Degree Of Irregularity Research Articles

Generalizable classification methodology for quantification of atomized feedstock powder by 3D X-ray tomography data and machine learning

Laser powder bed fusion (LPBF) is currently being applied to manufacture engineering-crucial components. To maintain consistent part quality, accuracy and speed in the quality assurance of atomized metal feedstock powder is critical. 3D x-ray tomography (XRT), coupled with machine learning algorithms, provides a transformative route to powder characterization and classification. A recycled AA7050 feedstock powder was studied through XRT to demonstrate a scheme for classification of highly deformed particles which vary both in geometric morphology and degree of surface irregularity. Manual, unsupervised, and supervised classification algorithms were optimized to reproduce visual classification, demonstrating how different approaches to algorithm training may provide a balance between the amount of training data and acceptable final accuracy. The reported approach provides a robust methodology that links 3D measurements and powder classification as means to control powder-induced defects and improve mechanical performance in printed parts.

A New Method for Determining the Safety Distance Between Irregular Karst Cave and Circumferential Shield Tunnel

ABSTRACTWhen a shield tunnel passes through a karst area, the water‐filled cave can easily make the surrounding rock metamorphic, resulting in water inrush, ground collapse, and shield machine failure and other engineering hazards. Natural cavities have a significant degree of geometric irregularity due to groundwater alteration and soluble rock erosion. Considering the difficulties in describing the shape of a natural irregular cavity, circular, rectangular, and elliptical geometries have been simplified in most related studies. Based on the upper bound theorem of limit analysis, we established a three‐dimensional failure model including the karst caves located directly above and below the circumferential side of the tunnel. Then, we deduced the corresponding analytical solution of the critical safety distance (CSD). Furthermore, the effects of rock mass parameters, cave parameters, and geometric parameters on the CSD were analyzed. Then we designed the numerical simulation considering the irregular geometry shape at the circumferential side of tunnel using the Fourier descriptors. In addition, we estimated the CSDs for two failure models using the revised dichotomy and failure criterion. The findings demonstrated a quantifiable association between CSD and Fourier descriptors of irregular cave shape, resulting in the development of a CSD prediction model. These test results can provide a theoretical foundation and direction for predicting water inrush caused by the constrained irregular cave.

The Effects of Ghrelin on Spike Activity of the Suprachiasmatic Nucleus Neurones of the Rat

In one of the most important non-photic mechanisms of the circadian biological clock synchronization with environmental geophysical 24 h rhythm, information on feeding schedule, composition and calorie content of food is used. Hormone ghrelin, a product of the neuroendocrine oxyntic cells of the gastric mucosa to be a signal molecule within this mechanism. In experiments on sagittal hypothalamic slices of male Wistar rats, the effects of 25 nM ghrelin on spike activity and parameters of spike information coding were investigated. Application of ghrelin induced an increase in spike frequency and a decrease in entropy of interspike interval distribution in 32.1% of the neurones recorded. In 29.6% of the cells, opposite responses in the form of a reduction of activity and an increase in the entropy of interspike interval distribution were observed. Parameters of spike activity of the reminder 38.3% neurones of the suprachiasmatic nucleus did not change. The observed responses of the entropy of interspike interval distribution indicate the appropriate changes in a degree of irregularity of interspike interval induced by ghrelin. Application of selective high-affinity antagonist of GHS-R1a receptor, JMV 2959 (100 nM) did not induce responses of the investigated parameters of spike activity but completely prevented changes of both, spike frequency and entropy of interspike interval distribution observed in the presence of ghrelin. The obtained data show that hormone ghrelin by a direct influence on the suprachiasmatic nucleus in vitro modulates the activity level and spike code of relatively numerous population of neurones of the nucleus, wherein the effects of ghrelin are implemented via GHS-R1a receptors. The results of the current study provide additional evidence in favour of the hypothesis on the involvement of ghrelin in mechanisms of non-photic entrainment of the circadian biological clock in accordance with severity of food motivation and level of metabolism.

The Amount and Pattern of Reciprocal Compensations Predict Performance Stability in a Visually Guided Finger Force Production Task.

Previous work suggests that synergistic activity among motor elements implicated in force production tasks underlies enhanced performance stability associated with visual feedback. A hallmark of synergistic activity is reciprocal compensation, that is, covariation in the states of motor elements that stabilizes critical performance variables. The present study examined if characteristics of reciprocal compensation are indicators of individuals' capacity to respond adaptively to variations in the resolution of visual feedback about criterion performance. Twenty healthy adults (19.25 ± 1.25years; 15 females and five males) pressed two sensors with their index fingers to produce a total target force equivalent to 20% of their maximal voluntary contraction under nine conditions that differed in the spatial resolution of real-time feedback about their performance. By combining within-trial uncontrolled manifold and sample entropy analyses, we quantified the amount and degree of irregularity (i.e.,non-repetitiveness) of reciprocal compensations over time. We found a U-shaped relationship between performance stability and gain. Importantly, this relationship was moderated by the degree of irregularity of reciprocal compensation. Lower irregularity in reciprocal compensation patterns was related to individuals' capacity to maintain (or minimize losses in) performance under changes in feedback resolution. Results invite future investigation into how interindividual variations in reciprocal compensation patterns relate to differences in control strategies supporting adaptive responses in complex, visually guided motor tasks.

Mechanical and failure behaviors of adhesively bonded dissimilar materials joints incorporating bio-inspired morphological irregularities

Adhesive dissimilar material joints between stainless steel grade 316L and polyethylene terephthalate glycol (PETG) plastic were examined, in which irregular interface morphologies inspired by natural sutures were incorporated. The joint interfaces exhibited various teeth-like, non-repetitive zigzag patterns based on a pseudo-randomization method and sutural interdigitation index. Effects of their irregularities on mechanical and failure characteristics of adhesive butt joints were studied by means of experiments and FE simulations. The cohesive zone model, Drucker-Prager plasticity model and ductile failure criterion were applied for the interface and PETG, respectively. Predicted load-displacement curves of joints with different teeth profiles were well validated. The degree of irregularity became higher to 20%, 40%, and 60%, the joint strengths decreased by 1.47%, 5.39%, and 11.95%, while the total energies to failure increased by 110.74%, 129.33%, and 161.23%, accordingly. More inhomogeneous morphologies led to earlier local damage initiation, but enhanced damage evolution range by impeding abrupt joint separation. Smaller teeth angles provided higher joint strength, whereas significant declines of bonding strength were observed by too acute teeth angle due to excessive stress localization and resulting teeth breakage. The teeth angle of 45º enabled the superior joint performance owing to a proper combination of interlocking and large adhesive force under shear stress state. Finally, a key insight for designing an optimal dissimilar joint with morphological irregularities was provided.

Study on single particle compression crushing characteristics of iron ore with five different particle sizes

The mechanical properties of particulate materials are among the main factors affecting the grinding and crushing of ball mills. To quantitatively describe the relationship between the breakage characteristics and the stress intensity of irregular particulate materials, this study takes iron ore particles as the research object. It selects five particle size grades of iron ore particles (−4.75 + 3.35, −6.7 + 4.75, −9.5 + 6.7, −13 + 9.5, and −16 + 13 mm) for single particle strength tests. The results showed that the iron ore particles were irregular with certain slenderness and flatness characteristics. The larger the particle size, the lower the sphericity, and the greater the degree of irregularity. As the size of the iron ore particles increased, the number of peak points on the pressure–displacement curve of the particles increased significantly, and the crushing load increased. The single-particle strength of the iron ore particles followed a Weibull distribution, and the Weibull modulus parameter ranged between 2.03 and 2.49.

Effect of the particle shape on the shear mechanical behavior of coral sand

Abstract Coral sand particles exhibit a wide range of shapes, which can be divided into four shapes, e.g., blocky, dendritic and rodlike, flaky, and shell debris. The particle shape of these mixtures is defined by the sphericity, concavity, aspect ratio, flatness and overall regularity, which ranges from 0 to 1. The effect of particle shape on the strength, crushing characteristics, and critical state parameter is systematically investigated through a series of triaxial drainage shear tests under different confining pressures. And the relationship between critical state parameters and mechanical parameters is established. The test results demonstrate the existence of an evident strain-hardening phenomenon in the stress–strain curve of coral sand, accompanied by a strain-softening phenomenon when the bias stress reaches its peak value. The sample is initially subjected to shear shrinkage, followed by shear expansion. The volumetric deformation of the coral sand decreased with increasing peripheral pressure. The particles are transformed from rough irregular shapes to smooth spheres as evidenced by an increase in the shape parameter. The greater the degree of irregularity in the shape of the particles, the more pronounced the resulting change in size reduction. In addition, the critical state parameter was found to be influenced by the shape of the coral sand particles and the mode of particle accumulation. The overall shear resistance of coral sand particles was found to depend on particle rearrangement in addition to particle surface roughness and interparticle friction. It is proposed that the general regularity critical state parameter equation relates the particle shape of coral sand to its critical state mechanical properties, which is of great importance to the practical application and research of coral sand in engineering, and provides an effective means of predicting mechanical properties granular materials.

In-situ study on the effect of Li concentration on hydrogen microporosity evolution in Al-Li alloys by synchrotron X-ray radiography

The nucleation and growth of hydrogen microporosity during the solidification of Al-Li alloys were in situ observed by synchrotron radiation X-ray radiography, and the effect of initial Li concentration on its evolution kinetics was investigated. The results show that the high Li concentration effectively contributes to the high-temperature nucleation effect of hydrogen microporosity during the solidification of Al-Li alloys, and significantly increases the nucleation and growth rates of hydrogen microporosity. When the initial Li concentration was 2.0 wt%, the nucleation supersaturation of hydrogen microporosity was 1.96, which was 3.5 times higher than that at low Li concentration (1.5 wt%), and the growth rate was up to 2.61 μm/s. In addition, the quantitative results of the final size, morphology, and distribution of the hydrogen microporosity based on 3D X-ray computed tomography (X-CT) showed that high Li concentration not only increased the volume of monolithic hydrogen microporosity, and increased the total number of microporosities, but also increased the degree of irregularity of hydrogen microporosity. The in-situ observation results can provide a new dataset for the establishment and validation of the hydrogen microporosity model of Al-Li alloys.

Importance of the electron plasma parameter for excitation of chorus and formation of magnetic field irregularity in the region of their excitation

A threshold condition has been established for excitation of VLF electromagnetic radiation with a chorus structure of the dynamic spectrum in the daytime magnetosphere using the BPA (Beam Pulse Amplifier) mechanism for amplifying short noise electromagnetic pulses. The kappa distribution was used as a model function of the electron velocity distribution in the magnetosphere. Calculations performed for this distribution have shown that the threshold for excitation of chorus largely depends on the electron plasma parameter equal to the ratio of gas-kinetic pressure of electrons to magnetic pressure. This pattern is not contradicted by the dependence of the probability of excitation of chorus on the degree of magnetic field irregularity, which we derived from observations made by the Van Allen Probe spacecraft. It is sharp fluctuations in the magnetic field strength near its local minima outside the plasmasphere where the radiation under study can be excited. If there is an irregularity, the probability of detecting chorus is >70 %; and if there is no or very low irregularity, the probability of the absence of any emissions is ~80 %. The results indicate a common reason for the excitation of chorus and the magnetic field irregularity — a small but finite value of the plasma parameter.

Существенность величины плазменного параметра электронов для возбуждения хоров и формирования нерегулярности магнитного поля в области их возбуждения

A threshold condition has been established for excitation of VLF electromagnetic radiation with a chorus structure of the dynamic spectrum in the daytime magnetosphere using the BPA (Beam Pulse Amplifier) mechanism for amplifying short noise electromagnetic pulses. The kappa distribution was used as a model function of the electron velocity distribution in the magnetosphere. Calculations performed for this distribution have shown that the threshold for excitation of chorus largely depends on the electron plasma parameter equal to the ratio of gas-kinetic pressure of electrons to magnetic pressure. This pattern is not contradicted by the dependence of the probability of excitation of chorus on the degree of magnetic field irregularity, which we derived from observations made by the Van Allen Probe spacecraft. It is sharp fluctuations in the magnetic field strength near its local minima outside the plasmasphere where the radiation under study can be excited. If there is an irregularity, the probability of detecting chorus is >70 %; and if there is no or very low irregularity, the probability of the absence of any emissions is ~80 %. The results indicate a common reason for the excitation of chorus and the magnetic field irregularity — a small but finite value of the plasma parameter.

Investigation of torsion in asymmetric mid-rise structures on the pile-raft system considering soil-structure interaction

The adverse conditions of the soil such as soft soil can have seismic consequences that may either amplify seismic response or render the structure vulnerable. On one hand, the design and construction of asymmetric structures have become prevalent due to aesthetic considerations and structural space limitations. Studies indicate that structures with geometric irregularities are susceptible to seismic forces, leading to non-uniform distribution of floor drifts, excessive torsional behavior, and more, depending on the degree of irregularity. In this research, the main goal was to investigate the effect of soil and structure interaction on the torsion of asymmetric Mid-Rise Structures. To achieve this goal two asymmetric Steel moment frame system 15-story structures aim to address the effect of interaction between soil and structure on the seismic performance, one with a rigid base and the other with a flexible base, one with a rigid base and the other with a flexible base. To mitigate the settlement of soil-associated structures, a pile-raft system is employed, considering the softness of the soil. Additionally, to study the torsional behavior of these structures, their planes are asymmetrically designed in L-shape and C-shape configurations, subjected to four ground motion excitations in both far and near-field scenarios. Three-dimensional finite element numerical simulations are performed using Abaqus software. Various configurations of the pile-raft system for the asymmetric C-shape structure are examined to assess the effects of pile diameter and length on the torsional irregularity coefficient. The results show that the soil-structure interaction increases the maximum floor rotation angle, placing these structures in critical conditions concerning torsional irregularity under near-field and far-field seismic excitations.

Comparison of TEVA vs. PRAAT in the Acoustic Characterization of the Tracheoesophageal Voice in Laryngectomized Patients.

Background: Previous studies have assessed the capability of PRAAT for acoustic voice analysis in total laryngectomized (TL) patients, although this software was designed for acoustic analysis of laryngeal voice. Recently, we have witnessed the development of specialized acoustic analysis software, Tracheoesophageal Voice Analysis (TEVA). This study aims to compare the analysis with both programs in TL patients. Methods: Observational analytical study of 34 TL patients where a quantitative acoustic analysis was performed for stable phonation with vowels [a] and [i] as well as spectrographic characterization using the TEVA and PRAAT software. Results: The Voice Handicap Index (VHI-10) showed a mean score of 11.29 ± 11.16 points, categorized as a moderate handicap. TEVA analysis found lower values in the fundamental frequency vs. PRAAT (p < 0.05). A significant increase in shimmer values was observed with TEVA (>20%). No significant differences were found between spectrographic analysis with TEVA and PRAAT. Conclusions: Tracheoesophageal speech is an alaryngeal voice, characterized by a higher degree of irregularity and noise compared to laryngeal speech. Consequently, it necessitates a more tailored approach using objective assessment tools adapted to these distinct features, like TEVA, that are designed specifically for TL patients. This study provides statistical evidence supporting its reliability and suitability for the evaluation and tracking of tracheoesophageal speakers.

Historical Evolution of the Impact of Seismic Incident Angles on the Safety Assessment of Various Building Construction Typologies

In the existing building stock, typically characterised by a high degree of irregularity, the effects of earthquakes are strongly dependent on the epicentre–structure direction and the angle of incidence of the seismic motion. However, the scientific community has not yet reached a unanimous consensus on the evaluation of the effects of seismic incidence angles. Therefore, this paper conducts an extensive investigation of the international literature on current methods to consider seismic directionality, systematically reviewing more than 80 publications on this topic. Following a brief overview of the problem and an analysis of the initial developments of the multidirectionality concept of seismic input, a state-of-the-art review is presented based on the considered analysis methods, specifically response spectrum analysis, nonlinear static analysis, and nonlinear response history analysis. Moreover, the adoption of multidirectional seismic input in popular codes and standards is presented and discussed. This study provides the first comprehensive synthesis of research on the seismic incidence angles across diverse building typologies, offering crucial insights for future code revisions and highlighting significant gaps in current analytical methods and standards, thereby setting a new direction for subsequent empirical investigations. Specifically, the extensive state-of-the-art review revealed that, until now, the evaluation of the angle of incidence was primarily conducted on existing reinforced concrete buildings with a limited number of storeys, analysed with nonlinear response history analysis. This underscores the need for future research to extensively investigate the impact of the angle of incidence on other types of construction typologies.

Assessment of the Alignment Acceleration of the Lower Incisors Using a Single Aligner Appliance Modified with Nickel-Titanium Coils: A Randomized Controlled Clinical Trial in Adults.

OBJECTIVE: The aim of this study was to investigate the effects of a single aligner appliance modified with nickel-titanium coils in accelerating the alignment of crowded lower incisors. MATERIALS AND METHODS: 36 patients with mild crowding of their lower incisors were randomly divided into two groups: one group received a modified aligner appliance with nickel-titanium coils (Experimental group), while the other group received traditional orthodontic brackets (Control group). The degree of irregularity in the alignment of the incisors was measured every 2 weeks using Little's irregularity index, and this was done at different time points throughout the study: before treatment (T0), after 2 weeks (T1), after 4 weeks (T2), after 6 weeks (T3), after 8 weeks (T4). RESULTS: A total of 87 patients with anterior mild crowding in the lower dental arch were initially assessed for eligibility. Out of these, 64 patients met the inclusion criteria. Eventually, 36 participants were assigned to receive the treatment. Accordingly, the data from 36 patients were analyzed statistically. There was no significant difference when comparing the two groups at T0, T1, T3, and T4. However, the difference was significant at T2 (p = 0.037). The differences were statistically significant at all time periods within each group (P &lt; 0.001). CONCLUSION: The use of a modified aligner appliance with nickel-titanium coils effectively treats lower incisors crowding, but it does not accelerate the alignment process compared to the traditional fixed orthodontic appliance.

Fractal Characteristics and Microstructure of Coal with Impact of Starch-Polymerized Aluminum Sulfate Fracturing Fluids

The degree of irregularity and complexity of the pore structure are comprehensively reflected in the fractal dimension. The porosity of coal was determined by its fractal dimension, where a larger dimension indicates a lower porosity. Fractal theory and the Frenkel–Halsey–Hill (FHH) model were applied to explore the variation rules of concentration on functional groups and pore structure in this study. Combined with infrared spectroscopy (FTIR) and low-temperature nitrogen adsorption, a starch-polymerized aluminum sulfate composite fracturing fluid was prepared, which plays an important role in methane adsorption and permeability of coal samples. The test results showed that, compared with the original coal, the pore volume and specific surface area of each group of coal samples were reduced, the average pore diameter was initially enlarged and then declined, and fractal dimension D1 dropped by 5.4% to 15.4%, while fractal dimension D2 gained 1.2% to 7.9%. Moreover, the nitrogen adsorption of each group of coal samples was obviously lower than the original coal, and the concentration of starch-polymerized aluminum sulfate solution existed at a critical optimal concentration for the modification of the coal samples, and the nitrogen adsorption reached a minimum value of 0.6814 cm3/g at a concentration of 10%. The novel composite solution prepared by the combination of starch and flocculant in this paper enhanced the permeability of the coal seam, which is of great significance in improving the efficiency of coalbed methane mining.

Detection of Threshold-Level Stimuli Modulated by Temporal Predictions of the Cerebellum.

The cerebellum has the reputation of being a primitive part of the brain that mostly is involved in motor coordination and motor control. Older lesion studies and more recent electrophysiological studies have, however, indicated that it is involved in temporal perception and temporal expectation building. An outstanding question is whether this temporal expectation building cerebellar activity has functional relevance. In this study, we collected magnetoencephalographic data from 30 healthy participants performing a detection task on at-threshold stimulation that was presented at the end of a sequence of temporally regular or irregular above-threshold stimulation. We found that behavioral detection rates depended on the degree of irregularity in the sequence preceding it. We also found cerebellar responses evoked by above-threshold and at-threshold stimulation. The evoked responses to at-threshold stimulation differed significantly, depending on whether it was preceded by a regular or an irregular sequence. Finally, we found that detection performance across participants correlated significantly with the differences in cerebellar evoked responses to the at-threshold stimulation, demonstrating the functional relevance of cerebellar activity in sensory expectation building. We furthermore found evidence of thalamic involvement, as indicated by responses in the beta band (14-30 Hz) and by significant modulations of cerebello-thalamic connectivity by the regularity of the sequence and the kind of stimulation terminating the sequence. These results provide evidence that the temporal expectation building mechanism of the cerebellum, what we and others have called an internal clock, shows functional relevance by regulating behavior and performance in sensory action that requires acting and integrating evidence over precise timescales.

Estimating the optimal duration of random loading as part of machine part durability research

Aim. Making an informed decision regarding the durability of machine parts requires information on the operational load that needs to be measured on a representative section of the track. It should not be too long as well. Thus, it is required to determine the optimal duration of implementation. The duration of implementation that is optimal in terms of the reliability of load registration is defined for a process that is stationary in a special sense. Stationarity in a special sense is defined specifically for the task of assessing the durability of a specific part. Methods. The use of spectral theory for the study of random processes is probably not the best way of examining non-stationary loading processes in the context of durability assessment. We believe it would be optimal to use a cycle counting procedure (rain flow method) with subsequent calculation of durability. A lemma and a theorem were formulated on the sufficient duration of implementation for a process that is stationary in a special sense. A sufficient duration of implementation is defined as a limit past which its increase will not lead to a noticeable change in the calculated durability. Results. The matters of stationarity of a process in a narrow sense and the required duration of implementation will help in planning operational tests to measure and record random processes of machine part loading. Both matters were examined in terms of fatigue damage accumulation using Miner linear damage rule, as well as the adjusted linear damage summation hypothesis taking into account the fatigue curve slope parameter m. Some practical engineering problems were examined, including the problem of the optimal duration of implementation of a mining machine whose loading process is characterized by a high degree of irregularity and the problem of finding the required duration of implementation of load recording in a rolling stock component. Conclusion. A theorem on the required and sufficient duration of implementation was formulated. In order to test the method, Markov transition matrix-based model processes were used. In addition, the method and theorem were tested using examples of some experimental processes obtained from operational tests of vehicles and production machines.

The role of optical coherence tomography biomarkers in predicting the outcome of epiretinal membrane removal surgery

Epiretinal membrane (ERM) is a common condition that can cause visual impairment. ERM removal surgery is an effective treatment option, but predicting postoperative visual outcomes is challenging. Imaging modalities, particularly optical coherence tomography (OCT), have emerged as valuable tools for preoperative evaluation and predicting surgical outcomes. This presentation focuses on the role of preoperative OCT biomarkers in estimating postoperative vision improvement after ERM removal surgery. Such biomarkers include the disorganization of retinal inner layers (DRIL), the presence of ectopic inner foveal layer (EIFL), the cotton ball sign, the cone outer segment tips (COST) line, the photoreceptor outer segment (PROS) length, the inner retina irregularity index, and the presence of posterior vitreous detachment (PVD).DRIL refers to the abnormal appearance of the inner retinal layers on OCT, and has been found to be associated with poorer postoperative visual outcomes in ERM removal surgery. Significant EIFL has also been associated with poorer visual outcomes after surgery. The cotton ball sign, which appears as a hyper‐reflective area in the inner nuclear layer, has been found to be associated with increased difficulty in ERM removal and poorer visual outcomes. These biomarkers suggest that a greater degree of retinal disorganization and irregularity may lead to more challenging surgeries and poorer visual outcomes.In contrast, the presence of intact COST line and normal PROS length have been associated with better visual function. PVD, which represents separation of the vitreous from the retina, has been shown to be associated with less surgical trauma and better postoperative outcomes. The inner retina irregularity index, which measures the extent of disorganization of the inner retinal layers, has also been found to correlate with the changes in metamorphopsia and quality of vision after surgery.These biomarkers have the potential to improve the accuracy of preoperative evaluation and prediction of surgical outcomes in ERM removal surgery. By identifying patients with a greater degree of retinal disorganization and irregularity, we can anticipate more challenging surgeries and poorer visual outcomes. Conversely, patients with minimal COST line defects, normal PROS length and full PVD may have better postoperative visual outcomes.In summary, preoperative OCT findings can help predict postoperative visual outcomes in ERM removal surgery. The use of imaging modalities and specific biomarkers can provide useful insight in management decisions, case selection, and timing of surgery.

Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin.

Repeated acute exposure to ultraviolet B (UVB) rays can cause photoaging. Musa balbisiana peel contains flavonoid compounds which act as antioxidants. However, the physicochemicals of flavonoids are unstable, have high molecular weight, and are easily oxidized, causing their use is still limited and transdermal delivery to be inefficient. To investigate the ameliorative effect of transfersome gel of M. balbisiana peels against photoaging in Wistar rat skin. Transfersome gel was characterized by transmission electron microscopy (TEM). In vivo research was used to determine the ameliorative effects of M. balbisiana peel. The composition of transfersome consists of ethanol extracts of M. balbisiana peel, soybean phosphatidylcholine, and tween 80. The gel was applied three times a week for 4 weeks with a total UVB radiation dose of 840 mJ/cm2. To evaluate the repair mechanism by measuring the degree of wrinkles, epidermal thickening, dermal thinning, collagen fiber irregularity, matrix metalloproteinase 1 (MMP-1), and transforming growth factor-β (TGF-β) expression, malondialdehyde (MDA) and tumor necrosis factor-α (TNFα) levels. TEM results show that gel transfersome M. balbisiana peel has a round morphology with a diameter of ±50 nm and no aggregation, which are defined as nanoparticles. Transfersome gel ameliorated the degree of wrinkle, epidermal thickening, dermal thinning, and irregularity of collagen fibers caused by UVB exposure, suppresses lipid peroxidation by decreasing MDA and TNFα level, also collagen imbalance by inhibiting MMP-1 expression and activating TGF-β expression, which was found statistically significantly different from non-transfersome gel group. Transfersome gel of M. balbisiana peel can act as an alternative medicine to ameliorate clinical photoaging due to exposure to UVB.

A MIXTURE OF ACACIA BARK EXTRACT (Acacia mangium Willd) AND POTASSIUM IODIDE AS A CORROSION INHIBITOR IN SULFURIC ACID SOLUTION

Corrosion is a decrease in the quality of a metal material caused by a reaction with the environment. Corrosion cannot be eliminated, but corrosion can be slowed down in several ways by adding corrosion inhibitors and synergistic effects. Acacia bark extract (Acacia mangium Willd) with the addition of 0.02 M KI has the potential as a corrosion inhibitor for steel because it contains secondary metabolites, so it can provide a synergistic effect and increase the value of inhibition efficiency on steel. This research aimed to analyze the effect of a mixture of acacia bark extracts (Acacia mangium Willd) with the addition of KI on inhibition efficiency corrosion of mild steel in sulfuric acid media. The method used in this study is the method of weight loss, adsorption isotherms, and thermodynamic parameters, which were carried out by varying the concentration of acacia bark extract and the immersion temperature of the steel. To strengthen the research results, characterization was carried out using FTIR and SEM. The results showed that the corrosion rate of mild steel immersed in 0.75 M H2SO4 corrosive medium with the addition of 0.02 M KI increased with increasing immersion temperature. These results are reinforced by the results of FTIR and SEM analysis which show that there is an interaction between mild steel and acacia bark extract (Acacia mangium Willd) and KI 0.02 M. Based on the thermodynamic parameters, the resulting values of ∆Hads, ∆Gads, and ∆Sads show that the adsorption process of acacia bark extract (Acacia mangium Willd) in corrosive medium H2SO4 0.75 M with the addition of 0.02 M KI took place spontaneously, showing the type of physical adsorption, adsorbed stable, the adsorption process was exothermic and the degree of irregularity in the adsorption process. The inhibition efficiency of acacia bark extract (Acacia mangium Willd) with the addition of 0.02 M KI was highest at 60 °C with an extract concentration of 2.5 g/L of 81%. The higher the immersion temperature, the greater the resulting synergistic effect