Delta Type Research Articles

Establishment and application of autoverification system for HbA1c testing.

This study aimed to determine autoverification rules for routine glycated hemoglobin (HbA1c) analysis based on high-performance liquid chromatography (HPLC) principle. Laboratory information system (LIS) and Bio-Rad D-100 Advisor software (Bio-Rad, Hercules, USA) with graphics recognition function were carriers for the autoverification system. A total of 105,126 HbA1c results, including 98,249 HbA1c matching fast plasma glucose (FPG) results of real-world data from May 2019 to June 2020, were collected to determine autoverification rules including flags, delta checks, reporting limits, and logical rules. The validation database was composed of 48,045 HbA1c results and 41,083 matching FPG results. Autoverification passing rate and the reduction of turnaround time (TAT) were evaluated. Four autoverification systems (A, B, C, D) were established by two types of delta check rules, 28 flags, one reporting limits, and two kinds of logical rules. The autoverification passing rates were 80.6%, 78.8%, 83.7%, and 81.3%, and the average time saved in TAT were 117.5 min, 116.7 min, 121.1 min, and 121.7 min, respectively. Autoverification system C was the optimal one. Application of distribution of FPG corresponding to HbA1c groups had better performance as logical rules. Established HbA1c autoverifcation system shortened the auditing report time and improved work efficiency.

Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex.

The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 (GRID2) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in all species, whereas region-selective gene expression was predominantly observed in the granular layer of primates and in the Purkinje layer of mice. Gene expression gradients in the cerebellar cortex matched well with functional connectivity gradients revealed with awake functional magnetic resonance imaging, with more lobule-specific differences between primates and mice than between two primate species. These comprehensive atlases and comparative analyses provide the basis for understanding cerebellar evolution and function.

Hanning FIR window filtering analysis for EEG signals

The window function is a mathematical function in signal processing that is multiplied by a signal to lessen or eliminate the impact of undesired characteristics such as spectral leakage and edge effects that might arise while analyzing finite-duration signals. The Hanning window is just one of several window functionalities available. It is designed to gradually taper the endpoints of a signal to zero, reducing spectral leakage in the frequency domain. Filtering is commonly employed in Electroencephalography (EEG) signal processing to remove noise, artifacts, or undesired frequency components while retaining the desired information. Filtering techniques include band pass, low pass, and high pass and band reject filtering. Hanning window technique using low pass, high pass, band pass, and band reject is used for filtering of EEG signal. The response time analysis for the Hanning window is calculated using low, high, band pass, and band-reject filters for different types of EEG waves alpha, beta gamma, theta, and delta using the signal processing simulation tool MATLAB 2023. The response time for delta wave using a low pass filter has a low response time of 14.125 sec which is comparatively less than another filter. For theta wave high pass filter has a low response time of 11.965 seconds. For alpha wave low pass filter has a low response time of 16.706 seconds whereas for beta wave low pass filter has a low response time of 15.202 seconds. For gamma waves high pass filter has a low response time of 11.349 seconds. Hanning band-reject filter has proven low response time for delta, theta, and gamma waveforms of 16.475 seconds, 16.182 seconds, and 17.743 seconds respectively. The novelty of the work is that the Hanning window improves frequency resolution by balancing the main lobe width with side lobe attenuation Hanning band-reject filter is suited best to figure out the widest main-lobe peak and highest peak for different EEG waveforms.

Effects of heavy metals and environmental variables on soil microbial communities in different land-use types of Yellow River Delta (YRD), China

Effects of heavy metals and environmental variables on soil microbial communities in different land-use types of Yellow River Delta (YRD), China

Assessment of smell disturbances 6months after COVID-19 in Polish population.

Considering the frequency and severity of olfactory disorders associated with SARS-CoV-2 infection, attention to the olfactory loss has expanded. The aim of our study was to assess of smell disturbances 6months after COVID-19. The study population consisted of 2 groups: 196 Post-COVID-19 patients who were hospitalized because of COVID-19, control sample-130 patients without reported smell disorders from general population-Bialystok PLUS study. People from both groups were asked to participate in the Sniffin Sticks Test (half year after the disease). Sniffin Sticks Test consisted of 12 standardized smell samples. The participant's test score was counted based on correct scent recognition. Middle/older age was related with lower likelihood of olfaction recovery. The biggest differences in recognition of particular fragrances were observed for: orange and lemon, lemon and coffee (p.adj < 0.001). Patients had the greatest problem in assessing smell of lemon. The comparison of scores between Delta, Omicron, Wild Type, Wild Type Alpha waves showed statistically significant difference between Delta and Wild Type waves (p = 0.006). Duration of the disease (r = 0.218), age (r = -0.253), IL-6 (r = -0.281) showed significant negative correlations with the score. Statistically significant variables in the case of smell disorders were Omicron wave (CI = 0.045-0.902; P = 0.046) and Wild Type wave (CI = 0.135-0.716; P = 0.007) compared to Delta wave reference. Moreover, patients with PLT count below 150 000/μl had greater olfactory disorders than those with PLT count over 150 000/μl. There are: smell differences between post-COVID-19 patients and healthy population; statistically significant difference between Delta and Wild Type waves in Post-COVID-19 group in score of the Sniffin Sticks Test. Smell disturbances depend on the age, cognitive impairments, clinical characteristics of the COVID-19 disease and sex of the patient.

LabVIEW based Mental Status Monitoring System for Cognitive Wellness

This paper delves into the analysis of various cognitive states by identifying the percentages of different types of brain waves, like alpha, beta, delta, and theta, present in an individual's EEG recording. These brain waves carry crucial information about an individual's cognitive health, and accurate readings are essential to classify and represent the signals accurately. To achieve this, the project aimed to develop a robust platform that utilizes LabVIEW software to obtain EEG signals and interpret cognitive health. The acquired data is meticulously preprocessed and filtered to obtain clean EEG signals, which are then subjected to several methods to determine the content of different brain waves present in the filtered EEG signals. Based on these values, the cognitive status of an individual can be accurately determined, providing valuable insights into their cognitive health. Understanding cognitive states through brain wave analysis has been an intriguing area of research, utilizing various electroencephalography (EEG) techniques to interpret neural activity. This paper aims to provide a detailed discussion on how cognitive states are mapped and interpreted based on brain waves. By exploring the characteristics of each brain wave frequency band, we elucidate their implications in cognitive processes such as attention, memory, and relaxation. This research aims to contribute in the advancement of cognitive neuroscience by consolidating current knowledge and identifying potential avenues for future research.

Biolayer-Interferometry-Guided Functionalization of Screen-Printed Graphene for Label-Free Electrochemical Virus Detection.

Additive manufacturing holds promise for rapid prototyping and low-cost production of biosensors for diverse pathogens. Among additive manufacturing methods, screen printing is particularly desirable for high-throughput production of sensing platforms. However, this technique needs to be combined with carefully formulated inks, rapid postprocessing, and selective functionalization to meet all requirements for high-performance biosensing applications. Here, we present screen-printed graphene electrodes that are processed with thermal annealing to achieve high surface area and electrical conductivity for sensitive biodetection via electrochemical impedance spectroscopy. As a proof-of-concept, this biosensing platform is utilized for electrochemical detection of SARS-CoV-2. To ensure reliable specificity in the presence of multiple variants, biolayer interferometry (BLI) is used as a label-free and dynamic screening method to identify optimal antibodies for concurrent affinity to the Spike S1 proteins of Delta, Omicron, and Wild Type SARS-CoV-2 variants while maintaining low affinity to competing pathogens such as Influenza H1N1. The BLI-identified antibodies are robustly bound to the graphene electrode surface via oxygen moieties that are introduced during the thermal annealing process. The resulting electrochemical immunosensors achieve superior metrics including rapid detection (55 s readout following 15 min of incubation), low limits of detection (approaching 500 ag/mL for the Omicron variant), and high selectivity toward multiple variants. Importantly, the sensors perform well on clinical saliva samples detecting as few as 103 copies/mL of SARS-CoV-2 Omicron, following CDC protocols. The combination of the screen-printed graphene sensing platform and effective antibody selection using BLI can be generalized to a wide range of point-of-care immunosensors.

Sentiments Analysis on Twitter Towards Hoax Information on Social Media News

Sentiments Analysis on Twitter Towards Hoax Information on Social Media News

Comparative Morphology of the Carnassial Teeth Root Canals in Mixed-Breed Dogs and German Shepherds.

Root canal treatment of carnassial teeth in dogs is a common endodontic technique which aims to re-establish or maintain the health of the periapical tissues. In total, 43 dogs were used in this study. Root canal morphology was evaluated in 86 superior fourth premolars and 86 inferior first molars. Apical delta was present in 247 roots, while obliteration of the root canal was found in 11 roots. The most common type of apical delta of the roots of superior fourth premolars was type II, with up to 10 apical ramifications, while type IIIA, with 10-20 apical ramifications, was most commonly present in the roots of inferior first molars. Considering that knowledge of the morphology of root canals is essential for a successful endodontic procedure, the aim of this study was to analyze and compare the morphology of root canals in the carnassial teeth of German shepherds and mixed-breed dogs. Apical resection for the purpose of endodontic therapy of the superior fourth premolar and the inferior first molar is indicated at a length of 4 to 6 mm from the anatomical tip of the roots, which would completely remove the apical delta of these two teeth.

Features of the Dermatoglyphic Foot Pattern in Suicider Males

Since suicide is one of the most common types of violent death among people of working age (including military personnel) and children, it is necessary to conduct in-depth studies of the structure of skin patterns in a group of people with completed suicide in order to develop methods of active suicide prevention. In order to determine the propensity to commit suicide, the dermatoglyphs of the distal phalanges and metacarpal pads of the toes of 138 male subjects aged 18 to 59 years who committed suicide and 100 control subjects aged 18 to 59 years were studied. The type of pattern (arc, tibial or fibular loop, curl, complex pattern), delta and comb counts were determined. It was found that the suicide group differs from the control group mainly in a higher number of interruptions (ending X) of the main plantar lines A, B and C; an increase in the frequency of arc patterns on most toes of both feet with a degree of reliability; a decrease in the frequency of curls on the third toe of the left foot to 44.5±11.2 (p&lt;0.001) and an increase in the frequency of this pattern on the second toes of both feet; an increase in the value of the comb count in the area of the tibial edge of the foot, with a decrease in the values near the fibular edge of the foot.

Deltas: New paradigms

AbstractDeltas are deposits directly accumulated by land‐generated gravity flows in a standing body of water. The paradigm of deltaic sedimentation has dramatically changed during recent years, from the popular very simplified ternary models of marine littoral deltas towards more realistic and comprehensive models, considering the importance of sediment‐laden river discharges. Ternary delta models were designed for clean rivers, where a stream flow drags the sediments. Depending on the basin dynamics, these littoral deposits can be modified, forming tidal‐dominated, wave‐dominated or fluvial‐dominated littoral deltas. In recent years, a new classification of delta systems was proposed, based on contrasting the salinity of the receiving water body with the bulk density of the incoming fluvial discharge. Rivers are highly dynamic systems, and their discharges can be very variable in terms of flow duration and sediment concentration. Additionally, the salinity of the receiving water body can exhibit significant variability, especially in closed lakes and epicontinental seas, ranging from freshwater to brines. This scenario allows the distinction of three major delta categories (hypopycnal, homopycnal and hyperpycnal deltas) which can be in turn subdivided, defining seven delta types. Hypopycnal deltas form when the bulk density of the incoming flow is lower than the density of the water in the basin, allowing the definition of three delta types, corresponding to hypersaline littoral deltas, marine littoral deltas and brackish littoral deltas. Homopycnal deltas form when the bulk density of the incoming flow is similar to the density of the water in the basin, defining a delta type termed homopycnal littoral deltas. Hyperpycnal deltas form when the bulk density of the incoming flow is higher than the density of the water in the basin, allowing the definition of three categories termed hyperpycnal littoral deltas, hyperpycnal subaqueous deltas and hyperpycnal fan deltas.

Vertical distributions and potential contamination assessment of seldom monitored trace elements in three different land use types of Yellow River Delta

The Yellow River Delta (YRD) is the second largest petrochemical base in China and the impact of human activities has been continuously increasing in recent decades, however, the contamination status of seldom monitored trace elements (SMTEs) in YRD has rarely been reported. This study evaluated the levels, vertical distributions, contamination status and sources of SMTEs in soil samples of three different land use types in YRD. The results indicated that the vertical distributions of SMTEs contents showed a gradually upward increasing trend for the soil profiles of black locust forest, while the SMTEs contents displayed a gradually upward decreasing trend for the soil profiles of cotton field. However, the SMTEs contents in the oil field area showed no significant difference among different depths. The vertical distributions of SMTEs were very likely related to the anthropogenic disturbance in the later stage. The environmental pollution status assessment of SMTEs showed obvious enrichment of Cs, Sn, and U in the soils of YRD. Moreover, the potential source analysis based on multivariate statistical methods indicated that Ga, Rb, Cs, Sc, Sn, Tl, Be, Bi, Ca and Mo were clustered together and positively correlated with Al, Fe, Mg and K, and may be mainly associated with geochemical weathering process, while the Ce, La, Th, U, Nb, Ta, and Hf may be impacted by both natural process and human activities. Though the SMTEs pollution status was not very serious, our results highlighted the non-negligible influence of anthropogenic activities on vertical distributions of SMTEs in three different land use types from YRD. Our results provide valuable information for understanding the vertical distribution and pollution status of SMTEs in YRD.

Effect of Roll Angle Configurations of a Reverse Delta Type Add-on Device on Wing Tip Vortex Alleviation

An add-on device in the shape of a reverse delta has shown the ability to alleviate wake vortices. The present work studies the interaction of the wing tip vortex and the reverse delta type add-on device vortices. This paper looks at the vortex interactions generated downstream of the wing tip in planes perpendicular to the free stream direction and their dependence on roll angles φ at a mean chord-based Reynolds number of Rec=2.75×105. The study reveals that the add-on device causes a reduction in the tangential velocity V and vorticity of the resultant vortex by up to 44.1% and 59.4%, respectively. Also, it is found that the resultant vortex core radius increased by 305%. The results indicate that the reverse delta type add-on device implants countersign vorticity into the wing tip vortex and modifies its roll-up process.

Structural Analysis and Petrography of High-Grade Gneisses and Associated Mafic / Ultramafic Dikes Around Salem, Southern India

Southern Granulite Terrane (SGT) of India preserves extensive high-grade granulite facies rocks of Archaean and Proterozoic age. The SGT is divided into number of blocks by several suture/shear zone. Structural investigations on the basement gneisses and younger mafic/ultramafic dikes have been carried out within the Salem block which is part of Northern Granulite Block (NGB), north of the Cauvery Suture Zone (CSZ). The present work emphasizes various scale fold styles and other structural patterns of the area, which includes regionally metamorphosed high-grade rocks as basement for the multiple ultramafic intrusions to the north of Cauvery Suture Zone (CSZ) which highlights the finite strain geometry, complex deformation pattern and high-grade metamorphism. Structural map of the study area is prepared showing two generations of folding, namely F1 whose axial trend is NE-SW, subparallel with general trend of gneissic foliation and are tight isoclinal folds while F2 which are open folds with axial trend NW-SE.E-W structural cross section across the foliation planes, characterizes antiformal and synformal fold patterns of the basement due to varying dip directions which also reflects type-3 interference pattern of folding. Mesoscopic scale shear zones of dextral kinematics in response to E-W collision during Paleo-Meso Archean time, delta type porphyroclasts, S-C fabrics with the dextral movement of CSZ system, Riedel shear, thrust imbricates implying duplex structures, rotation of mafic boudins along shear zones are the most prominent ductile structural features of this area. Brittle structures like different sets of cross cutting joints and faults indicate younger deformation as well. Petrography of major lithologies has classified them into amphibolite gneiss, migmatite gneiss, charnockites, granulites and mylonites as basement rocks to the younger pyroxenite intrusions. Typical textures like, perthite, granulose, reaction rims, sieve textures and microstructures like S-C fabrics, kink bands, rotated porphyroclasts, etc are observed within the basement rocks. Coarse grained textures with fractured porphyroclasts of garnets indicating the water interactions and retrogradations within the granulite facies rocks. Reaction rims observed in charnockites and granulites are indicative of retrogression during shearing. The coarse grained cummulate nature of pyroxenites neither represent deformation nor metamorphism. Keywords: Southern Granulite Terrane, Salem, Structural Analysis, Mafic/Ultramafics, Dikes, Petrography

Grid1 regulates the onset of puberty in female rats.

The study aimed to investigate the effect of Grid1, encoding the glutamate ionotropic receptor delta type subunit 1 (GluD1), on puberty onset in female rats. Grid1 mRNA and protein expression was detected in the hypothalamus of female rats at prepuberty and puberty. The levels of Grid1 mRNA in the hypothalamus, the fluorescence intensity in the arcuate nucleus and paraventricular nucleus of the prepubertal rats was significantly lower than pubertal. Additionally, the expression of Grid1 was suppressed in primary hypothalamus cells and prepubertal rat. Finally, investigated the effect of Grid1 knockdown on puberty onset and reproductive performance. Treatment of hypothalamic neurons with LV-Grid1 decreased the level of Grid1 and Rfrp-3 (encoding RFamide-related peptide 3) mRNA expression, but increased the Gnrh (encoding gonadotropin-releasing hormone) mRNA levels. After an ICV injection, the time for the rat vaginal opening occurred earlier. Moreover, Gnrh mRNA expression was increased, whereas Rfrp-3 mRNA expression was decreased in the hypothalamus. The concentration of progesterone (P4) in the serum was significantly decreased compare with control group. Ovary hematoxylin-eosin staining revealed that the LV-Grid1 group mainly contained primary and secondary follicles. The reproductive performance of the rats was not affected by the Grid1 knockdown. Therefore, Grid1 may affect the onset of puberty in female rats by regulating the levels of Gnrh, and Rfrp-3 in the hypothalamus, as well as the concentrations of P4, but not reproduction performance.

Response of surface soil microbial communities to heavy metals and soil properties for five different land-use types of Yellow River Delta

Response of surface soil microbial communities to heavy metals and soil properties for five different land-use types of Yellow River Delta

A pharmacogenetic study of perampanel: association between rare variants of glutamate receptor genes and outcomes

Introduction: The selection of antiseizure medication usually requires a trial-and-error process. Our goal is to investigate whether genetic markers can predict the outcome of perampanel (PER) use in patients with epilepsy.Method: The studied participants were selected from our previous epilepsy genetics studies where whole exome sequencing was available. We reviewed the medical records of epilepsy patients older than 20 years old treated with PER. The outcome of PER treatment included the response to PER, the occurrence of any adverse drug reaction (ADR), the presence of behavior ADR, and the ability to adhere to PER for more than 1 year. We investigated the association between the rare variants of the glutamate receptor genes and the outcomes of PER use.Result: A total of 83 patients were collected. The gene group burden analysis showed that enriched genetic variants of the glutamate receptor gene group were statistically significantly associated with the occurrence of ADR, while the glutamate ionotropic receptor delta type subunit had a nominal association with the occurrence of ADR. The gene collapse analysis found that GRID1 had a nominal association with the occurrence of ADR and GRIN3A had a nominal association with the occurrence of behavior ADR. However, these nominal associations did not remain statistically significant once adjusted for multiple testing.Discussion: We found that enriched rare genetic variants of the glutamate receptor genes were associated with the occurrence of ADR in patients taking PER. In the future, combining the results of various pharmacogenetic studies may lead to the development of prediction tools for the outcome of antiseizure medications.

Sensitivity of Subsurface Permeability in Coastal Deltas to Their Morphodynamic and Geomorphic Characteristics

AbstractThe amount of fresh water moving through coastal deltas worldwide is controlled by the complex subsurface structures within a delta. Morphodynamic influences produced by the feeding river, waves, and tides, in addition to sea level transgressions and regressions, have resulted in deltaic aquifers that are highly heterogeneous. We use 171 unique two‐dimensional morphodynamic models to explore the range of subsurface permeability, hydraulic gradient, and groundwater flux within three end‐member delta types (fluvial, wave, and tidal). We quantify the connectiveness of the subsurface permeability and estimate the horizontal heterogeneity and anisotropy of the permeability. A distance‐based generalized sensitivity analysis is used to investigate the impact morphodynamic influences (fluvial, wave, and tidal), basin conditions (sediment concentration and bathymetric gradient), and geomorphic characteristics (number of channels, shape of the delta plain, and shoreline rugosity) have on the subsurface permeability, hydraulic gradient, and connectivity. We find that the median permeability in deltaic landforms is 4.0 × 10−12 m2 (relating to a hydraulic conductivity of 2.1 × 10−5 m/s), the average hydraulic gradient is 3.9 × 10−4, and the mean specific discharge is 1.3 × 10−8 m/s. High permeability bodies are highly connected and are associated with channelization. Subsurface permeability, hydraulic gradient, and the connectiveness of high permeability areas are sensitive to morphodynamic influences (fluvial, wave, and tidal) and the geomorphic characteristics (number of channels and shoreline rugosity) within a delta. Since morphodynamic influences and geomorphic characteristics are easily identified by looking at the surface of the delta, we suggest that the deltaic subsurface can be characterized by identifying features on the delta surface.

Architecture Differences and Hydrocarbon Accumulation in Passive Continental Margin Basins in East Africa

In this paper, we study the structural characteristics and sedimentary filling differences of the passive continental margin basins of East Africa and establish hydrocarbon accumulation models in different basins. In the research process, the research methods of prototype basin and lithofacies paleogeography restoration, oil and gas reservoir anatomy, two-dimensional seismic data interpretation, etc. The passive continental margin basins in East Africa are divided into four types of passive continental margin basins, namely “rifted type,” “depressed type,” “faulted depression type,” and “reformed delta type,” based on the three prototype stages of intracontinental aborted rift, intracontinental-intercontinental rift, and passive continental margin basin, and the difference in sedimentary filling thickness between rift and depression periods. Finally, the accumulation models of different types of basins are established, and the favorable accumulation combinations and future exploration directions are discussed.

Quantifying Formative Processes in River‐ and Tide‐Dominated Deltas for Accurate Prediction of Future Change

AbstractAlthough most deltas are expected to lose land due to climate change and urbanization, tide‐dominated deltas have been suggested to gain land. The processes of land change in such deltas are, however, not well understood, and tide‐dominated deltas with all their known morphological attributes have not been simulated before. Our Delft3D simulations successfully reproduce tide‐dominated delta morphology, and show that tide‐dominated deltas with seaward widening and stable channels, elongate tidal bars and a funnel shape form when bidirectional tidal flow occurs along the whole delta. In contrast, tide‐influenced but river‐dominated deltas protrude from shoreline, and are efficient at gaining land by mouth bar deposition and bifurcations. These differences are a function of tidal‐fluvial interactions expressed by month‐averaged seaward and lateral velocities. Identification of delta types is thus critical for predicting future land change. We propose morphological metrics to differentiate river‐ and tide‐dominated deltas and test metrics on 40 modern deltas.