The popularity of translucent materials in construction, especially in high-rise buildings, creates challenges for improving approaches to fire safety. Translucent designs have a limited. During a fire, they can quickly heat up, crack or even collapse, which helps the fire to spread to other parts of the building and increases the speed of fire spread. Practical methods and methods of limiting the spread of fire on building facades are considered in the work, including the use of fire eaves, protective screens made of fire-resistant material, limiting the area of the window opening, as well as the use of water irrigation. Water irrigation is an effective method of extinguishing fire and cooling facade elements, but its parameters, such as working pressure, water flow, location, etc., require careful research to achieve maximum efficiency. The purpose of this work is to use the PyroSim software complex to investigate the effectiveness of sprinklers for the protection of transparent structures on the facade of high-rise buildings and to determine their main parameters. With the help of PyroSim, a detailed three-dimensional model was created, which takes into account the complex geometric shapes of the building and the impact of fire protection systems, taking into account the features of translucent facades. In the course of research, structural elements that can affect the spread of fire and smoke are also taken into account, namely the characteristics of materials, fire load, installation of window openings. PyroSim, simulating the spread of a fire, made it possible to take into account heat and smoke flows, convective effects occurring during a fire, as well as the interaction of sprinklers with the heat load. The results of such modeling can be used to optimize the design of fire protection systems and ensure the compliance of building regulations with fire safety issues. In particular, modeling allows you to determine the most effective ways to place sprinklers, taking into account the specific conditions and structural features of the building. Thanks to this, it is possible not only to increase the level of protection of buildings against fires, but also to minimize the costs of installing and maintaining fire systems.