Ring Derivatives Research Articles

A synthetic bis-triazine ring derivative based on ammonium phosphonate towards durable flame-retardant modification of cotton fabrics

Cotton is widely used in daily life. However, its flammability limits its application in certain areas. In this study, a novel formaldehyde-free reactive flame retardant, ASBSMP, derived from a bis-triazine ring ammonium phosphonate, was successfully synthesized. The ASBSMP/cotton exhibited excellent flame-retardant properties, with self-extinguishing characteristics and a LIMITING OXYGEN INDEX (LOI) of 41.8%. Even after 50 washing cycles, the LOI remained at a high level of 30.3%, indicating outstanding durability. Thermogravimetric analysis (TGA) revealed its superior thermal stability. Cone calorimeter tests further confirmed the superior flame retardancy of the treated cotton, showing a 44.6% reduction in total heat release (THR) and a 90.1% reduction in peak heat release rate (PHRR) compared to pure cotton. Results from Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), and char residue analyses demonstrated that ASBSMP exhibited flame-retardant activity in both the gas and condensed phases. ASBSMP/cotton exhibited outstanding mechanical integrity for a wide range of applications.

Engel condition of composition of generalized derivations in prime rings

Let [Formula: see text] be a prime ring, [Formula: see text] a noncentral Lie ideal of [Formula: see text] and [Formula: see text] the extended centroid of [Formula: see text], where [Formula: see text] is the Utumi quotient ring of [Formula: see text]. Suppose that [Formula: see text] are two nonzero generalized derivations of [Formula: see text]. Recently, [Dhara et al., Engel conditions of generalized derivations on left ideals and Lie ideals in prime rings, Comm. Algebra 48(1) (2020) 154–167] studied the case [Formula: see text] for all [Formula: see text], where [Formula: see text] is a derivation (which is independent of [Formula: see text]) and [Formula: see text] fixed positive integers and obtained the structure of [Formula: see text] and the ring [Formula: see text]. [Liu, An Engel condition with two generalized derivations on Lie ideals of prime rings, J. Algebra and Its Applications, 22(5) (2023) 2350115] studied a similar identity replacing derivation [Formula: see text] with another generalized derivation [Formula: see text]. Recently, [Pandey, Pair of generalized derivations on Lie ideals in prime rings, Asian-European J. Math. 16(1) (2022) 2350002] studied an identity considering composition of mapping, that is [Formula: see text] for all [Formula: see text]. In this paper, we consider the situation containing composition of mappings as well as Engel condition, that is, [Formula: see text] for all [Formula: see text], where [Formula: see text] are fixed integers and then obtain the nature of mappings [Formula: see text], [Formula: see text] and the ring [Formula: see text].

The stability of high ring homomorphisms and derivations on fuzzy Banach algebras

Abstract In this article, we focus on exploring the fuzzy version of the Hyers-Ulam-Rassias stability of n n -ring homomorphisms and n n -ring derivations in the context of fuzzy Banach algebras. Our investigation utilizes the direct method.

Application of infrared and nuclear magnetic resonance spectra in studying the bacterial efficacy of some oxazepane derivatives derived from hydrazones

This research included the utilisation of infrared and nuclear magnetic resonance spectra in studying and preparing new derivatives of the oxazepan ring by a series of reactions, where the triazole ring was prepared from the reaction of the carboxylic acid with carbothiohydrazide, and from the resulting reaction (triazole) with aqueous hydrazine. The latter was reacted with benzaldehyde compensators to prepare hydrazones, which is the basic intermediate for the preparation of the oxazepan ring. The hydrazones were reacted with succinic anhydride, and the validity of the structures was proven using infrared and nuclear magnetic resonance spectra of proton and carbon. Its biological activity has also been tested for two species of Gram-positive bacteria, Staphylococcus epidermidis and Gram-negative Klebsiella pneumoniae.

Antifungal activity of Cinnamaldehyde derivatives against fluconazole-resistant Candida albicans

BackgroundCandida albicans is an opportunistic pathogen commonly found in human mucous membranes. In light of the escalating challenge posed by antibiotic resistance of C. albicans strains worldwide, it is an urgently necessary to explore alternative therapeutic options. ObjectiveThis study aims to assess the efficacy of two Cinnamaldehyde derivatives, 2-Cl Cinnamaldehyde (2-Cl CA) and 4-Cl Cinnamaldehyde (4-Cl CA), against C. albicans through both in vitro experiments and in vivo murine models and to evaluate their potential as new drug candidates for treating C. albicans. Methods and resultsThe minimum inhibitory concentrations (MICs) of Cinnamaldehyde 2-Cl and 4-Cl benzene ring derivatives against C. albicans were 25 μg/mL. Time-killing experiments revealed that both Cinnamaldehyde derivatives exhibited fungicidal activity against C. albicans at concentrations of 5 MIC and 10 MIC. In the checkerboard experiment, 4-Cl CA did not show any antagonistic effect when combined with first-line antifungal drugs. Instead, it exhibited additive effects in combination with nystatin. Both 2-Cl and 4-Cl CA demonstrated inhibitory activity against C. albicans biofilm formation, especially at 8 MIC and 16 MIC concentrations. In C. albicans biofilm eradication experiments, although high drug concentrations of 2-Cl and 4-Cl CA were unable to eradicate the biofilm completely, they were still effective in killing C. albicans cells within the biofilm. Moreover, sub-inhibitory concentrations of 4-Cl CA (ranging from 5 to 20 μg/mL) significantly inhibited cell aggregation and hyphal formation. Furthermore, 4-Cl CA effectively inhibited intracellular C. albicans infection in macrophages. Lastly, the effectiveness of 4-Cl CA was evaluated in a mouse model of hematogenous disseminated candidiasis caused by C. albicans, which revealed that 4-Cl CA significantly reduced fungal burden and improved mouse survival compared to the untreated controls. ConclusionThe 4-Cl CA exhibited inhibitory effects against C. albicans through both in vivo and in vitro models, demonstrating its therapeutic potential as a promising new drug candidate for treating drug-resistant candidiasis albicans.

DERIVATION ON SEVERAL RINGS

Research on ring derivation is one of the studies that is quite popular among algebra lovers. The definition of the derivation on the ring is motivated by the derivation in calculus which has Leibniz's rule. The purpose of this paper is to show some of the derivation properties on several rings, namely divisor rings, cartesian product rings, and factor rings. Let be a commutative ring with multiplicative identity and A the set of multiplicative closed that has non-zero divisor. In this paper, we have shown some results of derivation on ring theory. If is a ring derivation of R and is a divisor ring of , we can construct for all , then the map is a derivation on . The concept of embedding one ring into another ring can be used so that the ring of constant of , namely , is a subring of the divisor ring . Related to the ideal on ring theory, if I is an ideal of R, then where is also a derivation on the ring . The last result in this paper comes from the ring of cartesian product, take be a ring with derivation for . The cartesian product ring have a derivation ring defined by for any .

One-Pot Tandem/Spirocyclization Reaction: Synthesis of Spiro[pyridine-thiazolidine] Ring Derivatives.

An efficient one-pot, three-component approach was devised to synthesize spiro[pyridine-thiazolidine] ring skeletons using thiazole salts, aldehydes, and enaminones. This method allows the assembly of structurally diverse spiroazepines through [3 + 1 + 2] tandem/spirocyclization reactions. This spirocyclization reaction offers several advantages, including transition metal-free conditions, high chemoselectivity, and the ability to construct structurally novel polycyclic compounds.

In Silico Evaluation of Molecular Docking, Molecular Dynamic, and ADME Study of New Nabumetone Schiff Base Derivatives (1,3,4-oxadiazole or 1,3,4-thiadiazole ring) Promising Antiproliferation Action Against Lung Cancer

A total of eight novel Nabumetone Schiff Base Derivatives with 1,3,4-oxadiazole or 1,3,4-thiadiazole rings have been proposed to evaluate their potential effectiveness against the epidermal growth factor receptor (EGFR). Molecular docking was conducted with the crystalline structure of EGFR (code: 4HJO), wherein the eight compounds of Nabumetone Schiff Base Derivatives with 1,3,4-oxadiazole or 1,3,4-thiadiazole ring derivatives docked to determine their binding affinity to the target binding site. Using GOLD software (CCDC) version 5.43, computer predictions were made, and the compounds were designed using ChemDraw version 22.2 (professional version). Subsequently, their selectivity with EGFR was assessed, with erlotinib selected as a control for comparison. In silico ADME studies were conducted, revealing the significant potential for binding, and drug-likeness was assessed using the Swiss ADME website. Additionally, Molecular Dynamic simulations of compound N3 complexes with EGFR were performed using Schrodinger Suite 2023 software for 50 ns, estimating RMSD, RMSF, Ligand-Protein Contacts, and Ligand Torsion Profile results. Result Showing the best binding energy within receptor pocket with a promising activity against EGFR protein receptor. The highest PLP fitness levels were found in compounds N1, N2, and N3 for lung cancer cell protein (89.1, 89.02, and 87.95, respectively, average value), All compounds were found to adhere to Lipinski's rule of five, with high absorption from the gastrointestinal tract (except N4), and none of the proposed compounds were able to pass through the blood-brain barrier. Molecular dynamic result, Mean Protein RMSD 1.8 Å, ligand RMSD 1.6 Å, and RMSF reveals that the protein amino acids interacting with the ligand remain within a distance of less than 1 Å. In conclusion, these findings offer a promising direction for the development of effective treatments for lung cancer

Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin

Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid. 1HNMR and 13CNMR nuclear magnetic resonance spectroscopies, as well as Fourier-transform infrared spectroscopy, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin are of interest to us due to their potential antioxidant and anticancer properties. The MTT assay ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)) was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines which compound 14 (IC50=79.85, IC50=39) after 24 hours and 48 hours showed good cytotoxicity compared with drug reference tamoxifen. synthesized compounds 6-20 were evaluated for against antioxidant activity by using DPPH assay. In molecular docking, Promising compounds were used to reveal potential cytotoxic activity mechanisms.

Identities involving b-generalized skew derivations in prime rings acting as Jordan derivation

Let R symbolize a prime ring with a characteristic other than 2, and let ρ ( η 1 , … , η n ) represent a non-central multilinear polynomial over the extended centroid C of R . Assuming the presence of three b-generalized skew derivations on R , namely D 1 , D 2 , and D 3 that satisfy the equation D 1 ( ρ ) ρ + ρ D 2 ( ρ ) = D 3 ( ρ 2 ) for all ρ = ρ ( η 1 , … , η n ) , where η 1 , … , η n are elements of R . In this research paper, our goal is to elucidate all potential configurations of D 1 , D 2 , and D 3 .

Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors.

SOS1, a guanine nucleotide exchange factor (GEF), plays a critical role in catalyzing the conversion of KRAS from its GDP- to GTP-bound form, regardless of KRAS mutation status, and represents a promising new drug target to treat all KRAS-driven tumors. Herein, we employed a scaffold hopping strategy to design, synthesize, and optimize a series of novel binary ring derivatives as SOS1 inhibitors. Among them, compound 10f (HH0043) displayed potent activities in both biochemical and cellular assays and favorable pharmacokinetic profiles. Oral administration of HH0043 resulted in a significant tumor inhibitory effect in a subcutaneous KRAS G12C-mutated NCI-H358 (human lung cancer cell line) xenograft mouse model, and the tumor inhibitory effect of HH0043 was superior to that of BI-3406 at the same dose (total growth inhibition, TGI: 76% vs 49%). On the basis of these results, HH0043, with a novel 1,7-naphthyridine scaffold that is distinct from currently reported SOS1 inhibitors, is nominated as the lead compound for this discovery project.

SYNTHESIS OF NEW γ-LACTONE RING DERIVATIVES CONTAINING PYRIDINE AND TRICONDENSED SYSTEMS

Lactone-pyridone rings contain many biologically active molecules of natural and artificial origin. The molecules contained in these two rings, represented by Cerpegine and its derivatives, will also exhibit high biological activity. It is also necessary to take into account that both natural and synthetic multi-substituted lactones have high biological activity. Thus, research in the field of multi-substituted lactones and further transformations are of particular interest. The synthesis of such systems began with the synthesis of a 2-acetylfuranone ring. In the next step, condensation of ethylcyanoacetate with 2-acetylfuranone by Knewenegel produced 3-substituted lactones, which according to the NMP 1H spectroscopy are a mixture of E and Z isomers. Then, when 3-substituted lactones were heated with dimethylformamide dimethylacetal DMFA/DMA, 3-substituted lactones containing a diene fragment in the structure were obtained. Stereoselective attachment E was detected using the NMR 1H spectrum. Then, under the action of the corresponding amine, the intermolecular substitution reactions produce compounds containing a lactone and pyridine group isolated by a σ-bond (serpegenous compound). Due to the proximity of the cyanide group of the pyridine ring and the fourth blight group of the lactone ring, intramolecular cyclization occurs during heating in the alkaline medium to form new tricondensed systems. Thus, an optimal method of synthesis of serpegenous compounds has been developed. These systems are of interest because in their skeleton they have not only a condensed system but also spirocycles. The connections themselves may be a promise for further exploration. For citation: Hakobyan R.M., Kharatyan L.A., Hayotsyan S.S., Attaryan H.S., Melikyan G.S. Synthesis of new γ-lactone ring derivatives containing pyridine and tricondensed systems. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2024. V. 67. N 7. P. 28-40. DOI: 10.6060/ivkkt.20246707.7068.

Algebraic identities and generalized derivations in prime rings

Let R be a prime ring with center Z(R). A map F from R to R is called a multiplicative generalized derivation associated with d (not necessarily additive) if F(xy)= F(x)y + xd(y) for all x and y in R. In this paper, our intention is to study the commutativity of R, using a multiplicative generalized derivation that satisfies some algebraic identities.

A Note on the Trace of Generalized Permuting Tri-Derivations

Many researchers have studied permuting tri-derivation and generalized derivation in prime or semi-prime rings, BCK-algebras, lattices, d-algebras, MV-algebras and many algebraic structures. Later, they introduced the concept of generalized permuting tri-derivation by combining the concepts of generalized derivation and permuting tri-derivation. In this article, we have examined the properties of generalized permuting triderivation by adding conditions on their traces in prime or semi-prime rings. In addition, we examined the properties of two permuting triderivation by giving a relation between their traces.

On generalized derivations in factor rings

Abstract The main purpose of this paper is to scrutinize the deportment of generalized derivations of R satisfying some functional * {*} -identities involving the center of the factor ring R / P {R/P} where P is a prime ideal of the ring R. Moreover, we suggest to give generalization of some well known results.

Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study

Abstract: Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold a position of interest in the fields of synthetic and medicinal chemistry, pharmacology, material sciences and physics. Spirobarbiturate compounds which incorporate barbituric ring derivatives into spirocyclic structures have emerged as attractive synthetic targets for drug discovery as they are known to exhibit far-ranging pharmacological applications. In this review, we aim to bring to light the extensive, contemporary research applied to the synthesis of different spirobarbiturates having varied ring sizes (3, 5, 6 and 7 membered) in a classified manner. It presents the reported methods of synthesis along with their mechanistic pathways as well as the pharmacological activities of some of these synthesized biologically significant motifs.

On Reverse Derivations in d-algebras

In the present paper, we apply the concept of reverse derivation in rings on the concept of d − algebra to obtain the concept called a left-right (resp. right-left) reverse derivations of d−algebra X (briefly, (l, r) resp. (r, l)− reverse derivation of d − algebra ), we will also, define some concepts such as regular map, composition two maps and study the related properties. Moreover, the notions of partial ordered edge d − algebra as well as d − subalgebra and their relation to our current study are obtained. In addition, some illustrative examples and counterexamples are discussed.

A note on b-generalized (α,β)-derivations in prime rings

Abstract Let R be a prime ring, let 0 ≠ b ∈ R {0\neq b\in R} , and let α and β be two automorphisms of R. Suppose that F : R → R {F:R\rightarrow R} , F 1 : R → R {F_{1}:R\rightarrow R} are two b-generalized ( α , β ) {(\alpha,\beta)} -derivations of R associated with the same ( α , β ) {(\alpha,\beta)} -derivation d : R → R d:R\rightarrow R , and let G : R → R G:R\rightarrow R be a b-generalized ( α , β ) (\alpha,\beta) -derivation of R associated with ( α , β ) (\alpha,\beta) -derivation g : R → R g:R\rightarrow R . The main objective of this paper is to investigate the following algebraic identities: (1) F ⁢ ( x ⁢ y ) + α ⁢ ( x ⁢ y ) + α ⁢ ( y ⁢ x ) = 0 {F(xy)+\alpha(xy)+\alpha(yx)=0} , (2) F ⁢ ( x ⁢ y ) + G ⁢ ( x ) ⁢ α ⁢ ( y ) + α ⁢ ( y ⁢ x ) = 0 {F(xy)+G(x)\alpha(y)+\alpha(yx)=0} , (3) F ⁢ ( x ⁢ y ) + G ⁢ ( y ⁢ x ) + α ⁢ ( x ⁢ y ) + α ⁢ ( y ⁢ x ) = 0 {F(xy)+G(yx)+\alpha(xy)+\alpha(yx)=0} , (4) F ⁢ ( x ) ⁢ F ⁢ ( y ) + G ⁢ ( x ) ⁢ α ⁢ ( y ) + α ⁢ ( y ⁢ x ) = 0 {F(x)F(y)+G(x)\alpha(y)+\alpha(yx)=0} , (5) F ⁢ ( x ⁢ y ) + d ⁢ ( x ) ⁢ F 1 ⁢ ( y ) + α ⁢ ( x ⁢ y ) = 0 {F(xy)+d(x)F_{1}(y)+\alpha(xy)=0} , (6) F ⁢ ( x ⁢ y ) + d ⁢ ( x ) ⁢ F 1 ⁢ ( y ) = 0 {F(xy)+d(x)F_{1}(y)=0} , (7) F ⁢ ( x ⁢ y ) + d ⁢ ( x ) ⁢ F 1 ⁢ ( y ) + α ⁢ ( y ⁢ x ) = 0 {F(xy)+d(x)F_{1}(y)+\alpha(yx)=0} , (8) F ⁢ ( x ⁢ y ) + d ⁢ ( x ) ⁢ F 1 ⁢ ( y ) + α ⁢ ( x ⁢ y ) + α ⁢ ( y ⁢ x ) = 0 {F(xy)+d(x)F_{1}(y)+\alpha(xy)+\alpha(yx)=0} , (9) F ⁢ ( x ⁢ y ) + d ⁢ ( x ) ⁢ F 1 ⁢ ( y ) + α ⁢ ( y ⁢ x ) - α ⁢ ( x ⁢ y ) = 0 {F(xy)+d(x)F_{1}(y)+\alpha(yx)-\alpha(xy)=0} , (10) [ F ⁢ ( x ) , x ] α , β = 0 {[F(x),x]_{\alpha,\beta}=0} , (11) ( F ⁢ ( x ) ∘ x ) α , β = 0 {(F(x)\circ x)_{\alpha,\beta}=0} , (12) F ⁢ ( [ x , y ] ) = [ x , y ] α , β {F([x,y])=[x,y]_{\alpha,\beta}} , (13) F ⁢ ( x ∘ y ) = ( x ∘ y ) α , β {F(x\circ y)=(x\circ y)_{\alpha,\beta}} for all x , y {x,y} in some suitable subset of R.

Jordan left derivations in infinite matrix rings

Jordan left derivations in infinite matrix rings

DBU-catalyzed substitution-controlled synthesis of oxa[3.3.1] bridged ring and naphthylamine derivatives

A switchable cascade cyclization reaction of ortho-alkynyl arylketones with amines has been developed, where the different reaction pathways are controlled by the substituent on the α-carbon of in-situ-generated ortho-alkynyl arylaldimines.