The ecological water transfer project (EWTP) plays a pivotal role in reinstating the flow of dried-up rivers in arid regions, promoting river connectivity and vegetation resurgence. An essential facet in ensuring the efficacious execution of the EWTP lies in determining the optimal duration of irrigation to facilitate vegetation recovery. Nevertheless, comprehensive reports concerning the EWTP process in arid river ecosystems are scarce. Here, we leverage remote sensing imagery to assess changes in surface water and vegetation dynamics before and after the implementation of the EWTP in a dried-up river. The results show that before the EWTP (1987–2016), riparian vegetation’s mean normalized difference vegetation index (NDVI) decreased from 0.181 to 0.066. After EWTP (2017–2022), the river’s flow was restored for a distance of 347 km. This restoration resulted in the formation of 81.47 km2 of intermittent water bodies along the river. The mean NDVI increased from 0.065 to 0.093. As irrigation duration increased, the NDVI growth rate exhibited an initial rise followed by a subsequent decline, reaching its peak growth rate by irrigating for 18 days per year. The regions showing increased NDVI values exhibited a pronounced spatial correlation with the areas subjected to water transfer. These improvements in NDVI were predominantly concentrated on both sides of the river within a 550 m range. Interestingly, as moves farther away from the river, the growth rate of NDVI exhibited an initial increase followed by a subsequent decline. The pinnacle of NDVI growth rate materialized at a distance of 40–50 m from the river. These findings reveal the response characteristics of desert riparian vegetation to EWTP, providing valuable insights for selecting appropriate water transfer timing in future EWTP.