Dental Implantology Research Articles

Importance of CBCT diagnostics in dental implantology

ABSTRACT In today's world, the aesthetic demands of patients in dentistry are very high, followed by functional requirements. CBCT diagnostics facilitate the achievement of these goals. Modern dentistry involves replacing missing teeth with dental implants. In dental implantology, precise imaging techniques are essential to accurately capture the area where implants will be placed, in order to avoid damaging adjacent vital structures during surgery. Today, radiological analysis of CBCT scans is considered the best method of choice, or the gold standard, in the pre-implantation procedure. On CBCT scans, we can visualize the height, width, and density of the available bone for implant placement, the precise location of the maxillary sinus, mandibular canal, mental foramen, incisive canal, and diagnose certain present pathological changes.

Propolis in Dental Implantology: A Systematic Review of Its Effects and Benefits

Dental implants are widely recognized for their effectiveness in restoring missing teeth, yet their success is often compromised by infections or inadequate osseointegration. Propolis, a natural resinous substance with potent antimicrobial, anti-inflammatory, and osteogenic properties, has emerged as a promising adjunct in dental implantology. This systematic review critically evaluates the current evidence on the incorporation of propolis into dental implants, focusing on its impact on antimicrobial efficacy, bone healing, and overall implant stability. The study protocol was registered in PROSPERO under the registration number CRD42024577122. The PRISMA diagram visually represented the search strategy, screening, and inclusion process. Two reviewers conducted a comprehensive literature search across five databases: PubMed, PubMed Central, Embase, Scopus, and Web of Science. The review synthesized findings from 13 studies; in vitro, in vivo, and clinical studies, highlighting that propolis significantly enhances antibacterial and antifungal activities against pathogens such as Staphylococcus aureus, Candida albicans, and Streptococcus mutans, thereby reducing the risk of peri-implant infections. Additionally, propolis promotes osseointegration by stimulating osteoblast activity and reducing inflammatory cytokine expression, leading to improved bone formation and implant stability. The anti-inflammatory and antioxidant properties of propolis further contribute to a favorable healing environment, enhancing the long-term success of dental implants. The systematic review underscores the potential of propolis as a safe, biocompatible, and effective material for improving dental implant outcomes. However, it also identifies the need for more extensive clinical trials to fully establish standardized protocols for propolis application in implantology. This review provides an overview of propolis’s potential role in dental implants and suggests promising avenues for future research to optimize its benefits in clinical practice.

From Tradition to Technology: Robotic Artificial Intelligence in Dental Implantology

From Tradition to Technology: Robotic Artificial Intelligence in Dental Implantology

Knowledge maps as a complementary tool to learn and teach surgical anatomy in virtual reality: A case study in dental implantology

AbstractA thorough understanding of surgical anatomy is essential for preparing and training medical students to become competent and skilled surgeons. While Virtual Reality (VR) has shown to be a suitable interaction paradigm for surgical training, traditional anatomical VR models often rely on simple labels and arrows pointing to relevant landmarks. Yet, studies have indicated that such visual settings could benefit from knowledge maps as such representations explicitly illustrate the conceptual connections between anatomical landmarks. In this article, a VR educational tool is presented designed to explore the potential of knowledge maps as a complementary visual encoding for labeled 3D anatomy models. Focusing on surgical anatomy for implantology, it was investigated whether integrating knowledge maps within a VR environment could improve students' understanding and retention of complex anatomical relationships. The study involved 30 master's students in dentistry and 3 anatomy teachers, who used the tool and were subsequently assessed through surgical anatomy quizzes (measuring both completion times and scores) and subjective feedback (assessing user satisfaction, preferences, system usability, and task workload). The results showed that using knowledge maps in an immersive environment facilitates learning and teaching surgical anatomy applied to implantology, serving as a complementary tool to conventional VR educational methods.

A Vision-Guided Robotic System for Safe Dental Implant Surgery.

Background: Recent advancements in dental implantology have significantly improved outcomes, with success rates of 90-95% over a 10-year period. Key improvements include enhanced preplanning processes, such as precise implant positioning, model selection, and optimal insertion depth. However, challenges remain, particularly in achieving correct spatial positioning and alignment of implants for optimal occlusion. These challenges are pronounced in patients with reduced bone substance or complex anthropometric features, where even minor misalignments can result in complications or defects. Methods: This paper introduces a vision-guided robotic system designed to improve spatial positioning accuracy during dental implant surgery. The system incorporates advanced force-feedback control to regulate the pressure applied to bone, minimizing the risk of bone damage. A preoperative CBCT scan, combined with real-time images from a robot-mounted camera, guides implant positioning. A personalized marker holder guide, developed from the initial CBCT scan, is used for patient-robot calibration. The robot-mounted camera provides continuous visual feedback of the oral cavity during surgery, enabling precise registration of the patient with the robotic system. Results: Initial experiments were conducted on a 3D-printed mandible using a personalized marker holder. Following successful patient-robot registration, the robotic system autonomously performed implant drilling. To evaluate the accuracy of the robotic-assisted procedure, further tests were conducted on 40 identical molds, followed by measurements of implant positioning. The results demonstrated improved positioning accuracy compared to the manual procedure. Conclusions: The vision-guided robotic system significantly enhances the spatial accuracy of dental implants compared to traditional manual methods. By integrating advanced force-feedback control and real-time visual guidance, the system addresses key challenges in implant positioning, particularly for patients with complex anatomical structures. These findings suggest that robotic-assisted implant surgery could offer a safer and more precise alternative to manual procedures, reducing the risk of implant misalignment and associated complications.

Comparative analysis of alveolar bone volume reconstruction outcomes using the guided bone regeneration technique

Relevance. The success of dental implant treatment in cases of reduced alveolar bone volume hinges on restoring bone to the required dimensions in each case. The guided bone regeneration (GBR) technique, which encompasses various techniques, holds a central role in oral reconstructive surgery and dental implantology due to its capacity for continuous improvement. The authors' experience with a modified GBR technique incorporating a situational Vicryl framework (SVF) has demonstrated enhanced effectiveness, with the potential to restore vertical bone volume by 5 mm or more. This study aimed to evaluate the advantages of the modified GBR technique using SVF compared to the conventional GBR technique.Materials and methods. This study is based on a comprehensive comparative analysis of two datasets: a retrospective evaluation of dental implant treatment outcomes in 210 patients who required alveolar bone volume restoration using the classical GBR technique, and clinical data from 40 patients treated with both the classical GBR technique and the proposed modified SVF technique The oral status of 40 patients included in the clinical analysis was characterized by partial edentulism, accompanied by mild to moderate alveolar bone deformities resulting from either inflammatory resorption or natural atrophy. The retrospective group 1 (comparisons) consisted of archival data of 210 patients. Retrospective data from 210 patients and clinical data from 40 patients were subjected to statistical analysis using parametric and non-parametric methods with IBM SPSS Statistics software.Results. A comprehensive comparative analysis of retrospective and clinical data revealed the following results. The value of the integrated "restored bone volume" parameter after vertical reconstruction in group 1 was 2-3 mm. The mean value of the integrated "restored bone volume" parameter after vertical reconstruction in group 2 was 3.20±0.96 mm, while in group 3, it was 4.60±1.63 mm for patients of both sexes. Comparison of the integrated "baseline deformation" parameter by technique showed a median deformation of 2.95 mm in group 2, treated with the classical GBR technique, and 4.95 mm in group 3, treated with the modified SVF technique. Similarly, the integrated "restored bone volume" parameter showed a median value of 2.95 mm in group 2 and 4.85 mm in group 3. The average value of the integrated "restored bone volume" parameter in group 2 was comparable to retrospective data from 210 patients in group 1.Conclusion. The comprehensive analysis of alveolar bone volume reconstruction using two GBR techniques, based on "baseline deformation" and "restored bone volume" parameters, demonstrated a significant advantage of the modified GBR technique compared to the classical technique.

Investigating the Impact of Various Abutment Materials on Peri-Implant Tissue Health at Tripoli-Libya

This research investigates the impact of different abutment materials, including titanium, zirconia, and hybrid materials, on peri-implant tissue health in dental implantology. A prospective cohort study design was employed, involving 150 participants who received single or multiple dental implants from Banzi & Bianco s.r.l. (B&B) a dental implant company based in Italy. Clinical parameters, such as peri-implant probing depth, bleeding on probing, and radiographic analysis, were measured at baseline and at 3-, 6-, and 12-months post-abutment placement. Statistical analyses, including ANOVA and regression, were conducted to identify significant associations between abutment materials and peri-implant tissue health parameters. The results revealed nuanced relationships among the abutment materials and their impact on peri-implant tissue health. Interestingly, the hybrid material group exhibited more favorable outcomes in maintaining optimal tissue health compared to the titanium and zirconia groups. This finding suggests that the choice of abutment material can significantly influence the long-term health of peri-implant tissues. This study contributes valuable insights for clinicians in selecting abutment materials for dental implant restorations, highlighting the importance of considering hybrid materials as a potential option for better clinical outcomes (p< 0.001).

A novel methodology for analysing dental implant positional changes from virtual planning to placement without CBCT.

Introduction This paper introduces a novel methodology for analysing dental implant positioning in vivo, advancing beyond traditional methods that rely on post-placement cone beam computed tomography (CBCT) scans.Method The core of the methodology is comparing stereolithography (STL) files, representing pre-planned and actual post-placement implant positions. These STL files, exported from guided surgery planning and computer-aided design software, focus on clinically significant key points, like the apical and coronal midpoints. Additionally, the method uses pose detection, differing fundamentally from CBCT scan approximations.Discussion Relying on pose detection instead of scanner resolution, this method aligns with international standards and overcomes CBCT and intra-oral scanner limitations. It allows for a more precise and accurate assessment of implant positions, independent of scanner technology constraints. Further refinements include potential detailed reporting of apical deviations, enhancing implant placement accuracy.Conclusion This research has significant implications for dental implantology, enhancing implant placement precision and overall procedure success. Introducing an automated process for report generation through a batch script improves efficiency and precision, streamlining the analysis process. This innovation sets the stage for future technological advancements, improving both the accuracy and reliability of implant placement assessments.

The Effects of Smoking on Dental Implant Failure: A Current Literature Update.

Background: This systematic review assesses the current literature (2020-2024) evaluating the impact of smoking on dental implant failure rates. Methods: A non-funded Pubmed database review was conducted according to PRISMA guidelines, and the results were tabulated to extract the study design, patient characteristics, follow-up time, comparison, outcome, and strengths and weaknesses, including risk of bias. This review included 33 studies with 29,519 implants placed in over 18,301 patients. We included prospective and retrospective clinical studies, randomized and non-randomized controlled trials, cohort studies, and observational studies that examined smoking's effects on implant failure rates. Studies had to classify individuals into two groups, smokers and non-smokers, with at least ten implants. Exclusions included reviews, case reports, experimental studies, guidelines, non-English publications, studies lacking comparative data on failure rates, those excluding smokers, and studies focusing on head and neck cancer patients or specialized implants. Results: Our findings indicate a significant correlation in 25 out of 33 studies between smoking and increased implant failure rates, affecting both early and late stages of implant integration and survival as well as revealing a dose-response relationship, with higher daily cigarette consumption significantly increasing the risk of implant failure. Conclusions: This review highlights the importance of smoking cessation efforts, patient education, and tailored patient care in dental implantology. Future research should explore the effects of smoking frequency and alternative tobacco products, such as e-cigarettes, aiming to improve success rates among smokers.

Current view of inflammatory postprosthetic complications of dental implantation and methods of their prevention (literature review)

Subject. A literature review was conducted on a current topic in dental implantology – long-term complications of dental implantation of inflammatory nature detected after the placement of prosthetic structures. The purpose of this literature review is to analyze studies that address inflammatory complications in dental implant treatment. Methods: The study reviewed full-text publications in English and Russian that deal with postprosthetic complications of dental implantation. The following search engines were used in the literature search process: Pubmed, e-Library, Cyberleninka by keywords. The time period was designated as 2019-2024. There were 948 publications identified on this topic. Of these, 32 publications corresponded to the purpose of our study. Results. Studies on the prevalence and identification of risk factors of late complications encountered in dental implantation are extremely important for planning complex rehabilitation of patients with partial secondary oral adentia, for understanding the occurrence and progression of these complications. The study of measures to eliminate one of the main causes of these complications, namely the lack of attached keratinized gingiva, will improve the strategy of prevention and treatment of this pathology to improve the quality of life of patients. Conclusions. Current trends in dental implantation require not only achieving implant osseointegration, but also obtaining healthy peri-implant soft tissues to avoid late implant complications such as peri-implant mucositis and peri-implantitis. There are many studies describing surgical methods of increasing the volume of attached keratinized gingiva necessary for stable implant functioning.

Applications of Nano Graphene Oxides in Prosthodontics and Implant Dentistry- Current Trends and Future Outlook

The world of Material Science has constantly evolved with newer materials being introduced constantly. One such material is Graphene which possessed excellent electrical, mechanical, thermal, optical, and biological properties due to which it has been used extensively in the fields of Optoelectronics, Energy harvesting, Films and Coatings, Water Filtration, Structural Engineering applications, Thermal management Devices and Sensors. Graphene-based Nanoparticles have also shown promising results in biomedicine, Tissue engineering scaffolds, Biomarker detectors, Biosensors, and Drug Delivery systems. Furthermore, extensive investigation is being performed on graphene-based Nanomaterials for their use in Dentistry, as it is shown to have promising results when incorporated into various Dental Restorative and Prosthetic Materials. This narrative review aims to give an overview of the application of graphene derivatives in dentistry, particularly on their application in Prosthodontics and Dental Implantology based on available research data and clinical studies. Further research is imperative to fully explore the potential of graphene to ensure its safe usage in dental practice.

Per-Ingvar Brånemark (1929-2014): A Homage to the Father of Osseointegration and Modern Dentistry.

Dr. Professor Per-Ingvar Brånemark (Branemark), a Swedish professor of anatomy, is widely acknowledged as a pioneer in modern implant dentistry. His accidental discovery of the strong bond between titanium and bone, which he named "osseointegration," signifies a revolutionary progression in dentistry. This significant contribution has earned him global recognition among scholars and the general public. His work, which spans across disciplines, has introduced a new era of implant reconstruction and fostered the formulation of principles rooted in bone biology. This interdisciplinary advancement has paved the way for diverse craniofacial and orthopedic applications, including facial prostheses and limb replacements, owing to titanium's biocompatibility within the human body. This article stands as a tribute to Brånemark and his remarkable innovation. Despite not being a dentist, Brånemark, an orthopedic surgeon, has left an enduring legacy in dental implantology that continues to impact the field today and will undoubtedly do so in the future, deserving lasting recognition.

Aesthetic Rehabilitation of Edentulous Spaces with Dental Implants Using Single-stage and Two-stage Systems: A Case Series

Abstract Dental implants are a useful tool in the treatment of missing teeth. Dental implantology has a long history that reaches back to ancient times when attempts were made to replace missing teeth with various materials. Modern dental implants are designed to osseointegrate with the jawbone. There are two main surgical techniques: One-stage surgery and two-stage surgery. One-stage surgery involves placing the implant and allowing a healing abutment to protrude through the gums. This eliminates the need for a second surgery but carries the risk of overloading the implant during the healing phase. Two-stage surgery is the standard approach, where the implant is initially submerged, and a second surgery is performed to connect the abutment. The choice between one-stage and two-stage surgeries depends on many factors. This article aims to discuss a series of cases comparing the two modalities of implant placement.

Accuracy of Dental Implant Placement using Robotics. A Systematic Review of in vitro Studies.

Robotic-assisted techniques have the potential to revolutionize dental implantology by offering enhanced precision, accuracy, and clinical outcomes compared to computer-assisted implant placement techniques. This study aimed to evaluate the accuracy of dental implant placement using robot-assisted implant surgery in vitro settings. An unrestricted search of indexed databases along with a manual search was performed up to March 2024. In vitro, studies comparing the positioning accuracy of robotic systems in dental implant placement of planned pre-operative coordinates and postoperative outcomes in phantom and simulated models were included. QUIN Tool was used to assess the quality of the included studies. A total of 13 in vitro studies were included. All studies except one used entry, exit, or angle deviation as parameters to assess the accuracy of implants placed on phantom models or simulated virtual implant placement. Overall, pooled entry deviations were 0.72 ± 0.68 mm, exit deviations were 0.86 ± 0.92 mm, and angular deviations were 1.47 ± 1.610 favoring robot-assisted implant surgery. Based on the current evidence, robotic-placed implants have the potential to revolutionize dental implantology by offering enhanced precision, accuracy, and clinical outcomes compared to dynamic and static computer-assisted implant surgery techniques.

A review on modern prosthodontic practice using laser.

Lasers are a very appealing technology in many areas of dentistry because of their minimally invasive nature, quick tissue interaction & response, and ability to heal. Numerous investigations on the possible uses of lasers in dentistry have been carried out since Maiman developed the ruby laser in 1960. Numerous applications such as quick prototyping and computer-aided design, and the study of occlusion in complete denture using three-dimensional laser scanning has been used to develop dentures. Its uses are numerous from fixed prosthodontics to dentinal hypersensitivity treatment to surface treatment of base metal alloys. These days, it even encompasses maxillofacial prosthodontics and dental implantology. Hence, it is of interest to review the use of lasers in clinical prosthodontics.

Materials Evolution in Dental Implantology: A Comprehensive Review

This comprehensive review navigates the dynamic landscape of dental implant materials, exploring historical milestones, mechanical intricacies, and emerging innovations. Tracing the evolution from early experimentation to the establishment of titanium as a benchmark, the review sheds light on the critical interplay of strength, elasticity, and fatigue resistance in materials' biomechanical performance. The diverse array of materials, including metals like titanium, ceramics such as zirconia, and polymers like polyetheretherketone (PEEK), is examined in depth, emphasizing their unique attributes and contributions to clinical needs. Surface modifications emerge as transformative elements, accentuating the role of precision engineering in optimizing implant performance. Challenges, encompassing biocompatibility, mechanical incongruity, and infection vulnerabilities, underscore the intricacies of material selection in implant dentistry. The ongoing pursuit of solutions to esthetic limitations and long-term stability constitutes a focal point for future research. Emphasizing the importance of ongoing research, the review highlights emerging materials, such as bioactive ceramics and advanced polymer composites, driven by nanotechnology and 3D printing. Smart implants, antimicrobial surfaces, and regenerative approaches signal a transformative era in precision dentistry. The journey towards refined materials transcends disciplines, uniting researchers, clinicians, and materials scientists in a collaborative pursuit. As the narrative of dental implant materials unfolds, the future beckons with promises of seamless integration with biological tissues, esthetic advancements, and redefined standards in oral rehabilitation. This review encapsulates a dynamic field in continual evolution, extending an invitation to collectively shape the future of dental implantology.

Biologics Agents in Periodontal Regeneration:A Review

The field of periodontology and dental implantology has witnessed significant advancements in the use of molecular mediators and biologic agents over the past decade. Periodontal regeneration, which involves the complete restoration of cementum, bone, and connective tissue following removal of epithelial tissues, is considered superior to tissue repair. Recent research has focused on utilizing biologic materials as complementary therapies to enhance regeneration by accelerating wound healing. These biologic agents were investigated using the following search terms: tissue engineering, intercellular signaling molecules, and biological factors. Enamel matrix derivative (EMD), platelet-derived growth factor (PDGF), platelet-rich plasma, bone morphogenetic proteins (BMPs), fibroblast growth factor (FGF), and parathyroid hormone (PTH) have demonstrated the capacity to stimulate both hard and soft tissue regeneration. However, no single biologic agent is universally effective, necessitating a case-by-case evaluation for optimal treatment selection. Currently, EMD and PDGF are the only biologic therapies approved by the FDA for periodontal regeneration, while BMP-2 is indicated for bone augmentation. Due to a lack of FDA approval for periodontal applications, the clinical use of FGF and PTH in this context is not recommended.

Improved new bone formation capacity of hyaluronic acid-bone substitute compound in rat calvarial critical size defect

BackgroundBone loss of residual alveolar ridges is a great challenge in the field of dental implantology. Deproteinized bovine bone mineral (DBBM) is commonly used for bone regeneration, however, it is loose and difficult to handle in clinical practice. Hyaluronic acid (HA) shows viscoelasticity, permeability and excellent biocompatibility. The aim of this study is to evaluate whether high-molecular-weight (MW) HA combined with DBBM could promote new bone formation in rat calvarial critical size defects (CSDs).Materials and methodsRat calvarial CSDs (5 mm in diameter) were created. Rats (n = 45) were randomly divided into 3 groups: HA-DBBM compound grafting group, DBBM particles only grafting group and no graft group. Defect healing was assessed by hematoxylin-eosin staining and histomorphometry 2, 4 and 8 weeks postop, followed by Micro-CT scanning 8 weeks postop. Statistical analyses were performed by ANOVA followed by Tukey's post hoc test with P < 0.05 indicating statistical significance.ResultsAll rats survived after surgery. Histomorphometric evaluation revealed that at 2, 4 and 8 weeks postop, the percentage of newly formed bone was significantly greater in HA-DBBM compound grafting group than in the other two groups. Consistently, Micro-CT assessment revealed significantly more trabecular bone (BV/TV and Tb.N) in HA-DBBM compound group than in the other two groups, respectively (P < 0.05). Moreover, the trabecular bone was significantly more continuous (Tb.Pf) in HA-DBBM compound group than in the other two groups, respectively (P < 0.05).ConclusionHA not only significantly promoted new bone formation in rats calvarial CSDs but also improved the handling ability of DBBM.

Evaluation of Peri-Implantitis Bone Defect Healing: Comparing the Efficacy of Small-Particle Dentin and Bio-Oss in Bone Density Attenuation.

Introduction: Peri-implantitis is a serious complication in dental implantology that, if left untreated, may lead to implant loss and systemic diseases. Effective regeneration of bone defects resulting from peri-implantitis is crucial to maintaining the functionality of dental implants. Purpose of the Study: The study aimed to compare the effectiveness of fine-particle dentin and Bio-Oss in the reconstruction of bone defects caused by peri-implantitis. Materials and Methods: The study included a comprehensive radiological assessment of changes in bone density over time. Bone density was assessed using Hounsfield Units (HUs) as a measure of bone attenuation, with radiological assessments performed at 8- and 12-week intervals during the healing process. The study included participants ranging in age from 30 to 65 years. Fifty-seven patients were divided into three groups: 22 patients received small-particle dentin, 15 received Bio-Oss, and 20 controls without bone substitute material. Results: The fine-dentin group showed a 20% increase in bone density after 8 weeks (p < 0.05), while the Bio-Oss group showed a 15% increase after 12 weeks (p < 0.05). The control group showed minimal changes in bone density (5% after 12 weeks), which was not statistically significant. Clinical evaluations showed 95% successful integration in the fine dentin group, 85% in the Bio-Oss group, and 70% in the control group. The fine-dentin group showed a 20% increase in bone density after 8 weeks (p < 0.05), while the Bio-Oss group showed a 15% increase after 12 weeks (p < 0.05). The control group showed minimal changes in bone density (5% after 12 weeks), which was not statistically significant. Clinical evaluations showed 95% successful integration in the fine-dentin group, 85% in the Bio-Oss group, and 70% in the control group. Conclusions: Both fine-particle dentin and Bio-Oss significantly improved bone density compared to the control group. Fine-particle dentin is suitable for immediate bone regeneration due to its rapid initial regeneration, while Bio-Oss provides long-term support, ideal for maintaining implant stability over a longer period of time. The results highlight the importance of selecting appropriate bone replacement materials depending on the clinical scenario to improve patient outcomes after dental implant placement.

Impact of Silicon Carbide Coating and Nanotube Diameter on the Antibacterial Properties of Nanostructured Titanium Surfaces.

This study aimed to comprehensively assess the influence of the nanotube diameter and the presence of a silicon carbide (SiC) coating on microbial proliferation on nanostructured titanium surfaces. An experiment used 72 anodized titanium sheets with varying nanotube diameters of 50 and 100 nm. These sheets were divided into four groups: non-coated 50 nm titanium nanotubes, SiC-coated 50 nm titanium nanotubes, non-coated 100 nm titanium nanotubes, and SiC-coated 100 nm titanium nanotubes, totaling 36 samples per group. P. gingivalis and T. denticola reference strains were used to evaluate microbial proliferation. Samples were assessed over 3 and 7 days using fluorescence microscopy with a live/dead viability kit and scanning electron microscopy (SEM). At the 3-day time point, fluorescence and SEM images revealed a lower density of microorganisms in the 50 nm samples than in the 100 nm samples. However, there was a consistently low density of T. denticola across all the groups. Fluorescence images indicated that most bacteria were viable at this time. By the 7th day, there was a decrease in the microorganism density, except for T. denticola in the non-coated samples. Additionally, more dead bacteria were detected at this later time point. These findings suggest that the titanium nanotube diameter and the presence of the SiC coating influenced bacterial proliferation. The results hinted at a potential antibacterial effect on the 50 nm diameter and the coated surfaces. These insights contribute valuable knowledge to dental implantology, paving the way for developing innovative strategies to enhance the antimicrobial properties of dental implant materials and mitigate peri-implant infections.