A set of 63 wheat genotypes were charac-terized for leaf & stem rusts and spot blotch diseas-es resistance following detached leaf technique dur-ing 2012–13. Leaf segments of resistant genotypes were compared with susceptible cultivars i.e., Agra Local (leaf rust), Lal Bahabur (stem rust) and spot blotch (Sonalika) in the presence of their respective virulent pathotypes. In case of leaf rust, genotypes viz., K-9533 (Naina) (14.33), EGPSN 137 (13.76) and EGPSN 153 (13.66) were found resistant when tested against 21R55 (104-2) while, EGPSN-137, EGPSN-160, Golden Halna, K-7410 and K-9533 (Naina) were found promising against leaf rust pathotype 121R63-1 (77-5). In case of stem rust pathotype 62G29, genotypes i.e., EGPSN-157 (14.66, 13.66), EGPSN-148 (13.00, 12.66), Halna (13.33, 12.33), K-65 (13, 13.33), K-9162 (13.33, 12.66) and Raj-3765 (13.00, 12.41) were found promising based on latent as well as incubation pe-riod under artificial epiphytotic conditions Geno-types i.e., EGPSN-135, EGPSN-137, EGPSN-152, EGPSN-159, EGPSN-164, Golden Halna and K-9851(Sona) were found promising for spot blotch. Genotype viz., EGPSN-137, EGPSN-153, EGPSN-164, K-68 and DBW-17 showed comparatively longer latent and incubation period and less disease severity against all three diseases compared to sus-ceptible cultivars. Hence, these genotypes may be included as parental lines in breeding program for developing multiple disease resistant cultivars in future.