State Of Dehydration Research Articles

Integrated identification and detection of hydration state and its evolution using terahertz technology

The accurate detection of dehydration processes in hydrated drugs can reveal various intermolecular vibration modes mediated by hydrogen bonds between water molecules and other components, which underpin the further development of pharmaceutical science, food safety and biophysics. Herein, terahertz (THz) technology is utilized to investigate the dehydration state of d(+)-Raffinose pentahydrate (Rf·5H2O), in conjunction with imaging-based point by point scanning data acquisition and barcodes methods, to establish an innovative platform integrated identification, trace detection, and application capabilities. Our study demonstrates that the dehydration process of Rf·5H2O can be dynamically monitored through the evolution of its THz absorption peaks, offering more precise results compared to XRD and Raman spectroscopies. Moreover, the absorbance spectra data collected at each individual pixel is utilized to build visualized THz images, achieving an ultralow minimum content required for detection of 0.032 μg/(50 μm)2. Additionally, we introduce a THz spectra-barcode conversion system that not only ensures efficient electronic recordkeeping but also enhances user readability, thereby facilitating the practical applications of THz technology.

Acute kidney injury in patient with acute gastroenteritis and history of consuming energy drink

An abrupt decline in kidney function is a characteristic of acute kidney injury (AKI), a disorder that affects the structure and function of the kidneys. Hypovolemia from gastroenteritis is known as one of the causes from prerenal AKI. Energy drinks, which are consumed a lot by workers and young people are also known can decrease kidney function and liver function even without having any pre-existing diseases. There were two reported cases of consumption energy drink that worsening kidney and liver function in gastroenteritis patient with mild-moderate dehydration state.

Nutritional management of hyperlipaemia in a jenny: a brief report

An adult jenny (5-years-old, non-pregnant) was presented to the Veterinary Teaching Hospital (VTH) of the University of Sassari, with a recent history of appetite loss, extreme underweight condition and reluctance to move. On physical inspection, emaciation [body condition score, BCS: 3/9], muscular waste [muscular condition score, MCS: 1/5], loose/running faeces [faecal score, FS: 2/8], and a general state of mild dehydration were found. Blood analyses outlined a general undernourishment condition [circulating albumins, ALB: 17.6 g/L (21.6–31.6 g/L)] with underlying systemic inflammatory profile and moderate increase in circulating enzymes to explore liver function [aspartate amino-transferase, AST: 657 u/L (279–430 u/L); alanine amino-transferase ALT: 60 u/L (5–14 u/L); gamma-glutamyl-transferase, γ-GT: 87 IU/L (14–69 IU/L); total bilirubin close to the upper limit, TB: 0.20 mg/dL(0.07–0.21 mg/dL)]and hyperlipaemia [TG: 8.70 mmol/L (0.60–2.87 mmol/L)], following fat depots mobilisation, with total cholesterol closed to the lower limit of the physiological range. Hyper-phosphataemia was linked to haemolytic anaemia [P:1.81 mmol/L (0.77–1.39 mmol/L) and red blood cells, RBC: 4.14 1012/L (4.40–7.10 1012)] aligned with the TB to the upper limit. On ultrasound abdominal imaging, enlarged and hyper-echogenic liver was observed. Based on the clinical evaluation, a condition of hepatic lipidosis was diagnosed, requiring dedicated nutritional treatment to solve the extreme emaciation along with the metabolic disorder in support of medical therapy. A two-step feeding protocol was planned to support treatments aiming at immediate re-hydration (Ringer lactate solution 2 ml/kg/8 h). The nutritional objectives were meant at first to restart the voluntary feed intake. Gradual increasing energy provision through a palatable hay-based diet was planned to cover one fourth of daily metabolizable energy requirement calculated on the expected metabolic weight, adjusted according to the daily intake of feed and clinical condition. At the conclusion of this first 7-day phase, circulating blood parameters were closer to the reference values and the BCS moved from 3 to 4 out of 9. Bowel motility was restored, and faecal score improved (4/8). In the second phase, allowance to pasture and a combination diet with compound mixed feed were designed. Within four weeks of starting the nutritional plan, blood parameters were re-established to reference values. The gradual feed provision calculated in this two-phase approach proved successful in support of the overall clinical improvement observed after four weeks of treatment, in a severely undernourished jenny with compromised liver functions.

Clinical Effect of the Traditional Japanese Herbal Medicine "Goreisan" on Water Balance in Patients With Severe Acute Pancreatitis.

Since severe acute pancreatitis (SAP) involves inflammatory mediators produced by local inflammation of the pancreas that trigger a systemic inflammatory response, intensive fluid management is required to maintain hemodynamics in the early stages of the onset of SAP. Goreisan is considered to have a diuretic effect in a state of excess water and an antidiuretic effect in a state of dehydration, regulating water balance in both directions. We investigated the clinical effects of Goreisan on water balance in SAP patients. Patients and methods: SAP patients admitted to our ICU within 72 hours of being diagnosed with SAP were divided into two groups: the Rikkunshito group (before October 2015) and theGoreisan group (after November 2015). Cumulative volume of fluid infusion, urine, fluid removal by CHF, nasogastric tube drainage, and water balance from day 1 to day 5 of ICU admission. Thirty patients were included. The median age was 57 (40-69) years, and 21/30 (70%) were male. The prognostic factor score in Japanese criteria for acute pancreatitis was 5.5 (3.3-7). Of the thirty patients, 14 were in the Rikkunshito group, and 16 were in the Goreisan group. There were no differences in the cumulative volume of fluid infusion, urine, fluid removal by CHF, or nasogastric tube drainage from day 1 to day 5 of ICU admission between the two groups. However, the cumulative water balance from day 1 to day 5 of admission was 4,957 ± 6,091 mL in the Rikkunshito group, whereas it was lower in the Goreisan group at 498 ± 3,918 mL (P = 0.023). Our study showed that Goreisan administration in patients with severe acute pancreatitis might improve water balance in the early phase of onset. Early administration of Goreisan at the onset of severe acute pancreatitis may regulate fluid movement between capillaries and interstitium and alleviate fluid overload due to water refill.

Dehydration followed by restraint sustains high circulating corticosterone and improves immunity in toads

Amphibians are suffering population declines due to a variety of factors such as increased ultraviolet radiation, climate change, habitat loss, pathogens, and pollution, or a combination of these. Such changes are associated with a reduction in the availability of water, exposing these animals to a greater risk of desiccation. In this context, understanding how dehydration can modulate the hypothalamic-pituitary-interrenal axis (HPI) and the immune response is an imperative question to predict how stressors can affect amphibian species. We investigated whether dehydration promotes long-lasting effects on toads' ability to respond to a consecutive stressor (restraint) even if the toads are allowed to rehydrate, as well as its effects on the immune function. We also tested the hypothesis that the toads showing more severe dehydration would exhibit lower responsiveness to restraint challenge, even if the animals were allowed to rehydrate. Individuals of R. ornata were dehydrated mildly and severely. Thereafter, they were submitted to a restraint stress challenge for 1 and 24 h. Our results show that dehydration increased hematocrit and CORT in R. ornata toads. The restraint induced an acute stress response in fully hydrated toads (increased CORT and neutrophil: lymphocyte ratio). Otherwise, restraint in moistened cloth bags allowed full rehydration in previously dehydrated toads and did not induce an additional increase in CORT, but those toads sustained elevated CORT up to 24 h of restraint. Also, these animals showed increased neutrophil: lymphocyte ratio and the phagocytic activity of blood cells, even when they rehydrated during restraint. These results point to a continuous activation of the HPA during dehydration and subsequent restraint, even when they recovered from the dehydration state. Also, acute stressors seem to promote immune cell redistribution and augmentation of immune cellular function in R. ornata toads.

Rudimentary Overview: Dehydration (Loss of Body Water) Recognition and Management

Dehydration occurs when the body loses more water than it gains, mostly from the intracellular volume (ICV). Low-intake dehydration is the consequence of consuming insufficient amounts of pure water, which increases the osmolality of both compartments and resulting in the loss of intracellular and extracellular fluid. Clinically, volume depletion affects the interstitial compartment and is brought on by excessive losses of fluid and salt, especially sodium and occasionally other elements. The main cause of the fluid loss is a decrease in extracellular volume (ECV); the serum osmolality will either be low or normal. From a physiological standpoint, it makes sense that many clinicians refer to any loss of total body water as dehydration in their routine clinical practice. Most people who have mild to moderate dehydration as a result of vomiting, diarrhoea, or fever can recover by drinking more liquids, such water. Full-strength fruit juice and soft drinks might make diarrhoea worse. If you work outside or exercise in hot or muggy weather, your best bet is cool water. The best way to treat dehydration is to replenish the body with enough of fluids, such as water, diluted squash, or diluted fruit juice. A salty snack can help you replace lost salt, while a sweet drink can help you replace lost sugar. We go over the causes, prevalence, accessible therapies, and present state of dehydration in this review study.

Oesophageal granulomas in free-ranging wild Booted Eagles (Hieraaetus pennatus) caused by Trichomonas gallinae

Two free-ranging Booted Eagles were rescued in a severe state of cachexia and dehydration. Both had huge oesophageal granulomas, blocking the passage of food. A complete physical examination, x-rays and blood haematology and biochemistry were performed. Samples were taken for fine needle aspiration cytology and the diagnosis was avian trichomoniasis in both cases. Treatment and outcomes of the cases are described below. The aim of this study is to highlight the importance of early recognition of this disease for a more favourable prognosis, and the impact that avian trichomoniasis may have on wild populations of endangered species.

Association between Anxiety Status and Hydration Status in Spanish University Students.

Anxiety disorders are a very common psychiatric pathology among young university students, and the strategies for its mitigation are limited to the consumption of anxiolytic substances. Adequate hydration is essential for staying healthy, as water is the main component of the human body and of several physiological processes. A state of dehydration, in addition to a negative water balance, has serious consequences on health status. We aimed to determine the association between the degree of anxiety and the level of hydration in Spanish university students. A cross-sectional, observational research study with a sample of 65 female university students was conducted. Over 90% of the study population shows anxiety levels above the 95th percentile. The individuals with anxiety above the 95th percentile showed a negative water balance. The consumption of coffee and herbal teas shows correlations with state anxiety and trait anxiety.

THU359 A Classical Case Of SGLT-2 Inhibitor Euglycemic Ketoacidosis In A Patient With Glucotoxicity

Abstract Disclosure: S. Amankwah: None. O.B. Olajide: None. Background: SGLT-2 inhibitors have been demonstrated to be beneficial in protecting comorbid cardiovascular or kidney disease while providing modest improvement in glycemia. However, they are not ideal for initial therapy for patients with very poorly controlled type 2 diabetes. This is a case where SGLT-2 inhibitor monotherapy led to diabetic ketoacidosis. Clinical Case: A 68-year-old woman with type 2 diabetes for 30 years, hypertension, hyperlipidemia, and depression presented to the hospital with complaints of headache, nausea, vomiting, dizziness, fatigue for the past three days. She had no fever, cough, shortness of breath or dysuria. She had not been taking any oral hypoglycemic agents for many months as she was trying to control her diabetes with lifestyle modifications. However, after the passing of her husband three months prior, she became less motivated in managing her health. Ten days prior to her hospitalization, the patient was newly prescribed empagliflozin 10 mg daily by her primary care provider due to uncontrolled hyperglycemia. She refused to resume metformin due to her history of gastrointestinal intolerance. She was previously on glipizide, but this was not restarted as she previously had poor glycemic control on it. On arrival at the ER, her temperature was 97.9 F, heart rate 112 bpm, respiratory rate 22 bpm, blood pressure 105/63 mmHg, and pulse oximetry on room air was 97%. Physical exam was unremarkable. Her serum glucose was 228 mg/dL, anion gap 15, pH 7.1, serum bicarbonate 15 mEq/L, serum acetone 3+, urine ketones greater than 150 mg/dL, serum creatinine 1.26 mg/dL and hemoglobin A1c was 13.2%. Her chest X-ray was unremarkable and COVID 19 test was negative. Euglycemic diabetic ketoacidosis (EDKA) was suspected secondary to the use of empagliflozin. This was discontinued and the patient was treated with intravenous insulin and fluids. Her serial blood tests showed resolution of ketoacidosis within 12 hours, and she was then transitioned to subcutaneous insulin. She was discharged home after 2 days of hospitalization on insulin therapy. Discussion: This case demonstrates the potential for SGLT-2 inhibitors to cause EDKA. It is important to acknowledge this complication can happen in cases where SGLT-2 inhibitors are used as monotherapy in diabetic patients with glucotoxicity. The mechanism of action of SGLT2 inhibitors is to enhance excretion and block reabsorption of filtered glucose from the proximal convoluted tubule. The resultant glycosuria creates a state of carbohydrate starvation and volume depletion, increasing the glucagon/insulin ratio, resulting in a state of severe dehydration and ketosis. Patients with glucotoxicity are at a higher risk to develop ketoacidosis as they have marked beta cell insufficiency. It is thus highly recommended to initially treat these patients with insulin rather than oral agents. Presentation: Thursday, June 15, 2023

Exercise-Induced Gastrointestinal Symptoms in Endurance Sports: A Review of Pathophysiology, Symptoms, and Nutritional Management

Strenuous exercise can be associated with “Exercise Induced Gastrointestinal Syndrome” (Ex-GIS), a clinical condition characterized by a series of gastrointestinal (GI) disturbances that may impact the physical and psychological performance of athletes. The pathophysiology comprises multi-factorial interactions between the GI tract and the circulatory, immune, enteric, and central nervous systems. There is considerable evidence for increases in the indices of intestinal damage, permeability, and endotoxemia associated with impaired gastric emptying, slowing of small intestinal transit, and malabsorption of nutrients. Heat stress and racing mode seem to exacerbate these GI disturbances. GI symptomatology that derives from strenuous exercise is similar to that of IBS and other GI functional disorders defined in the Rome IV Criteria. To manage Ex-GIS, the exercise modality, state of dehydration, environmental temperature, concomitant therapies, and self-managed diet should be evaluated, and if risk elements are present, an attempt should be made to modify them. Multiple strategies can be successively adopted to manage Ex-GIS. Nutritional and behavioral interventions appear to be the principal ones to avoid symptoms during the exercise. The aim of this review will be to explore the pathophysiology, clinical aspect, and current literature on behavioral and nutritional strategies to manage Ex-GIS, regarding a gluten-free diet and low-fermentable oligo-, di-, and mono-saccharides and polyols (FODMAP) diet.

Examining the effects of pre-competition rapid weight loss on hydration status and competition performance in elite judo athletes

The prevalence of rapid weight loss (RWL) among martial arts athletes including judo is very high. Many applied RWL strategies could be dangerous to health and even lead to death. Therefore, the International Judo Federation (IJF) introduced changes in the weigh-in rules, changing the official weigh-in for the day before the competition. Thus, the purpose of this study was to examine the impact of the new IJF rules on hydration status and weight loss strategies among professional judo athletes. Seventeen elite judo athletes participated in the study. Body mass and hydration status, were analyzed before the competition. Moreover, competition result and practice of RWL survey were collected. All subjects reached their weight category limits for the competition. RWL resulted in body mass changes (p < 0.001, ηp2 = 0.79) and dehydration among participants (urine osmolality > 700 [mOsmol*kg]−1 and urine specific gravity > 1.020 [g*cm3]−1). However, urine osmolality (p > 0.05, ηp2 = 0.18), as well as urine specific gravity (p > 0.05, ηp2 = 0.16), at subsequent time points of measurement revealed no statistical differences. The prevalence of RWL was 100%, and only 17.6% of the athletes declared that they would compete in a different weight category if the competition would be conducted on the same day of the weigh-in. All judo athletes applied RWL procedures using traditional methods to achieve the required body mass (i.e., increased exercise, reduced fluid, and food intake). Dehydration state was not associated with competitive performance (p > 0.05).

Pyometra and mammary gland tumor in a Beagle dog at the Veterinary Teaching Hospital of Brawijaya University, Malang, Indonesia

A 12-year-old Beagle dog weighing 7.7 kg was brought to the Brawijaya University Veterinary Teaching Hospital in a state of dehydration, lethargy, and jaundice. On the 2nd day of hospitalization, the dog had mucopurulent discharge from the vagina. From the results of a complete blood count and ultrasonography (USG), the patient was diagnosed with pyometra and was treated with an ovariohysterectomy. After surgery the dogs was given cefotaxime 10 mg/kg bw, meloxicam 0.2 mg/kg bw, 0.9 ml vitamin K, and supportive therapy with Biodin® 0.5 mL and Modivitasan® 0.5 mL. Pyometra infection causes progesterone levels to rise, thereby triggering mammary gland tumor. On the 23rd day of hospitalization, a lump was found in the mammary gland. Fine needle aspiration (FNA) results showed the presence of Mott cells. The mammary gland tumor was treated with a single mastectomy. Mastectomy was performed when the dog was in stable condition, about a month after the ovariohysterectomy. Ovariohysterectomy and mastectomy were not performed simultaneously due to consideration of the patient's clinical condition, which made it impossible to get prolonged exposure to anesthesia. Post-mastectomy surgery the dogs were given cefixime 10 mg/kg bw, the analgesic meloxicam 0.2 mg/kg BW, and Biodin® 0.5 ml as supportive therapy. The postoperative wound healed well without complications. The patient recovered after one month of treatment.

Pyometra and mammary gland tumor in a Beagle dog at the Veterinary Teaching Hospital of Brawijaya University, Malang, Indonesia

A 12-year-old Beagle dog weighing 7.7 kg was brought to the Brawijaya University Veterinary Teaching Hospital in a state of dehydration, lethargy, and jaundice. On the 2nd day of hospitalization, the dog had mucopurulent discharge from the vagina. From the results of a complete blood count and ultrasonography (USG), the patient was diagnosed with pyometra and was treated with an ovariohysterectomy. After surgery the dogs was given cefotaxime 10 mg/kg bw, meloxicam 0.2 mg/kg bw, 0.9 ml vitamin K, and supportive therapy with Biodin® 0.5 mL and Modivitasan® 0.5 mL. Pyometra infection causes progesterone levels to rise, thereby triggering mammary gland tumor. On the 23rd day of hospitalization, a lump was found in the mammary gland. Fine needle aspiration (FNA) results showed the presence of Mott cells. The mammary gland tumor was treated with a single mastectomy. Mastectomy was performed when the dog was in stable condition, about a month after the ovariohysterectomy. Ovariohysterectomy and mastectomy were not performed simultaneously due to consideration of the patient's clinical condition, which made it impossible to get prolonged exposure to anesthesia. Post-mastectomy surgery the dogs were given cefixime 10 mg/kg bw, the analgesic meloxicam 0.2 mg/kg BW, and Biodin® 0.5 ml as supportive therapy. The postoperative wound healed well without complications. The patient recovered after one month of treatment.

Behavioural response to predation risks depends on experimental change in dehydration state in a lizard

Behavioural response to predation risks depends on experimental change in dehydration state in a lizard

DNA Detection Using a Single-Layer Phosphorene Nanopore

Over the past decade, two-dimensional (2D) materials have been emerging as promising candidates for detecting and characterizing DNA using nanopore technology. With an artificially created nanopore, their ability to distinguish between different nucleotides holds promise for single-read, high-throughput, and label-free DNA sequencing. Different 2D membranes have demonstrated potential for distinguishing between different nucleotides contingent on fluctuations in ionic current as the nucleotides pass through the nanopore. Among the 2D materials, phosphorene bears outstanding properties such as high carrier mobility, low deformation potential, and tunable band gaps. Here, we investigated the potential of nanoporous phosphorene for DNA detection. By conducting hundreds of molecular dynamics simulations, we evaluate the phosphorene nanopore’s sensitivity to distinguish between different nucleotides through the generation of characteristic features such as fluctuations in ionic current, residence time, and the dehydration state of the nanopore. We are able to demonstrate that phosphorene is a promising candidate for distinguishing between certain bases.

Investigating the Prevalence of Contrast-associated Nephropathy and the Related Risk Factors in Patients Undergoing Elective Angioplasty.

Contrast-associated nephropathy (CAN) is a sudden decrease in kidney function following contrast media administration. Considering the importance of CAN in the patient's outcome and the high prevalence of this complication in cardiac catheterizing centers, this study was designed to investigate the prevalence and the related risk factors of CAN in patients undergoing angioplasty in Chamran Heart Hospital, Isfahan, Iran, from January 2022 to June 2022. The inclusion criteria were adult patients above 18 admitted for elective percutaneous coronary intervention (PCI). Patient demographic information, underlying diseases and medications, dehydration state, type and amount of contrast media, and serum levels of blood urea nitrogen (BUN) and serum creatinine (SrCr) at 24 and 72 h after contrast injection were all recorded. Out of 340, 128 patients developed CAN after PCI, giving an incidence of 37.64%. Adjusted analysis showed a significant relation between age over 65, the amount of contrast media administered, and the use of furosemide with the incidence of CAN. However, adjusted logistic regression analysis failed to show any significant relationship between the risk of CAN and the hydration status of the patients at 24 and 48 h after receiving contrast media as diagnosed by BUN/SrCr >20. The prevalence of CAN in this study was higher than in other studies since this high-risk population was under risk factors such as arterial injection of contrast material and a higher amount of contrast material administration. In addition, advanced age, volume of contrast material, and previous or concurrent furosemide administration were associated with an increased risk of CAN.

Unusual cases of chlamydiosis in psittacine birds.

Avian chlamydiosis is a common disease found in domesticated and nondomesticated avian species caused by several species of chlamydiae including but not limited to Chlamydia psittaci, Chlamydia avium, Chlamydia gallinacea, Chlamydia buteonis, and Chlamydia ibidis. Generally, early in the disease course, birds present with mild nonspecific clinical signs associated with gastrointestinal and respiratory tract disease. During end-stage disease, birds may present in a severe state of emaciation, dehydration, and/or acute death with no known history of prior illness. Between 2000 and 2009, 14 unusual cases of avian chlamydiosis were submitted to the California Animal Health and Food Safety Laboratory System. Histologic lesions noted in the 14 birds included meningoencephalomyelitis (3 of 13, 23%), otitis media (3 of 8), bursitis (9 of 11, 81%), nephritis (8 of 13, 61%), and orchitis (1 of 8). Corresponding immunopositive chlamydiae intracytoplasmic inclusions were detected in all tissues. Positive immunolabeling was detected in optic nerves (5 of 10, 50%), meninges (5 of 13, 38%), and endothelial cells (14 of 14, 100%) in the absence of significant microscopic lesions. This study highlights unusual gross, histological, and immunohistochemical findings of chlamydiosis in psittacines and highlights the importance of a thorough diagnostic approach when confirming or excluding chlamydiosis in psittacine birds.

Imaging the subducting slab and mantle upwelling under the Japan islands revealed by double-difference tomography

In this paper, we collected the seismic phase arrival data of 14,033 local natural earthquakes above magnitude 3.0 recorded by 435 seismograph stations in the study area provided by the International Seismological Centre (ISC), covering the period from January 2011 to April 2020. We selected the first arrival P- and S-wave arrival time data and obtained 281,859 P- and 112,926 S-wave absolute arrival times and 528,250 P-differential and 207,968 S-differential arrival times. Then we determined 3-D P and S wave velocity structures from the Japan Trench to the back arc area under the Japan Islands by using double-difference tomography method. The results show strong lateral heterogeneities under the forearc region. The subducting Pacific slab is imaged clearly as a high-velocity (high-V) faster than the surrounding mantle. Low-velocity (low-V) zones are imaged in the mantle wedge with significant along arc variations under the volcanic front. The vertical section shows that the low velocity zone extends to a depth of approximately 70–150 km below the arc. The crust and mantle wedges beneath the front and back arcs of the volcanoes reveal a low-V anomaly, the likely main source of which is the partial melting of plate and mantle wedge material. Referring to the previous results of plate dehydration, mineral composition and thermal state, it is found that fluids play a crucial role in the arc magmatism and plate melting of mantle wedge behind Japan Trench. The fluids brought down by the Pacific subducting plate are released into the mantle wedge by dehydration and subsequently transported upward by the upwelling flow in the mantle wedge. The present results obtained using new and advanced imaging methods enrich the understanding of the velocity structure beneath Japan Islands, which may improve the understanding of the dynamic processes of subduction zones and mantle upwelling.

Flexible and printable integrated biosensors for monitoring sweat and skin condition

Wearable and flexible sensors are playing increasing roles in health monitoring (like physiological electrical signals and components of biofluids). Therein, sweat as a carrier of informative biomarkers would attract great attention for health status identification. However, most wearable biosensors have a short lifetime with complex fabrication processes and expensive costs, which would largely limit the application scene to some extent. Here, we developed a state-of-the-art flexible and integrated sensor patch with screen-printing technology for in-situ and real-time monitoring of electrolyte balance and skin state. The screen-printed sensor patch was easily fabricated, highly reproducible, disposable and relatively stable, which was extremely for sweat sensors with low cost. The state of art sensors on the patch of Na+, pH, skin impedance and temperature all showed excellent performance with high linearity (coefficient of determinations (R2) are 0.998, 0.994, 0.998 and 0.997, respectively). Besides, the detection ranges of Na+ and pH sensors are wide enough for sweat analysis of 10–100 mM and 2–8, respectively. The proposed device provides a new strategy for real-time sweat analysis, preventing dehydration and skin state monitoring during exercise.

Studi kasus : Feline panleukopenia virus pada kucing abel

A domestic cat with short hair, approximately three months old, was brought to the Tabby Pet Care clinic with complaints that the cat's owner had vomiting and diarrhea. The results of clinical examination showed a state of dehydration and swollen popliteal. Supportive examinations include hematological examinations and rapid test kits. Hematological examination results showed anemia and leukocytosis. The results of the rapid test kit examination showed a positive FPV result. Based on clinical symptoms and the results of investigations, the patient was diagnosed as positive for Feline Panleukopenia Virus. Treatment of FPV is carried out with supportive therapy. Therapy was carried out for 7 days. On the seventh day, based on the results of the hematological examination and the patient's body condition, his condition progressed and he was allowed to continue outpatient therapy.