We are in the midst of a renaissance in the study and interpretation of fundamental quantum mechanics, from quantum coherence and quantum entanglement to the quantum measurement process. This stems partly from the impressive advances in experimental techniques that are making yesterday's gedanken experiment today's reality. Another reason quantum coherence and entanglement have come to the forefront is the emerging and tantalizing field of quantum information science. The ability to store information in quantum systems may someday yield devices that process quantum superpositions of inputs in parallel or improve communication through the `wiring' implicit in quantum entanglement. Indeed, quantum computing has the remote prospect of revolutionizing the way we store and process information. This has become particularly important in the face of impending limits on the miniaturization of conventional computers due to quantum effects. Of course, all real systems face limits imposed by decoherence, or the environmentally-induced destruction of quantum coherence. Here, superpositions of quantum states suddenly become probabilistic mixtures of states when they interact with the environment or when the system parameters are fluctuating. Decoherence theory is commonly interpreted as a way to quantify the elusive boundary between quantum and classical worlds and almost always precludes the existence of complex quantum superpositions, except at extremely short time scales. In practice, it is very important to study how decoherence appears in particular quantum systems and try to fight against it. In this special issue of Journal of Optics B: Quantum and Semiclassical Optics, we highlight recent results in the exciting area of quantum coherence and entanglement, including generating interesting and complex quantum states, characterizing coherence and entanglement in these systems, and triumphing over relevant decoherence processes. We hope this issue will not only act as a bookmark in the ongoing study of fundamental quantum mechanics, but will also help guide the rapid developments in quantum information science.