As demand for fresh fruit is increasing day by day, there is a need for antimicrobial packaging of food that provides the food with better shelf life and protection from foodborne diseases. The ongoing search for the antimicrobials for food industry to provide protection from foodborne diseases leads to the development of nanotechnology. Silver nanoparticles (AgNPs) show antifungal, antiviral, anti-yeast and antibacterial activities, therefore, they have great potential for applications in the processing and packaging of food. In the formation of active packaging, to increase the shelf life AgNP’s can be combined with both edible & non-degradable polymers that also improve the safety of food. The authentic application of silver nanoparticles in the packaging of food is regulated by USA food safety and European Union authorities in a practical way, because of the incapability to make convincing statements on their toxicity. Thus, AgNPs use is assessed in the terms of migration of silver into packed food. Though, it is significant for the new food packages that are incorporated with AgNPs to carry out the migration tests. Otherwise, it can cause the toxicity of mammalian cells and organs.