Deep Learning-based Computer-aided Diagnosis Research Articles

Deep Learning-Based Computer-Aided Diagnosis of Osteochondritis Dissecans of the Humeral Capitellum Using Ultrasound Images.

Ultrasonography is used to diagnose osteochondritis dissecans (OCD) of the humerus; however, its reliability depends on the technical proficiency of the examiner. Recently, computer-aided diagnosis (CAD) using deep learning has been applied in the field of medical science, and high diagnostic accuracy has been reported. We aimed to develop a deep learning-based CAD system for OCD detection on ultrasound images and to evaluate the accuracy of OCD detection using the CAD system. The CAD process comprises 2 steps: humeral capitellum detection using an object-detection algorithm and OCD classification using an image classification network. Four-directional ultrasound images of the elbow of the throwing arm of 196 baseball players (mean age, 11.2 years), including 104 players with normal findings and 92 with OCD, were used for training and validation. An external dataset of 20 baseball players (10 with normal findings and 10 with OCD) was used to evaluate the accuracy of the CAD system. A confusion matrix and the area under the receiver operating characteristic curve (AUC) were used to evaluate the system. Clinical evaluation using the external dataset resulted in high AUCs in all 4 directions: 0.969 for the anterior long axis, 0.966 for the anterior short axis, 0.996 for the posterior long axis, and 0.993 for the posterior short axis. The accuracy of OCD detection thus exceeded 0.9 in all 4 directions. We propose a deep learning-based CAD system to detect OCD lesions on ultrasound images. The CAD system achieved high accuracy in all 4 directions of the elbow. This CAD system with a deep learning model may be useful for OCD screening during medical checkups to reduce the probability of missing an OCD lesion. Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Enhancing cancer prediction in challenging screen-detected incident lung nodules using time-series deep learning

Lung cancer screening (LCS) using annual computed tomography (CT) scanning significantly reduces mortality by detecting cancerous lung nodules at an earlier stage.Deep learning algorithms can improve nodule malignancy risk stratification. However, they have typically been used to analyse single time point CT data when detecting malignant nodules on either baseline or incident CT LCS rounds. Deep learning algorithms have the greatest value in two aspects. These approaches have great potential in assessing nodule change across time-series CT scans where subtle changes may be challenging to identify using the human eye alone. Moreover, they could be targeted to detect nodules developing on incident screening rounds, where cancers are generally smaller and more challenging to detect confidently.Here, we show the performance of our Deep learning-based Computer-Aided Diagnosis model integrating Nodule and Lung imaging data with clinical Metadata Longitudinally (DeepCAD-NLM-L) for malignancy prediction. DeepCAD-NLM-L showed improved performance (AUC = 88%) against models utilising single time-point data alone. DeepCAD-NLM-L also demonstrated comparable and complementary performance to radiologists when interpreting the most challenging nodules typically found in LCS programs. It also demonstrated similar performance to radiologists when assessed on out-of-distribution imaging dataset. The results emphasise the advantages of using time-series and multimodal analyses when interpreting malignancy risk in LCS.

Deep learning-based computer-aided diagnosis system for the automatic detection and classification of lateral cervical lymph nodes on original ultrasound images of papillary thyroid carcinoma: a prospective diagnostic study.

This study aims to develop a deep learning-based computer-aided diagnosis (CAD) system for the automatic detection and classification of lateral cervical lymph nodes (LNs) on original ultrasound images of papillary thyroid carcinoma (PTC) patients. A retrospective data set of 1801 cervical LN ultrasound images from 1675 patients with PTC and a prospective test set including 185 images from 160 patients were collected. Four different deep leaning models were trained and validated in the retrospective data set. The best model was selected for CAD system development and compared with three sonographers in the retrospective and prospective test sets. The Deformable Detection Transformer (DETR) model showed the highest diagnostic efficacy, with a mean average precision score of 86.3% in the retrospective test set, and was therefore used in constructing the CAD system. The detection performance of the CAD system was superior to the junior sonographer and intermediate sonographer with accuracies of 86.3% and 92.4% in the retrospective and prospective test sets, respectively. The classification performance of the CAD system was better than all sonographers with the areas under the curve (AUCs) of 94.4% and 95.2% in the retrospective and prospective test sets, respectively. This study developed a Deformable DETR model-based CAD system for automatically detecting and classifying lateral cervical LNs on original ultrasound images, which showed excellent diagnostic efficacy and clinical utility. It can be an important tool for assisting sonographers in the diagnosis process.

Optimised deep k-nearest neighbour's based diabetic retinopathy diagnosis(ODeep-NN) using retinal images.

Diabetes mellitus has been regarded as one of the prime health issues in present days, which can often lead to diabetic retinopathy, a complication of the disease that affects the eyes, causing loss of vision. For precisely detecting the condition's existence, clinicians are required to recognise the presence of lesions in colour fundus images, making it an arduous and time-consuming task. To deal with this problem, a lot of work has been undertaken to develop deep learning-based computer-aided diagnosis systems that assist clinicians in making accurate diagnoses of the diseases in medical images. Contrariwise, the basic operations involved in deep learning models lead to the extraction of a bulky set of features, further taking a long period of training to predict the existence of the disease. For effective execution of these models, feature selection becomes an important task that aids in selecting the most appropriate features, with an aim to increase the classification accuracy. This research presents an optimised deep k-nearest neighbours'-based pipeline model in a bid to amalgamate the feature extraction capability of deep learning models with nature-inspired metaheuristic algorithms, further using k-nearest neighbour algorithm for classification. The proposed model attains an accuracy of 97.67 and 98.05% on two different datasets considered, outperforming Resnet50 and AlexNet deep learning models. Additionally, the experimental results also portray an analysis of five different nature-inspired metaheuristic algorithms, considered for feature selection on the basis of various evaluation parameters.

Consecutive knowledge meta-adaptation learning for unsupervised medical diagnosis

Deep learning-based computer-aided diagnosis has garnered significant attention in both academic research and clinical applications. Due to the challenges in collecting well-labeled clinical data, unsupervised domain adaptation methods have become widely used in medical image analysis. However, existing unsupervised domain adaptation methods in the clinic field fail to adapt to scenarios where new, unlabeled target data continually arrive in an online manner. To tackle this real-world clinical challenge, a meta-adaptation framework is innovatively developed, termed consecutive lesion knowledge meta-adaptation, primarily comprising semantic adaptation and representation adaptation phases. Specifically, the semantic knowledge learned from the source lesion domain will be transferred to the consecutive target lesion in the semantic adaptation phase. To further align the transferable representation knowledge across the source and multiple target lesion domains, the feature-extractor is optimized in the representation adaptation phase. Furthermore, to mitigate catastrophic forgetting during continuous unsupervised domain adaptation, a domain-quantizer is designed to preserve utility knowledge from previously learned target lesion domains. Moreover, as semantic knowledge is continuously evolving and artificially designed kernels struggle to model such complex distributions, a self-adaptive kernel is designed to flexibly measure the shift between the source and consecutive target lesion domains during the semantic adaptation phase. Experimental results on medical image classification tasks demonstrate the effectiveness of the proposed method.

A Trustworthy and Explainable Framework for Benchmarking Hybrid Deep Learning Models Based on Chest X-Ray Analysis in CAD Systems

Evaluating the trustworthiness of deep learning-based computer-aided diagnosis (CAD) systems is challenging. There is a need to optimize trust and performance in model selection. A wide range of models based on evaluation metrics can make it challenging to choose the best one, especially for complex multi-criteria decision-making problems. In the case of COVID-19 diagnosis, using both physicians’ evaluation and AI techniques to establish trust is essential. In this study, 1551 chest X-rays were analyzed using deep transfer learning (DTL) with six models and four SVM kernels. This resulted in 24 hybrid DTL–SVM models. Seven metrics were evaluated using fuzzy multiple-criteria decision-making (MCDM), which uses a dynamic decision matrix to select the best model. This matrix incorporates fuzzy-weighted zero-inconsistency (FWZIC) for weight coefficients and Kriterijumska Optimizacija I Kompromisno Resenje (VIKOR) for benchmarking. The Grad-CAM technique compared the best model with 16 images, ensuring explainability. Top-performing models were identified, including SqueezeNet-SVM linear, VGG19-SVM linear, and VGG19-SVM. Sensitivity analysis was used to quantify the impact of changing weighted criteria values. A physician expert validated fuzzy MCDM through Grad-CAM analysis, a new aspect of this study. The framework presented in this study was benchmarked against seven other studies and achieved a perfect score in four crucial areas. Trustworthiness is essential for CAD systems, and this study effectively addresses trust and performance challenges in AI model-based CAD systems. The study systematically evaluated the requirements for trustworthiness, including accountability, fairness, robustness, accuracy, and reproducibility, and the results supported this.

YOLO-based CAD framework with ViT transformer for breast mass detection and classification in CESM and FFDM images

Breast cancer detection is considered a challenging task for the average experienced radiologist due to the variation of the lesions’ size and shape, especially with the existence of high fibro-glandular tissues. The revolution of deep learning and computer vision contributes recently in introducing systems that can provide an automated diagnosis for breast cancer that can act as a second opinion for doctors/radiologists. The most of previously proposed deep learning-based Computer-Aided Diagnosis (CAD) systems mainly utilized Convolutional Neural Networks (CNN) that focuses on local features. Recently, vision transformers (ViT) have shown great potential in image classification tasks due to its ability in learning the local and global spatial features. This paper proposes a fully automated CAD framework based on YOLOv4 network and ViT transformers for mass detection and classification of Contrast Enhanced Spectral Mammography (CESM) images. CESM is an evolution type of Full Field Digital Mammography (FFDM) images that provides enhanced visualization for breast tissues. Different experiments were conducted to evaluate the proposed framework on two different datasets that are INbreast and CDD-CESM that provides both FFDM and CESM images. The model achieved at mass detection a mean Average Precision (mAP) score of 98.69%, 81.52%, and 71.65% and mass classification accuracy of 95.65%, 97.61%, and 80% for INbreast, CE-CESM, and DM-CESM, respectively. The proposed framework showed competitive results regarding the state-of-the-art models in INbreast. It outperformed the previous work in the literature in terms of the F1-score by almost 5% for mass detection in CESM. Moreover, the experiments showed that the CESM could provide more morphological features that can be more informative, especially with the highly dense breast tissues.

Uncertainty-aware deep learning-based CAD system for breast cancer classification using ultrasound and mammography images

ABSTRACT Breast cancer is one of the most common types of cancer in women. Early and accurate diagnosis of breast cancer can increase the treatment chances and decrease the mortality rate. Thus, the development of accurate and reliable Computer-Aided Diagnosis (CAD) systems using breast cancer images is an immediate priority for early diagnosis. Deep learning methods have had a widespread role in CAD systems. In spite of the advantages, most deep learning-based CADs cannot quantify the uncertainty of their predictions. Uncertainty in the predicted results from a CAD system might endanger people’s life in these crucial steps for breast cancer classification. Therefore, in this study, the Monte Carlo Dropout method is utilised as an uncertainty quantification method. Furthermore, differently from most existing studies, we present an uncertainty-aware deep learning model which can classify accurately from different types of images, namely, mammograms and ultrasound. The results show the proposed model achieved the accuracy of 99.95% in mammogram dataset, namely, DDSM and 98.40% and 91.34% in ultrasound datasets, namely, BUSM and BUSI, respectively. Finally, since we found the proposed model shows high uncertainty in misclassifications, we suggested to use the uncertainty values to find appropriate subsets for further inspection to increase the performance.

CAM-QUS guided self-tuning modular CNNs with multi-loss functions for fully automated breast lesion classification in ultrasound images

Objective. Breast cancer is the major cause of cancer death among women worldwide. Deep learning-based computer-aided diagnosis (CAD) systems for classifying lesions in breast ultrasound images can help materialise the early detection of breast cancer and enhance survival chances. Approach. This paper presents a completely automated BUS diagnosis system with modular convolutional neural networks tuned with novel loss functions. The proposed network comprises a dynamic channel input enhancement network, an attention-guided InceptionV3-based feature extraction network, a classification network, and a parallel feature transformation network to map deep features into quantitative ultrasound (QUS) feature space. These networks function together to improve classification accuracy by increasing the separation of benign and malignant class-specific features and enriching them simultaneously. Unlike the categorical crossentropy (CCE) loss-based traditional approaches, our method uses two additional novel losses: class activation mapping (CAM)-based and QUS feature-based losses, to capacitate the overall network learn the extraction of clinically valued lesion shape and texture-related properties focusing primarily the lesion area for explainable AI (XAI). Main results. Experiments on four public, one private, and a combined breast ultrasound dataset are used to validate our strategy. The suggested technique obtains an accuracy of 97.28%, sensitivity of 93.87%, F1-score of 95.42% on dataset 1 (BUSI), and an accuracy of 91.50%, sensitivity of 89.38%, and F1-score of 89.31% on the combined dataset, consisting of 1494 images collected from hospitals in five demographic locations using four ultrasound systems of different manufacturers. These results outperform techniques reported in the literature by a considerable margin. Significance. The proposed CAD system provides diagnosis from the auto-focused lesion area of B-mode BUS images, avoiding the explicit requirement of any segmentation or region of interest extraction, and thus can be a handy tool for making accurate and reliable diagnoses even in unspecialized healthcare centers.

Investigating Effective Data Augmentation Techniques for Accurate Gastric Classification in the Development of a Deep Learning-Based Computer-Aided Diagnosis System

Gastric cancer is a significant health concern, particularly in Korea, and its accurate detection is crucial for effective treatment. However, a gastroscopic biopsy can be time-consuming and may, thus, delay diagnosis and treatment. Thus, this study proposed a gastric cancer diagnostic method, CADx, to facilitate a more efficient image analysis. Owing to the challenges in collecting medical image data, small datasets are often used in this field. To overcome this limitation, we used AutoAugment’s ImageNet policy and applied cut-and-paste techniques using a sliding window algorithm to further increase the size of the dataset. The results showed an accuracy of 0.8317 for T-stage 1 and T-stage 4 image classification and an accuracy of 0.8417 for early gastric cancer and normal image classification, indicating improvements of 7 and 9%, respectively. Furthermore, through the application of test-time augmentation to the early gastric cancer and normal image datasets, the image classification accuracy was improved by 5.8% to 0.9000. Overall, the results of this study demonstrate the effectiveness of the proposed augmentation methods for enhancing gastric cancer classification performance.

Automated diagnosis of anterior cruciate ligament via a weighted multi-view network.

Objective: To build a three-dimensional (3D) deep learning-based computer-aided diagnosis (CAD) system and investigate its applicability for automatic detection of anterior cruciate ligament (ACL) of the knee joint in magnetic resonance imaging (MRI). Methods: In this study, we develop a 3D weighted multi-view convolutional neural network by fusing different views of MRI to detect ACL. The network is evaluated on two MRI datasets, the in-house MRI-ACL dataset and the publicly available MRNet-v1.0 dataset. In the MRI-ACL dataset, the retrospective study collects 100 cases, and four views per patient are included. There are 50 ACL patients and 50 normal patients, respectively. The MRNet-v1.0 dataset contains 1,250 cases with three views, of which 208 are ACL patients, and the rest are normal or other abnormal patients. Results: The area under the receiver operating characteristic curve (AUC) of the ACL diagnosis system is 97.00% and 92.86% at the optimal threshold for the MRI-ACL dataset and the MRNet-v1.0 dataset, respectively, indicating a high overall diagnostic accuracy. In comparison, the best AUC of the single-view diagnosis methods are 96.00% (MRI-ACL dataset) and 91.78% (MRNet-v1.0 dataset), and our method improves by about 1.00% and 1.08%. Furthermore, our method also improves by about 1.00% (MRI-ACL dataset) and 0.28% (MRNet-v1.0 dataset) compared with the multi-view network (i.e., MRNet). Conclusion: The presented 3D weighted multi-view network achieves superior AUC in diagnosing ACL, not only in the in-house MRI-ACL dataset but also in the publicly available MRNet-v1.0 dataset, which demonstrates its clinical applicability for the automatic detection of ACL.

TS-DSANN: Texture and shape focused dual-stream attention neural network for benign-malignant diagnosis of thyroid nodules in ultrasound images.

Recently, accurate diagnosis of thyroid nodules has played a critical role in precision medicine and healthcare system management. Due to complicated changes in ultrasound features of texture, and similar visual appearance of benign-malignant nodules, the identification of cancerous thyroid lesions from a given ultrasound image still faces challenges for even experienced radiologists. Learning-based computer-aided diagnosis (CAD) systems have accordingly attracted more and more attention recently. However, little research is committed to developing a deep learning-based CAD system that has greater conformity with radiologists' diagnostic decision-making. In this study, we devise a texture and shape focused dual-stream attention neural network, dubbed TS-DSANN. Specifically, in the texture focused stream, we utilize the ImageNet pre-trained ResNet34 to guide the network to recognize texture-related nodule attributes. Meanwhile, in the shape focused stream, in addition to using ResNet34 backbone, jointly learning from scratch with the contour obtained by contour detection module to enhance the extraction of shape features. Afterward, we employ a concatenation operation to aggregate the abovementioned two stream networks for capturing richer and more representative features. Finally, we further utilize an online class activation mapping mechanism to assist the dual-stream network in generating a localization heatmap to obtain more visualization attention to the nodule from the whole image, and supervise classifier's attention in decision-making. Experimental results conducted on the two-center thyroid nodule ultrasound datasets verify that our proposed method has improved the classification performance, superior to the state-of-the-art methods.

TransResU-Net: A Transformer based ResU-Net for Real-Time Colon Polyp Segmentation.

Colorectal cancer (CRC) is one of the most common causes of cancer and cancer-related mortality worldwide. Performing colon cancer screening in a timely fashion is the key to early detection. Colonoscopy is the primary modality used to diagnose colon cancer. However, the miss rate of polyps, adenomas and advanced adenomas remains significantly high. Early detection of polyps at the precancerous stage can help reduce the mortality rate and the economic burden associated with colorectal cancer. Deep learning-based computer-aided diagnosis (CADx) system may help gastroenterologists to identify polyps that may otherwise be missed, thereby improving the polyp detection rate. Additionally, CADx system could prove to be a cost-effective system that improves long-term colorectal cancer prevention. In this study, we proposed a deep learning-based architecture for automatic polyp segmentation called Transformer ResU-Net (TransResU-Net). Our proposed architecture is built upon residual blocks with ResNet-50 as the backbone and takes advantage of the transformer self-attention mechanism as well as dilated convolution(s). Our experimental results on two publicly available polyp segmentation benchmark datasets showed that TransResU-Net obtained a highly promising dice score and a real-time speed. With high efficacy in our performance metrics, we concluded that TransResU-Net could be a strong benchmark for building a real-time polyp detection system for the early diagnosis, treatment, and prevention of colorectal cancer. The source code of the proposed TransResU-Net is publicly available at https://github.com/nikhilroxtomar/TransResUNet.

Identification of TLE Focus from EEG Signals by Using Deep Learning Approach.

Temporal lobe epilepsy, a neurological disease that causes seizures as a result of excessive neural activities in the brain, is the most common type of focal seizure, accounting for 30-35% of all epilepsies. Detection of epilepsy and localization of epileptic focus are essential for treatment planning and epilepsy surgery. Currently, epileptic focus is decided by expert physician by examining the EEG records and determining EEG channel where epileptic patterns begins and continues intensely during seizure. Examination of long EEG recordings is very time-consuming process, requires attention and decision can vary depending on physician. In this study, to assist physicians in detecting epileptic focus side from EEG recordings, a novel deep learning-based computer-aided diagnosis system is presented. In the proposed framework, ictal epochs are detected using long short-term memory network fed with EEG subband features obtained by discrete wavelet transform, and then, epileptic focus identification is realized by using asymmetry score. This algorithm was tested on EEG database obtained from the Ankara University hospital. Experimental results showed ictal and interictal epochs were classified with accuracy of 86.84%, sensitivity of 86.96% and specificity of 89.68% on Ankara University hospital dataset, and 96.67% success rate was obtained on Bonn EEG dataset. In addition, epileptic focus was identified with accuracy of 96.10%, sensitivity of 100% and specificity of 93.80% by using the proposed deep learning-based algorithm and university hospital dataset. These results showed that proposed method can be used properly in clinical applications, epilepsy treatment and surgical planning as a medical decision support system.

Deep Learning-Based Computer-Aided Diagnosis Model for the Identification and Classification of Mammography Images

Deep Learning-Based Computer-Aided Diagnosis Model for the Identification and Classification of Mammography Images

Computer-aided diagnosis systems: a comparative study of classical machine learning versus deep learning-based approaches.

The diagnostic phase of the treatment process is essential for patient guidance and follow-up. The accuracy and effectiveness of this phase can determine the life or death of a patient. For the same symptoms, different doctors may come up with different diagnoses whose treatments may, instead of curing a patient, be fatal. Machine learning (ML) brings new solutions to healthcare professionals to save time and optimize the appropriate diagnosis. ML is a data analysis method that automates the creation of analytical models and promotes predictive data. There are several ML models and algorithms that rely on features extracted from, for example, a patient's medical images to indicate whether a tumor is benign or malignant. The models differ in the way they operate and the method used to extract the discriminative features of the tumor. In this article, we review different ML models for tumor classification and COVID-19 infection to evaluate the different works. The computer-aided diagnosis (CAD) systems, which we referred to as classical, are based on accurate feature identification, usually performed manually or with other ML techniques that are not involved in classification. The deep learning-based CAD systems automatically perform the identification and extraction of discriminative features. The results show that the two types of DAC have quite close performances but the use of one or the other type depends on the datasets. Indeed, manual feature extraction is necessary when the size of the dataset is small; otherwise, deep learning is used.

Multi-scale convolution based breast cancer image segmentation with attention mechanism in conjunction with war search optimization

Numerous studies have explored different techniques for segmenting breast cancer images, in particular deep learning-based Computer-Aided Diagnosis (CAD) has recently netted attention. However, due to their down-and-out pursuance, the existing approaches like FCN (Fully Convolutional Network), PSPNet (Pyramid Scene Parsing Network), U-Net, and SegNet still required improvement for offering better semantic segmentation while identifying breast cancer. In this paper, the newly proposed breast cancer tumor segmentation method consists of four steps pre-processing, augmentation, segmenting image using multi-scale convolution and multi- attention mechanisms respectively. The proposed method utilizes the ResNet (Residual Network) backbone network with multi-scale convolution for feature map prediction. Also, the effectiveness of the multi-channel attention module with a pyramid dilated nodule is employed for semantic segmentation. Gated axial, position, and channel attention are combined to create a multi-channel attention mechanism. Additionally, War Search Optimization (WSO) algorithm is being utilized to enhance the accuracy of the segmented images. Experimentations are conducted on two datasets, viz., Breast Cancer Cell Segmentation Database and Breast Cancer Semantic Segmentation (BCSS) Database, with different existing networks. The effectiveness of the network is evaluated based on various criteria in terms of precision, accuracy, recall, (mean Intersection of Union), (Intersection of Union), etc.

An interpretable and interactive deep learning algorithm for a clinically applicable retinal fundus diagnosis system by modelling finding-disease relationship

The identification of abnormal findings manifested in retinal fundus images and diagnosis of ophthalmic diseases are essential to the management of potentially vision-threatening eye conditions. Recently, deep learning-based computer-aided diagnosis systems (CADs) have demonstrated their potential to reduce reading time and discrepancy amongst readers. However, the obscure reasoning of deep neural networks (DNNs) has been the leading cause to reluctance in its clinical use as CAD systems. Here, we present a novel architectural and algorithmic design of DNNs to comprehensively identify 15 abnormal retinal findings and diagnose 8 major ophthalmic diseases from macula-centered fundus images with the accuracy comparable to experts. We then define a notion of counterfactual attribution ratio (CAR) which luminates the system’s diagnostic reasoning, representing how each abnormal finding contributed to its diagnostic prediction. By using CAR, we show that both quantitative and qualitative interpretation and interactive adjustment of the CAD result can be achieved. A comparison of the model’s CAR with experts’ finding-disease diagnosis correlation confirms that the proposed model identifies the relationship between findings and diseases similarly as ophthalmologists do.

Tuberculosis chest X-ray detection using CNN-based hybrid segmentation and classification approach

Tuberculosis still significantly impacts the world's population, with more than 10 million people getting sick each year. Researchers have focused on developing computer-aided diagnosis (CAD) technology based on X-ray imaging to support the identification of tuberculosis, and deep learning is a popular and efficient method. However, deep learning-based CAD approaches usually ignore the relationship between the two vision tasks of specific region segmentation and classification. In this research, we introduced a novel TB-UNet, which is based on dilated fusion block (DF) and Attention block (AB) block for accurate segmentation of lungs regions and achieved the highest results in terms of Precision (0.9574), Recall (0.9512), and F1score (0.8988), IoU (0.8168) and Accuracy (0.9770). We also proposed TB-DenseNet which is based on five dual convolution blocks, DenseNet-169 layer, and a feature fusion block for the precise classification of tuberculosis images. The experiments have been performed on three chest X-ray (CXR) datasets, segmented images, and original images are fed to TB-DenseNet for better classification. Furthermore, the proposed method is tested against simultaneously three different diseases, such as Pneumonia, COVID-19, and Tuberculous. The highest results are achieved in terms of Precision (0.9567), Recall (0.9510), F1score (0.9538), and Accuracy (0.9510). The achieved results reflect that our proposed method produces the highest accuracy compared to the state-of-the-art methods. The source code is available at: https://github.com/ahmedeqbal/TB-DenseNet.

CNN-Wavelet scattering textural feature fusion for classifying breast tissue in mammograms

Visual interpretation from radiologists employs computer-aided diagnosis (CAD) to make clinical diagnoses by analyzing breast tissue images and assessing their texture. Aside from needing more training images for Convolutional Neural Network (CNN), selecting textural feature input to the deep learning-based CAD is challenging to control since the entire feature map is extracted automatically and only considers spatial domain analysis. Hence, integrating spatial and frequency information from the images requires complex feature representation in a classification problem. Wavelet representation could improve the feature descriptors in acquiring information from the spatial-frequency analysis. However, wavelet transforms’ shift insensitivity may affect class feature representation by suppressing high-frequency information. This study uses CNN, and wavelet scattering (WS) features to classify fatty and fibroglandular tissue with benign and malignant masses from digital mammograms to overcome CNN overfitting based on a limited dataset. Scattered WS coefficients formed from layers of wavelet dilations and averaging are utilized to retain the loss of high-frequency signal from the images, while simultaneously, the added CNN features improve sparse image representation resulting from convoluted spatial information of the images. Finally, the model is cascaded with an ensemble classifier for classifying fatty and fibroglandular tissue and mass images, n = 112, from the INbreast mammogram dataset. The best performance of mass and breast tissue classification models reach 98.0 % and 99.3 % on 10-fold cross-validation accuracy. By combining textural features from WS and deep learning model architecture, the model may adopt a training system with fewer data without augmentation to achieve good performance and low complexity costs.