Dermatology Practice Research Articles

Practical guide for the diagnosis and treatment of localized and generalized cutaneous pruritus (chronic itch with no underlying pruritic dermatosis).

Itch, also known as pruritus, is one of the most prevalent symptoms observed in dermatological practices. Itch frequently arises from primary pruritic dermatoses, although it may also manifest in the absence of a primary pruritic skin rash. The latter itchy condition is referred to as "cutaneous pruritus" in the Japanese guidelines published in 2020. Cutaneous pruritus can be classified into two categories based on its distribution: localized cutaneous pruritus and generalized cutaneous pruritus. Localized cutaneous pruritus is indicative of a neuropathic cause, whereas generalized cutaneous pruritus suggests underlying systemic disease(s), drug-induced itch, psychogenic itch (also known as functional itch disorder), or chronic pruritus of unknown origin (CPUO). Systemic diseases associated with cutaneous pruritus include disorders of iron metabolism, chronic kidney disease, chronic liver disease (especially cholestasis), endocrine/metabolic diseases, hematological disorders, and malignant solid tumors. CPUO is a term used to describe chronic itch that is often generalized and for which no underlying cause can be identified despite a comprehensive and careful diagnostic workup. A variety of treatment approaches are available for cutaneous pruritus, including device-based physical therapies (such as phototherapy) and medications that act on the itch-perception processing pathway from the skin, peripheral sensory nerves, the spinal cord, to the brain. This review presents an overview of the current knowledge regarding cutaneous pruritus, from its underlying pathophysiologic mechanisms to the diagnostic procedures and treatment approaches that are currently available.

Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDС was founded on October 4, 1891) Bulletin of the MSDС № 1158

On May 17th we held our last meeting of Moscow Society of Dermatologists and Cosmetologists named after A.I. Pospelov in person within XLI Rachmanov Readings conference. There were 61 participants. Our agenda included two clinical cases: the first one was dedicated to the PASH-syndrome as the most common manifestation of gangrenous pyoderma syndromic form; the second one was about diagnostic difficulties in mycosis fungoides (Sechenov University). Two reports were presented in the scientific part of the meeting: the experience of using bacteriorhodopsin in patients with psoriasis vulgaris (Sechenov University), tattoos in dermatology practice (the Fomin clinic).

Knowledge, Attitude, And Practice of Dermatologists and Family Physicians Regarding Probiotics in Atopic Dermatitis in Saudi Arabia

Background: Despite the growing evidence of significant probiotics’ role in various diseases, including dermatological conditions, there is limited data on awareness dermatologists and family phsycians about its role in atopic dermatitis in Saudi Arabia. Objectives: To assess knowledge, attitude, and practice of dermatologists and family physicians regarding probiotics in atopic dermatitis in Saudi Arabia Methods: This study was a web-based cross-sectional study. Data were collected via an online questionnaire, targeting dermatologists and family physicians from different Saudi regions.The questionnaire included closed-ended questions on sociodemographic characteristics, knowledge, attitude, and practice of probiotic in atopic dermatits. Knowledge level and atitude scoring were assessed and compared based on participants’ characteristics. Results: The study analyzed responses from 273 participants, with a mean age of 34.5 ± 8.3 years. The majority of respondents were dermatologists (71.8%). Among the participants, 23.1% demonstrated good knowledge about probiotics in relation to atopic dermatitis, with a significantly higher level of knowledge observed among consultants (38.5%), dermatologists (24%), and those with 10 or more years of experience. While most respondents displayed a positive attitude toward the use of probiotics, actual prescription rates were low. Notably, 53.8% of participants did not engage in prescribing probiotics, and only 33.3% monitored patient outcomes associated with their use. The main barrier identified was a lack of knowledge, with 66.7% of respondents citing this as a significant challenge. Conclusion: The study highlights the need for improved educational resources to enhance healthcare providers' understanding and confidence in using probiotics for atopic dermatitis. This research contributes to the growing body of literature on probiotics and underscores the need for targeted interventions to support healthcare professionals in delivering evidence-based care.

Artificial Intelligence in the Non-Invasive Detection of Melanoma

Skin cancer is one of the most prevalent cancers worldwide, with increasing incidence. Skin cancer is typically classified as melanoma or non-melanoma skin cancer. Although melanoma is less common than basal or squamous cell carcinomas, it is the deadliest form of cancer, with nearly 8300 Americans expected to die from it each year. Biopsies are currently the gold standard in diagnosing melanoma; however, they can be invasive, expensive, and inaccessible to lower-income individuals. Currently, suspicious lesions are triaged with image-based technologies, such as dermoscopy and confocal microscopy. While these techniques are useful, there is wide inter-user variability and minimal training for dermatology residents on how to properly use these devices. The use of artificial intelligence (AI)-based technologies in dermatology has emerged in recent years to assist in the diagnosis of melanoma that may be more accessible to all patients and more accurate than current methods of screening. This review explores the current status of the application of AI-based algorithms in the detection of melanoma, underscoring its potential to aid dermatologists in clinical practice. We specifically focus on AI application in clinical imaging, dermoscopic evaluation, algorithms that can distinguish melanoma from non-melanoma skin cancers, and in vivo skin imaging devices.

Zelsuvmi: a promising treatment for molluscum contagiosum

Molluscum contagiosum (MC) is a common skin infection caused by a poxvirus, primarily affecting children and immunocompromised adults. It manifests as single or multiple raised, pearl-like papules and is highly contagious, spreading through skin contact or contaminated objects. Traditional treatments include cryosurgery, curettage, and pulsed dye laser ablation. However, in early 2024, berdazimer topical gel, 10.3% (ZELSUVMITM), was approved as the first topical treatment for MC. This review explores the potential of Zelsuvmi gel as a significant advancement in treatment due to its nitric oxide (NO)-producing properties. NO is a naturally occurring molecule in the body with multiple roles, including immune defense, antimicrobial activity, and modulation of apoptosis, inflammation, and cytokine production. The novel mechanism of action of Zelsuvmi, utilizing NO’s antiviral properties, has demonstrated compelling efficacy in clinical settings. The article also considers the broader implications of this treatment, not only for current dermatological practice but also for future research into innovative therapies for viral skin infections. Through an evaluation of clinical data, this review highlights Zelsuvmi’s potential to transform treatment approaches for MC, offering a non-invasive, effective option that may influence both clinical management and future prevention strategies.

DIFFERENTIATING VULGAR PSORIASIS AND TINEA INCOGNITO: CHALLENGES AND IMPLICATIONS FOR HEALTHCARE PROFESSIONALS

Differentiating between vulgar psoriasis and tinea incognito presents a significant challenge for healthcare professionals due to their overlapping clinical manifestations. Both conditions exhibit erythematous and scaly lesions but differ fundamentally in etiology and treatment approaches. Psoriasis is a chronic autoimmune disorder requiring targeted therapies such as topical agents, phototherapy, and systemic medications. In contrast, tinea incognito, a fungal infection, necessitates appropriate antifungal treatments. Recent studies emphasize the critical need for accurate diagnosis, highlighting that a thorough clinical history, distinctive lesion characteristics, and laboratory tests—such as fungal cultures and skin biopsies—are essential to prevent misdiagnosis. The rising incidence of tinea incognito, often exacerbated by the inappropriate use of topical corticosteroids, illustrates the importance of recognizing its atypical manifestations and underscores the need for careful clinical assessment. Interdisciplinary collaboration among healthcare professionals, alongside continuous education, is vital for ensuring the proper identification and management of these dermatological conditions. This proactive approach can significantly reduce the risk of incorrect diagnoses and inappropriate treatments. Understanding the underlying mechanisms and clinical presentations of both vulgar psoriasis and tinea incognito is crucial for improving patient outcomes. It also highlights the importance of monitoring at-risk populations to promote more effective, evidence-based dermatological practices. Overall, a heightened awareness and comprehensive understanding of these conditions will facilitate better clinical decision-making, leading to improved patient care and enhanced management strategies for dermatological disorders.

The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics in the United States and Review of the Literature.

Image guided superficial radiation therapy (IGSRT) is a novel technology which combines traditional superficial radiation therapy (SRT) with high resolution dermal ultrasound (HRDUS) to treat non-melanoma skin cancers (NMSC). Since development, IGSRT use has expanded dramatically in outpatient clinics. We review the IGSRT literature and state-of-the-art operating principles in US dermatologic practices. A literature search of electronic databases (Medline, Pubmed, Cochrane Library, Science Direct) combined with various authors' published and unpublished documents, procedures, and clinical experience with IGSRT were synthesized for this paper. Studies have demonstrated IGSRT consistently delivers high cure rates (> 99%) with low complications for early stage (stage0, I, or II) squamous cell and basal cell carcinomas. Control rates are statistically superior to non-image guided SRT and external beam radiation (XRT) as well as Mohs micrographic surgery (MMS). This improvement is attributed to invivo dermal tumor visualization via HRDUS and using an interdisciplinary approach to deliver care. IGSRT use in the dermatologic clinic for early stage NMSCs has become common practice and continues to expand. While the safety and cosmetic benefits of SRT/XRT have been long documented, IGSRT represents a significant leap forward in efficacy (statistically significant) by adding in vivo dermal tumor imaging. Results rival and appear on one study to surpass tumor control obtained with MMS. A contributing factor to the success may be the availability and use of an interdisciplinary team approach that includes dermatologists, radiation therapists, radiation oncologists, and medical physicists. The high tumor control rates, minimal side effects, favorable cosmesis, and ability to treat multiple lesions per session using IGSRT are establishing this modality as a standard first-line therapy for early stage NMSCs in dermatology clinics. IGSRT may represent the most effective option for the non-surgical treatment of early stage NMSC to date.

Environmental Impact and Sustainability Associated with the Practice of Dermatology

Purpose: The environmental impact of the practice of medicine including dermatology can be significant, driven by a growing and aging population that increasingly demands medical resources. This review explores the environmental effects of the practice of dermatology and identifies actionable solutions to reduce negative environmental impacts. Methods: A PubMed search was conducted using the terms (“environmental impact” OR “sustainability”) AND “dermatology.” Results were screened to include English-only articles between 2018 - 2024 and excluded duplicates. Further exploration of dermatology’s environmental effects was enhanced through citation tracking and additional PubMed searches. Results: A total of 25 articles were included based on relevance and search terms and an additional 21 were added. Results were categorized into six categories for data representation. Patient travel was the largest contributor to negatively impact the environment, followed by waste management practices, journal publication and written patient material, and traveling to medical conferences. The environmental impact of pharmaceuticals, including topicals, is also notable. Potential sustainable alternatives include teledermatology, more appropriate waste production and segregation, and electronic versus printed formats and more virtual conferences. Additionally, dermatologic disease evolves in response to a changing environment, with new data indicating epidemiological shifts due to climate change. More sustainable practices within dermatology also have the potential to cut total overhead expenses. Conclusions: Clinical and surgical subspecialties, specifically dermatology, can contribute significantly to environmental pollution, leading to environmental and financial impacts, but implementing simple, documented methods can reduce their ecological footprint and provide potential financial benefits.

Retrospective Analysis of the Impact of Screening for Psoriatic Arthritis (PsA) with the Psoriasis Epidemiology Screening Tool (PEST) in Clinical Dermatology Practice

Introduction: Patients with plaque psoriasis (PSO) have an increased risk of developing PsA as the disease severity progresses. While it is estimated that 30% of patients with PSO have PsA, nearly 16% of patients with PSO may have undiagnosed PsA.1,2 Implementing the PEST questionnaire for PsA screening in dermatologic practice may increase early intervention by improving rates of timely diagnosis.3 This observational study aimed to assess the proportion of patients with PSO and no previous PsA diagnosis who screened positive on the PEST and were then diagnosed with PsA by a healthcare provider in the PEST deployment period within the Advanced Dermatology and Cosmetic Surgery (ADCS) specialty dermatology network. Procedure/Study: De-identified, real-world patient data [2018–2019 and 2021–2022] were sourced from electronic health records within the ADCS network of outpatient facilities across 14 states in the United States. Patients were included in the analysis if they received care at an ADCS facility where the PEST was deployed, had ≥1 encounter with a diagnosis code for PSO, and never had a diagnosis code for PsA before their first diagnosis code for PSO. For outcomes directly related to PEST evaluations, data from 1/1/2021–12/31/2022 (PEST deployment period) were used. For outcomes not directly related to PEST results, data from 1/1/2018–12/31/2019 (period before PEST deployment) were evaluated. Descriptive statistics, including frequencies, percentages, and 95% confidence intervals (CIs) for categorical variables, were used to characterize the patient cohorts by study period. Results: Among ADCS facilities using the PEST during the deployment period (44% of practices in the network), the final study population included 14,308 and 21,142 patients with PSO in the period before PEST deployment and during the PEST deployment period, respectively. In the PEST deployment cohort, 1,100 (5.2%; 95% CI: 4.9–5.5) patients were screened using the PEST. In the period before PEST deployment, 327 (2.3%; 95% CI: 2.0–2.5) patients with PSO and no previous PsA diagnosis were subsequently diagnosed with PsA. During the PEST deployment period, 449 (2.1%; 95% CI: 1.9–2.3) patients with PSO and no previous PsA diagnosis received a subsequent PsA diagnosis without PEST screening. Of all patients with PSO who screened positive for PsA on the PEST (score ≥3; n=296), 10.8% (n=32; 95% CI: 7.6–15.1) subsequently received a formal PsA diagnosis during the PEST deployment period. Conclusion: These results suggest that a meaningful proportion of patients with PsA may be underdiagnosed in the dermatology setting. Deployment of the PEST in the clinical dermatologic workflow may provide an opportunity to diagnose PsA earlier and improve patient outcomes.

Tissue-Engineered Skin Substitutes for Use in Clinical Dermatological Practice

Skin replacements are essential in dermatology as they serve to connect the gap between conventional wound care and surgical procedures. Due to pioneering innovations from the last century, tissue-engineered skin substitutes have significantly advanced in the field of dermatology, offering new hope for patients with complex wound healing needs. Whilst before, skin grafting was performed to act as an intermediary to promote skin healing, it has now evolved to also mimic skin structure and function. To our knowledge, there have not been any summaries on the use of tissue-engineered in dermatology. Therefore, we conducted a scoping review to summarize research papers which performed human clinical trials and follow-up work using synthetic lab-made skin with a clear clinical application from the last 30 years.

Advanced Artificial Intelligence Techniques for Comprehensive Dermatological Image Analysis and Diagnosis

With the growing complexity of skin disorders and the challenges of traditional diagnostic methods, AI offers exciting new solutions that can enhance the accuracy and efficiency of dermatological assessments. Reflectance Confocal Microscopy (RCM) stands out as a non-invasive imaging technique that delivers detailed views of the skin at the cellular level, proving its immense value in dermatology. The manual analysis of RCM images, however, tends to be slow and inconsistent. By combining artificial intelligence (AI) with RCM, this approach introduces a transformative shift toward precise, data-driven dermatopathology, supporting more accurate patient stratification, tailored treatments, and enhanced dermatological care. Advancements in AI are set to revolutionize this process. This paper explores how AI, particularly Convolutional Neural Networks (CNNs), can enhance RCM image analysis, emphasizing machine learning (ML) and deep learning (DL) methods that improve diagnostic accuracy and efficiency. The discussion highlights AI’s role in identifying and classifying skin conditions, offering benefits such as a greater consistency and a reduced strain on healthcare professionals. Furthermore, the paper explores AI integration into dermatological practices, addressing current challenges and future possibilities. The synergy between AI and RCM holds the potential to significantly advance skin disease diagnosis, ultimately leading to better therapeutic personalization and comprehensive dermatological care.

Chronic Spontaneous Urticaria-New Predictor on the Horizon?

Chronic urticaria is one of the most common diseases in allergology and dermatology practice with unclear causes of occurrence. Background: Some studies emphasize the correlation between inflammation in chronic urticaria and disturbed intestinal microbiota. It raises the question about the role of some intestine-related substances in the pathogenesis of urticaria as well as their potential role as disease predictors. Calprotectin is an acute-phase protein with a well-established diagnostic position in the field of gastroenterology. There are some data on the relationship between this parameter and gut microbiota. The major aim of this preliminary study is to investigate whether calprotectin can be potentially taken into account as a disease course predictor in urticaria. Methods: We included in our study 54 chronic spontaneous urticaria (CSU) patients (of whom 26 manifested the symptoms of recurrent angioedema) and 29 patients allergic to Hymenoptera venom for the reference group (in these patients, before venom immunotherapy induction, full diagnostics is performed including intestinal problems). Disease activity in the CSU patients was assessed using the Urticaria Activity Score (UAS) and the disease control in this group was assessed with the Urticaria Control Test (UCT). Moreover, we analyzed fecal and serum calprotectin concentrations. Results: Positive correlation was found only between the values of serum calprotectin concentration and the control level of CSU symptoms with the lack of other relations. Conclusions: Our results do not supply unequivocal evidence for calprotectin as a potential marker of CSU course, though this concept, in the light of growing evidence for microbiota's role in urticaria, requires further research.

SkinHealthMate app: An AI-powered digital platform for skin disease diagnosis

Accurate diagnosis of skin diseases remains a significant challenge due to the inherent limitations of traditional visual and manual examination methods. These conventional approaches, while essential to dermatological practice, are prone to misdiagnoses and delays in treatment, particularly for conditions like skin cancer. To address these gaps, this paper presents the SkinHealth App, an innovative AI-driven solution that enhances the accuracy and efficiency of skin disease diagnosis. The app integrates a robust ensemble learning model, combining the strengths of EfficientNetB1 and EfficientNetB5 architectures. This ensemble model improves disease classification performance through advanced image processing techniques such as noise reduction and data augmentation. The key contributions of this work include the development of a scalable and secure server-side structure that ensures the safe handling of patient data and efficient processing of diagnostic queries. Experimental results on the HAM10000 dataset demonstrate the model's superior performance, achieving an accuracy of 93%, along with high precision and recall scores, thereby reducing false positives and false negatives. These outcomes clearly establish the app's potential to enhance dermatological diagnosis by providing timely and accurate disease identification. Ultimately, this work bridges the gap between traditional diagnostic methods and modern AI-driven technology, offering a transformative tool for improving patient care in dermatology.

Protecting your dermatology practice from cyber threats: tips and tricks for everyday safety.

Protecting your dermatology practice from cyber threats: tips and tricks for everyday safety.

Antibiotic Resistance in Acne Treatment: Emerging Challenges and Implications for Dermatology Practice in Developing Countries like Bangladesh

Background: Antibiotic resistance in acne treatment is an escalating global issue, particularly in developing countries like Bangladesh, where misuse of antibiotics is prevalent. Objective: To assess the prevalence of antibiotic-resistant Cutibacterium acnes and its implications for acne treatment efficacy at Aurora Skin and Aesthetics in Dhaka, Bangladesh. Methods: A cross-sectional study was conducted from September 2021 to March 2022 at Aurora Skin and Aesthetics, Dhaka. A total of 100 acne patients were selected, and antibiotic sensitivity tests were performed on C. acnes strains isolated from lesion swabs. The data was analyzed to determine the resistance to commonly prescribed antibiotics like tetracyclines, erythromycin, and clindamycin. Results: Out of 100 patients, 45% were male and 55% were female. Among the isolated C. acnes strains, 60% showed resistance to erythromycin, 40% to clindamycin, and 35% to tetracyclines. A significant percentage (25%) of patients resisted more than one antibiotic. Patients with antibiotic-resistant acne exhibited a 30% longer treatment duration compared to non-resistant cases, with only 50% achieving satisfactory Improvement after 12 weeks of standard antibiotic therapy. Conclusions: The study highlights the growing problem of antibiotic resistance in acne treatment in Bangladesh, emphasizing the need for stricter antibiotic use guidelines and alternative therapies to improve treatment outcomes.

Update on Platelet-Rich Plasma and Platelet-Rich Fibrin for Dermatologic Surgery: Addressing Knowns and Unknowns.

Autologous and allogeneic platelet-rich plasma (PRP) in addition to its derivatives, such as platelet-rich fibrin (PRF), are broadly accepted therapeutic approaches in orthopedics, otolaryngology, sports medicine, plastic surgery, and oral and maxillofacial surgery. However, the absence of expert consensus, standardized protocols, and varying outcomes pose challenges to their broader acceptance in cosmetic dermatology and dermatologic surgery. To offer a contemporary literature overview of PRP and PRF, focusing on fundamental aspects of the technology, diversity of commercially accessible systems, and shed light on present-day controversies within the field. A systemic review of PRP and PRF literature was conducted, utilizing search engine databases: Cochrane Database of Systematic Reviews, Embase, Ovid MEDLINE, and PubMed. Emphasis was placed on scrutinizing higher level-of-evidence articles, specifically randomized control trials, systematic reviews, and meta-analyses (Level 1A-2A), with particular emphasis on recent data that have not been well reviewed in other publications from January 2022 to May 2024. An increasing body of literature affirms advantages of PRP products in dermatology, spanning wound care, facial rejuvenation, scar revision, and hair growth. A foundational understanding of variation in preparation protocol, outcomes, and timing of administration is needed to better comprehend market dynamics, patient demand, and strategies for integrating PRP into dermatologic practice.

Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview.

Aging-related changes in the skin, such as dullness, dehydration, and loss of elasticity, significantly affect its appearance and integrity. Injectable "skin boosters," comprising various biological materials, have become increasingly prominent in addressing these issues, offering rejuvenation and revitalization. This review offers a comprehensive examination of these injectables, detailing their types, mechanisms of action, and clinical uses. It also evaluates the evidence for their effectiveness and safety in treating age-related skin alterations and other conditions. The goal is to provide an insightful understanding of injectable skin boosters in contemporary dermatological practice, summarizing the current state of knowledge.

Häufigkeit von sexuell übertragbaren Infektio-nen in deutschen Facharztpraxen

The aim of this study is to analyze the incidence of sexually transmitted infections (STI) in dermatological, urological, and gynecological practices in Germany. Data from the nationwide IQVIA Disease Analyzer database was used for this study. This cross-sectional study included 6,535 patients in 2014 and 6,491 patients in 2023 with an insured diagnosis of a sexually transmitted disease in 69 dermatology, 148 gynecology and 55 urology practices. The number of patients treated for sexually transmitted diseases in these practices changed only minimally between 2014 and 2023. On average, each dermatology practice treated 31 patients with STIs in 2023, each gynecology practice treated 21 patients and each urology practice treated 23 patients. Anogenital warts were the most commonly diagnosed STI in all specialties, with prevalence varying by specialty. Interestingly, the number of patients per practice with anogenital warts increased slightly in dermatology and urology practices between 2014 and 2023, while it decreased in gynecology practices. The average age of patients treated for STDs increased between 2014 and 2023 In summary, this study highlights that despite vaccination efforts and awareness campaigns in various medical specialties, STI patient numbers remain almost the same and thus STI continues to be a persistent and increasing challenge in the ageing patient population. The findings call for further initiatives in the public health sector and an adjustment of everyday practice to the special needs of these patient groups.

Dupilumab Efficacy in Children with Palmoplantar Eczema

Background. Atopic dermatitis (AD) is a chronic inflammatory skin disease with such clinical manifestations as eczematous lesions and itching. One of its clinical forms is palmoplantar eczema. It is urgent and unresolved issue in pediatric dermatology as this disease significantly affect the patients’ quality of life due to involvement of functionally significant areas, symptoms severity, difficult induction of remission. Clinical case description. This article presents case series of patients with AD involving palms and soles who have shown positive results to the treatment with genetically engineered biologic drug — dupilumab. Conclusion. Palmoplantar eczema, as one of the forms of AD, hardly responds to topical therapy in clinical practice of dermatologist. Moreover, systemic treatment is not only limited in pediatrics, but also is not effective enough. Prescription of the genetically engineered biologic drug, dupilumab, seems to be one of the effective methods for management of this disease in these patients.

Assessing the Impact of ChatGPT in Dermatology: A Comprehensive Rapid Review.

Background/Objectives: The use of artificial intelligence (AI) in dermatology is expanding rapidly, with ChatGPT, a large language model (LLM) from OpenAI, showing promise in patient education, clinical decision-making, and teledermatology. Despite its potential, the ethical, clinical, and practical implications of its application remain insufficiently explored. This study aims to evaluate the effectiveness, challenges, and future prospects of ChatGPT in dermatology, focusing on clinical applications, patient interactions, and medical writing. ChatGPT was selected due to its broad adoption, extensive validation, and strong performance in dermatology-related tasks. Methods: A thorough literature review was conducted, focusing on publications related to ChatGPT and dermatology. The search included articles in English from November 2022 to August 2024, as this period captures the most recent developments following the launch of ChatGPT in November 2022, ensuring that the review includes the latest advancements and discussions on its role in dermatology. Studies were chosen based on their relevance to clinical applications, patient interactions, and ethical issues. Descriptive metrics, such as average accuracy scores and reliability percentages, were used to summarize study characteristics, and key findings were analyzed. Results: ChatGPT has shown significant potential in passing dermatology specialty exams and providing reliable responses to patient queries, especially for common dermatological conditions. However, it faces limitations in diagnosing complex cases like cutaneous neoplasms, and concerns about the accuracy and completeness of its information persist. Ethical issues, including data privacy, algorithmic bias, and the need for transparent guidelines, were identified as critical challenges. Conclusions: While ChatGPT has the potential to significantly enhance dermatological practice, particularly in patient education and teledermatology, its integration must be cautious, addressing ethical concerns and complementing, rather than replacing, dermatologist expertise. Future research should refine ChatGPT's diagnostic capabilities, mitigate biases, and develop comprehensive clinical guidelines.