The hydrogen evolution reaction (HER) in Ag12M clusters with first-row 3d metal (M) dopants is evaluated by means of density functional theory (DFT). The results show that the M dopants favor the highest coordination positions, except for M = Zn, favoring the surface position. The findings indicate that Ag12Ti and Ag12Cu clusters are suitable catalysts for HER applications, according to the adsorption energy and Gibbs free energy parameters. The interactions of the clusters with H can be explained by density of states analyses. The obtained results suggest that atomically precise doped Ag clusters are suitable targets as relevant candidates for HER applications.