Purpose – My goal in conducting this study is to clarify and present the relationship and strong connections between the innovation index and the B2C E-Commerce index worldwide, as a response to the new normalcy, because innovation and B2C E-commerce issues, as well as quality and quality management, have been subject to an increasing interest all over the world, and the position of Western Balkan countries for innovation index and B2C E-commerce index, using descriptive and interdisciplinary methods. Design/methodology/approach – The article used exploratory research based on correlation and regression analysis to discover relationships between innovation and the B2C E-commerce index, using data supplemented by the Global Innovation Index and the B2C E-commerce index. The study technique consisted of gathering data and information regarding the global innovation index and B2C E-commerce index as well as explaining the recently launched ISO 56000 family of standards, handling a correlation and a regressive analysis for relations between the innovation index and the B2C E-commerce index, which resulted in the main conclusion of this study that statistically verified relations between the innovation and the B2C E-commerce are strong, so ISO standards in general, and ISO 56000 standards family application in particular, is required in the time of B2C E-commerce, achieving competitive advantage. In terms of descriptive statistics, a comparison between the Western Balkans and the rest of the globe has been conducted. Findings – Because innovation is covered by the ISO 56000 standard, this research gives statistical insights into the relationships between innovation and the B2C E-commerce index. It indicates that to get a competitive edge, successful business organizations should invest in innovation, B2C E-commerce, and quality management. The main recommendation is that the use of ISO standards in general, and the ISO 56000 family of standards in particular, helps companies strengthen their commitment to their clients by improving innovation and B2C E-commerce activities, processes, and procedures, and economies worldwide to gain a competitive advantage. The study's descriptive data on Western Balkan economies reveal that a significant effort is still required for EU integration. Research limitations/implications – Because of the selected study technique, the research results may necessitate more examination; consequently, researchers are urged to investigate the presented propositions further. Practical implications – The study discusses the implications of developing a strong tool that combines innovation, B2C E-commerce, and quality control to gain a competitive edge. Originality/value – This work addresses for the first time, using correlation and regression analysis, a recognized need to investigate how innovation, B2C E-commerce, and the ISO 56000 family of standards are significantly connected, as well as descriptive data for a region (the Western Balkans). Article Type – Research paper.