From 1991 onwards federalism has been introduced as the best option of governance to ensure constitutionalism and democracy in Ethiopia in particular and in the Horn of Africa in general for the first time in history. Despite this fact, currently there are numerous political parties, Liberation Fronts, and governments, basing their political questions on quest for federation, unification, and secession (Independence) in Ethiopia. As a result of these divergent political questions; ethnic conflicts, inter-state and intra-state conflicts, rampant corruptions, and poverty are still remained as a brand of Ethiopia in particular and in the Horn of Africa in general. Consequently, the Horn of Africa, in which Ethiopia is considered as the center is globally known as a center of crisis. Accordingly, Ethiopia has been suffering from the prevailing contending political ideologies, legal, and practical problems; though she has been introducing and practicing multicultural federalism as her state structure since 1991. Hence, this research has the objective of analyzing the prevailing legal and political challenges against the present-day Ethiopian multicultural federalism. Consequently, as its research methodology; this research has employed: critical legal and political analyses, historical interpretations of multicultural federalism in Ethiopia and beyond, document analyses, observation and personal experiences of the researcher. Therefore, it has utilized a qualitative research method. Consequently, the findings of this research has pointed out that there is a legal, political, and practical problems in order to ensure genuine multicultural federalism in the present-day Ethiopia. Keywords: Constitutionalism, Ethiopia, Federalism, Law, Politics DOI: 10.7176/JLPG/109-02 Publication date: May 31 st 2021