Introduction Dental caries is a worldwide disease affecting children and older populations.There aremultiple interventionsto treatdentalcariesthat could be sometimeshard todeliver,due to the general statusof patientssuch as insufficient cooperationormedicallycompromising conditions. Therefore, another alternative to control dental caries is being used andhasbeenrecentlyintroduced and approved by the Saudi FDA which is silver diamine fluoride (SDF). Objectives This study aimed toinvestigate the level of knowledge, attitudes, and practices about the use of SDF among dentists in Riyadh, Saudi Arabia. Materials and methods Thiscross-sectionalstudywas conductedusingpretested,anonlinedigitally designedquestionnairesentto500 Saudi Commission for Health Specialties (SCFHS) registereddentists working in the following specialties: general practitioners, interns,restorative,family, pediatric, and public health dentistswho are working in public and private hospitals and clinics. One-way ANOVAwas usedto determine the comparison of participants'knowledge and Practice with three variables (participants' specialty, place of work, and years of experience), while Chi-square was used for the comparison of respondent's attitudes about the use of SDF and the above same variables. Result A totalof265responseswerereceived(response rate is53%). Themajority of therespondents were general practitioners and interns 144 (54.3%).Over50% of dentists believedthat theywereveryinformedaboutSDF. The mean score of knowledgeand practices of SDF of participants was found below average 49.13 (19.81) and 43 (26.12), respectively. Correlation ofthemeanscoreknowledgeand practicing SDFwith the type of specialty showed that pediatric dentists had statically significant (P<0.05)higher mean of knowledge 66.94 (SD=17.64)and practicing of SDF 61.93 (22.12) as compared to other specialties,whileno statistically significant differences were found among the groups in the overall knowledge andpractices based on years of experience andworkplace.Attitudeswere correlated with the three above variables (specialty, years of experience, and place of work)and showed thatpediatric dentists had the highest satisfaction with the results of SDF (85.3%)andweremorewilling to recommend using it to others(91.2%) as compared totheother groups(P<0.05).Nostatistically significant differenceswerefound with respect to the latervariables. Conclusion The findings of this studyshowed that irrespective of the positive attitude of participants towards SDF,pediatric dentistswere found to have higher knowledge and use SDF more than other dentists in different specialties. Furthermore, they showed higher satisfaction with its use. Years of experienceand workplace had no effect on the level of knowledge or practice among participants.