Introduction. Loss of firmness and elasticity of the skin is a complex phenomenon involving changes in the dermis, epidermis; and is a distinctive feature of skin aging. Peelings with recombinant enzymes may constitute an effective tool to improve the signs mentioned above because those enzymes combine keratinase PB333, collagenase PB220, DMAE, vitamin C, and hyaluronic acid. Objective. A study was carried out to evaluate the efficacy and tolerability of the pbserum Extreme Firmness Professional product in subjects between 24 and 70 years old to measure the firmness and elasticity of the skin before and after continued use of the product. Material and Methods. Following the instructions, participants applied the product containing PB333 keratinase, PB220 collagenase, DMAE, vitamin C, and hyaluronic acid weekly and avoided using other skin care products in the test area. The firmness and elasticity of the skin were evaluated using the Cutometer® dual MPA 580, the organoleptic properties and the result of the treatment, as well as adverse events and dermatological reactions. Results. The study's results showed that after 28 days of use, skin elasticity improved by an average of 11 % compared to baseline, which was statistically significant. Additionally, 96 % of the subjects were satisfied with the results of the product on their skin, with no reports of adverse events. Discussion. Our findings prove, in a statistically significant way, an improvement in the skin's elasticity, hydration, and softness in the subjects who used the product compared to the control group. Conclusions. The study concluded that combining recombinant enzymes of keratinase PB333, collagenase PB220, DMAE, vitamin C, and hyaluronic acid effectively improves skin elasticity in people with sagging skin.