The application of energy supply systems based on fuel cells contributes to meeting the requirement of sustainable development, and developing high-efficiency, low-pollution, and multifunction poly-generation systems coupled with fuel cells is increasingly attractive. This study proposes a novel combined cooling, heating, power poly-generation and dehumidification system including a solid oxide fuel cell, a gas turbine, a double effect absorption refrigerator, a condensation dehumidification unit, an organic Rankine cycle, and a heat exchanger. Thermodynamic, economic, and environmental analysis models of the entire system are developed to evaluate system comprehensive performance. The effects of system parameters such as the inlet temperature of fuel cell, steam to carbon ratio, air flow rate, and high temperature generator temperature on system performance are analyzed. The analysis findings reveal that the proposed system can provide power, cooling, and heating of 551.904 kW, 20.307 kW, and 193.009 kW, and the dehumidification capacity per unit is 14.516 g/kg when 1.238 kg/s of humid air is treated. The system exergy efficiency is found to be 70.534 %, and the system cost rate is 15.578 $/h with carbon dioxide emission being 0.301 kg/kWh at the design condition. Two groups of multi-objective optimizations of the whole system are further conducted to acquire the optimal system performance and working conditions. The optimization results demonstrate that the optimal exergy efficiency of 72.912 % appears at point C1 in the first group of optimization with the lowest carbon dioxide emission being 0.293 kg/kWh, and the optimal qualities of humid air are found to be 1.606 kg/s at C2 and D2 in the second group of optimization. After optimization, the system carbon dioxide emission is decreased by 0.008 kg/kWh, the exergy efficiency is increased by 2.378 %, and the quality of humid air in dehumidification process is developed by 0.368 kg/s. In summary, the proposed poly-generation and dehumidification system can meet multifunction energy demands and achieve good performance, and the research work could also provide theoretical basis for developing evaluation and optimization technologies of fuel cell-based poly-generation systems.