Deep-seated structures can exhume deep crustal rocks (>20 km), transmitting the signal of geodynamic processes from the subduction zone to the interiors of the continents. The role of deep-seated structures can be analyzed with low-temperature thermochronological dating techniques. However, studies coupling low-temperature thermochronology with structural geological analyses of the deformational style are not common in the Northern Andes. In this contribution, we present new apatite (AFT) and zircon (ZFT) fission-track data coupled with meso- and microstructural analyses to reveal the deformational and exhumation history of the Santander Massif (SM; Northern Andes) and the related cortical Bucaramanga strike-slip fault (BF). Samples for thermochronological analyses were collected along an elevation profile with a significant elevation difference of 2.4 km across the western flank of the SM, crossing the BF. The time-temperature history modeling of ZFT data reveals phases of prolonged residence in the zircon partial annealing zone from âŒ125 to 94 Ma and a cooling phase related to an exhumation episode at around 25 Ma based on samples collected near the BF. Inverse modeling of AFT data reveals structurally-controlled Pliocene exhumation rates of 0.6â0.7 km/Myr mediated by the action of secondary faults. A shift in the deformation style resulting from the oblique interaction of the SM and MĂ©rida Andes domain is interpreted as the main driver of the Pliocene exhumation. This deformation phase is observed in the fault damage zone, where evidence of brittle-ductile deformation was exhumed. Finally, we discuss the geodynamic implications of our thermochronological and structural analyses, contrasting local and more regional competing hypotheses (Pamplona Indenter vs. slab break-off of the Caribbean plate), which may explain the tectonic evolution of the northern part of the Eastern Cordillera and the SM in the Colombian Northern Andes.