Department Of Biomedical Research Articles

Comparison between IOL MASTER 500 and MYAH with vector analysis in low and mild anterior corneal astigmatism.

Evaluate the agreement between IOL Master 500 (Carl Zeiss Meditec AG, Germany) and MYAH (Topcon EU, Visia Imaging, Japan) in measuring axial length, keratometry, and anterior corneal astigmatism. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Ophthalmology Clinic, University of Messina, Messina, Italy. In this prospective study, 40 eyes (right eye 25, left eye 15) of 40 patients were included. Axial length (AL), keratometry (K1, K2), and anterior corneal astigmatism (ACA) were measured. AL, mean K (Kavg) and magnitude of ACA were compared using Bland - Altman plot analysis, parametric and nonparametric statistical analysis. The difference vector and angle of error of the ACA measured by the two devices were evaluated by vector analysis using polar diagrams. Mean and standard deviation with IOL Master and with MYAH device was for AL 24.25 ± 1.22 mm and 24.25 ± 1.22 mm (p = .99), for Kavg 42.75 ± 1.53 D and 42.85 ± 1.52 D (p = .78), for Magnitude of ACA 1.00 ± 0.58 D and 0.89 ± 0.56 D (p = .38) respectively. High correlations were found for AL (R² = 0.999), Kavg (R² = 0.996), and ACA Magnitude (R² = 0.889). Bland-Altman analysis of the two devices found high agreement and absence of proportional bias (MYAH-IOL MASTER) were found between the two assessments for AL (bias = -0.0005 mm, p = .93), Kavg (bias = 0.0955 D, p = .76) and ACA (bias = 0.11 D, p = .41). Limit of agreement (upper/lower LoA, 95%CI) were respectively +0.057/-0.058 mm for AL, + 0.29/-0.09 D for Kavg and +0.49/-0.27 D for ACA. No statistical difference was found between the x-component and y-component of the ACA vector (p > .01), the difference vector (IOL MASTER-MYAH) was +0.14 D axis 159 with an absolute mean angle of error of 7.2 ± 7.5 degree. The instruments appear to be interchangeable for measurements of AL, keratometry, and magnitude of ACA with high agreement between the two devices. Also, in the presence of low astigmatism, the two instruments give the same results in terms of ACA.

The intertwined epidemics of HIV and COVID-19 - emerging data and responses.

aDivision of HIV, Infectious Diseases, and Global Medicine; Department of Medicine; University of California, San Francisco (UCSF), USA bIII Division of Infectious Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Luigi Sacco University Hospital, University of Milan, Italy Correspondence to Agostino Riva, and Monica Gandhi, MD, Universita degli Studi di Milano, Milano, Italy. E-mail: [email protected]; [email protected]

How Effective Are Current Interventions for Preventing Falls in Parkinson Disease?: A Cochrane Review Summary With Commentary.

1Department of Biomedical, Surgical and Dental Sciences, University “La Statale”, Milan, Italy. 2IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Correspondence to: Claudio Cordani, PT, PhD (s). Department of Biomedical, Surgical and Dental Sciences, University “La Statale”, Via della Commenda 10, 20122 Milan, Italy. Email: [email protected]

In search of clinical targets for suicide prevention in major depressive disorder.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Received 10 February 2023 Accepted 13 February 2023. Correspondence to Alessandro Serretti, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna, Viale Carlo Pepoli, 5, Bologna 40123, Italy, Tel: +39 051 6584233, +39 320 4269332, +39 347 3024020; fax +39 051 521030; e-mail: [email protected]

Recycled Carbon Fibre Composites in Automotive Manufacturing

Article Recycled Carbon Fibre Composites in Automotive Manufacturing Jean-Baptiste R. G. Souppez 1, * , and Geethanjali S. Pavar 2 1 Department of Mechanical, Biomedical and Design Engineering, School of Engineering and Technology, College of Engineering and Physical Sciences, Aston University, Birmingham B4 7ET, UK. 2 Institute for Energy Systems, School of Engineering, University of Edinburgh, Edinburgh EH9 3JW, UK. * Correspondence: j.souppez@aston.ac.uk Received: 9 January 2023 Accepted: 22 February 2023 Published: 6 March 2023 Abstract: The contemporary need for lightweight and sustainable materials in automotive manufacturing has made recycled carbon fibre an attractive option. Yet, aspects such as the mechanical properties of short fibre composites need to be characterised to fully identify the capabilities and opportunities for recycled carbon fibre in the automotive industry. Consequently, this paper aims to ascertain the potential of recycled carbon fibre materials for automotive manufacturing by considering mechanical properties, design implications, and resulting costs and sustainability. Destructive testing is employed to characterise the mechanical properties of virgin carbon fibre (VCF), recycled carbon fibre (RCF) using pyrolysis, and blended recycled carbon fibre (BRCF) comprising 50% polypropylene fibre. Here we quantify (i) the reduction in mechanical properties, namely the tensile modulus and breaking strength, (ii) the resulting increase in required thickness and therefore mass for manufactured parts and (iii) the reduction in cost and embodied energy achieved for RCF and BRCF compared to VCF, based on both a stiffness- and a strength-driven design criterion. Furthermore, we present a decision-making methodology revealing BRCF as the most cost-effective solution, while RCF proves to be the most sustainable alternative. These results provide a novel quantitative assessment of recycled carbon fibre for automotive manufacturing and may contribute to future developments in sustainable composite manufacturing in the automotive industry.

Fine-tuning of psychopharmacological treatments.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Received 26 October 2022 Accepted 27 October 2022. Correspondence to Alessandro Serretti, MD, Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy Tel: +39 051 6584233; fax: +39 051 521030;e-mail: [email protected]

Open issues in bipolar and antipsychotic treatments.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Received 9 September 2022 Accepted 14 September 2022 Correspondence to Alessandro Serretti, MD, Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy, Tel: +39 051 6584233; fax +39 051 521030; e-mail: [email protected]

Double safe suture during cataract surgery on post radial keratotomy patients using clear corneal incisions.

the aim of this study is to find a safer surgical approach in cataract surgery on eyes previously treated with radial keratotomy using clear corneal incisions. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Ophthalmology Clinic, University of Messina, Messina, Italy. Prospective study. A prospective study was conducted on a group of 20 patients, 21 eyes with 16 RK incisions were evaluated for cataract phacoemulsification. Samples were divided into two groups: Group 1 underwent surgery with pre-operative one corneal stitch along radial keratotomy incisions near the main access site whereas Group 2 underwent modified surgery with two corneal stitches. After surgery, visual acuity, corneal hysteresis and corneal strength was evaluated. In all cases, an increased visual acuity was observed. Group 1 showed an UCVA of logMAR 0.22 ± 0.14, while group 2 presented a logMAR of 0.1 ± 0.07. Data did not show a statistically significant difference in UCVA after surgery between the two groups (P = 0.133). Instead, a significant difference in corneal hysteresis (CH), respectively with values of 8.65 ± 1.6 mmHg in group 1 and 9.2 ± 1.8 in group 2 (P = 0.031), and a corneal resistance factor (CRF) with values of 7.87 ± 1.4 mmHg in the first group and 8.65 ± 1.6 mmHg in the second one (P = 0.039) was observed. Double safe suture technique offers better stabilization of corneal structure during surgery in patients preventively treated with 16 incisions RK.

Clinical implications of assessing frailty in elderly patients treated with permanent cardiac pacing

aCardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena bClinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy Correspondence to Professor Giuseppe Boriani, MD, PhD, FESC, FEHRA, Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41124 Modena, Italy Tel: +39 59 4225836; fax: +39 59 4224498; e-mail: [email protected] Received 12 May, 2021 Accepted 29 May, 2021

Sleep disorders and the autonomic nervous system

SLEEP DISORDERS AND AUTONOMIC NERVOUS SYSTEM Federica Provini IRCCS, Istituto delle Scienze Neurologiche di Bologna Department of Biomedical and Neuromotor Sciences, University of Bologna Italy Sleep and autonomic nervous system (ANS) are interdependent by virtue of their common controls, neurobiological substrates and functions. Major confirmation of this is the presence of dynamic and synchronous fluctuations in sleep phases and autonomic variables during the physiological sleep. Much evidence from experimental and clinical studies supports the bidirectional nature of the relationship between sleep disorders and ANS dysfunctions.

First person – Elin Schoultz and Ellen Johansson

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Elin Schoultz and Ellen Johansson are co-first authors on ' Tissue architecture delineates field cancerization in BrafV600E-induced tumor development', published in DMM. Elin is an MD, PhD student in the lab of Mikael Nilsson at Sahlgrenska Centre for Cancer Research, Gothenburg University, Gothenburg. She has a great interest in the thyroid gland in particular, and the mechanisms of tumor development, progression and treatment associated with epithelial carcinomas in general. Ellen is an MD, resident physician in oto-rhino-laryngology and postdoctoral researcher in the lab of Karin Roberg at Department of Biomedical and Clinical Sciences, Division of Cell Biology, Linköping University, Linköping, with broad interest the thyroid gland, tumors of the head and neck region, and the molecular mechanisms that are important for tumor initiation, development, and treatment.

Covid-19: Side Effects on Orthopaedic Patients

Orthopedic Research Online Journal Covid-19: Side Effects on Orthopaedic Patients Michelangelo Palco1*, Alito Angelo2, Antongiulio Bruschetta3, Demetrio Milardi1 and Danilo Leonetti1 1Department of Biomedical, Dental and Morphological and Functional Images, Section of Orthopaedic and Traumatology, University of Messina, Messina, Italy 2U.O.C of Physical and Rehabilitation Medicine and Sports Medicine, Italy 3Orthopaedic Institute of Southern Italy, Franco Scalabrino, Italy *Corresponding author:Michelangelo Palco, Department of Biomedical, Dental and Morphological and Functional Images, Section of Orthopaedic and Traumatology, University of Messina, Messina, Italy Submission: June 21, 2021;Published: July 06, 2021 DOI: 10.31031/OPROJ.2021.08.000687 ISSN: 2576-8875 Volume8 Issue3

Cephalometric Changes Following Maxillary Expansion with Ni-Ti Leaf Springs Palatal Expander and Rapid Maxillary Expander: A Retrospective Study

Background: The aim of this study is to evaluate and compare, through bidimensional cephalometry, skeletal and dental changes obtained from a rapid maxillary expander (RME) and a Ni-Ti leaf spring expander (Leaf) and compare them with an untreated control group. Methods: Records consisted of lateral cephalograms obtained before and after maxillary expansion of patients that underwent orthodontic treatment at the Department of Biomedical, Surgical and Dental Sciences. The Leaf expander group consisted of 9 males (mean age = 7.5 ± 0.9 years old) and 11 females (mean age = 8.2 ± 0.6 years old). The RME group of the present study was composed of 11 males (mean age = 7.8 ± 0.6 years old) and 12 females (mean age = 8.1 ± 0.5 years old). Digital cephalograms were traced using Dolphin Imaging software v.11.1 (Dolphin Imaging and Management Solutions; Los Angeles, CA, USA), which calculated all reported measurements. Each subject was assigned a random identification number, and the examiner was blinded to the subject when measuring. The difference between the two experimental times in all groups was evaluated using the Student’s t-test for dependent variables. The difference between the two evaluation times in each group for all the variables was used to perform a one-way ANOVA test between the three groups. Results: No statistically significant difference was noted, apart from the angle between the upper incisor and the SN and PP planes, which showed an average decrease of 3.25 and 2.55, respectively, and the angle between the lower incisors and the mandibular plane, which showed an average increase of 2.85 degrees. The one-way ANOVA showed no statistically significant difference between the three groups. Conclusions: It appears that the leaf expander and the RME present similar effects such as dental and skeletal changes.

Efficacy of personal protective equipment and H2O2‐based spray against coronavirus in dental setting

Oral DiseasesVolume 28, Issue S1 p. 1010-1012 LETTER TO THE EDITOR Efficacy of personal protective equipment and H2O2-based spray against coronavirus in dental setting Andrei Cristian Ionescu, Corresponding Author Andrei Cristian Ionescu Andrei.ionescu@unimi.it orcid.org/0000-0001-9051-4109 Oral Microbiology and Biomaterials Laboratory, Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy Correspondence Andrei Cristian Ionescu, Microbiology Institute, via Pascal, 36, 20133 Milan, Italy. Email: Andrei.ionescu@unimi.it Contribution: Conceptualization, Methodology, Writing - original draftSearch for more papers by this authorEugenio Brambilla, Eugenio Brambilla orcid.org/0000-0003-0094-4565 Oral Microbiology and Biomaterials Laboratory, Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy Contribution: Conceptualization, Validation, Writing - original draftSearch for more papers by this authorLamberto Manzoli, Lamberto Manzoli orcid.org/0000-0002-8129-9344 Department of Medical Sciences, University of Ferrara, Ferrara, Italy Contribution: Formal analysis, Resources, Writing - review & editingSearch for more papers by this authorGiovanna Orsini, Giovanna Orsini orcid.org/0000-0002-2641-0695 Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Ancona, Italy Contribution: Writing - review & editingSearch for more papers by this authorValentina Gentili, Valentina Gentili orcid.org/0000-0003-4572-5497 Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy Contribution: Data curation, MethodologySearch for more papers by this authorRoberta Rizzo, Roberta Rizzo orcid.org/0000-0001-9507-9126 Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy Contribution: Data curation, Writing - review & editingSearch for more papers by this author Andrei Cristian Ionescu, Corresponding Author Andrei Cristian Ionescu Andrei.ionescu@unimi.it orcid.org/0000-0001-9051-4109 Oral Microbiology and Biomaterials Laboratory, Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy Correspondence Andrei Cristian Ionescu, Microbiology Institute, via Pascal, 36, 20133 Milan, Italy. Email: Andrei.ionescu@unimi.it Contribution: Conceptualization, Methodology, Writing - original draftSearch for more papers by this authorEugenio Brambilla, Eugenio Brambilla orcid.org/0000-0003-0094-4565 Oral Microbiology and Biomaterials Laboratory, Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy Contribution: Conceptualization, Validation, Writing - original draftSearch for more papers by this authorLamberto Manzoli, Lamberto Manzoli orcid.org/0000-0002-8129-9344 Department of Medical Sciences, University of Ferrara, Ferrara, Italy Contribution: Formal analysis, Resources, Writing - review & editingSearch for more papers by this authorGiovanna Orsini, Giovanna Orsini orcid.org/0000-0002-2641-0695 Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Ancona, Italy Contribution: Writing - review & editingSearch for more papers by this authorValentina Gentili, Valentina Gentili orcid.org/0000-0003-4572-5497 Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy Contribution: Data curation, MethodologySearch for more papers by this authorRoberta Rizzo, Roberta Rizzo orcid.org/0000-0001-9507-9126 Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy Contribution: Data curation, Writing - review & editingSearch for more papers by this author First published: 28 November 2020 https://doi.org/10.1111/odi.13736Citations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume28, IssueS1Special Issue: COVID-19, Part 2 of a 2-Part SeriesApril 2022Pages 1010-1012 RelatedInformation

Are we on brink of a second COVID-19 wave in Italy? Let’s look at Google Trends

Ciaffi J, Meliconi R, Landini MP, Ursini F (2020) Google trends and COVID-19 in Italy: could we brace for impact? Intern Emerg Med. https://doi.org/10.1007/s11739-020-02371-7(Ahead of print 25 May 2020) Article PubMed PubMed Central Google Scholar Fu L, Wang B, Yuan T et al (2020) Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. J Infect 80(6):656–665. https://doi.org/10.1016/j.jinf.2020.03.041 CAS Article PubMed PubMed Central Google Scholar Eysenbach G (2011) Infodemiology and infoveillance tracking online health information and cyberbehavior for public health. Am J Prev Med 40(5 Suppl 2):S154–S158. https://doi.org/10.1016/j.amepre.2011.02.006 Article PubMed Google Scholar Download references Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli (IOR), via Pupilli 1, 40136, Bologna, Italy Jacopo Ciaffi, Riccardo Meliconi & Francesco Ursini Department of Biomedical and Neuromotor Sciences (DIBINEM), Section of Rheumatology, University of Bologna, Bologna, Italy Riccardo Meliconi & Francesco Ursini Scientific Direction, IRCCS Istituto Ortopedico Rizzoli (IOR), Bologna, Italy Maria Paola Landini You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Jacopo Ciaffi. The authors declare they have no conflict of interest. Not applicable. Not applicable. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions Ciaffi, J., Meliconi, R., Landini, M.P. et al. Are we on brink of a second COVID-19 wave in Italy? Let’s look at Google Trends. Intern Emerg Med (2020). https://doi.org/10.1007/s11739-020-02502-0 Download citation Received: 23 August 2020 Accepted: 05 September 2020 Published: 17 September 2020 DOI: https://doi.org/10.1007/s11739-020-02502-0

Queen's University Faculty of Health Sciences.

Queen's University Faculty of Health Sciences.

Effectiveness of physical therapy in addition to occlusal splint in myogenic temporomandibular disorders: protocol of a randomised controlled trial

IntroductionTemporomandibular disorders (TMDs) are considered a collection of musculoskeletal conditions involving the masticatory muscles, the temporomandibular joint and associated structures. The myogenous group appears to represent the most frequently diagnosed...

Adherence to Pediatric Universal Cholesterol Testing Guidelines Across Body Mass Index Categories: A CER2 Cohort Study.

Adherence to Pediatric Universal Cholesterol Testing Guidelines Across Body Mass Index Categories: A CER2 Cohort Study.

Ultrasonographic Examination: The "X-Factor" in Physiatry.

IRCCS Rizzoli Orthopaedic Institute Department of Biomedical and Neuromotor Science Physical and Rehabilitation Medicine Unit Bologna, Italy Hacettepe University Medical School Department of Physical and Rehabilitation Medicine Ankara, Turkey

Influence of Genistein and Exercise on Lipid Metabolism in High Fat‐High Sugar Fed Mice

Intake of diets high in saturated fat with sugar have been associated with chronic diseases including type 2 diabetes and Alzheimer's disease (AD). This study varied diet and exercise and assessed the changes in adipose metabolism by measuring serum markers, hepatosteatosis, and skeletal muscle lipid metabolism. Male and female 5–6 week old C57BL/6J mice were randomly assigned one of the following groups for 12 weeks (n=8–10/group): lean control (Ln), high fat diet, HFD (60% of calories from fat), and high sucrose/fructose (42 g combined/L drinking water) (HFHS), HFHS with genistein (Gen), HFHS with exercise (Ex), or HFHS with genistein and exercise (Gen‐Ex). Exercise consisted of 150 min/week forced treadmill running. Genistein dose was 600 mg genistein/kg HFD. We hypothesize that Ex and Gen will improve deficits in lipid metabolism associated with diabetes and obesity. Males and females had significant weight increase in HFHS groups compared to Ln groups (40.8% and 27.5% respectively, P<0.05). In males, body weight was significantly lower in Ex (8.9%), Gen (19.2%) and Gen‐Ex mice (32.6%, P<0.05) compared to HFHS controls. In females, body weight was significantly lower in the Gen‐Ex (20.7%, P<0.05) compared to HFHS controls. Weight loss was not attributed to reduced food intake, nor correlated to comparable changes in serum triglyceride. Male liver weight/body weight was increased in HFHS (31.8%, P<0.05) versus Ln, and subsequently reduced by Ex (23.5%), Gen (39%) and Gen‐Ex (52%, P<0.05) compared to HFHS controls. Female liver/body weight was comparable between groups. Glucose tolerance tests (GTT) in subgroups of mice (n=3–5/group) showed rescue of serum glucose in Gen‐Ex males (not females), which reflected concomitant changes in serum insulin. Protein expression of the skeletal muscle lipid metabolism marker, carnitine palmitoyltransferase 1b (CPT1b) was greater (80.5%, n=5/group, P<0.05) in males fed HFHS compared to Ln controls, with no differences in treatment interventions. We aim to provide mechanistic evidence for sex‐dependent effects and to demonstrate an association between genistein‐ and exercise‐mediated improvements in diet induced diabetic‐obesity. Current studies continue to evaluate other metabolic markers. Data currently suggests significant weight changes are not correlated with concomitant changes in skeletal muscle lipid metabolism markers.Support or Funding InformationLayla Al‐Nakkash, and Tom Broderick were supported by Midwestern‐Arizona Alzheimer's Consortium and Midwestern Intramural funds. Amy Fisher and Chaheyla St Aubin were supported by the Department of Biomedical Sciences.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.