Order Of Decreasing Probability Research Articles

Gift of the Mamelukes: Animal ambassades as vectors of exotic fauna introductions in the Spanish Middle Ages

The number of exotic animal species that were introduced in Iberia during the Middle Ages constitute a defectively documented area of research, mostly addressed through historiographic methods. In this paper we evidence that even in the case of large, exotic animals exchanged as gifts among dignitaries the documentary data can be painfully incomplete. This is the case of the animal embassy that the Mamluk sultan Baybars al Bunduqdari sent in 1261 to the Castilian king Alfonso X. Although the written sources do not specify the complete list of species nor the reasons for mentioning some but not others, documentary and iconographic data suggest that, in addition to an elephant, a giraffe and a zebra, this lot included, in a decreasing order of probability, a lion, a dromedary, an ostrich, and a Nile crocodile. If such conspicuous beasts could pass unnoticed in a royal chronicle, one may contend that even in the most thoroughly documented cases, written sources may refer but a minimal fraction of the animals translocated into Iberia during the Medieval period. Such information vacuum stresses the difficulties of granting “indigenous” status to species traditionally assumed to constitute elements of the Iberian fauna when their historical contingencies are defectively known, a matter of concern for the current rewilding debate in Spain.

Induction of mitotic micronuclei by X-ray contrast media in human peripheral lymphocytes

In vitro and in vivo cytogenetic effects of X-ray contrast media (CM) were determined by scoring micronuclei (MN) in 72-h cultures of human peripheral lymphocytes. Both ionic (sodium meglumine diatrizoate, methylglucamine diatrizoate, and sodium meglumine ioxaglate and nonionic CM (iosimide, iopromide, iohexol and iotrolan) were able to induce MN in lymphocytes. Based upon their calculated percent probabilities for MN induction, these agents could be ranked in their decreasing order of probability, as iosimide > sodium meglumine ioxaglate > iohexol > sodium meglumine diatrizoate > iopromide > methylglucamine diatrizoate > iotrolan. Stepwise logistic regression analysis of the data indicated that the frequency of MN in CM-exposed lymphocyte cultures was significantly higher than the frequency of MN in control cultures ( P < 0.001). In clinical studies where 14 patients were injected with an ionic CM methylglucamine diatrizoate, lymphocyte cultures from 10 patients showed higher frequencies of MN. The differences between pre- and post-CM counts of MN were significant in a Mann-Whitney U test ( P < 0.05). The effect of X-irradiation on MN formation in lymphocytes was separately determined and was found to be insignificant. These results indicate that irrespective of ionic and osmolality differences, X-ray contrast agents are capable of producing chromosomal damage in peripheral lymphocytes. Further studies are required to establish molecular mechanisms in the observed cytogenetic effects of CM in cell cultures.

Identification of carcinogenic and noncarcinogenic polycyclic aromatic hydrocarbons through computer programming.

A computer program has been developed for rapid screening and identification of carcinogenic and noncarcinogenic polycyclic aromatic hydrocarbons. The program utilizes the ultraviolet absorption spectra for these hydrocarbons. It uses three classification schemes based on tolerance limits of 1, 2, and 5 nanometers and lists ten possibilities at each tolerance level in the decreasing order of probability. The number of probabilities at each tolerance level provides a measure for identification of hydrocarbons. The shifts in the absorption peaks due to the solvent, and the usefulness of the program and its application are discussed.