With the booming demands of global consumers, the grand total of international e-commercial procurement in 2024 will be expected to exceed 6.3 trillion USD. Under the pressure of huge orders and shipping lag, figuring out a cost-effective last mile delivery achieving real door-to-door service, especially in rural areas, has become one of the focuses in the international e-commercial market. To better solve this problem, this paper starts with the analysis of international e-commercial status and the feasibility of UAV mobile terminal station launch, taking good account of drone delivery route setting, time schedule, and costs spent to optimize the mobile station moving. Based on a series of experiments to iterate the Unmanned Aerial Vehicle (UAV) mobile terminal station delivery mode, it will provide some insights to the market about how the last mile delivery will develop in the next decade. This paper will focus on applying the hybrid ant colony algorithm to improve truck-drone collaborative last mile delivery route settings and figure out the best delivery route combo for cost saving.