Desirable Goal Research Articles

Smart Nanocarriers for the Treatment of Retinal Diseases.

Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand as the leading causes of irreversible vision impairment and blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to the presence of complex ocular barriers and elimination mechanisms. Over time, various approaches have been developed to fabricate drug delivery systems for improving retinal therapy including virus vectors, lipid nanoparticles, and polymers. However, conventional nanocarriers encounter issues related to the controllability, efficiency, and safety in the retina. Therefore, the development of smart nanocarriers for effective or more invasive long-term treatment remains a desirable goal. Recently, approaches have surfaced for the intelligent design of nanocarriers, leveraging specific responses to external or internal triggers and enabling multiple functions for retinal therapy such as topical administration, prolonged drug release, and site-specific drug delivery. This Review provides an overview of prevalent retinal pathologies and related pharmacotherapies to enhance the understanding of retinal diseases. It also surveys recent developments and strategies employed in the intelligent design of nanocarriers for retinal disease. Finally, the challenges of smart nanocarriers in potential clinical retinal therapeutic applications are discussed to inspire the next generation of smart nanocarriers.

Implementation of the Small Fishers Empowerment Policy in Tikke Village, Tikke Raya District, Pasangkayu Regency

Fishermen still want to live in poverty because of their own desire to experience life itself. Formulation of the problem in the journal How to Implement the Empowerment Policy for Small Fishermen in Tikke Village, Tikke Raya District, research benefits, theoretical benefits and practical benefits. The type of research used in the research is qualitative research. The results of this research are that policy implementation is a crucial stage in the public policy process. . A policy or program must be implemented to have the desired impact or goal. Policy implementation is seen in a broad sense as a public administration tool where actors, organizations, procedures, related parties and resources are organized together to carry out policies to achieve the desired impact or goal. The conclusion of this research is that based on the research results, it can be concluded that the implementation of the Small Fishers Empowerment Policy in Tikke Village, Tikke Raya District, Pasangkayu Regency was found. This did not work well because 4 aspects, namely Communication, Resources, Disposition and Bureaucratic Structure, were used as tools in Edward III's theory. So it can be concluded that the policy has not worked optimally as expected. Therefore, it is necessary to improve fishing equipment such as rumpong.

Validation and genetic parameters of the X-ray method for phenotyping individual feed intake in Atlantic salmon

Feed efficiency is a highly desirable breeding goal trait as it can potentially reduce the relative economic cost of feed and concurrently reduce the environmental footprint of fish production. However, recording feed intake is a bottleneck in Atlantic salmon production. We recorded feed intake in 700 Atlantic salmon parr from 34 full sibling families using the X-ray method, where fish were fed feed containing radio-opaque beads and subsequently X-ray imaged one time after a full meal corresponding to the daily ration. In parallel, we cultured siblings from the same 35 families in duplicate family tanks of 25 individuals per tank and recorded the daily feed intake of each family at the tank level, which is known as the gold standard tank-based method. The heritability estimate for daily feed intake in Atlantic salmon using the X-ray method was significantly different from zero (0.19 ± 0.06) and was genetically correlated to growth-related traits (rg = 0.48–0.81). Daily feed intake at the family level with the X-ray method was highly genetically correlated to the daily feed intake traits using the tank-based feeding method at 0.78–0.82, depending on whether the comparison was made at a common time, common weight, or cumulative feed intake for the entire period. Whilst the X-ray method holds promise for research on the genetic background of feed intake and feed efficiency, more studies are needed to investigate the feasibility during the sea phase of Atlantic salmon production.

Dead people aren’t resilient

Resilience, achieving rapid recovery so that society can bounce back from a disaster, is a desirable goal, but sometimes the focus should be only on safety. The 2023 Turkey/Syria earthquake illustrates the case where limited resources should be prioritized on safety, that is, the collapse prevention performance objective, rather than the significantly more expensive goal of post-earthquake functionality.

Prediction and explainability in AI: Striking a new balance?

The debate regarding prediction and explainability in artificial intelligence (AI) centers around the trade-off between achieving high-performance accurate models and the ability to understand and interpret the decisionmaking process of those models. In recent years, this debate has gained significant attention due to the increasing adoption of AI systems in various domains, including healthcare, finance, and criminal justice. While prediction and explainability are desirable goals in principle, the recent spread of high accuracy yet opaque machine learning (ML) algorithms has highlighted the trade-off between the two, marking this debate as an inter-disciplinary, inter-professional arena for negotiating expertise. There is no longer an agreement about what should be the “default” balance of prediction and explainability, with various positions reflecting claims for professional jurisdiction. Overall, there appears to be a growing schism between the regulatory and ethics-based call for explainability as a condition for trustworthy AI, and how it is being designed, assimilated, and negotiated. The impetus for writing this commentary comes from recent suggestions that explainability is overrated, including the argument that explainability is not guaranteed in human healthcare experts either. To shed light on this debate, its premises, and its recent twists, we provide an overview of key arguments representing different frames, focusing on AI in healthcare.

Perceptions of Afghan EFL undergraduate learners towards autonomous learning

Autonomous learning is extensively acknowledged as a desirable goal in undergraduate education as it is found to comply with learner-centered approaches and enable learners to pursue life-long learning. However, very few empirical researchers have closely examined the actual practices of autonomous learning in the Afghan context. Therefore, the main purpose of the current research project was to investigate EFL undergraduates’ perceptions of autonomous learning, strategies used for improving language proficiency, and the extent to of these strategies are deployed. With regard to achieving these objectives, a mixed-method approach was adopted. The quantitative data were analyzed through SPSS v24 by conducting descriptive and inferential statistics. The findings revealed that EFL learners had positive perspectives on autonomous learning and were ready to take the initiative in autonomous learning. Qualitative analysis of nine EFL students’ interviews revealed that they have to create learning goals for their learning, assess themselves for controlling their learning, and take part in inside and outside classroom activities to improve their language proficiency. This case study concludes that the findings cannot be generalized to other contexts, and the study makes an original contribution to understanding the promotion of autonomous learning at Kandahar University. In addition, this study offers practical implications for policymakers and lecturers who are interested in adopting autonomous learning as a worthwhile educational goal.

Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying─Comparison of In Vitro and In Vivo Performance.

Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable from an economic and ecological perspective but also limited to thermostable active pharmaceutical ingredients (APIs). A potential technology shift from spray-drying to hot-melt extrusion at later stages of drug product development is a desirable goal, however bearing the risk of insufficient comparability of the in vitro and in vivo performance of the final dosage form. Hot-melt extrusion was performed using API/polymer/surfactant mixtures with hydroxypropyl methylcellulose acetate succinate (HPMCAS) as the polymer and evaluated regarding the extrudability of binary and ternary amorphous solid dispersions (ASDs). Additionally, spray-dried ASDs were produced, and solid-state properties were compared to the melt-extruded ASDs. Tablets were manufactured of a ternary ASD lead candidate comparing their in vitro dissolution and in vivo performance. The extrudability of HPMCAS was improved by adding a surfactant as plasticizer, thereby lowering the high melt-viscosity. d-α-Tocopheryl polyethylene glycol succinate (TPGS) as surfactant showed the most similar solid-state properties between spray-dried and extruded ASDs compared to those of poloxamer 188 and sodium dodecyl sulfate. The addition of TPGS, however, barely affected API/polymer interactions. The in vitro dissolution experiment and in vivo dog study revealed a higher drug release of tablets manufactured from the spray-dried ASD compared to the melt-extruded ASD; this was attributed to the different particle size. We could further demonstrate that the drug release can be controlled by adjusting the particle size of melt-extruded ASDs leading to a similar release profile compared to tablets containing the spray-dried dispersion, which confirmed the feasibility of a technology shift from spray-drying to HME upon drug product development.

Engineering a Hybrid Ti6Al4V-Based System for Responsive and Consistent Osteogenesis.

As the aging population increases worldwide, the incidence of musculoskeletal diseases and the need for orthopedic implants also arise. One of the most desirable goals in orthopedic reconstructive therapies is de novo bone formation. Yet, reproducible, long-lasting, and cost-effective strategies for implants that strongly induce osteogenesis are still in need. Nanoengineered titanium substrates (and their alloys) are among the most used materials in orthopedic implants. Although having high biocompatibility, titanium alloys hold a low bioactivity profile. The osteogenic capacity and osseointegration of Ti-based implantable systems are limited, as they critically depend on the body-substrate interactions defined by blood proteins adsorbed into implant surfaces that ultimately lead to the recruitment, proliferation, and differentiation of mesenchymal stem cells (MSCs) to comply bone formation and regeneration. In this work, a hybrid Ti6Al4V system combining micro- and nanoscale modifications induced by hydrothermal treatment followed by functionalization with a bioactive compound (fibronectin derived from human plasma) is proposed, aiming for bioactivity improvement. An evaluation of the biological activity and cellular responses in vitro with respect to bone regeneration indicated that the integration of morphological and chemical modifications into Ti6Al4V surfaces induces the osteogenic differentiation of MSCs to improve bone regeneration by an enhancement of mineral matrix formation that accelerates the osseointegration process. Overall, this hybrid system has numerous competitive advantages over more complex treatments, including reproducibility, low production cost, and potential for improved long-term maintenance of the implant.

Infant feeding-a scoping review for Nordic Nutrition Recommendations 2023.

The 2012 edition of the Nordic Nutrition Recommendations (NNR) included recommendations on breastfeeding, based on the most recent guidelines and recommendations from major national food and health authorities and organizations, systematic reviews, and some original research. For NNR 2023, the scope has been expanded and also includes formula feeding and the introduction of solid food. The main focus in this scoping review is on infants aged 0-12 months but also considers parts both before and beyond the first year, as the concept of 'the first 1000 days' emphasizes the importance of factors during pregnancy and the first 2 years of life for immediate and later health: physical as well as emotional and mental health. Breastmilk is the natural and sustainable way to feed an infant during the first months of life. Numerous studies have indicated immediate as well as long-term beneficial effects of breastfeeding on health for both the infant and the breastfeeding mother, and from a public health perspective, it is therefore important to protect, support, and promote breastfeeding. For full-term, normal weight infants, breastmilk is sufficient as the only form of nutrition for the first 6 months, except for vitamin D that needs to be given as supplement. The World Health Organization (WHO) and several other authoritative bodies therefore recommend exclusive breastfeeding during the first 6 months. Starting solids at about 6 months is necessary for both nutritional and developmental reasons. According to the European Food Safety Authority (EFSA) and the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN), solid foods are safe to give from 4 months although exclusive breastfeeding until 6 months is the desirable goal. Breastfeeding can continue together with complementary foods as long as it is mutually desired by the mother and child. If breastfeeding is not enough or for some reason discontinued before the infant is 4 months of age, the infant should be fed infant formula, and, when possible, breastfeeding should be continued alongside the formula feeding. If the infant is 4 months or older, starting with solids together with continued breastfeeding and/or formula feeding is an option. Infant formulas have been developed for infants who are not breastfed or do not get enough breastmilk. Home-made formula should not be given.

Two-dimensional coherent electronic spectrometer with switchable multi-color configurations.

Broadband implementation of two-dimensional electronic spectroscopy (2DES) is a desirable goal for numerous research groups, yet achieving it presents considerable challenges. An effective strategy to mitigate these challenges is the utilization of two-color approaches, effectively broadening the spectral bandwidth accessible with 2DES. Here, we present a simple approach to include multi-color configurations based on adjustable mirror mounts. This enables seamless toggling between single-color, two-color, and transient 2DES within the same spectroscopic apparatus, which is benchmarked on two common laser dyes, Rhodamine 6G and Nile blue. Upon mixing the dyes, single-color 2DES shows overlapping signals, whereas a high selectivity toward Nile blue responses is maintained in two-color and transient 2DES, owing to the fully resonant excitation that is spectrally shifted relative to the detection window. This method is readily implemented in other setups with similar experimental layouts and can be used as a simple solution to overcome existing bandwidth limitations. With the inclusion of transient 2DES, additional insights into excited-state processes can be gained due to its increased sensitivity toward excited-state coherences.

Pengaruh Motivasi Belajar Terhadap Minat Belajar Siswa Akuntansi Dan Keuangan Lembaga Kelas X SMK Negeri 1 Banjarmasin

Delays in submitting individual assignments often occur due to a lack of learning initiative. Learning motivation can foster enthusiasm for learning so that students are encouraged to carry out learning activities and provide passion or enthusiasm for learning. Interest is an initial movement so that students have an interest in the material being taught which can be used to achieve the desired learning goals. The aims of this research are: (1) to determine students' learning motivation, (2) to determine students' interest in learning, and (3) to determine the influence of learning motivation on students' interest in learning. The method used is causal associative with a quantitative approach. The population of this study was 141 students of class x accounting and finance at SMK Negeri 1 Banjarmasin. The analysis used is simple linear regression. Based on the results of the regression test, it can be shown with a level of significance or probability that there is a significant influence between the variable learning motivation on interest in learning.

Pengujian Perangkat Lunak Metode Black Box Pada Aplikasi Sistem Pakar Pola Latihan dan Asupan Makanan

Software testing is an important part of expert system application development. This software testing aims to ensure optimal performance and functionality of this application, where the application must be able to run according to a previously created design and application testing must ensure that the program is free from errors.
 The testing methodology includes a series of steps designed to identify potential bugs, ensure proper integration between components, and verify that the application meets functional and non-functional requirements. Testing is carried out using various functional testing scenarios.
 Test results show that this application is able to provide accurate and relevant solutions in the context of exercise patterns to achieve the desired body goals. Additionally, application performance is tested to ensure fast response and good user experience, even under high load conditions. The findings from this test provide confidence that the "Exercise Pattern and Food Intake Expert System" is ready for use by end users.

Predictors of lack of glycemic control in persons with type 2 diabetes

BackgroundProfessional guidelines recommend an HbA1c < 7% for most people with diabetes and < 8.5% for those with relaxed glycemic goals. However, many people with type 2 diabetes mellitus (T2DM) are unable to achieve the desired HbA1c goal. This study evaluated factors associated with lack of improvement in HbA1c over 3 years.MethodsAll patients with T2DM treated within a major academic healthcare system during 2015–2020, who had at least one HbA1c value > 8.5% within 3 years from their last HbA1c were included in analysis. Patients were grouped as improved glycemic control (last HbA1c ≤ 8.5%) or lack of improvement (last HbA1c > 8.5%). Multivariate logistic regression analysis was performed to assess independent predictors of lack of improvement in glycemic control.ResultsOut of 2,232 patients who met the inclusion criteria, 1,383 had an improvement in HbA1c while 849 did not. In the fully adjusted model, independent predictors of lack of improvement included: younger age (odds ratio, 0.89 per 1-SD [12 years]; 95% CI, 0.79–1.00), female gender (1.30, 1.08–1.56), presence of hypertension (1.29, 1.08–1.55), belonging to Black race (1.32, 1.04–1.68, White as reference), living in low income area (1.86,1.28–2.68, high income area as reference), and insurance coverage other than Medicare (1.32, 1.05–1.66). Presence of current smoking was associated with a paradoxical improvement in HbA1c (0.69, 0.47—0.99). In a subgroup analysis, comparing those with all subsequent HbA1c values > 8.5% (N = 444) to those with all subsequent HbA1c values < 8.5% (N = 341), similar factors were associated with lack of improvement, but smoking was no longer significant.ConclusionWe conclude that socioeconomic factors like race, type of insurance coverage and living in low-income areas are associated with lack of improvement in HbA1c over a period of 3-years in people with T2DM. Intervention strategies focused on low-income neighborhoods need to be designed to improve diabetes management.

Restorative Justice in Criminal Law Enforcement from a Legal Perspective as a Social Engineering Tool

Restorative justice has emerged as an alternative approach in criminal law enforcement that regards crime as a violation of the relationship between the individual and society, not just as a crime against the state. This study investigates the concept of restorative justice in the context of criminal law enforcement, focusing on the perspective of law as a tool of social engineering. From the point of view of the law as the tool of social engineering, this study explains how restaurative justice is applied in Indonesia in relation to criminal law. The conclusion of this study is that it is necessary to reconstruct the establishment of restorative mechanisms ranging from the stages of mediation, divorce, to rehabilitation and supervision. This research provides an in-depth understanding of the concept of restorative justice in the context of criminal law enforcement, emphasizing the vital role of law as a social engineering tool for achieving desired goals.

Nano‐Au‐decorated hierarchical porous cobalt sulfide derived from ZIF‐67 toward optimized oxygen evolution catalysis: Important roles of microstructures and electronic modulation

AbstractEnhancing both the number of active sites available and the intrinsic activity of Co‐based electrocatalysts simultaneously is a desirable goal. Herein, a ZIF‐67‐derived hierarchical porous cobalt sulfide decorated by Au nanoparticles (NPs) (denoted as HP‐Au@CoxSy@ZIF‐67) hybrid is synthesized by low‐temperature sulfuration treatment. The well‐defined macroporous–mesoporous–microporous structure is obtained based on the combination of polystyrene spheres, as‐formed CoxSy nanosheets, and ZIF‐67 frameworks. This novel three‐dimensional hierarchical structure significantly enlarges the three‐phase interfaces, accelerating the mass transfer and exposing the active centers for oxygen evolution reaction. The electronic structure of Co is modulated by Au through charge transfer, and a series of experiments, together with theoretical analysis, is performed to ascertain the electronic modulation of Co by Au. Meanwhile, HP‐Au@CoxSy@ZIF‐67 catalysts with different amounts of Au were synthesized, wherein Au and NaBH4 reductant result in an interesting “competition effect” to regulate the relative ratio of Co2+/Co3+, and moderate Au assists the electrochemical performance to reach the highest value. Consequently, the optimized HP‐Au@CoxSy@ZIF‐67 exhibits a low overpotential of 340 mV at 10 mA cm–2 and a Tafel slope of 42 mV dec–1 for OER in 0.1 M aqueous KOH, enabling efficient water splitting and Zn–air battery performance. The work here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.

The Web of Life: A Critique of Nature, Wilderness, Gaia and the «Common Household»

A two-word summary of the following article might be «Words matter». It matters whether we conceive of the non-built world as nature, as «wilderness», as Gaia/Mother Earth, or as «our common home». We analyze the emergence of each of these four notions. Nature, by far the most multi-layered of the words, has a complex history rooted in the Greek word phusis. Nature is problematic because of its opposites: supernatural; nurture, culture and civilization. Nature seems to require dualism. Wilderness started out as something terrifying (the realm of the wild beasts), later acquiring a specific American understanding of an area conserved for recreation, of nature partially preserved, all desirable goals inspired by John Muir. In the Scriptures, wilderness becomes filled by promise. Gaia is short for the Gaia hypothesis of Earth as a living, self-regulating organism. It was coined by James Lovelock and Lynn Margulis and discussed critically by Bruno Latour. Compared with the view of the Earth as dead matter, «Gaia» is conducive to respect for all living beings. When it is coupled with Mother Earth, the concept becomes problematic from a feminist point of view. The common home or household stem from the teachings of Pope Francis. Although Laudato si’ is rightly viewed as a prophetic text regarding ecology and spirituality, «common home» implies a domestication of all that lives in a worldview that remains anthropocentric (homes are artefacts). A better concept is the «web of life» of which humankind is a part, but not the master. It is such a decentering that may herald hope for the Earth.

Compact Goal Representation Learning via Information Bottleneck in Goal-Conditioned Reinforcement Learning.

We propose an Information bottleneck (IB) for Goal representation learning (InfoGoal), a self-supervised method for generalizable goal-conditioned reinforcement learning (RL). Goal-conditioned RL learns a policy from reward signals to predict actions for reaching desired goals. However, the policy would overfit the task-irrelevant information contained in the goal and may be falsely or ineffectively generalized to reach other goals. A goal representation containing sufficient task-relevant information and minimum task-irrelevant information is guaranteed to reduce generalization errors. However, in goal-conditioned RL, it is difficult to balance the tradeoff between task-relevant information and task-irrelevant information because of the sparse and delayed learning signals, i.e., reward signals, and the inevitable task-relevant information sacrifice caused by information compression. Our InfoGoal learns a minimum and sufficient goal representation with dense and immediate self-supervised learning signals. Meanwhile, InfoGoal adaptively adjusts the weight of information minimization to achieve maximum information compression with a reasonable sacrifice of task-relevant information. Consequently, InfoGoal enables policy to generate a targeted trajectory toward states where the desired goal can be found with high probability and broadly explores those states. We conduct experiments on both simulated and real-world tasks, and our method significantly outperforms baseline methods in terms of policy optimality and the success rate of reaching unseen test goals. Video demos are available at infogoal.github.io.

An Object-Oriented Approach to the Modular Design of Mechatronic Systems

The design of modern mechatronic systems involves multidisciplinary and high-level integration, creating challenging and complex tasks for industrial designers and engineers. Their development requires intricate interaction between heterogeneous subsystems, and necessitates coordinated trans-sectoral cooperation between mechanical, electronic, and software engineers. Although efforts have been made to create efficient methods to guide the design of mechatronic systems, no existing solutions solve the complexity of design problems experienced during their design. This article, therefore, proposes a structured step-by-step approach to guide the design of mechatronic systems using an object-oriented methodology. Three information streams are employed that flow through the logical layers of a mechatronic system to track requirements and define modular specifications during the design process. The proposed approach benefits those developing mechatronic systems by improving collaboration, minimizing errors, reducing chances of design failure, and helping meet the desired functionality and goal of multidisciplinary integration. To evaluate the proposed approach and demonstrate the practicability of the systematic framework, we present a case study of a library book returning system. Our results highlight the capability of the proposed approach to guarantee top&#x2013;down consistency and traceability of derived specifications among logical layers and contribute to the successful integration of requirements during the design process of mechatronic systems.

Effectiveness of self-awareness training for young adults on improving their professional skills: a Quasi-experimental study

Background: Young adulthood is a productive phase in an individual's life, marked by a shift towards achieving higher academic success and pursuing desired career paths. In this context, awareness of merits and demerits is vital in attaining desired goals. Therefore, the objective of the current study is to evaluate the differences in self-awareness skills among undergraduate students before and after participating in a life skills intervention program. Method: The study used a quasi-experimental design involving 243 students from four private undergraduate colleges. A half-day self-awareness training program was provided using activity-based participatory approaches. Data were collected pre and one-month post-intervention through a semi-structured questionnaire validated by two mental health professionals and three industry experts. Results: Of the 243 participants, 55.55% were female, and 44.44% were male. A significant number of female participants were in the age group of 18 to 20 (Male: 68 (62.96), Female: 113 (83.7), p&lt;0.001) compared to male participants. The life skills intervention significantly enhanced participants' abilities to connect with like-minded individuals (Pre-in: 46.5%, post-in: 52.26%, p&lt;0.01), make new friends (pre-in: 54.32%, post-in: 66.67%, p&lt;0.002), and engage in team interaction (pre-in: 39.09%, post-in: 68.72%, p&lt;0.001). additionally, there were improvements in adopting a positive approach towards tasks (pre-in: 62.14%, post-in: 64.2%, p&lt;0.058) and prioritizing assignments (pre-in: 27.57%, post-in: 53.91%, p&lt;0.001). Conclusions: Our study observed a significant improvement in the domains of harmony, self-belief, adaptability, and discipline post-intervention among students.

Precise arrangement of metal atoms at the interface by a thermal printing strategy.

The kinetics and pathway of most catalyzed reactions depend on the existence of interface, which makes the precise construction of highly active single-atom sites at the reaction interface a desirable goal. Herein, we propose a thermal printing strategy that not only arranges metal atoms at the silica and carbon layer interface but also stabilizes them by strong coordination. Just like the typesetting of Chinese characters on paper, this method relies on the controlled migration of movable nanoparticles between two contact substrates and the simultaneous emission of atoms from the nanoparticle surface at high temperatures. Observed by in situ transmission electron microscopy, a single Fe3O4 nanoparticle migrates from the core of a SiO2 sphere to the surface like a droplet at high temperatures, moves along the interface of SiO2 and the coated carbon layer, and releases metal atoms until it disappears completely. These detached atoms are then in situ trapped by nitrogen and sulfur defects in the carbon layer to generate Fe single-atom sites, exhibiting excellent activity for oxygen reduction reaction. Also, sites' densities can be regulated by controlling the size of Fe3O4 nanoparticle between the two surfaces. More importantly, this strategy is applicable to synthesize Mn, Co, Pt, Pd, Au single-atom sites, which provide a general route to arrange single-atom sites at the interface of different supports for various applications.