This study introduces a zero-brine discharge approach, eliminating the necessity for continuous seawater input and brine disposal—major drawbacks in traditional desalination methods. This research’s core is a humidification-dehumidification (HDH) system operating under variable pressures, significantly boosting efficiency. The system comprises two synergistic components: a variable-pressure HDH unit and a desiccant-based moisture extractor utilizing a lithium chloride solution. After freshwater is extracted, the concentrated desiccant cycles through the moisture extractor to absorb atmospheric water vapor, diluting it for reuse and thus completing the desiccant loop. The heat and mass transfer processes were scrutinized through mathematical modeling, and parameters for maximizing the Gain Output Ratio (GOR) were optimized. The results underscore the system’s capacity for sustainable, efficient freshwater production. This methodology offers a feasible solution to challenges in desalination and significantly contributes to alleviating global water scarcity, particularly in coastal areas. Further analysis shows that systematic optimization of key parameters, such as pressure ratios and desiccant temperatures, considerably improves performance metrics. Adjusting the pressure ratio from 1.22, where the GOR peaks at 2.44, to 1.56 directly impacts system efficiency. Modulating the maximum desiccant temperature at an optimal pressure ratio of 1.25 reveals that the GOR can increase from 1.635 at 0.7 to 2.44 at an effectiveness of 0.8. Optimized manipulation of these parameters can potentially enhance the GOR by up to 50% and improve mass transfer efficiency by about 20% within the HDH process.
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