Mapping urbanization and built-up areas from remotely sensed data poses a formidable challenge, particularly when the spectral reflectance of built-up regions intersects with other land types. To address this, numerous spectral indices have been developed. This paper utilizes multiple indices: Normalized Difference Built-up Index (NDBI), Built-up Area Extraction Index (BAEI), Normalized Built-up Area Index (NBAI), New Built-up Index (NBI), Modified Built-up Index (MBI), Band Ratio for Built-up Area (BRBA), and Normalized Difference Vegetation Index (NDVI) to delineate built-up regions. An intersection approach between BAEI, NBAI, and NDVI refines the methodology, resulting in a final built-up map with 92.5 % accuracy and a 0.848 Kappa coefficient. Subsequently, a Deep Neural Network (DNN) model trained on this map achieves over 95 % accuracy in predicting built-up areas from Landsat 5 imagery, and the resultant built-up map achieved an overall accuracy of 92 % and a Kappa coefficient of 0.85. The proposed methodology demonstrates efficiency for time-series analysis and addresses misclassification in built-up areas. Moreover, the optimization of the DNN model proves effective when meticulous training and validation processes incorporate more precise sample datasets.