Nonlinear friction, system uncertainty, and external disturbances have a significant impact on the performance of high-precision servo feed systems. In order to achieve higher tracking accuracy, a sliding mode controller based on a generalized extended state observer with the double critic deep deterministic policy gradient algorithm is designed. Firstly, a flexible two mass drive model (FTMDM) is established for the two-axis differential micro-feed system (TDMS). Next, a generalized extended state observer (GESO) is designed to estimate matched interference and mismatched interference. And it is proved that the observation error of GESO is bounded. A sliding mode controller based on GESO is further proposed. The stability of the controller has been proven through Lyapunov theory, and the error is bounded and converges to zero in finite time. The tuning process of controller parameters is simplified by using quadratic optimal control principle. Furthermore, a double critic deep deterministic policy gradient algorithm (DCDDPG) is proposed to achieve dynamic optimization of parameters about GESO. The simulation results show that GESO with DCDDPG can reduce the observation error of step signal and sinusoidal signal, and improve the observation accuracy of nonlinear friction significantly. Finally, experimental results show that the proposed control method achieves more accurate position tracking performance on TDMS.