ObjectiveDescription of typical kinds of EEG reactivity (EEG-R) in post-anoxic coma using a quantitative method. MethodsStudy of 101 out-of-hospital cardiac arrest patients, 71 with good outcome (cerebral performance category scale ≤ 2). EEG was recorded 12–24 hours after cardiac arrest and four noxious, one auditory, and one visual stimulation were applied for 30 seconds each. Individual reference intervals for the power in the delta, theta, alpha, and beta bands were calculated based on six 2-second resting epochs just prior to stimulations. EEG-R in consecutive 2-second epochs after stimulation was expressed in Z-scores. ResultsEEG-R occurred roughly equally frequent as an increase or as a decrease in EEG activity. Sternal rub and sound stimulation were most provocative with the most pronounced changes as an increase in delta activity 4.5–8.5 seconds after stimulation and a decrease in theta activity 0.5–4.5 seconds after stimulation. These parameters predicted good outcome with an AUC of 0.852 (95 % CI: 0.771–0.932). ConclusionsQuantitative EEG-R is a feasible method for identification of common types of reactivity, for evaluation of stimulation methods, and for prognostication. SignificanceThis method provides an objective measure of EEG-R revealing knowledge about the nature of EEG-R and its use as a diagnostic tool.