Objectives This study aimed to compare computer-guided arthrocentesis with conventional double puncture technique in the treatment of anterior disc displacement with reduction of the temporomandibular joint. Patient and methods 16 adult patients were included in the study and were divided into two equal groups: group I: treated with guided arthrocentesis using ringer’s lactate solution and injection of hyaluronic acid, group II: treated with conventional double puncture technique of arthrocentesis using ringer’s lactate solution and injection of hyaluronic acid. Patients were evaluated clinically and radiographically preoperatively and postoperatively: clinically for evaluation of pain intensity, maximal mouth opening, and clicking at 1 week and 2 weeks and 1, 2, 3, and 6 months. Radiographically by MRI imaging at 3 and 6 months to determine any changes in the disc position and inflammatory changes within the joint. Results 16 patients (13 females and 3 males), their ages ranged from 17 to 35 years the results of the clinical data including pain intensity, maximal mouth opening, and clicking presented with significant improvements of all outcomes from preoperative to 6 months postoperatively for group I when compared with group II. Radiographically MRI after 3 and 6 months presented with no changes in the disc condyle relationship. Conclusion Arthrocentesis is a useful minimally invasive technique in the treatment of anterior disc displacement with reduction. It plays a role in decreasing joint pain and improving its function and by making arthrocentesis computer-guided this makes the procedures more accurate, safe, less painful, and time-saving and preventing postoperative complications.