Greater Hazelwood, a neighborhood located in Pittsburgh, Pennsylvania, saw a decline in residents, businesses, and services at the decline of the steel industry. Residents, philanthropic organizations, advocates, health centers, schools, universities, and community-based organizations continue to collaborate to revitalize the Greater Hazelwood neighborhood. Duquesne University Center for Integrative Health was engaged by a place-based grantmaking strategy in Greater Hazelwood to explore the creation of a collaborative partnership between universities, federally qualified health centers (FQHCs), schools, residents, and community-based organizations to improve access to comprehensive and quality healthcare in Greater Hazelwood. This collaborative designed health and wellness programs based on community-identified health priorities to improve health outcomes. These programs provide opportunities to for multi-sector partners and interdisciplinary health professionals to meet residents where they are, decrease disease disparity, and promote health equity.