Dentin Sensitivity Research Articles

Constructing the Enamel-Like Dentin Adhesion Interface to Achieve Durable Resin-Dentin Adhesion.

Enamel adhesion is acknowledged as durable; however, achieving long-lasting dentin adhesion remains a formidable challenge due to degradation of exposed collagen matrix after acid-etching of dentin. The idea of developing an enamel-like adhesion interface holds great promise in achieving enduring dentin adhesion. In this study, we constructed an enamel-like adhesion interface using a rapid remineralization strategy comprising an acidic primer and a rapid remineralization medium. Specifically, the acidic primer of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) and epigallocatechin-3-gallate (EGCG) nanocomplex (MDP@EGCG primer) was utilized to partially demineralize dentin within 30 s, and the MDP@EGCG nanocomplex showed a strong interaction with exposed collagen, enhancing collagen remineralization properties. Then, the rapid remineralization medium containing polyaspartate (Pasp) stabilized amorphous calcium and phosphorus nanoclusters (rapid Pasp-CaP) was applied to modified dentin collagen for 1 min, which caused rapid collagen remineralization within a clinically acceptable time frame. This strategy successfully generated an inorganic rough and porous adhesive interface resembling etched enamel, fundamentally addressed issues of collagen exposure, and achieved durable dentin adhesion in vitro and in vivo while also ensuring user-friendliness. It exhibited potential in prolonging the lifespan of adhesive restorations in clinical settings. In addition, it holds significant promise in the fields of caries and dentin sensitivity treatment and collagen-based tissue engineering scaffolds.

HIPERSENSIBILIDADE DENTINÁRIA: Causas, sintomas e abordagens terapêuticas

Dentin Hypersensitivity (DH) is a condition that affects a large portion of the population, DH causes acute painful symptoms that can profoundly affect the individual's quality of life since it has a multifactorial etiology and, in many cases, is related directly to the diet performed by the person and his∕her oral hygiene habits. It is important to highlight that dentin sensitivity and dentin hypersensitivity are different situations, the first being a physiological situation and the second a pathological condition which requires treatment to stop the painful symptoms. This work aims to explore the causes, symptoms and treatment options of Dentin Hypersensitivity. A descriptive narrative literature review was carried out about Dentin Hypersensitivity using, as a bibliographical basis, scientific articles available on the online databases BVSAlud, Lilacs, Scielo, PUBMed and Google Scholar, published between 2015 and 2024 and available in Portuguese and/or English. After analyzing all the material used as a bibliographical basis for the development of this work, it is concluded that it is extremely important that dental surgeons have knowledge about Dental Hypersensitivity since this condition affects a considerable portion of the population and causes acute painful symptoms which affects the quality of life of individuals considerably.

Stannous fluoride toothpaste efficacy for dentin sensitivity: Systematic review meta-analysis

Stannous fluoride toothpaste efficacy for dentin sensitivity: Systematic review meta-analysis

Predicting the risk of dentin sensitivity development in dental patients

The main predisposing factors for DS occurrence and development in dental patients have been identified, and the DS prognosis program and the DS prognosis index have been developed.The program and the prognosis index were tested in 95 dental patients. The control group consisted of 30 patients. Clinical parameters were assessed before treatment, after 1 week, and 1, 6, 12 months. The treatment effectiveness was assessed using the number of good, satisfactory, and unsatisfactory treatment results in each group.The results of clinical observation of patients showed that the use of the DS prognosis program and the DS prognosis index makes it possible not only to clearly inform patients about the level of risk of developing DS, but also to constantly monitor prognostic signs, which increases the treatment effectiveness by 47 %.Good treatment results in 97 % of cases in a long-term period determine the feasibility of including the program we developed and the prognosis index in the complex treatment of DS in dental patients.

Ozone and Laser Effects on Dentin Hypersensitivity Treatment: A Randomized Clinical Study

IntroductionThe aim of this study was to evaluate and compare the clinical efficacy of diode laser and ozone gas in the treatment of dentin hypersensitivity (DHS). MethodsOne hundred thirty-two teeth from 44 patients with moderate DHS were randomized into 3 groups according to a split-mouth design. In the diode laser group, the operator irradiated the superficial dentin exposed with an 808-nm wavelength and incremental power from 0.2 to 0.6 W with a 20-second interval. In the ozone gas group, the operator applied a high dose of ozone (32 g/m3) for 30 seconds using a silicon cup. In the placebo group, no therapy was applied. The dentin sensitivity level was evaluated upon enrollment (T0), immediately after treatment (T1), 3 months post-treatment (T2), and 6 months post-treatment (T3) with a cold air blast challenge and tactile stimuli. The pain severity was quantified according to the visual analogue scale. The Wilcoxon signed rank test was used to scrutinize potential statistical disparities among the treatments. Statistical significance was predetermined at P < .05. ResultsA significant decrease of DHS was observed in the ozone gas group and the `diode laser group immediately after treatment and after 3 and 6 months of the therapy. After 6 months from the therapy, the sensitivity values in the teeth treated with ozone gas remained statistically lower than those treated with diode lasers (P < .05). ConclusionsA laser diode and ozone gas are both efficient as dentin sensitivity treatment. Ozone maintains an invariable effectiveness after 6 months.

Effectiveness of Auriculotherapy in Reducing Dentin Sensitivity During and After the Bleaching Procedure

Abstract Tooth sensitivity is a common side effect of whitening treatment. The popularity of alternative and complementary therapies such as auriculotherapy has grown steadily. The purpose of this research is to assess the efficacy of acupuncture as an integrative technique for reducing sensitivity during and after the whitening operation. The study is a clinical trial with two study groups: group 1 (n=3) volunteers who got auriculotherapy before and during the whitening operation, and group 2 (n=3) participants who did not get auriculotherapy, for a total of (n=6) volunteers (pilot study). The volunteers were males between the ages of 18 and 30, chosen based on inclusion and exclusion criteria. The auriculotherapy technique was performed by batches. Six envelopes with the process to be performed, auricle without crystal, merely micropore, and auricle with crystal on the predefined locations were separated. Two sessions were performed, one 7 days before whitening and the second shortly before whitening, to replace the crystals in the participants chosen for this operation. Only the micropore was altered in the case of the others. Sensitivity was assessed using the Wong-Baker Face Scale in conjunction with the Visual Analog Scale. It was discovered that the group that used auriculotherapy had lower sensitivity than the group that did not. As a result, auriculotherapy seems to be useful in lowering dentin sensitivity during and after the whitening operation. Keywords: Tooth Sensitivity. Clinical Trial. Whitening. Auriculotherapy. Resumo A sensibilidade dentária é um efeito adverso comum associado ao tratamento clareador. A procura por terapias alternativas e complementares, como a auriculoterapia tem aumentado progressivamente. Nessa perspectiva, o objetivo deste estudo é analisar a eficácia da acupuntura como prática integrativa para diminuir a sensibilidade durante e após o procedimento clareador. A pesquisa é um ensaio clínico, constituído por 2 grupos de estudo: o grupo 1, representado pelos voluntários que receberam a auriculoterapia antes e durante o procedimento clareador (n=3), e o grupo 2, representado pelos voluntários que não receberam a auriculoterapia (n=3), totalizando (n=6) voluntários (estudo piloto). Os voluntários são do sexo masculino, com idade entre 18 e 30 anos, selecionados seguindo critérios de inclusão e exclusão. O procedimento de auriculoterapia foi realizado com base em um sorteio. Foram separados 6 envelopes, nos quais continha o procedimento a ser realizado, auriculo sem cristal, apenas micropore e auriculo com cristal nos pontos pré-determinados. Foram realizadas 2 sessões, sendo uma prévia 7 dias antes do clareamento e a outra imediatamente antes do clareamento, substituindo os cristais em seus respectivos acupontos para os voluntários sorteados com esse procedimento. Para os demais era feita apenas a troca do micropore. Foi utilizado a Escala Wong-Baker Face associada à Escala Visual Analógica como meio avaliativo da sensibilidade. Verifcamos uma redução na sensibilidade para o grupo que utilizou a auriculo em comparação ao grupo que não utilizou. Sendo assim, podemos sugerir que a auriculoterapia foi efetiva na redução da sensibilidade dentinária durante e após o procedimento clareador. Palavras-chave: Sensibilidade Dental. Ensaio Clínico. Clareadores. Auriculoterapia.

Influence of Er:YAG and ND:YAG laser irradiation and fluoride application on surface roughness and dentin surface wear after erosive challenge - An in vitro study.

To evaluate the effectiveness of Er:YAG and Nd:YAG laser on dentin hypersensitivity prevention, associated or not to acidulated phosphate fluoride (APF) after erosive challenge. 104 specimens were obtained from bovine dentine and divided into groups (n=13): G1: Er:YAG; G2: Er:YAG followed by application of APF; G3: application of APF followed by Er:YAG, simultaneously; G4: Nd:YAG; G5: Nd:YAG followed by application of APF; G6: application of APF followed by Nd:YAG, simultaneously; G7:application of APF; G8: untreated. The parameters for Er:YAG were:10s, distance of 4mm, water cooling flow of 2mL/min, 2Hz, 3.92J/cm2. For the Nd:YAG: 10s, distance of 1mm, without cooling, 10Hz, 70.7J/cm2. The erosive drink was a cola at 4°C, 3×/day for 1 minute, for 5 days. Roughness and wear analysis were done in confocal laser microscope. Data were statistically analyzed (α=0.05). As regards roughness, there was no statistically difference among the groups. The groups irradiated with Er:YAG had a volume loss lower. G6 showed higher values than the groups irradiated with Er:YAG and lower than the other groups. The other groups irradiated with Nd:YAG showed similar wear results to the control. The Er:YAG laser showed the lowest volume loss from wear analysis, suggesting the increased the acid resistance of dentin. Key words:Dentine sensitivity, Lasers, Sodium fluoride.

Pathogenesis, diagnosis, and management of dentin hypersensitivity

Dentin sensitivity is a problem characterized by brief sharp pain that occurs in response to things like changes in temperature, sweet or sour substances and mechanical factors. This condition significantly affects the lives of patients leading to restrictions and changes in oral hygiene routines. It is crucial for care to understand the causes, symptoms, diagnosis and management of dentin sensitivity. The development of dentin sensitivity is closely related to the structure of teeth which involves the exposure of tubes in the dentin that contain nerve endings sensitive to stimuli. Different theories, such as the theory and direct innervation theory provide insights into how this pain occurs. Diagnosis involves an evaluation of signs and symptoms along with patient history and specific tests to confirm sensitivity. Management options include adjusting behaviors using desensitizing toothpaste or fluoride applications utilizing bonding agents or even undergoing procedures like gingival grafts. These approaches aim to reduce pain and improve the quality of life for individuals affected by dentin sensitivity. Dental professionals play a role, in diagnosing, treating and educating patients about this condition to ensure results and better oral health.

Case Report: Case report: Rapidly progressing tooth wear dominated by intrinsic and extrinsic erosion

Tooth wear is multi-factorial presenting as a combination of abrasion, attrition, and erosion. This case report represents a case of combined tooth wear in a 46-year-old Indo-Trinidadian male, with a predominant erosive component with both the clinical signs and features of intrinsic and extrinsic erosion. This patient case is unique since the wear predominated by dental erosion has occurred rapidly evidenced by the physical clinical appearance of a lack of compensation and the upper left premolars and molars relatively unaffected by the overall effects of tooth wear. This lack of compensation, where opposing teeth have not supra-erupted to maintain inter-arch stability, and the maintenance of occlusal vertical dimension on the left due to the non-worn posterior maxillary teeth, provides the benefit of simplifying subsequent restorative management. The medical and diet history corroborates the diagnoses of intrinsic and extrinsic erosion respectively. Complications noted with rapid tooth wear, such as dentine sensitivity and pulpal necrosis are known sequelae of tooth wear however the patient presented in this case report shows a concomitant high caries experience and poor oral hygiene. Cases such as the one presented here require not only comprehensive dental management, utilizing a restorative approach but also medical referral for confirmation of a diagnosis and management of gastroesophageal reflux disease. Inherent to the management of this patient should be a multidisciplinary medical and dental approach, with confirmation and management of the cause of the intrinsic erosion as well as restorative dental management, together with dietary counseling to mitigate the effect of intrinsic and extrinsic sources of acid on dental hard tissue. A key lesson learned from this case is the importance of history and targeted questioning when trying to determine the cause of tooth wear dominated by intrinsic and extrinsic erosion.

ACTIVE ROLE OF POTASSIUM NITRATE TOOTHPASTE FOR TREATING DENTINE HYPERSENSITIVITY AND MAINTAINING THEIR NORMAL PHYSIOLOGY

Background: Prevalence of dentine hypersensitivity in individuals is increasing globally due to the intake of erosive acidic food beverages and improper brushing protocols in turn adversely affecting the tooth surfaces. Toothpastes containing various potassium salts are very effective in treating the dentine sensitivity when used properly for some time. Herein, we have investigated the association between the dentine sensitivity and 5% potassium nitrate toothpaste usage for a period of one month. Methods: For this interventional study, one hundred and forty participants with dentine sensitivity were analysed before and after using 5% potassium nitrate toothpaste. Visual Analog Scale (VAS) scoring tool was employed where sensitivity to Air among the participants was calculated by VAS-Air scoring and sensitivity to cold was tested by VAS-Cold scoring. Paired t-test was incorporated for performing the statistical analysis through the IBM SPSS-22. Results: There was a strong association between the dentine sensitivity and usage of 5% potassium nitrate toothpaste. After using the 5% potassium nitrate toothpaste for one month, the calculated VAS-Air scoring and VAS-Cold scoring reduced significantly against both the air and cold stimuli which was found to be 2.67±1.12 and 1.86±0.83 (p=0.001). Conclusions: The 5% potassium nitrate toothpaste was potent enough to reduce the dentine hypersensitivity in the participants against both the thermal and air stimuli. Pak J Physiol 2023;19(3):39–42

Evaluation of dentinal tubule occlusion and pulp tissue response after using 980-nm diode laser for dentin hypersensitivity treatment.

To evaluate the effectiveness of the 980-nm diode laser for dentinal tubule occlusion, measure the intrapulpal temperature, and investigate the dental pulp response. The dentinal samples were randomly divided into G1-G7 groups: control; 980-nm laser irradiation (0.5 W, 10s; 0.5 W, 10s × 2; 0.8 W, 10s; 0.8 W, 10s × 2; 1.0 W, 10s; 1.0 W, 10s × 2). The dentin discs were applied for laser irradiation and analyzed by scanning electron microscopy (SEM). The intrapulpal temperature was measured on the 1.0-mm and 2.0-mm thickness samples, and then divided into G2-G7 groups according to laser irradiation. Moreover, forty Sprague Dawley rats were randomly divided into the laser-irradiated group (euthanized at 1, 7, and 14days after irradiation) and the control group (non-irradiated). qRT-PCR, histomorphology, and immunohistochemistry analysis were employed to evaluate the response of dental pulp. SEM indicated the occluding ratio of dentinal tubules in the G5 (0.8 W, 10s × 2) and G7 (1.0 W, 10s × 2) were significantly higher than the other groups (p < 0.05). The maximum intrapulpal temperature rises in the G5 were lower than the standard line (5.5 ℃). qRT-PCR showed that the mRNA expression level of TNF-α and HSP-70 upregulated significantly at 1day (p < 0.05). Histomorphology and immunohistochemistry analysis showed that, compared with the control group, the inflammatory reaction was slightly higher at the 1 and 7days (p < 0.05) and decreased to the normal levels at 14days (p > 0.05). A 980-nm laser at a power of 0.8 W with 10s × 2 defines the best treatment for dentin hypersensitivity in terms of compromise between the efficacy of the treatment and the safety of the pulp. The 980-nm laser is an effective option for treating dentin sensitivity. However, we need to ensure the safety of the pulp during laser irradiation.

Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study.

Propolis is a natural resinous substance collected by honeybees, chiefly from buds and the leaves, branches, and bark of trees. Its role as a wound-healing gel has been studied, but the use of a propolis hydrogel in the treatment of dentinal hypersensitivity has not been evaluated. Dentin hypersensitivity (DH) is commonly treated via iontophoresis using fluoridated desensitizers. The aim of the present study was to compare and evaluate the effects of a 10% propolis hydrogel, 2% sodium fluoride (NaF), and 1.23% acidulated phosphate fluoride (APF) when used in conjunction with iontophoresis for the treatment of cervical dentin hypersensitivity (DH). Systemically healthy patients complaining of DH were selected for this single-centre, parallel, double-blind randomized clinical trial. Three substances were selected as desensitizers for study in the present trial: a 10% propolis hydrogel, 2% sodium fluoride, and 1.23% acidulated phosphate fluoride, all in conjunction with iontophoresis. Any decrease in DH following the application of specific stimuli was assessed at baseline, before and after application, on the 14th day following use, and on the 28th day following the intervention. Intra-group comparisons show diminished values of DH at maximum post-op follow-up intervals which were significantly trimmed down from the baseline (p < 0.05). The 2% NaF demonstrated a significant reduction in DH over 1.23% APF and the 10% propolis hydrogel (p < 0.05). However, there was no statistically significant difference in the mean difference between the APF and propolis hydrogel groups assessed via tactile, cold, and air tests (p > 0.05). All three desensitizers have proved to be useful when used in conjugation with iontophoresis. Within the limitations of this study, a 10% propolis hydrogel can be used as a naturally occurring alternative to commercially available fluoridated desensitizers.

Polytetrafluoroethylene tape to combat tooth sensitivity during complete mouth rehabilitation

Dentin sensitivity is a common complaint from patients during and after tooth preparation for complete coverage restorations. Techniques to reduce sensitivity during tooth preparation include immediate dentin sealing and application of desensitizers. However, managing dentin sensitivity during complete mouth rehabilitation on natural teeth can be challenging, especially for patients with dentin hypersensitivity. A technique to protect the prepared teeth during complete mouth rehabilitation using polytetrafluoroethylene (PTFE) tape is described.

Controversy Related to Interdisciplinary Periodontal-Orthodontic Approach in Gingival Recession Coverage

The aim of this review is to present controversial issue and available evidences in the literature related to the treatment of gingival recession associated with mal-aligned tooth using interdisciplinary periodontal-orthodontic approach. Gingival recession often causes dentin sensitivity, increase vulnerability to root caries and esthetic concern. Tooth mal-alignment is an important predisposing factor associated with gingival recession. In current era, people are often concerned about their esthetics and approach for root coverage. Clinicians must be aware about current evidences regarding treatment of gingival recession associated with mal-alignment.

A Comparative Evaluation of the Effects of Three Remineralizing Agents on Bleached Enamel: A Scanning Electron Microscopy (SEM) Analysis.

With the emerging concern of patients on esthetics, bleaching has become quite popularto get that "Shining White Smile."However, bleaching chemicals used on enamel's surface have been a clinical issue due to the fact that they might cause a variety of side effects, including sensitivity, gingival irritation, dentinal sensitivity, demineralization, and changes in the enamel's surface morphology. As a result, it is important to investigate different remineralizing agentsthat help to reduce the adverse effects. The researchers in this in-vitro study used a scanning electron microscope (quanta 200 SEM, California, USA) and a universal testing machine to assess the effects of three remineralizing productssuch asTooth Mousse Plus (GC Corporation, India), Tooth Min (Abbott, India), and Elsenz (Group Pharmaceuticals Ltd, India) on bleached enamel. Based on the data available, we determined that bleaching greatly reduces the enamel microhardness of permanent human premolars; however, this loss could be recovered with a remineralizing agent. Tooth Mousse Plus is the most effective remineralizing agent among the three, followed by Elsenz and, finally, Tooth Min.

Histomorphological study of gingival recession in the experiment

Among periodontal diseases, one of the most common forms is gingival recession, which is a progressive displacement of the marginal gingiva in the apical direction. Studies by a number of authors indicate an increase in the prevalence and intensity of recession from 9.7 % to 99.3 % (at the age of 15 years to adult age, respectively) [1–3]. The reasons for the development of recession may be the following factors: anatomical and physiological features of the structure of the alveolar process, anomalies of teeth, dentition and dental occlusion, microbial factor (hard and soft dental deposits), acute or chronic gum injury, bad habits, and iatrogenic causes [10, 9, 11, 17]. Gingival recession is the cause of dentin sensitivity, as well as a factor in additional plaque retention, which stimulates further loss of periodontal attachment [11, 17]. Any aesthetic violations significantly reduce the quality of life. In this aspect, gum recession, which causes exposure of the roots of the teeth, has an extremely negative effect on the psycho-emotional state of a patient. An integrated approach to the problem under consideration is of great importance, in particular, in elderly and senile people, where systemic disorders of mineral metabolism often come to the fore [4, 8, 12, 14, 15, 16]. Experimental modeling of periodontal pathologies is of great clinical and rehabilitation significance [6, 7, 10, 11, 13]. Currently, there are various methods of treating gingival recession using a complex of therapeutic, surgical, orthodontic, and orthopedic methods. However, the results of observations and monitoring of the effectiveness of known methods of treating gingival recession do not indicate long-term restoration of periodontal tissues [5, 10, 11, 17]. Thus, the foregoing indicates the feasibility of conducting experimental and clinical studies to find methods aimed at activating recovery processes in periodontal tissues and allowing to increase the effectiveness of treatment of patients with gingival recession.

Effectiveness of a Single Chair Side Application of NovaMin® [Calcium Sodium Phosphosilicate] in the Treatment of Dentine Hypersensitivity following Ultrasonic Scaling-A Randomized Controlled Trial.

Dentinal hypersensitivity or cervical dentinal sensitivity is one of the commonest clinical problems. The aim of this randomized controlled trial was to evaluate the effectiveness of a single chair side application of 100% pure calcium sodium phosphosilicate (NovaMin®) in reducing dentin hypersensitivity following ultrasonic scaling as evaluated on a visual analogue scale (VAS). The study included 50 subjects who were selected based on an evaluation of dentinal hypersensitivity on a VAS carried out using a metered air blast from a three-way syringe and divided into two groups (n = 25/group); i.e., the test group (Group A) received the NovaMin® paste and the control group (Group B) received a placebo paste made from pumice. All the 50 subjects included in the study were had VAS scores of 3 or more. The NovaMin® powder mixed with distilled water was applied. Dentinal hypersensitivity was reassessed immediately and after 1, 2 and 4 weeks after the procedure. Results showed that the percentage reduction of dentinal hypersensitivity following a single application of NovaMin® in powder form was about 76.38% immediately, 67.72% one week postoperatively, 52.76% two weeks postoperatively and 26.78% four weeks postoperatively. It can be concluded from the results of the current clinical study demonstrated that a single chair side application of NovaMin® in powder form has a significant and immediate reduction in dentinal hypersensitivity, which lasted nearly for four weeks.

Assessment of Cervical Abrasion, Dentin Hypersensitivity, and Its Treatment Needs Using the Cervical Abrasion Index of Treatment Needs Probe.

Objective This study was intended to compare the mean buccolingual measurement of abraded teeth with/without sensitivity. The hypothesis was that the suggested treatment approaches would be in agreement with that of the treatment needs (TN) elicited using the Cervical Abrasion Index of Treatment Needs (CAITN) probe and aid in the development of a prospective CAITN index for clinical/community studies of effective therapeutic measures. Materials and methods A cross-sectional study was carried out on 30 individuals with a mean age of 48.4±12.54 years, comprising 840 teeth with/without cervical abrasion. The buccolingual measurement of each tooth was recorded using the CAITN probe. The response to air-blast was assessed by a short blast of one-second duration at a distance of 1 cm for each tooth. An endodontist was also asked to indicate the treatment methods used by him for the treatment of abrasions. His opinions regarding the TN were later compared with the data collected by an investigator. Results The mean buccolingual measurements of all the teeth were compared with the dentinal sensitivity using the independent t-test and were statistically highly significant. Furthermore, one-way analysis of variancedisclosed that there was a statistically highly significant difference found for all the TN (p<0.01) such as none, preventive, basic, and advanced restorative TN followed by Tukey honestly significant difference post hoc tests for multiple pair-wise comparisons. The running receiver operator characteristic curve discloses the best cut-off value of the buccolingual measurement to predict the various categories of TN of each tooth. As the area under the curve is more close to 1 (noticed in the majority of the teeth in the sample), the model predicts the TN more precisely based on the buccolingual measurements. Conclusion The present study enables a correct diagnosis of cervical abrasions and determines the various TN with the most appropriate restorative material. These baseline data helpto design clinical studies that test relevant treatment and diagnostic strategies.

Bleaching effectiveness and cytotoxicity of new experimental formulation of niobium-based bleaching gel.

The development of new bleaching agents with minimum concentration of hydrogen peroxide (HP), without adverse effects, and with bleaching effectiveness, has great clinical relevance. The aim of this study was to evaluate the bleaching efficacy and cytotoxicity of a new niobium-based bleaching gel, compared to already available HP-based gels. For the bleaching efficacy analysis, 40 bovine incisors were randomly divided into 4 groups according to the established bleaching protocol: control, untreated; 35HP, 35% HP bleaching gel; 6HP, 6% HP bleaching gel; NbHP, niobium gel associated with 3% HP gel. The color variation was measured in a spectrophotometer and the values of ΔL, Δa, Δb, and ΔE obtained. For the cell viability assay by MTT, MC3T3 cells were exposed to bleaching gel extracts (1:500, 1:250, 1:125 dilutions; immediately and 24h). Statistical tests were performed (P < 0.05). The color alteration for all bleaching gels was significant compared to control (P < 0.05), but the NbHP gel showed a significant ΔE than other gels, with expressive color alteration at 14days (P < 0.05). The 35HP showed high cytotoxicity regarding control and the most groups in all periods and extracts analyzed (P < 0.05), while the NbHP showed greater cell viability than control in the immediate period, dilution of the 1:500 and superior to 6HP in the most extracts at 24h. The new experimental niobium-based gel has bleaching efficacy similar to that of gels with a high concentration of HP, and it has high cytocompatibility. The use of this new generation of niobium-based whitening gel associated with a low concentration of hydrogen peroxide represents the possibility of a tooth whitening with lower dentin sensitivity.

Comparative evaluation of desensitizing effect of three fluoride varnishes in patients with dentinal sensitivity under palliative care: A cross-sectional study

Comparative evaluation of desensitizing effect of three fluoride varnishes in patients with dentinal sensitivity under palliative care: A cross-sectional study