The structural design is a prerequisite for the creation of mechanical equipment. This study focuses on the structural synthesis of epicyclic chains (ECs), and proposes a new topological model and synthesis method of ECs to address the existing research problems (i.e. synthesis dependence on multiple graphic transformations and the generation of pseudo-isomorphism). First, the structural characteristics of ECs are analyzed to explore the relation between their axles, gears, and planet carriers, and the corresponding topological model and the adjacency matrix expression of ECs are provided. Then, the topological elements corresponding to the axles, gears, and gear pairs are added sequentially to the topological graph corresponding to the planet carriers, and the constraints are established based on similarity to inhibit the generation of isomorphism. Finally, all the databases of feasible ECs are obtained through gear loop discrimination. All processes are carried out with computer assistance. The synthesis results of the ECs with 1–3 degrees of freedom and up to 10 components are presented. The logic of this paper is to simplify (or optimize) the synthesis process to improve efficiency of structural synthesis, which will break through the threshold of computing power and provide more possibilities for the design of mechanical equipment.