The Mesoproterozoic Belt Basin of the northwestern United States and southwestern Canada contains a 5–20-km-thick metasedimentary succession deposited during an important transition in the Precambrian development of North America. Key unresolved issues for the Belt Basin include the chronology of deposition, sources of siliciclastic sediment, and regional paleogeography during Laurentian orogenesis. To address these topics, we acquired detrital zircon U-Pb geochronologic data for eastern exposures of the Belt-Purcell Supergroup in the Lewis thrust salient along the USA-Canada border. To define an integrated chronostratigraphic and provenance framework for the Belt Basin, we calculated maximum depositional ages and qualitatively and quantitatively compared our geochronologic data set to a compilation of Laurentian igneous and metamorphic zircon U-Pb ages using multidimensional scaling and an inverse Monte Carlo model. The results suggest a stratigraphic age range of ca. 1495–1380 Ma, constituting a depositional duration of ~115 m.y. with an average sediment accumulation rate of ~40 m/m.y. for the studied locality (extrapolated to ~155 m/m.y. for the basin depocenter). Variations in sediment provenance are expressed by three distinct intervals within the Belt-Purcell Supergroup. The lower Belt Supergroup succession (Waterton to lower Helena Formations; ca. 1495–1440 Ma) is dominated by Paleoproterozoic and Archean grains derived from the northeastern Canadian Shield. The middle Belt Supergroup succession (upper Helena to Sheppard Formations; ca. 1440–1420 Ma) displays mixed early Mesoproterozoic, late Paleoproterozoic, and Archean zircon age groups. The upper Belt Supergroup succession (Gateway to Roosville Formations; ca. 1420–1380 Ma) contains almost entirely late Paleo-proterozoic zircons sourced from the south (Yavapai-Mazatzal and Mojave crustal provinces). We interpret sediment provenance to reflect a continental-scale, fluvial drainage reorganization during middle Belt Supergroup deposition that can be linked to the recently recognized Picuris orogeny.