Historically, the development of new technologies has led to higher increase in productivity in Europe and the US compared to the rest of the world. This resulted in economic asymmetry in the global economy, which ultimately led to the geopolitical domination of Europe and the USA over Africa and Asia (Findlay, O'Rourke, 2007, p. 364). With the adoption of the Lisbon Treaty, the European Union has taken a step towards playing a significant role in trade, environment and social issues (Van Langenhove & Marchesi, 2009; Rudloff & Laurer, 2017). The aim of this work is to present the main challenges and changes taking place in transatlantic relations between the EU and the USA in the second and third decades of the 21st century. To achieve this goal, the descriptive method was applied.
 The reforms carried out by the EU allowed it to act in the spectrum of international affairs. The conflict between Russia and Ukraine (in 2014 and 2022) showed that the EU is increasingly resorting to sanctions and conditionality instruments to promote its interests. In addition, the EU aims to create a common army. Despite the fact that these changes contribute to the increase of the EU's competitiveness in the world, US relations between the EU are extremely durable, and the transatlantic community is repairing mutual relations relatively quickly. Meanwhile, the EU's relations with China, the largest trading partner in 2021 (Eurostat, 2022), are confrontational.
 Despite improvement in transatlantic relations, the earlier lack of communication led to a lack of confidence in the US on the part of Europeans. Relations between the US and the EU in the third decade of the 21st century remain tense – it is worth mentioning the AUKUS defense pact (agreement between Australia, Great Britain and the United States) on the exchange of defense technologies in this respect (Borges de Castro and Ricardo, 2021; Morcos 2021 ). It resulted in deterioration of relations between Paris and the US to such an extent that they were close to breaking. At the same time, at the beginning of the third decade of the 21st century, transatlantic relations sought stabilization. President Biden's administration has reaffirmed its commitment to alliances with European countries. In addition, the US returned to the Paris Agreement (United States Department of State, 2021) and rejoined the World Health Organization (WHO) (Keaten, 2021).
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