Reducing multiple contaminations in reflection seismic data remains one of the primary challenges in marine seismic data processing. Besides geological settings, its effectiveness is also dependent on the multiple removal methods. In this study, we undertook two legacy 2D multi-channel seismic data crossing the accretionary wedge off SW Taiwan to test the efficiency of various multiple-attenuation scenarios. The tectonic domain has resulted from the incipient arc-continent collision between the northern rifted margin of the South China Sea and the Luzon volcanic arc. The wedge extends from shallow water to deep water bathymetries, hence promoting both short-period and long-period multiples within the seismic records. A cascade of de-multiple methods was tested to attenuate multiple energy under various seafloor bathymetry and tectonic areas. The first step relies on the periodicity nature of multiples. Spatial dependent predictive deconvolution in the x-t domain was performed to attenuate reverberations and improve temporal resolution in the time domain. Wave-equation multiple attenuation (WEMA) was applied to suppress the water layer multiples based on a combination of numerical wave extrapolation in the shot domain through water layer and water bottom reflectivity. Surface-related multiple elimination (SRME) aimed to attenuate the residual water bottom multiple and peg-leg multiple by assuming surface-related multiples can be kinematically predicted via convolution of pre-stack seismic traces at possible surface multiple reflection locations. The second step exploits the spatial move-out difference behavior between primaries and multiples. Parabolic Radon transforms far-offset multiples by subtracting noise energy in the τ-p domain, whereas the frequency-wave number (F-K) filter aimed to eliminate any residual multiples energy in the F-K domain. Predictive deconvolution improved seismic resolution and suppressed sea-bottom reverberation energy in the continental and lower wedge slopes, but not in the upper wedge slope. WEMA, Radon filter, and F-K filter reduced multiples energy both at the continental slope and wedge slope; whereas SRME made minimal impact on both areas. Since the reflection seismic datasets stretch diverse tectonic environments and water depth, there was no single multiple attenuation method capable to suppress multiples in all tectonic environments and bathymetry.