Curcumin Delivery System Research Articles

An Updated Review Summarizing the Anticancer Potential of Poly(Lactic-co-Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers.

The utilization of nanoformulations derived from natural products for the treatment of many human diseases, including cancer, is a rapidly developing field. Conventional therapies used for cancer treatment have limited efficacy and a greater number of adverse effects. Hence, it is imperative to develop innovative anticancer drugs with superior effectiveness. Among the diverse array of natural anticancer compounds, resveratrol, curcumin, and epigallocatechin gallate (EGCG) have gained considerable attention in recent years. Despite their strong anticancer properties, medicinally significant phytochemicals such as resveratrol, curcumin, and EGCG have certain disadvantages, such as limited solubility in water, stability, and bioavailability problems. Encapsulating these phytochemicals in poly(lactic-co-glycolic acid) (PLGA), a polymer that is nontoxic, biodegradable, and biocompatible, is an effective method for delivering medication to the tumor location. In addition, PLGA nanoparticles can be modified with targeting molecules to specifically target cancer cells, thereby improving the effectiveness of phytochemicals in fighting tumors. Combining plant-based medicine (phytotherapy) with nanotechnology in a clinical environment has the potential to enhance the effectiveness of drugs and improve the overall health outcomes of patients. Therefore, it is crucial to have a comprehensive understanding of the different aspects and recent advancements in using PLGA-based nanocarriers for delivering anticancer phytochemicals. This review addresses the most recent advancements in PLGA-based delivery systems for resveratrol, EGCG, and curcumin, emphasizing the possibility of resolving issues related to the therapeutic efficacy and bioavailability of these compounds.

Curcumin-loaded pickering emulsions based on soy protein isolate aggregates enhance diabetic wound healing

Wound healing in diabetic patients is more complex and prolonged in comparison to nondiabetic persons, and dealing with this problem has attracted considerable attention from researchers. According to its anti-inflammatory and anti-infective properties, Curcumin has a valued place in therapeutics, including wound healing. Still, its low stability and poor bioavailability are significant barriers to using its desirable properties. Hence, various biocompatible and biodegradable delivery systems have been developed to address this issue. In this study, Pickering emulsion (PE) prepared from soybean oil containing curcumin and modified SPI solution at 85 °C at pH 2.0 with 130 mM NaCl for different durations were used as a delivery system for curcumin. Changes in SPI properties were analyzed using fluorescence spectroscopy, Fourier transform infrared spectroscopy, and tensiometry methods. The prepared PEs were studied using microscopic techniques. Curcumin loading efficiency by PE was measured by UV–visible spectroscopy, and the impact of curcumin-loaded PE on wound healing was tested in diabetic rats. Spectroscopic studies and microscopy images revealed SPI amyloid-like aggregates suitable for stabilizing oil-in-water PEs. Tensiometry and creaming stability studies indicated that at least 6 h of heating (HSPI6) is necessary for optimal stability. Curcumin encapsulation efficiency was 95.7 ± 2.1 %. Curcumin-loaded PE-HSPI6 increased the healing rate of diabetic wounds in male Wistar rats by 1.46-fold. This study presents an approach for using biocompatible and biodegradable PEs to deliver hydrophobic compounds like curcumin for accelerating diabetic wound healing.

Eco-Friendly Microwave Synthesis of Sodium Alginate-Chitosan Hydrogels for Effective Curcumin Delivery and Controlled Release.

In this study, we developed sodium alginate-chitosan hydrogels using a microwave-assisted synthesis method, aligning with green chemistry principles for enhanced sustainability. This eco-friendly approach minimizes chemical use and waste while boosting efficiency. A curcumin:2-hydroxypropyl-β-cyclodextrin complex was incorporated into the hydrogels, significantly increasing the solubility and bioavailability of curcumin. Fourier Transform Infrared Spectroscopy (FTIR) analysis confirmed the structure and successful incorporation of curcumin, in both its pure and complexed forms, into the polymer matrix. Differential scanning calorimetry revealed distinct thermal transitions influenced by the hydrogel composition and physical cross-linking. Hydrogels with higher alginate content had higher swelling ratios (338%), while those with more chitosan showed the lowest swelling ratios (254%). Scanning Electron Microscopy (SEM) micrographs showed a porous structure as well as successful incorporation of curcumin or its complex. Curcumin release studies indicated varying releasing rates between its pure and complexed forms. The chitosan-dominant hydrogel exhibited the slowest release rate of pure curcumin, while the alginate-dominant hydrogel exhibited the fastest. Conversely, for curcumin from the inclusion complex, a higher chitosan proportion led to the fastest release rate, while a higher alginate proportion resulted in the slowest. This study demonstrates that the form of curcumin incorporation and gel matrix composition critically influence the release profile. Our findings offer valuable insights for designing effective curcumin delivery systems, representing a significant advancement in biodegradable and sustainable drug delivery technologies.

Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model.

The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), zeta potential (- 25.7 ± 1.80 mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.

Effects of various acids on physical stability, rheological characteristics and curcumin encapsulation of whey protein isolate Pickering emulsion gels

Acid treatment can alter the functional properties of whey protein isolate (WPI), but the effect of different acids on properties of WPI‐stabilised Pickering emulsion gel (PE) is unknown. Compared with WPI‐PE, droplet size of the acid‐treated WPI‐PE decreased but its zeta potential, apparent viscosity, binding water capacity and curcumin encapsulation were enhanced. Due to the formation of the tightest gel structure of malic acid‐Pickering emulsion gel, it showed the highest viscoelastic modulus, bound water content and gel stability. This work would introduce a novel method for the development of PEs with good gelatinisation and curcumin delivery system for food processing.

Bigel as a curcumin delivery system and its application in 3D-printed in-between-meal foods to boost the immune system of elderly people

Curcumin is highly beneficial to the functioning of the human immune system. We studied bigel, structured with collagen, monoglycerides and diglycerides, to improve the stability and bioavailability of curcumin. We noted a high stability of the encapsulated curcumin (97.55 %); the suitability of the bigel matrix for curcumin loading was also confirmed with an in vitro digestion study. We used curcumin-loaded bigel in meat-based, 3D-printed in-between-meal foods, intended to boost the immune system of elderly people. We characterized the foods' textural properties, chemical composition, behavior during in vitro digestion and sensory acceptability. The foods, contained roughly 24 % of a person's daily protein needs, 4 % of their fiber needs, 50 % curcumin and resveratrol needs and 100 % of their zinc, iron and selenium needs. Protein hydrolysis kinetics during in vitro digestion revealed that the technological steps we applied had no negative effect on the foods' digestibility. Elderly people perceived all of the foods to be delicious, easy-to-swallow and soft. In addition, people suffering from dysphagia attributed high scores for the mouthfeel-related question. Bigel holds great promise as a food-compatible curcumin delivery system for foods aimed at elderly people.

Enhanced Curcumin Delivery and Stability through Natural Deep Eutectic Solvent-Based Niosomes

Curcumin, a highly sought-after medicinal compound with diverse health benefits, encounters limitations regarding its oral bioavailability and aqueous solubility. To overcome these challenges, curcumin can be encapsulated within niosomal formulations, allowing controlled drug release and improving encapsulation efficacy. In this study, incorporating a natural deep eutectic solvent (NADES) with curcumin-loaded niosomes was investigated to enhance the bioavailability of curcumin. Initially, NADESs were synthesized using betaine as a hydrogen bond acceptor and a range of hydrogen bond donors. Among the different combinations tested, the NADES formed with betaine and glucose, fructose, or xylose exhibited the highest solubility of 6.16 ± 0.61 mg/g, 6.03 ± 0.25 mg/g and 5.57 ± 0.14 mg/g, respectively. Subsequently, these NADESs with the ideal combination were utilized to incorporate with curcumin niosomes denoted by the formulation abbreviations BG, BF, and BX. These formulations were prepared at varying masses, including 25 mg (BG1, BF1, and BX1), 50 mg (BG2, BF2, and BX2), 75 mg (BG3, BF3, and BX3), and 100 mg (BG4, BF4, and BX4). Optical microscopy results revealed that curcumin-loaded niosomes with NADES displayed a spherical morphology. The entrapment efficiency of eutectic-based curcumin niosomes ranged from 82.20 ± 0.46 % (BX1) to 97.61 ± 0.67 % (BG4), significantly outperforming blank niosomes, which achieved a mere 74.27 ± 0.20 %. The zeta potential measurements reveal distinct differences where the blank curcumin niosomes exhibit a relatively modest value of −17.57 ± 0.90 mV, whereas the eutectic-based niosomes display markedly elevated zeta potentials, spanning from −45.50 ± 2.55 mV to −53.70 ± 1.63 mV. Raman spectroscopy studies were performed to examine the interactions between the NADES and curcumin in the niosome, providing insights into the molecular interactions and potential improvements in drug delivery where BG4 achieved the optimum intensity ratio (I2930/I2850) at 0.3106. Stability investigations were conducted to evaluate the enduring stability of the NADES-niosome formulation, affirming its capacity to preserve its electrostatic coherence and underscoring its resilience across varying temperature conditions under 28 days. Moreover, comprehensive experiments were conducted to assess the photochemical stability, revealing that BG4 boasts the lengthiest half-life, reaching an impressive 158.56 days. The antioxidant assay results indicate that niosomes incorporating NADES exhibit lower IC50 values. Furthermore, in vitro studies coupled with Korsmeyer-Peppas and Peppas-Sahlin’s model fitting were performed to evaluate curcumin’s release profile and dissolution behavior from the NADES-niosome system. Overall, this study explores the potential of incorporating NADES with curcumin-loaded niosomes to enhance the bioavailability of curcumin. The comprehensive analysis and characterization techniques provide valuable insights into the formulation’s stability, efficiency, and drug release behavior, paving the way for potential advancements in curcumin delivery systems.

Hydroxypropyl methycellulose-galactomannan binary complexes achieving 55 wt% curcumin loading capacity: Mechanism and in vitro bioactivity

Curcumin is a turmeric-derived bioactive flavonoid that is beneficial to human health. Unfortunately, poor water solubility and low bioactivity of curcumin limit its applications. Multiple food-derived curcumin delivery systems have been developed, but their loading capacities still need to be improved. In this work, binary complexes of hydroxypropyl methycellulose-galactomannan (HPMC-GM) with different mannose to galactose (M:G) ratios in GM were manufactured for curcumin delivery. HPMC-GM achieved 40–55 wt% curcumin loading capacity depending on the M:G ratio, which was about twice that of other reported food-derived vehicles. Porous dense networks were observed in HPMC-GM, which were driven by hydrogen bonds and hydrophobic interactions. Curcumin bound tightly to hydrophobic cavities in the amorphous state via hydrophobic interactions and hydrogen bonds. The hydrophilic galactose branches of GM restrict complexation between HPMC and GM. Higher M:G ratios resulted in higher curcumin loading capacities of HPMC-GM. The results of in vitro dissolution and anti-proliferation activity showed that the bioactivity of curcumin loaded in HPMC-GM was superior to unloaded curcumin. This study created delivery systems with high curcumin loading capacities using 100% food-grade materials as vehicles, which circumvents the drawback of using artificial synthetic polymers to achieve high curcumin loading capacity. The HPMC-GM vehicle has great potential in developing curcumin products as dietary supplements as well as for medical purposes.

Effect of pH on the soybean whey protein–gum arabic emulsion delivery systems for curcumin: Emulsifying, stability, and digestive properties

A novel curcumin (CUR) delivery system was developed using soybean whey protein (SWP)-based emulsions, enhanced by pH-adjustment and gum arabic (GA) modification. Modulating electrostatic interactions between SWP and GA at oil/water interface, pH provides favorable charging conditions for stable distribution between droplets. GA facilitated the SWP form a stable interfacial layer that significantly enhanced the emulsifying properties and CUR encapsulation efficiency of the system at pH 6.0, which were 90.15 ± 0.67%, 870.53 ± 3.22 m2/g and 2157.62 ± 115.31%, respectively. Duncan's test revealed significant improvements in thermal, UV, oxidative, and storage stabilities of CUR (P < 0.05). At pH 6.0, GA effectively protected CUR by inhibiting SWP degradation during gastric digestion and promoting the release of CUR by decreasing steric hindrance with oil droplets during intestinal digestion, achieving the highest CUR bioaccessibility (69.12% ± 0.28%) based on Duncan's test. The SWP-GA-CUR emulsion delivery system would be a novel carrier for nutrients.

Mussel-inspired protein-based nanoparticles for curcumin encapsulation and promoting antitumor efficiency

Curcumin demonstrated therapeutic potential for cancer. However, its medical application is limited due to low solubility, poor stability and low absorption rate. Here, we used the mussel-inspired functional protein (MPKE) to fabricate the curcumin-carrying nanoparticle (Cur-MPKE) for encapsulating and delivering curcumin. The protein MPKE is composed of the mussel module and zwitterionic peptide. The Dopa group bonding characteristic of the mussel module was leveraged for the self-assembly of nanoparticles, while the superhydrophilic property of the zwitterionic peptide was utilized to enhance the stability of nanoparticles. As expected, MPKE and Cur are tightly bound through hydrogen bonds and dynamic imide bonds to form nanoparticles. Cur-MPKE showed improved solubility and stability in aqueous solutions as well as excellent biocompatibility. Besides, Cur-MPKE also exhibited pH-triggered release and enhanced uptake of curcumin by tumor cells, promoting the antioxidant activity and antitumor effect of curcumin. Moreover, systemic experiments of Cur-MPKE to rats demonstrated that Cur-MPKE significantly inhibited tumor tissue growth and proliferation without causing obvious systemic toxicity. This work provides a new strategy for fabricating the delivery system of curcumin with improved stability, sustainability and bioavailability.

Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

This research aimed to develop a novel, effective, and stable delivery system based on zein (ZE), sodium caseinate (SC), and quaternary ammonium chitosan (HACC) for curcumin (CUR). The pH-driven self-assembly combined with electrostatic deposition methods were employed to construct CUR-loaded ZE-SC nanoparticles with HACC coating (ZE-SC@HACC). The optimized nanocomposite was prepared at ZE:SC:HACC:CUR mass ratios of 1:1:2:0.1, and it had encapsulation efficiency of 89.3%, average diameter of 218.2 nm, and ζ-potential of 40.7 mV. The assembly of composites and encapsulation of CUR were facilitated primarily by hydrophobic, hydrogen-bonding, and electrostatic interactions. Physicochemical stability analysis revealed that HACC coating dramatically enhanced ZE-SC nanoparticles' colloidal stability and CUR's resistance to chemical degradation. Additionally, antioxidant activity and simulated digestion results indicated that CUR-ZE-SC@HACC nanoparticles showed higher free radical scavenging capacity and bio-accessibility of CUR than CUR-ZE-SC nanoparticles and free CUR. Therefore, the ZE-SC@HACC nanocomposite is an effective and viable delivery system for CUR.

Studying the Characteristics of Curcumin-Loaded Liposomal Nanoparticles

Overview: In this study, the physical and chemical properties of curcumin are extensively examined when it is incorporated into liposome nanoparticles, to enhance its therapeutic potency and bioavailability. Curcumin, a plant-derived polyphenol, has garnered attention for its anti-inflammatory, antioxidant, and anti-cancer activities. However, its clinical utility is hindered by several limitations, including poor water solubility, inadequate absorption, and rapid metabolism. By leveraging the potential of liposome nanoparticles to improve drug delivery and efficacy, this research aims to overcome these obstacles and unlock the full therapeutic potential of curcumin. Methods: Curcumin-loaded liposome nanoparticles (CLLNs) were fabricated employing a thin-film hydration method, after sonication. The physicochemical attributes of CLLNs were subsequently characterized, encompassing particle size and zeta potential assessment utilizing dynamic light scattering (DLS), encapsulation efficiency (EE%) and drug loading efficiency (DLE%) determination through high-performance liquid chromatography (HPLC), investigation of in vitro drug release patterns in simulated biological fluids. Results: The CLLNs optimized in this study had a mean particle diameter of less than 250 nm and a negative surface charge, implying good stability and potential for cellular uptake. The encapsulation efficiency and drug loading efficiency were both found to be high, indicating that curcumin was effectively loaded into the liposomes. In vitro release testing showed a sustained release pattern of curcumin from the CLLNs. Conclusion: The research offered important observations about the advantageous physicochemical features of curcumin-loaded liposome nanoparticles, highlighting their potential as a cutting-edge delivery system for curcumin. The study demonstrated that CLLNs have high encapsulation and drug loading efficiencies, as well as controlled release and improved stability, which suggests their ability to enhance the therapeutic benefits of curcumin. These findings set the stage for future in vivo and clinical trials to fully investigate the potential of CLLNs in medical applications.

Curcumin and its Analogues in Oral Squamous Cell Carcinoma: State-of-the-art and Therapeutic Potential.

Oral Squamous Cell Carcinoma (OSCC) is the most common cancer arising from squamous epithelium in the oral cavity and is characterized by high aggressiveness and metastatic potential, which together with a late diagnosis results in a 5-year survival rate of only 50% of patients. The therapeutic options for OSCC management are limited and largely influenced by the cancer stage. While radical surgery can be curative in early stage of disease, most cases require adjuvant therapies, including chemotherapy and radiotherapy which, however, often achieve poor curative rates and are associated with important negative effects. Therefore, there is an urgent need to discover new alternative treatment strategies to improve patients' outcomes. Several medicinal herbs are being studied for their preventive or therapeutic effect in several diseases, including cancer. In particular, the Indian spice curcumin, largely used in oriental countries, has been studied as a chemopreventive or adjuvant agent for different malignancies. Indeed, curcumin is characterized by important biological properties, including antioxidant, anti-inflammatory, and anticancer effects, which could also be exploited in OSCC. However, due to its limited bioavailability and poor aqueous solubility, this review is focused on studies designing new synthetic analogues and developing novel types of curcumin delivery systems to improve its pharmacokinetic and biological properties. Thus, this review analyses the potential therapeutic role of curcumin in OSCC by providing an overview of current in vitro and in vivo studies demonstrating the beneficial effects of curcumin and its analogues in OSCC.

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations.

Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes.

Chitosan/Histidine nanoparticles for controlled curcumin delivery: A potential strategy in anticancer treatment

Cancer, a life-threatening disease influenced by environmental factors, evolving lifestyles, and dietary choices, necessitates potent and sustained therapeutic interventions. This research explores the potential of chitosan/histidine nanoparticles (CS/HIS-NPs) as a controlled delivery system for curcumin (CUR), a promising anticancer agent. CUR was efficiently incorporated into CS/HIS-NPs via ionic gelation using sodium tripolyphosphate (TPP) as crosslinker, and its impact was evaluated on Human liver adenocarcinoma (HEP G2) cells. Comprehensive analyses, including structural (Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD)) and morphological (Scanning electron microscopy (SEM) and transmission electron microscopy (TEM)) assessments, were conducted, revealing a robust encapsulation efficiency of 98.4 %. The nanoparticles exhibited an average size of 31.183 ± 13.822 nm for CS/HIS-NPs and 127.86 ± 44.344 nm for CUR-CS/HIS-NPs. Cytotoxicity assessments and in vitro release studies with CUR-CS/HIS-NPs demonstrated promising results, indicating the potential efficacy of the delivery system. This study introduces a novel approach to curcumin delivery and underscores the capability of CS/HIS-NPs as a sophisticated pharmaceutical carrier for sustained curcumin release. By utilizing a polymer matrix to govern release kinetics, chitosan/histidine nanoparticles emerge as a promising avenue for advancing anticancer drug delivery.

An Effective Method to Prepare Curcumin-Loaded Soy Protein Isolate Nanoparticles Co-Stabilized by Carrageenan and Fucoidan.

In this study, a novel and simple strategy is proposed based on 3D network formed by easily blending polysaccharide carrageenan (Car) and fucoidan (Fuc) without a crosslinker. The Fuc/Car dual coating effectively assists the self-assembly of soy protein-isolated (SPI)/curcumin (Cur, C) composite microcapsules (SPI/C) and achieves an excellent curcumin encapsulation efficiency (EE) up to 95.28% with a 4.16% loading capacity (LC) under optimal conditions. The resulting nanocomposites achieved a satisfying redispersibility in aqueous solution and enhanced the water solubility with a lower size dispersity index (PDI) of 0.12 and a larger zeta potential of -29.67 mV. The Fuc/Car double-layer network not only dramatically improved its thermal stability and photostability, but also provided controlled release and enhanced antioxidant activity in in vitro conditions. The underlying mechanism of the self-assembly of the curcumin-loaded nanoparticles was also addressed. The results proved the feasibility of the encapsulation of unstable hydrophobic bioactive substances (curcumin) with the dual anionic polysaccharide Fuc/Car co-stabilized SPI nanoparticles. This study paves the way for an alternative way of developing novel curcumin delivery systems and will have broad prospects in the pharmaceutical industries.

Effect of Curcumin-Loaded Zein/Polysaccharides Nanoparticles on Fatigue Stress Injury

In this study, we prepare core–shell nanoparticles as a delivery system for curcumin (Cur). The nanoparticles are composed of Zein and two polysaccharides, namely gum arabic (GA) and flaxseed gum (FG). Furthermore, we investigate the effect of Cur-loaded nanoparticles on fatigue stress injury using an animal fatigue stress model. Furthermore, we design a microneedle patch to enhance the delivery and sustained release of these nanoparticles. The results demonstrated that compared to the model group, all treatment groups exhibited significantly prolonged exhausted swimming and running times (P &lt; 0.001), with the high-dose treatment group showing the longest running time. Moreover, our findings revealed that Cur-loaded nanoparticles possessed superior anti-fatigue stress activation properties compared to free Cur and Cur mixed with blank nanoparticles. Additionally, by enhancing drug penetration into the stratum corneum of the skin, our microneedle carrier greatly improved drug delivery efficiency.

Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells

Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells

Polysaccharide-fecal microbiota-based colon-targeted self-nanoemulsifying drug delivery system of curcumin for treating polycystic ovarian syndrome.

The gut microbiome is involved in the pathogenesis of many diseases including polycystic ovarian syndrome (PCOS). Modulating the gut microbiome can lead to eubiosis and treatment of various metabolic conditions. However, there is no proper study assessing the delivery of microbial technology for the treatment of such conditions. The present study involves the development of guar gum-pectin-based solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing curcumin (CCM) and fecal microbiota extract (FME) for the treatment of PCOS. The optimized S-SNEDDS containing FME and CCM was prepared by dissolving CCM (25mg) in an isotropic mixture consisting of Labrafil M 1944 CS, Transcutol P, and Tween-80 and solidified using lactose monohydrate, aerosil-200, guar gum, and pectin (colon-targeted CCM solid self-nanoemulsifying drug delivery system [CCM-CT-S-SNEDDS]). Pharmacokinetic and pharmacodynamic evaluation was carried out on letrozole-induced female Wistar rats. The results of pharmacokinetic studies indicated about 13.11 and 23.48-fold increase in AUC of CCM-loaded colon-targeted S-SNEDDS without FME (CCM-CT-S-SNEDDS (WFME)) and CCM-loaded colon-targeted S-SNEDDS with FME [(CCM-CT-S-SNEDDS (FME)) as compared to unprocessed CCM. The pharmacodynamic study indicated excellent recovery/reversal in the rats treated with CCM-CT-S-SNEDDS low and high dose containing FME (group 13 and group 14) in a dose-dependent manner. The developed formulation showcasing its improved bioavailability, targeted action, and therapeutic activity in ameliorating PCOS can be utilized as an adjuvant therapy for developing a dosage form, scale-up, and technology transfer.

Hydrocolloid-based nutraceutical delivery systems: Potential of κ-carrageenan hydrogel beads for sustained release of curcumin

This study investigates the potential of κ-carrageenan hydrogel beads as a delivery system for curcumin, a bioactive compound with various health benefits. Hydrogel beads were prepared using the extrusion technique with a hypodermic needle. The encapsulation efficiency of curcumin in the κ-carrageenan hydrogel beads was found to be 74.61 ± 3.2 %. FTIR spectroscopy analysis revealed shifts in absorption peaks, indicating possible hydrogen bonding and/or ionic interactions between the polymer and salt. An increase in the melting point of curcumin, by 25 °C, in curcumin- κ-carrageenan beads suggests the heat protection offered by the carrageenan chains to curcumin molecules. The in vitro release of curcumin from the beads suggests a sustained and pH-dependent release nature. The release kinetics follow the first order and the Korsmeyer-Peppas model. The outcome offers value-added delivery systems of bioactive compounds toward developing novel food and pharmaceutical applications.