Deep Periprosthetic Infection Research Articles

Short-term outcomes with routine use of size ≥40 femoral heads in THA: A retrospective cohort study

BackgroundUsing larger femoral heads during total hip arthroplasty (THA) may result in a more stable hip. Greater volumetric wear and frictional torque, however, may result in increased postoperative complications. The purpose of this study was to compare outcomes of patients with femoral head size ≥40 mm compared to those with femoral head size <40 mm. Materials and methodsA retrospective chart review of 504 THAs performed by a single surgeon at a single institution from 2009 to 2016 was conducted. Following exclusions, 131 THAs were identified with femoral heads ≥40 mm and 348 THAs were identified with femoral heads <40 mm. In addition to demographic data, all postoperative complications were recorded. Plain radiographs were used to rule out/in periprosthetic osteolysis and/or acetabular loosening. Chi-square tests and Student's t-tests were used to compare categorical and continuous variables, respectively. ResultsMean follow-up period for the entire cohort was 5.5 years. Complications with ≥40 mm femoral heads included 1 superficial infection and 1 deep periprosthetic joint infection (PJI). There were no cases of dislocation, osteolysis, acetabular loosening, or trunnionosis. In contrast, complications with <40 mm femoral heads included 9 dislocations and 7 PJIs. ConclusionThe routine use of large femoral heads (≥40-mm) during THA appears to be a safe option for patients at short-term clinical follow-up. Notably, 0 patients had a clinical course complicated by dislocation, osteolysis, acetabular loosening, or trunnionosis. Level of evidenceLevel III Retrospective Cohort Study.

Use of semi-constrained total knee arthroplasty in gonarthrosis with collateral ligament insufficiency: Clinical and functional outcomes

IntroductionAchieving stability in total knee arthroplasty (TKA) is crucial for long-term implant survival. In cases of severe deformity or ligament laxity, constrained implants may be required. Traditionally, increasing constraint involved intramedullary stems. However, there are intermediary alternatives, including employing a constrained polyethylene insert without stems, thereby avoiding complications related to them. The study aims to evaluate our experience with a non-modular constrained (NMC) implant in primary TKA. Material and methodsWe conducted a retrospective review of the clinical and radiographic outcomes of 108 non-stemmed primary TKAs performed at our institution between 2013 and 2021 in patients with at least 10° deformity or 10mm ligament laxity. Data included demographics, preoperative and postoperative deformities, clinical outcomes and revision rates. ResultsA total of 103 patients (108 knees) with a mean age of 74 were followed up for a minimum of 2 years. The mean postoperative range of motion was 105°/0°. The median Oxford Knee Score, Knee Society Score and Knee Society Function Score were 43.5, 92 and 90, respectively. 17 knees had varus deformity (mean tibiofemoral angle of 2.7°), and 87 knees had excessive valgus deformity (mean tibiofemoral angle of 15.1°). The remaining 4 knees had a neutral alignment. The mean postoperative tibiofemoral angle was 6.8°. The overall revision rate was 6.5% (7 patients): 3 deep periprosthetic infections, 2 patellar dislocations, 1 stiffness and 1 aseptic loosening. ConclusionOur experience demonstrates favorable mid-term outcomes with the NMC implant, providing a safe alternative to stemmed implants in primary TKA, particularly in cases of severe deformity or ligament laxity.

ОЦЕНКА РЕЗУЛЬТАТОВ РЕВИЗИОННОГО ЭНДОПРОТЕЗИРОВАНИЯ ТАЗОБЕДРЕННОГО И КОЛЕННОГО СУСТАВОВ ПРИ ПЕРИПРОТЕЗНОЙ ИНФЕКЦИИ

Background. Periprosthetic infection is a serious complication of large joint replacement surgery. To date, there is no consensus on the choice of surgical tactics for treating this category of patients. The aim of the work. To determine the effectiveness of one-stage and two-stage revision hip and knee replacement surgery in reducing periprosthetic infection. Materials and methods. We analyzed the results of revision replacement surgery in 78 patients with deep periprosthetic infection of the hip and knee joints. In 38 patients, one-stage revision replacement surgery was used, in 40 patients – two-stage. Treatment results were assessed 1 year after the surgery. Out of 78 patients, in 45 (57.7 %) choosing the type of revision replacement surgery was made according to the algorithm developed at the Irkutsk Scientific Centre of Surgery and Traumatology. Results. Using revision replacement surgery made it possible to stop the infectious process in 64.1 % of patients. The best results were obtained after two-stage revision surgery, in which relief of the infectious process was achieved in 72.5 % of cases. The choice of treatment tactics for patients according to the algorithm improved the results of two-stage revision joint replacement surgery up to 87.5 %. Using the criteria proposed in the algorithm when assessing the positive and negative results of revision surgery made it possible to confirm the effectiveness of the algorithm in 80% of patients and to identify the probable reasons for the maintenance of periprosthetic infection: incorrect choice of the type of surgery, the presence of extensive bone defects, the presence of polyallergy. Conclusion. Analysis of the results of revision arthroplasty for periprosthetic infection made it possible to confirm the effectiveness of the proposed algorithm for choosing the type of surgery, to establish the highest effectiveness of two-stage revision surgery compared to one-stage surgery, and also to determine the probable causes of negative treatment results.

Total Knee Arthroplasty in Hemodialysis Patients: Routine or Complex Surgery?

Background. Chronic hemodialysis significantly increases the risks associated with knee replacement. Among the late complications of knee arthroplasty in hemodialysis patients, deep periprosthetic joint infection (PJI) and aseptic loosening are more frequent. The frequency of revision interventions in patients with end-stage kidney disease (ESKD) is substantially higher compared to patients with normal kidney function.&#x0D; The aim of the study — based on the perioperative parameters and midterm outcomes to justify the primary knee replacement in chronic hemodialysis patients as complex case of arthroplasty.&#x0D; Methods. A retrospective randomized single-center cohort study was conducted, including 62 patients with various forms of knee osteoarthritis. Patients were divided into two groups: Group 1 — 29 (46.8%) patients with end-stage renal disease (ESRD) undergoing dialysis, Group 2 — 33 (53.2%) patients without kidney pathology. The average follow-up period in both groups was 3.7 years (min — 1, max — 6). The following parameters were assessed: patient age, length of hospital stay, morphocortical index, body mass index (BMI), duration of hemodialysis, functional assessment of the knee joint using the KSS Function Score and Forgotten Joint Score-12 (FJS-12), radiological results on the KRESS, and the frequency of various complications.&#x0D; Results. In Group 1, patients had significantly lower BMI compared to Group 2. Length of hospital stay in Group 1 were 1.7 times longer. According to the KSS Function Score, no significant differences were observed between the groups in the first 36 months after the operation. However, by the 4th year of follow-up, average KSS Function Score in Group 1 decreased to 77.3 points, which was due to infectious complications. The FJS-12 showed worse scores in Group 2, averaging 68.7 points. After more than three years post-operation, no statistically significant differences were observed between the groups, which was associated with an increase in the number of complications in Group 1. Results on the KRESS after 43 months did not differ between the groups and averaged 4.8 points. Group 1 had more orthopedic complications and cases of PJI, accounting for 7 out of 37.&#x0D; Conclusion. Age and constitutional characteristics of patients undergoing hemodialysis significantly differ from the normal population. The frequency of complications in Group 1 was 23.5%. These patients require the implantation of more constrained implant components and modular systems. Therefore, primary knee replacement in hemodialysis patients can be classified as a complex case of arthroplasty.

&lt;i&gt;Mycobacterium abscessus&lt;/i&gt; as a causative agent of periprosthetic infection

Introduction Mycobacterium abscessus species belongs to the group of non-tuberculosis mycobacteria responsible for chronic infections in people with weakened immunity. M. abscessus exist in various ecological niches and are able to colonize artificial surfaces, including medical and surgical instruments/ devices. Due tothe low incidence of M. abscessus as a causative agent of orthopedic infection, a rare clinical case of periprosthetic infection caused by M.abscessus would interest practitioners.The aim is to present a clinical case of periprosthetic infection caused by M. abscessus.Materials and methods From the medical records and discharge documents, it was known that female patient X. underwent total hip replacement at her residence hospital. Signs of acute infection of the postoperative wound appeared in the early postoperative period.Results Three months later, the patient was hospitalized in a specialized institution with a diagnosis of chronic deep periprosthetic infection. During the examination, the mycobacterial etiology of the process was established. During two hospitalizations, the patient underwent 4 consecutive revision surgeries (including muscle plastic surgery and installation of an antimicrobial spacer) and massive parenteral antibiotic therapy for 8 months, including at the outpatient stage, using at least 3 antibacterial agents. After 4 years, the patient does not complain of the infectious process. Postoperative scar is 45 cm. The residual shortening of the right lower limb of 3 cm was compensated by orthopedic shoes.Discussion Treatment of infection caused by M. abscessus is challenging due to the natural resistance of the pathogen to a wide range of antibacterial drugs. The literature describes separate cases of orthopedic infections caused by this pathogen. All authors agree that the key to successful treatment is a combination of radical surgical debridement and antibacterial therapy using at least three antimicrobial drugs.Conclusion A rare clinical case of periprosthetic infection caused by Mycobacterium abscessus after primary hip replacement is presented. This infectious agent is a rare pathogen, for which there is no proven therapeutic algorithm. Long-term aggressive antibiotic therapy in combination with stage-by-stage surgical treatment was successful.

Two-stage revision hip arthroplasty in the treatment of periprosthetic joint infection

Introduction. One of the rare complications following hip arthroplasty is periprosthetic joint infection (PJI). Two-stage revision arthroplasty is the gold standard in the treatment of deep periprosthetic infection of large joints, providing high probability of infection process resolution as well as functional recovery of the limb and elimination of pain syndrome.Aim: to improve the treatment results of patients with periprosthetic infection after primary hip arthroplasty.Materials and Methods. 121 patients (62 patients in the main group and 59 in the control group) after primary hip arthroplasty were included in the study. In the main group, treatment was performed using a two-stage technique with implantation of a preformed spacer and our proposed algorithm. In the control group, treatment was performed using a homemade spacer and without using the developed algorithm.Results. When using our developed treatment algorithm, a good result in the treatment of UTI was achieved. The infectious process was controlled in 80.6 % of cases, as compared with 64.4 % in the control group, which is comparable with the data of domestic and foreign literature.Conclusion. Treatment of patients with periprosthetic infection should be performed only in specialized centers that perform all stages of treatment, have all necessary instruments, an equipped operating room, necessary drugs in the hospital pharmacy, experienced staff and equipped bacteriological laboratory, as well as many years of experience of surgeons with these patients.

Diagnosis of Deep Periprosthetic Infection of the Hip

Periprosthetic infection (PJI) is one of the most frequent and devastating complications of total hip arthroplasty (THA). Early and accurate diagnosis of PJI allows timely initiation of treatment. Various diagnostic tools and algorithms for hip PJI diagnosis are described. The available serum (ESR, CRP, D-dimer, etc.) and synovial (alpha-defensin, leukocyte esterase, D-lactate) biomarkers are listed, as well as their combinations for the purpose of PJI verification. Combined serum and synovial tests can significantly improve the efficiency of PJI hip diagnosis.

Previous corrective osteotomies of femur and pelvis are a risk factor for complications following total hip arthroplasty in hip dysplasia

BackgroundModified anatomy of dysplastic hips, bone defects and previous operations make THA (total hip arthroplasty) in patients with hip dysplasia a technically challenging procedure. MethodsOne hundred and ten patients (mean 49.2 years of age, range 19–76, female:103, male:7) underwent 122 subsequent hip arthroplasties from 2012 to 2019. These patients were reviewed at least two years after THA. Plain radiography was used to determine Crowe classification of the affected hips. Fifty-three patients had an operation in childhood before THA was done (mean 47.0 years of age, standard deviation 8.3, range 19–62) and formed the “operated group”. Among these patients, there were Chiari pelvic osteotomies, periacetabular osteotomies, femoral osteotomies, greater trochanter distalizations and soft tissue operations. Fifty-seven were not operated in childhood (mean 52.3 years of age, standard deviation 10.9, range 19–76) and formed the “non operated group”. The functional status of the patients was assessed with the Oxford Hip Score (OHS). Results122 total hip arthroplasties were performed using uncemented femoral and acetabular components. There were 13 major complications identified. Ten were in the “operated group”, of which 5 needed revision surgery. Only 3 were in the “non operated group”, with no need for revision. Aseptic loosenings of the femoral component were seen in the patients that had femoral osteotomy done in childhood. Acetabular component migration and intrapelvic migration occurred due to the initial malposition and lack of osteointegration, thus requiring early revision after just 6 months. Other major complications were peroneal palsy, deep periprosthetic infection, severe trochanteritis and intraoperative femoral fracture. OHS was significantly higher in the “non operated group” 42.3 (10–48), opposed to 39.1 (10–48) in the “operated group” (p 0.017). ConclusionCorrective osteotomies in childhood are a risk factor for complications and lower medium-term survivorship of the THA in hip dysplasia patients.

Modern Technologies in the First Stage Treatment of Deep Periprosthetic Hip Joint Infection

Modern Technologies in the First Stage Treatment of Deep Periprosthetic Hip Joint Infection

How Should Antibiotics Be Used in Primary and Revision Hip and Knee Arthroplasty? An Introduction

Joint arthroplasty is a highly successful surgical treatment for symptomatic arthritis of the hip and knee. Despite excellent pain relief and prosthesis survival of approximately 90% at 20 years, complications occur [[1]Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR)Hip, Knee & Shoulder Arthroplasty: 2021 Annual Report. AOA, Adelaide2021: 1-432https://aoanjrr.sahmri.com/annual-reports-2021Google Scholar]. Deep periprosthetic joint infection (PJI) is among the top 2 causes of failure around the world after primary and revision, hip and knee replacement at both short-term and long-term follow-up [1Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR)Hip, Knee & Shoulder Arthroplasty: 2021 Annual Report. AOA, Adelaide2021: 1-432https://aoanjrr.sahmri.com/annual-reports-2021Google Scholar, 2Meyer J.A. Zhu M. Cavadino A. Coleman B. Munro J.T. Young S.W. Infection and periprosthetic fracture are the leading causes of failure after aseptic revision total knee arthroplasty.Arch Orthop Trauma Surg. 2021; 141: 1373-1383Crossref PubMed Scopus (9) Google Scholar, 3Le D.H. Goodman S.B. Maloney W.J. Huddleston J.I. Current modes of failure in TKA: infection, instability, and stiffness predominate.Clin Orthop Relat Res. 2014; 472: 2197-2200Crossref PubMed Scopus (183) Google Scholar]. In distinction to many other problems, such as dislocation and polyethylene wear that can be directly influenced by improvements in surgical technique and prosthesis design, surgeons may find it more frustrating to reduce surgical site infections. It is important to remember that appropriate use of prophylactic antibiotics, introduced over 50 years ago, remains the single most effective intervention available [[4]Burke J.F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions.Surgery. 1961; 50: 161-168PubMed Google Scholar]. In our well-intentioned pursuit of completely eliminating PJI we can sometimes fall victim to the more is better philosophy. Indeed, over the past few years we have seen the introduction of new delivery methods, dosing schedules, and adjunctive products that encourage us to expand our use of prophylactic antibiotics without conclusive evidence. Additionally, our own success has led us to implement change before results from level 1A studies are available. Although PJI remains a persistent concern, the absolute rate of PJI after hip and knee arthroplasty remains low. Consequently, proving the value of new interventions remains problematic due to the large number of patients and extended follow-up duration required for definitive studies [[5]Thompson K.M. Oldenburg W.A. Deschamps C. Rupp W.C. MD Smith C.D. Chasing zero: the drive to eliminate surgical site infections.Ann Surg. 2011; 254: 430-436Crossref PubMed Scopus (65) Google Scholar]. Furthermore, the distinctions among prophylactic, treatment, and suppressive use of antibiotics have become blurred at times. It is important to remember that overuse of antibiotics has potentially significant consequences including the emergence of antibiotic resistance at the individual and societal levels, and individual patient side effects that can have serious consequences, such as acute kidney injury and allergic reaction [[6]Kheir M.M. Dilley J.E. Ziemba-Davis M. Meneghini R.M. The AAHKS clinical research award: extended oral antibiotics prevent periprosthetic joint infection in high-risk cases: 3855 patients with 1-Year follow-up.J Arthroplasty. 2021; 36: S18-S25Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar]. In this series of papers, drawn from presentations from the AAHKS Annual Meeting Symposium: Antibiotic Use in Primary and Revision Total Hip and Knee Arthroplasty, we will discuss the most effective uses of antibiotics before, during, and after surgery in order to reduce deep PJI. Each paper, authored by an expert in the field, will summarize the published data and clinical guidelines pertinent to the topic and distill the information to pragmatic advice that is ready for use in your practice. Download .docx (.02 MB) Help with docx files Conflict of Interest Statement for Clarke

Frailty Transitions One Year After Total Joint Arthroplasty: A Cohort Study.

Total joint arthroplasty (TJA) is prevalent and offered to patients regardless of frailty status experiencing pain, disability, and functional decline. This study aims to describe changes in levels of frailty 1 year after TJA. We identified a retrospective cohort of adult patients undergoing primary TJA between 2005 and 2016 using an institutional total joint registry. Associations between categorized frailty deficit index (FI) and change in FI were analyzed using linear regression models. Mortality, deep periprosthetic joint infection, and reoperation were analyzed using time to event methods. In total, 5341 patients (37.6% non-frail, 39.4% vulnerable, and 23.0% frail) with items necessary to determine FI at 1 year after TJA were included. Preoperatively, 29% of vulnerable patients improved to non-frail 1 year later, compared to only 11% regressing to frail. Four in 10 frail patients improved to vulnerable/non-frail. Improvements in activities of daily living (ADL) were more evident in frail and vulnerable patients, with >30% reduction in the percentage of patients expressing difficulties with walking, climbing stairs, and requiring ADL assistance 1 year after TJA. Increases in frailty 1 year after TJA were associated with significantly increased rates of mortality (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.24-1.82, P < .001), deep periprosthetic joint infection (HR 3.98, 95% CI 1.85-8.58, P < .001), and reoperation (HR 1.80, 95% CI 1.19-2.72, P= .005). Frailty states are dynamic with patient frailty shown to be modifiable 1 year after TJA. Preoperative frailty measurement is an important step toward identifying those that may benefit most from TJA and for postoperative frailty surveillance.

Assessing risks of developing and persistence of infectious process in knee joint replacement

Despite of intensive work on improving endoprosthetic replacement constructions, using minimally invasive techniques, developing methods of prevention for and treatment of periprosthetic joint infection, relapse of infection process can reach up to 52 % after treatment.The aim of the study: to show the importance of identifying the risks of development and recurrence of periprosthetic infection after implantation of a knee joint endoprosthesis. A clinical case of the development of a deep periprosthetic infection in a patient after primary knee replacement and successful treatment of the resulting complication was demonstrated. The analysis of this case of an infectious complication using the proposed prognosis for the development of periprosthetic infection showed that before surgical treatment of the patient, the risk of an infectious process was not assessed, and appropriate preventive and therapeutic measures were not carried out.Materials and methods. In the treatment of developed periprosthetic infection of the knee joint, the author’s algorithm for choosing surgical tactics was used, which allowed to determine the high risk of recurrence of periprosthetic infection, evaluate additional criteria and choose the optimal type of surgical intervention – two-stage revision endoprosthetic, which allowed to stop the infectious process.New was the use of the proposed prognosis for the development of periprosthetic infection and the algorithm for choosing surgical tactics for periprosthetic infection, which make it possible to determine the necessary preventive measures to reduce the risk of an infectious complication and to apply the optimal type of surgical intervention to relieve periprosthetic knee infection.

A Simple Algorithmic Approach Allows the Safe Use of Cephalosporin in "Penicillin-Allergic" Patients without the Need for Allergy Testing.

Patients who report a penicillin allergy are often given second-line antibiotic prophylaxis during total joint arthroplasty (TJA), with only a minority of patients undergoing additional consultations and allergy testing. In an effort to increase the use of cephalosporin prophylaxis in TJA, the present study aimed to assess the effectiveness of a simple, protocol-driven penicillin allergy screening program without the need for additional work-up. Following implementation of a questionnaire-based screening protocol in May 2019, all patients scheduled for primary TJA were risk-stratified into low or high-risk categories. The low-risk cohort received cefazolin, and the high-risk cohort received non-cefazolin antibiotics. Patients were monitored prospectively, and data on antibiotic usage and adverse outcomes were documented. The protocol group (n = 2,078) was propensity score matched 1:1 with a control group that included patients who underwent TJA in the same institution prior to implementation of the protocol. The primary end point was the efficacy of the protocol in reducing unnecessary use of non-cephalosporin antibiotics for prophylaxis. Secondary outcomes included the rate of surgical site infections and allergic reactions to the administered antibiotic. A total of 357 patients (17.2%) reported a penicillin allergy in the protocol group compared with 310 patients (14.9%) with a recorded allergy in the control group (p = 0.052). The number of patients who received non-cephalosporin antibiotics was significantly lower in the protocol group (5.7% compared with 15.2% in the control group; p < 0.001), whereas there was no difference in the rate of total allergic reactions (0.8% compared with 0.7%, respectively; p = 0.857). Of the 239 low-risk patients (66.9%) in the protocol group, only 3 (1.3%) experienced a mild cutaneous reaction following cefazolin administration. There were no differences in the rates of superficial wound, deep periprosthetic, or Clostridioides difficile infections between the protocol and control groups. A simple screening protocol allowed two-thirds of patients with a self-reported allergy to receive cefazolin without the need for additional consultations or testing. We believe this protocol can be safely implemented to increase the rate of cefazolin usage without a corresponding increase in the number of allergic reactions. Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

Two-stage reimplantation for deep infection after total elbow arthroplasty.

Persistent infection rate after 2-stage reimplantation complicating elbow arthroplasty has been reported to be as high as 25%. The purposes of this retrospective study were to determine the infection eradication rates, complications and outcomes in a cohort of patients treated with two-stage reimplantation for deep periprosthetic joint infection (PJI) following total elbow arthroplasty (TEA) and to determine possible associated risk factors for treatment failure. Between 2000 and 2017, 52 elbows underwent a two-stage reimplantation for PJI after TEA. There were 22 males and 30 females with a mean age of 61 (range, 25-82) years. The most common bacterium was Staphylococcus epidermidis (28 elbows). Mayo Elbow Performance Scores were calculated at the latest follow-up. Mean follow-up time was 6 years (range, 2-14 years). PJI was eradicated in 36 elbows (69%). The remaining 16 elbows were considered treatment failures secondary to recurrent infection. The risk of persistent infection was 3.3 times higher in elbows with retained cement (p 0.04), and 3.5 times higher when the infecting organism was Staphylococcus epidermidis (p 0.06). Two-stage reimplantation for PJI after TEA was successful in eradicating deep infection in 69% of cases. The eradication of PJI after TEA still needs to be improved substantially.

Выбор спейсера на первом этапе лечения поздней глубокой перипротезной инфекции тазобедренного сустава

Abstract. Introduction Periprosthetic infection in hip arthroplasty is a social and economic problem. Its main reason is multidrug resistance of microorganisms. Purpose To evaluate the effectiveness of the first stage in two-stage revision arthroplasty for the treatment of deep periprosthetic infection of the hip joint by improving the constructive and antibacterial features of spacers. Materials and methods The treatment results of 127 patients with late deep periprosthetic hip joint infection who underwent two-stage revision arthroplasty in the period from 2015 to 2019 were analyzed. In the first group, 42 patients were fitted with a two-component (total) spacer based on the developed antimicrobial composition of bone cement with gentamicin, antiseptics and polymer (patent RU 191236). In the second group, a two-component spacer (patent RU 174697) based on conventional bone cement with gentamicin was implanted in 43 patients; the third group of 42 patients had a preformed spacer. Results A bactericidal and antiadhesive, nontoxic composition based on bone cement with gentamicin with antiseptics poviargol, dioxidine and high molecular weight polyvinylpyrrolidone with a prolonged action for 348 days against gentamicin-resistant staphylococci has been developed. All patients underwent the first stage of hip arthroplasty with removal of the implant and installation of a spacer. Recurrence of periprosthetic infection was observed in 1 (2.3 %) patient of the first group, in 5 (11.6 %) in the second and in 6 (14.2 %) patients of the third group. Non-infectious complications such as spacer dislocation and instability were observed in 12 cases, one case (2.3 %) in the first, 2 (4.6 %) in the second and 9 (21.4 %) in the third group. The average time from the first stage of treatment to the second stage of re-implantation was 7.5 months (range, 4–13 months). Discussion According to the literature, the introduction of new antibiotics into the bone cement with gentamicin does not increase the antimicrobial action of the spacer, especially against antibiotic-resistant isolates, and the use of a preformed spacer contributes to an increase in the number of non-infectious complications. Antiseptics with different mechanisms of action are able to act on antibiotic-resistant bacteria, and the polymer can prolong this effect. Conclusions Creation of two-component spacers based on bone cement with gentamicin using antiseptics with different mechanisms of action and polymer promotes long-term bactericidal action of the spacer, which leads to effective sanation of the joint area, reducing non-infectious complications.

Treatment of deep periprosthetic hip infection with articulating cement-antibiotic spacers with silver plates and antibiotics

The aim of this work is to improve the results of treatment of patients with a deep periprosthetic hip joint infection by using an articulating cement-antibiotic spacer in combination with silver plates and antibiotics.Material and methods. The treatment outcomes of 52 patients operated at the Swedish-Ukrainian Angelholm Medical Center for the period from 2017 to 2020, who underwent two-stage revision arthroplasty for the deep periprosthetic infectious-inflammatory process of the hip joint, were studied. In addition, 9 patients were examined in whom, during the first stage of a two-stage treatment of an artificial hip joint infection, an articulating cement-antibiotic spacer made of bone cement with a silver content was developed.Research results. Long-term results of two-stage revision arthroplasty with the introduction of our proposed cement-antibiotic spacers were studied in 49 (94.2%) patients. Among them, 9 patients used silver plates, which showed good patient tolerance and in all cases the infection was overcome. In 49 patients in whom the long-term results of two-stage revision hip arthroplasty were studied, 44 (89.8%) achieved eradication of the infection with restoration of the function of the operated limb. We rated such results as good. The average HHS score in this group was 87.18 ± 6.44 points.Conclusions. An innovative method of treatment of deep periprosthetic infection of the hip joint has been introduced into clinical practice, which consists in increasing the effectiveness of using an articulating cement antibiotic spacer by adding silver plates to it and, in addition, an antibiotic.

Photodynamic therapy for periprosthetic joint infection

Introduction. The increase in the number of patients with joint and hip diseases is an actual problem in the clinical medicine. Objective: to improve outcomes of the combined surgical treatment of patients with deep periprosthetic infection (PPI) by developing and improving surgical techniques using spacers and laser technologies.Material and methods. Thirty-five patients with suppurated large joints as a complication after their replacement were examined and treated. In 9 (25.7 %) patients, PPI developed within 3–12 months after the primary arthroplasty. Twenty (57.1 %) patients developed PPI within 1–2 years after the surgery. In 4 (11.4 %) cases, suppuration in the endoprosthetic area developed in 2–3 years, and in 2 (5.7 %) patients – in 3–3.5 years. The age of the patients was 47–70 years. The main group consisted of 20 patients, the control group – of 15 patients. Patients from the main group had laser photodynamic therapy (PDT) session after the removal of endoprosthetic elements and devitalized tissues.Results. Patients from the main group had uneventful postoperative course – less pain syndrome, rapid resolution of the infl ammatory process, wound healing by the primary tension.Conclusion. Application of a new intraoperative PDT technique, developed by the authors, promotes rapid resolution of purulent-infl ammatory process and better healing of postoperative wounds by primary tension.

Review of complications, functional outcome, and long-term survival following conversion of hip fusion to total hip arthroplasty.

Improvements in functional results and long-term survival are variable following conversion of hip fusion to total hip arthroplasty (THA) and complications are high. The aim of the study was to analyze the clinical and functional results in patients who underwent conversion of hip fusion to THA using a consistent technique and uncemented implants. A total of 39 hip fusion conversions to THA were undertaken in 38 patients by a single surgeon employing a consistent surgical technique and uncemented implants. Parameters assessed included Harris Hip Score (HHS) for function, range of motion (ROM), leg length discrepancy (LLD), satisfaction, and use of walking aid. Radiographs were reviewed for loosening, subsidence, and heterotopic ossification (HO). Postoperative complications and implant survival were assessed. At mean 12.2 years (2 to 24) follow-up, HHS improved from mean 34.2 (20.8 to 60.5) to 75 (53.6 to 94.0; p < 0.001). Mean postoperative ROM was flexion 77° (50° to 95°), abduction 30° (10° to 40°), adduction 20° (5° to 25°), internal rotation 18° (2° to 30°), and external rotation 17° (5° to 30°). LLD improved from mean -3.36 cm (0 to 8) to postoperative mean -1.14 cm (0 to 4; p < 0.001). Postoperatively, 26 patients (68.4%) required the use of a walking aid. Complications included one (2.5%) dislocation, two (5.1%) partial sciatic nerve injuries, one (2.5%) deep periprosthetic joint infection, two instances of (5.1%) acetabular component aseptic loosening, two (5.1%) periprosthetic fractures, and ten instances of HO (40%), of which three (7.7%) were functionally limiting and required excision. Kaplan-Meier Survival was 97.1% (95% confidence interval (CI) 91.4% to 100%) at ten years and 88.2% (95% CI 70.96 to 100) at 15 years with implant revision for aseptic loosening as endpoint and 81.7% (95% CI 70.9% to 98.0%) at ten years and 74.2% (95% CI 55.6 to 92.8) at 15 years follow-up with implant revision for all cause failure as endpoint. The use of an optimal and consistent surgical technique and cementless implants can result in significant functional improvement, low complication rates, long-term implant survival, and high patient satisfaction following conversion of hip fusion to THA. The possibility of requiring a walking aid should be discussed with the patient before surgery. Cite this article: Bone Joint J2021;103-B(7 Supple B):129-134.

Histological evaluation of periprosthetic infection using HOES scale and CD15 expression analysis at the stage of the hip revision arthroplasty

Background.The effectiveness improvement and standardization of the methods of histological diagnosing periprosthetic infection (PPI) is an urgent task in the treatment of complications after large joint arthroplasty. Purpose of the study— Histopathological evaluation of the infection involvement of periprosthetic tissues at the stage of revision arthroplasty for deep infection of the hip using HOES scale and immunohistochemical analysis of CD15 expression.Materials and Methods.A single-center prospective study was performed on the clinical intraoperative material obtained at the stage of revision arthroplasty of the hip in 27 patients at the age of 65 (55÷69) years. The group of examination included patients with acute and chronic forms of deep periprosthetic infection. Light-optical microscopic investigation of the samples of periprosthetic connective-tissue membrane and bone tissue from the foci of infectious involvement was made on paraffin sections stained with hematoxylin and eosin; with the immunohistochemical reaction to determine the expression of CD15 neutrophil granulocyte markers. HOES Scale for pathohistological assessment was used in order to objectify osteomyelitis signs in periprosthetic bone tissue.Results. The signs of acute and chronic stages of periprosthetic osteomyelitis were observed in 9/16 patients with PPI chronic course within 1–30 months of postoperative period, from one to 18 months after manifestation of the symptoms. The signs of subsided osteomyelitis were determined in 12/27 patients with PPI of acute and chronic forms. Infected periprosthetic membranes were found in 19/27 clinical cases in the early and longterm time periods after arthroplasty surgery. A direct significant correlation was revealed between histopathological signs of infecting the periprosthetic bone and the connective-tissue periprosthetic membrane, especially strong one in patients with acute and chronic PPI osteomyelitis.Conclusion. The use of HOES Scale and the analysis of CD15 expression ensure the objectivity of PPI histological diagnosing. The results obtained indicate an increased risk of osteomyelitis development in patients with chronic periprosthetic infection after the hip arthroplasty.

Complications of primary total hip arthroplasty in human immunodeficiency virus-positive patients with femoral head osteonecrosis.

Femoral head osteonecrosis (FHON) is a well-recognised complication in patients with human immunodeficiency virus (HIV) infection. Total hip arthroplasty (THA) is a reliable solution to FHON and has provided functional improvement and pain relief in these patients. Higher complication rates, in particular infections, have been reported in the series of THAs done in the HIV-positive patients. The purpose of this study was to evaluate the complication rate of THA for FHON in HIV-positive patients managed with the highly active antiretroviral therapy (HAART) protocols. A retrospective review was performed of HIV-positive patients with FHON who underwent THAs over a 10-year period at a single institution. A total of 56 THAs (44 patients) met the inclusion criteria. The mean age at the time of THAs was 47 (range 34-60) years. Of the 44 patients, 39 (88.6%) were males. The mean follow-up was 6.6 (range 2.0-11.3) years. The overall complication rate was 12.5%, with 2 (3.6%) cases of deep periprosthetic infections. HIV-positive patients with FHON undergoing THAs do have a considerable complication rate (12.5%). The deep periprosthetic infection rate (3.6%) in these patients, however, has decreased with contemporary disease modification protocols.