tumor Dataset cohort which contains 160 hematoxylin and eosin whole slide images of primary melanoma (86) and nevi (74). We randomly assigned 80% (134) as a training set and built an in-house deep learning method to allow for classification, at the slide level, of nevi and melanoma. The proposed method performed well on the other 20% (26) test dataset; the accuracy of the slide classification task was 92.3% and our model also performed well in terms of predicting the region of interest annotated by the pathologists, showing excellent performance of our model on melanocytic skin tumors. Even though we tested the experiments on a skin tumor dataset, our work could also be extended to other medical image detection problems to benefit the clinical evaluation and diagnosis of different tumors.

Self-supervised Domain Adaptation with Significance-Oriented Masking for Pelvic Organ Prolapse detection

Pelvic Organ Prolapse (POP) is a common disease in middle-aged and elderly women. The detection of POP is a challenging task, and using deep learning for detection has its practical significance. However, medical image detection tasks always face many problems, i.e., small sample size, data imbalance, and unobvious pathological characteristics. In this paper, we propose a new training framework, called self-supervised Domain Adaptation with Significance-Oriented Masking (DASOM), to address these problems and improve the performance of POP intelligent detection. DASOM includes a new pre-training process based on the masked image modeling task, and redesigns the masking strategy, bringing the local induction capability required for detection to the model. Meanwhile, we also adopt the data process method fitting the pelvic floor ultrasonic dataset to effectively solve the problem of data shortage and imbalance. Extensive experimental results and analysis confirm that the proposed method significantly improves the performance and reliability of POP detection.

Real-Time Object Detection in Medical Imaging Using YOLO Models for Kidney Stone Detection

Real-Time Object Detection in Medical Imaging Using YOLO Models for Kidney Stone Detection

From single to universal: tiny lesion detection in medical imaging

Accurate and automatic detection of tiny lesions in medical imaging plays a critical role in comprehensive cancer diagnosis, staging, treatment, follow-up, and prognosis. Numerous deep learning (DL) based studies have focused on single lesions, providing highly sensitive identification and precise localization. On the other hand, some recent studies have started to concentrate on whole-body lesions, as they could provide systemic clinical support. This paper presents a single-to-universal review of DL studies on tiny lesion detection in medical imaging, with a particular emphasis on detection models and techniques, as well as the data-related aspects such as modality, dimension, and dataset. A wide range of tasks are covered, including traditional single lesion detection tasks such as lung nodules, breast masses, thyroid nodules, and diseased lymph nodes, as well as the emerging task of universal lesion detection. Moreover, the paper provides in-depth analysis and discussion, with the hope of inspiring future research endeavors.

In Situ Growth of Lead‐Free Double Perovskite Micron Sheets in Polymethyl Methacrylate for X‐Ray Imaging

AbstractPb‐free double‐perovskite (DP) scintillators are highly promising candidates for X‐ray imaging because of their superior optoelectronic properties, low toxicity, and high stability. However, practical applications require Pb‐free DP crystals to be ground and mixed with polymers to produce scintillator films. Grinding can compromise film uniformity and optical properties, thereby affecting imaging resolution. In this study, an in situ fabrication strategy is proposed to facilitate the crystalline growth of Pb‐free Cs2AgInxBi1‐xCl6 micron sheets in polymethyl methacrylate in a single step. By adjusting the In3+/Bi3+ ratio, Cs2AgIn0.9Bi0.1Cl6/PMMA composite films (CFs) with excellent scintillation properties are obtained, including a light yield of up to 32000 photons per MeV and an X‐ray detection limit of 87 nGyairs−1. This strategy also enabled the production of large Cs2AgIn0.9Bi0.1Cl6/PMMA CFs, which demonstrated favorable flexibility and stability, fabricating products with advanced eligibility for commercial applications. The CFs exhibited outstanding performances in X‐ray imaging, producing high‐resolution structures and providing a new avenue for the development of Pb‐free DP materials in fields such as medical imaging and safety detection.

Advancing medical imaging with GAN-based anomaly detection

Anomaly detection in medical imaging is a complex challenge, exacerbated by limited annotated data. Recent advancements in generative adversarial networks (GANs) offer potential solutions, yet their effectiveness in medical imaging remains largely uncharted. We conducted a targeted exploration of the benefits and constraints associated with GAN-based anomaly detection techniques. Our investigations encompassed experiments employing eight anomaly detection methods on three medical imaging datasets representing diverse modalities and organ/tissue types. These experiments yielded notably diverse results. The results exhibited significant variability, with metrics spanning a wide range (area under the curve (AUC): 0.475-0.991; sensitivity: 0.17-0.98; specificity: 0.14-0.97). Furthermore, we offer guidance for implementing anomaly detection models in medical imaging and anticipate pivotal avenues for future research. Results unveil varying performances, influenced by factors like dataset size, anomaly subtlety, and dispersion. Our findings provide insights into the complex landscape of anomaly detection in medical imaging, offering recommendations for future research and deployment.

Deep learning for MRI lesion segmentation in rectal cancer.

Rectal cancer (RC) is a globally prevalent malignant tumor, presenting significant challenges in its management and treatment. Currently, magnetic resonance imaging (MRI) offers superior soft tissue contrast and radiation-free effects for RC patients, making it the most widely used and effective detection method. In early screening, radiologists rely on patients' medical radiology characteristics and their extensive clinical experience for diagnosis. However, diagnostic accuracy may be hindered by factors such as limited expertise, visual fatigue, and image clarity issues, resulting in misdiagnosis or missed diagnosis. Moreover, the distribution of surrounding organs in RC is extensive with some organs having similar shapes to the tumor but unclear boundaries; these complexities greatly impede doctors' ability to diagnose RC accurately. With recent advancements in artificial intelligence, machine learning techniques like deep learning (DL) have demonstrated immense potential and broad prospects in medical image analysis. The emergence of this approach has significantly enhanced research capabilities in medical image classification, detection, and segmentation fields with particular emphasis on medical image segmentation. This review aims to discuss the developmental process of DL segmentation algorithms along with their application progress in lesion segmentation from MRI images of RC to provide theoretical guidance and support for further advancements in this field.

Enhanced object detection in pediatric bronchoscopy images using YOLO-based algorithms with CBAM attention mechanism

Background and ObjectiveBronchoscopy is a widely used diagnostic and therapeutic procedure for respiratory disorders such as infections and tumors. However, visualizing the bronchial tubes and lungs can be challenging due to the presence of various objects, such as mucus, blood, and foreign bodies. Accurately identifying the anatomical location of the bronchi can be quite challenging, especially for medical professionals who are new to the field. Deep learning-based object detection algorithms can assist doctors in analyzing images or videos of the bronchial tubes to identify key features such as the epiglottis, vocal cord, and right basal bronchus. This study aims to improve the accuracy of object detection in bronchoscopy images by integrating a YOLO-based algorithm with a CBAM attention mechanism. MethodsThe CBAM attention module is implemented in the YOLO-V7 and YOLO-V8 object detection models to improve their object identification and classification capabilities in bronchoscopy images. Various YOLO-based object detection algorithms, such as YOLO-V5, YOLO-V7, and YOLO-V8 are compared on this dataset. Experiments are conducted to evaluate the performance of the proposed method and different algorithms. ResultsThe proposed method significantly improves the accuracy and reliability of object detection for bronchoscopy images. This approach demonstrates the potential benefits of incorporating an attention mechanism in medical imaging and the benefits of utilizing object detection algorithms in bronchoscopy. In the experiments, the YOLO-V8-based model achieved a mean Average Precision (mAP) of 87.09% on the given dataset with an Intersection over Union (IoU) threshold of 0.5. After incorporating the Convolutional Block Attention Module (CBAM) into the YOLO-V8 architecture, the proposed method achieved a significantly enhanced mAP0.5 and mAP0.5:0.95 of 88.27% and 55.39%, respectively. ConclusionsOur findings indicate that by incorporating a CBAM attention mechanism with a YOLO-based algorithm, there is a noticeable improvement in object detection performance in bronchoscopy images. This study provides valuable insights into enhancing the performance of attention mechanisms for object detection in medical imaging.

A Bayesian network for simultaneous keyframe and landmark detection in ultrasonic cine

Accurate landmark detection in medical imaging is essential for quantifying various anatomical structures and assisting in diagnosis and treatment planning. In ultrasound cine, landmark detection is often associated with identifying keyframes, which represent the occurrence of specific events, such as measuring target dimensions at specific temporal phases. Existing methods predominantly treat landmark and keyframe detection as separate tasks without harnessing their underlying correlations. Additionally, owing to the intrinsic characteristics of ultrasound imaging, both tasks are constrained by inter-observer variability, leading to potentially higher levels of uncertainty. In this paper, we propose a Bayesian network to achieve simultaneous keyframe and landmark detection in ultrasonic cine, especially under highly sparse training data conditions. We follow a coarse-to-fine landmark detection architecture and propose an adaptive Bayesian hypergraph for coordinate refinement on the results of heatmap-based regression. In addition, we propose Order Loss for training bi-directional Gated Recurrent Unit to identify keyframes based on the relative likelihoods within the sequence. Furthermore, to exploit the underlying correlation between the two tasks, we use a shared encoder to extract features for both tasks and enhance the detection accuracy through the interaction of temporal and motion information. Experiments on two in-house datasets (multi-view transesophageal and transthoracic echocardiography) and one public dataset (transthoracic echocardiography) demonstrate that our method outperforms state-of-the-art approaches. The mean absolute errors for dimension measurements of the left atrial appendage, aortic annulus, and left ventricle are 2.40 mm, 0.83 mm, and 1.63 mm, respectively. The source code is available at github.com/warmestwind/ABHG.

A review of deep learning and Generative Adversarial Networks applications in medical image analysis

Nowadays, computer-aided decision support systems (CADs) for the analysis of images have been a perennial technique in the medical imaging field. In CADs, deep learning algorithms are widely used to perform tasks like classification, identification of patterns, detection, etc. Deep learning models learn feature representations from images rather than handcrafted features. Hence, deep learning models are quickly becoming the state-of-the-art method to achieve good performances in different computer-aided decision-support systems in medical applications. Similarly, deep learning-based generative models called Generative Adversarial Networks (GANs) have recently been developed as a novel method to produce realistic-looking synthetic data. GANs are used in different domains, including medical imaging generation. The common problems, like class imbalance and a small dataset, in healthcare are well addressed by GANs, and it is a leading area of research. Segmentation, reconstruction, detection, denoising, registration, etc. are the important applications of GANs. So in this work, the successes of deep learning methods in segmentation, classification, cell structure and fracture detection, computer-aided identification, and GANs in synthetic medical image generation, segmentation, reconstruction, detection, denoising, and registration in recent times are reviewed. Lately, the review article concludes by raising research directions for DL models and GANs in medical applications.

Mn(II)-Based Metal Halide with Near-Unity Quantum Yield for White LEDs and High-Resolution X-ray Imaging.

Metal halides have drawn great interest as luminescent materials and scintillators due to their outstanding optical properties. Exploring new types of phosphors with easy production processes, excellent photophysical properties, high light yields, and environmentally friendly compositions is crucial and quite challenging. Herein, a novel Mn(II)-based metal halide (4-BTP)2MnBr4 was produced using a facile solvent evaporation method, which exhibited a strong green emission peaking at 524 nm from the d-d transition of tetrahedral-coordinated Mn2+ ion and a near-unity quantum yield. The prepared white light-emitting diode device has a wide color gamut of 100.7% NTSC with CIE chromaticity coordinates of (0.32, 0.32). In addition, (4-BTP)2MnBr4 demonstrates excellent characteristics in X-ray scintillation, including a high light yield of 98 000 photons/MeV, a sensitive detection limit of 37.4 nGy/s, excellent resistance to radiation damage, and successful demonstration of X-ray imaging with high resolution at 21.3 lp/mm, revealing the potential for application in diagnostic X-ray medical imaging and industry radiation detection.

Metal Halide Perovskites for Direct X‐Ray Detection in Medical Imaging: To Higher Performance

AbstractThis review discusses the utilization of metal halide perovskite (MHP) materials in X‐ray direct imaging detectors for medical application. Compared to traditional semiconductors, MHP has multiple advantages including high linear attenuation coefficient, low exciton binding energy, long carrier diffusion length, and high carrier mobility. These ascendancies allow for low‐dose and high‐resolution medical imaging. Apartment from a historical overview of the develop‐X‐ray direct imaging detectors and their performance indicators, this review specifically focuses on the development and innovation of X‐ray direct imaging detectors using MHP materials. The article concludes by identifying existing challenges and discussing the potential application of perovskite X‐ray direct imaging detectors in the medical industry.

Revolutionizing tumor detection and classification in multimodality imaging based on deep learning approaches: Methods, applications and limitations.

The emergence of deep learning (DL) techniques has revolutionized tumor detection and classification in medical imaging, with multimodal medical imaging (MMI) gaining recognition for its precision in diagnosis, treatment, and progression tracking. This review comprehensively examines DL methods in transforming tumor detection and classification across MMI modalities, aiming to provide insights into advancements, limitations, and key challenges for further progress. Systematic literature analysis identifies DL studies for tumor detection and classification, outlining methodologies including convolutional neural networks (CNNs), recurrent neural networks (RNNs), and their variants. Integration of multimodality imaging enhances accuracy and robustness. Recent advancements in DL-based MMI evaluation methods are surveyed, focusing on tumor detection and classification tasks. Various DL approaches, including CNNs, YOLO, Siamese Networks, Fusion-Based Models, Attention-Based Models, and Generative Adversarial Networks, are discussed with emphasis on PET-MRI, PET-CT, and SPECT-CT. The review outlines emerging trends and future directions in DL-based tumor analysis, aiming to guide researchers and clinicians toward more effective diagnosis and prognosis. Continued innovation and collaboration are stressed in this rapidly evolving domain. Conclusions drawn from literature analysis underscore the efficacy of DL approaches in tumor detection and classification, highlighting their potential to address challenges in MMI analysis and their implications for clinical practice.