This study investigates the demand response strategies employed by power distribution companies (DisCos) in Nigeria and their implications for efficient power system management. As the Nigerian power sector grapples with persistent inefficiencies and reliability issues, implementing effective demand response mechanisms emerges as a crucial strategy for improving overall performance. The research employs a quantitative methodology, utilizing a structured questionnaire administered to a sample of 316 stakeholders across various DisCos in Nigeria. Findings reveal a significant relationship between the implementation of demand response strategies and the efficiency of the power system (p < 0.05), indicating that such strategies can enhance operational efficiency. Moreover, the adoption of advanced metering infrastructure is shown to significantly improve the effectiveness of these strategies, underscoring the importance of technological integration in power distribution. However, the study also identifies key challenges faced by DisCos, such as regulatory hurdles and inadequate infrastructure, which hinder the adoption of demand response initiatives.