The article is devoted to a comparative analysis of the development of European scepticism and anti-Americanism in the public political process in the United States and the European Union. In the countries of the European Union, the term European scepticism refers to a negative attitude towards the process of European integration and its functional result in the form of the European Union. In the United States, mostly in ultra-conservative circles, European scepticism refers to a critical attitude towards the EU as the embodiment of the liberal democracy project. Anti-Americanism as an ideological attitude is present not only in European far-left political circles, but also in European far-right political circles. In the United States, the ideology of anti-Americanism was clearly manifested in the Black Lives Matter movement. European scepticism and anti-Americanism are actively used by Russian and Chinese propaganda as signs of an allegedly inevitable crisis of the ‘collective West’ and a ‘natural transition’ to a multipolar world in which Western democracies will not be crucial for further development. The conclusions emphasise that populist diseases of liberal democracies are actively used by autocracies to discredit the democratic experience of political life. At the same time, Russia, Iran, and China are trying to take advantage of discourses on scenarios of the US isolation from active foreign policy and the European Union's self-restrictions in pursuing its own common foreign policy and impose their own versions of ‘hybrid wars’, pushing Western influence out of key regions of Eastern Europe, the Middle East, and Southeast Asia. In view of this, the transfer of ideas of anti-Americanism and European scepticism from the circle of leading trends in public political life to its deep periphery can actually ensure greater stability not only for liberal democracies, but also for modern international relations.