To meet the needs of a large number of high-altitude meteorological detections, we need to perform fast, high-precision, and high-reliability calibrations of the sensors in the atmospheric detection system (ADS). However, using the traditional method to calibrate the sensor with high precision often takes a lot of time and increases the cost of workforce and material resources. Therefore, a method for realizing fast sensor calibration under the current system hardware conditions is required. A physical field model of Tube–Air–ADS is proposed for the first time, and the transfer function is obtained by combining the system identification, which provides the possibility for dynamic analysis of the calibration system. A Multi-Criteria Adaptive (MCA) PID controller design method is proposed, which provides a new idea for the parameter design of the controller. It controls the amplitude and switching frequency of the controller’s output signal, ensuring the safe and stable operation of the calibration system. Combined with the hardware parameters of the system, we propose the Variable Precision Steady-State Discrimination (VPSSD) method, which can further shorten the calibration time. Comparing and analyzing the current simulation results under Matlab/Simulink, the proposed MCA method, compared with other PID controller design methods, ensures the stable operation of the calibration system. At the same time, compared with the original system, the calibration time is shortened to 47.7%. Combined with the VPSSD method, the calibration time further shortens to 38.7 s.