Background of the Study: Language difficulties in the healthcare industry can cause misunderstandings or errors in care. Most of the Pakistani population communicates and comprehends in the Urdu language. Keeping this in mind, Urdu was chosen in the current study to gather information from patients with identified knee osteoarthritis in elderly individuals. To determine the validity of the translated version of Arthritis Impact Measurement Scale 2 URDU in knee osteoarthritis patients in Lahore, Pakistan. Methodology: This cross-sectional study was conducted with 234 participants. The data were collected from knee osteoarthritis patients at the University of Lahore teaching hospital. Data were collected using the AIMS-2 URDU questionnaire and the KOOS questionnaire. The sample was collected using a non-probability-convenient sampling technique. Results: Out of the total, 116 (49%) were males and 118 (51%) were females. The mean age was 51.1 years. Overall test-retest reliability and internal consistency of the Arthritis Impact scale were 0.990, excellent. The overall inter-item correlation of AIMS2-U was 0.981. For every subscale, the ceiling effect ranges from 5% to 10% and the floor effect ranges from 0% to 4%. The convergent validity between Arthritis Impact Measurement Scale 2—Urdu (arthritis pain, work) and KOOS (pain, symptom, ADLs, knee-related QOL) subscales when calculated through Pearson’s correlation coefficient was an excellent negative correlation. The highest factor loading demonstrated in arthritis pain was 0.960. Kaiser-Meyer-Olkin (KMO) degree of sampling adequacy confirmed a high significant value of 0.916. A value of 0.00 on Bartlett’s test is considered to be not significant. Conclusion: The Arthritis Impact Measurement Scale 2 Urdu Version portrays excellent test-retest reliability, excellent internal consistency, and strong positive correlation, i.e., excellent convergent validity.