As we reflect on the last 7decades since the first descriptions of modern orthognathic surgery (OGS) by Trauner and Obwegeser, we ponder what the next "game-changers" will be over the upcoming decades. We certainly recognize the prior contributions of Hullihen in 1849 and others in the 1920s and 1930s, and the pioneering work of Tessier, Obwegeser, and Bell in the 1960s and 1970s. Although there have been some changes in osteotomy design, as well as the landmark game-changing introduction of rigid internal fixation in the 1970s and 1980s, many of the more recent major changes have occurred only in the past decade or 2. The use of personalized and precision medicine with virtual surgical planning, and patient-specific implants has been transformational. Certainly, there will be more advances in the realm of diagnosis, surgical techniques and protocols, biomaterials and tissue engineering, and surgeon and patient education. But, as an international group of orthognathic surgeons, we believe that the most significant "next big thing" will be a clinical and research focus on patient-oriented outcomes and an improved quality of life. This will require outcome-driven planning and treatment with function, esthetics, and occlusion as key outcome indicators. Here we identify some shared visions and objectives for OGS with the aim to delineate future advancements to enhance the care of patients with dentofacial deformities. While we have organized the sections to cover key areas, the fundamental concepts include advances in these areas: diagnosis and treatment planning (eg, imaging, virtual surgical planning, artificial intelligence, and point-of-care workflows); materials development (eg, patient-specific implant, three-dimensional printing, tissue engineering, biodegradable implants, bone cements, titanium and magnesium implants, and developmental and regenerative medicine); and patient management (eg, minimally-invasive surgery, clear aligner therapy, temporary anchorage devices, outpatient OGS, age-centered treatment, and augmented reality/virtual reality).