Decline In Neonatal Mortality Rates Research Articles

Trends and population attributable risk estimates for individual and community-level factors of neonatal mortality in Pakistan (1990–2018)

PurposePakistan ranks third globally in terms of newborn deaths occuring within the first 24 hours of life. With a neonatal mortality rate of 42.0%, it carries the highest burden compared to neighboring countries such as Bangladesh (17%), India (22.7%) and Afghanistan (37%). While there has been a decline in neonatal mortality rates in Pakistan, the pace of this decline is slower than that of other countries in the region. Hence, it is crucial to conduct a comprehensive examination of the risk factors contributing to neonatal mortality in Pakistan over an extended period. This study aims to analyze the trends and determinants of neonatal mortality in Pakistan over three decades, providing valuable insights into this persistent issue.Design/methodology/approachThe study focused on neonatal mortality as the response variable, which is defined as the death of a live-born child within 28 days of birth. Neonates who passed away during this period were categorized as “cases,” while those who survived beyond a specific timeframe were referred to as “noncases.” To conduct a pooled analysis of neonatal mortality, birth records of 39,976 children born in the five years preceding the survey were extracted from four waves (1990–2018) of the Pakistan Demographic and Household Survey. The relationship between risk factors and the response variable was examined using the Cox Proportional Hazard Model. Neonatal mortality rates were calculated through the direct method using the “syncmrates” package in Stata 15.FindingsDuring the extended period in Pakistan, several critical protective factors against neonatal mortality were identified, including a large family size, improved toilet facilities, middle-aged and educated mothers, female children, singleton live births, large size at birth and longer birth intervals. These factors were found to reduce the risk of neonatal mortality significantly.Originality/valueThis study makes the first attempt to analyze the trends and patterns of potential risk factors associated with neonatal mortality in Pakistan. By examining a large dataset spanning several years, the study provides valuable insights into the factors influencing neonatal mortality.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2022-0604

Newborn signal functions in Bangladesh: Identification through expert consultation and assessment of readiness among public health facilities

BackgroundThis study aimed to identify a set of newborn signal functions (NSFs) that can categorize health facilities and assist policymakers and health managers in appropriately planning and adequately monitoring the progress and performance of health facilities delivering newborn health care in Bangladesh and similar low-income settings.MethodsA modified Delphi method was used to identify a set of NSFs and a cross-sectional health facility assessment among the randomly selected facilities was conducted to test them in public health facilities in Bangladesh. In the modified Delphi approach, three main steps of listing, prioritizing, and testing were followed to identify the set of NSFs. Then, to finalize the set of NSFs and its variables, a total of five Delphi workshops and three rounds of Delphi surveys were conducted. Finally, 205 public health facilities located in 41 randomly selected districts were assessed for the availability and readiness of finalized NSFs using the updated tool of Bangladesh Health Facility Survey (BHFS) 2017.ResultsTwenty NSFs were identified and finalized, nine of which were categorized as primary NSFs, 13 as basic NSFs, 18 as comprehensive NSFs, and 20 as advanced NSFs. Almost all district hospitals (DHs), Upazila health complexes (UHCs,) and maternal and child welfare centres (MCWCs) performed the primary NSFs in the last three months. However, around one-third of the union health and family welfare centres (UH&FWCs) and very few community clinics (CCs) performed them during the same period. The basic, comprehensive, and advanced NSF readiness was inadequate and inappropriate across all types of facilities, including DHs and UHCs.ConclusionsIn the absence of internationally or nationally agreed-upon NSFs to measure a health facility's service availability and readiness for providing newborn care, this study becomes the first to identify and finalize a set of NSFs and to incorporate relevant variables in the health facility assessment tool which can be used to monitor the availability and readiness of a newborn care facility. The identified NSFs can also be adapted for the countries with similar contexts and can serve as a standard base to determine a global set of NSFs.

Spatial Analysis of Antenatal Care and Low Birth Weight against Neonatal Mortality Rate in Aceh Province, Indonesia.

Background:Similar to Indonesia, Aceh Province also showed a slight decline in neonatal mortality rate. However, the rate is still high compared to other provinces. Efforts to reduce neonatal mortality rate are essential because neonatal deaths contributed up to 71% of all under-five deaths in 2017 in Aceh. Antenatal care and low birth weight are known to be associated with neonatal mortality. The purpose of this study was to map district-level neonatal mortality rate and its determinants (antenatal care and low birth weight) in Aceh to inform policymakers in planning the interventions.Methods:This was a cross-sectional study using publicly available secondary data obtained from Aceh Provincial Health Office. The study used the 2017 data of neonatal mortality rate, percent of 4th antenatal care visit and percent of low birth weight at district level. Thematic maps were produced using ArcMap (V.10.5). The correlation was analyzed using the Spearman rank test.Results:The results indicated the regional variation of neonatal mortality rate across Aceh Province. Districts in the Southern region had lower neonatal mortality rates compared to others. Low birth weight was positively correlated with neonatal mortality rate at district level (Spearman’s Rho=0.545, P=0.007). However, the percent of 4th antenatal care visit at district level was not correlated with neonatal mortality rate (Spearman’s Rho= −0.35, P=0.097).Conclusion:The study identified regional variations of neonatal mortality rate, low birth weight and ante natal care visit.

Factors contributing to neonatal mortality reduction in three regions in Ghana: a mixed-methods study using the Lives Saved (LiST) modelling tool

Background Ghana had significant reductions in neonatal mortality during the Millennium Development Goal (MDG) era. Few studies have attempted to identify the interventions, programs and policies that contributed to this progress. To understand the underlying factors which contributed to the reduction in neonatal mortality and to inform strategies to reach the Sustainable Development Goal (SDG) target to end preventable neonatal deaths, we conducted a mixed-methods study in the Northern, Upper West, and Volta Regions of Ghana. Methods The quantitative component consisted of an analysis of trends in coverage of key neonatal health interventions using subnational data from the Ghana Demographic and Health Surveys (DHS) and the Multiple Indicator Cluster Surveys (MICS). The Lives Saved Tool (LiST) was used to assess the contribution of various neonatal health interventions which resulted in reductions in neonatal mortality. Qualitative in-depth interviews (N=38) were conducted with government health officials, health workers, staff from non-government organizations, and community leaders, including traditional birth attendants and local chiefs from the Northern Region of Ghana. Findings Multiple interventions and contextual factors contributed to declines in the neonatal mortality rate (NMR) in all three regions. The Volta and Upper West Regions improved labor and delivery management practices which accounted for approximately one-third of the decline in NMR. The Northern Region had a substantial decline in NMR; the greatest proportion of the decline was attributed to control and management of infections in newborns (sepsis and pneumonia). Qualitative interviews suggest that improvements in neonatal survival were achieved through the prioritization of neonatal health at community-based health planning (CHPS) compounds and the development of a national-level strategic plan, coupled with neonatal health-related training for health workers. The establishment of neonatal intensive care units and strong partnership with local leaders and women’s groups to increase facility births and promote clean birth practices were also considered important. Conclusions The strategies that supported the reductions span from national-level policy intervention to facility-based quality improvement, to community level engagement. These strategies can be continued, strengthened, and scaled to improve neonatal survival in the SDG era.

Trends and Determinants of Newborn Mortality in the Kyrgyz Republic: A Countdown Country Case Study

Background: The Kyrgyz Republic has made great progress in reducing neonatal mortality rate (NMR), compared to the region, despite its regional comparatively low GDP per capita. Given the availability of an established civil registration and vital statistics system, the country is uniquely positioned to undertake a comprehensive assessment of trends and determinants of newborn mortality. Methods: We used publicly available data repositories and the national birth registry data to examine trends and inequalities of reproductive, maternal and newborn health and mortality between 1990 and 2018 at a national and subnational level. Coverage of newborn and maternal health interventions were assessed and disaggregating by equity dimensions. Oaxaca-Blinder decomposition was done to determine the contextual factors associated with the observed decline in NMR. We undertook a comprehensive review of national policies and programs, as well as a prospective Lives Saved Tool (LiST) analysis to highlight interventions that will save the most lives. Findings: In the past two decades, with the help of investments and appropriate policies, the Kyrgyz Republic has reduced NMR by 54%, with the leading causes of death attributable to prematurity and asphyxia. Neonates born pre-term small-for-gestational age are over 80 times more likely to die in their first month of life, compared to those born full term, appropriate-for-gestational age. With the exception of contraceptive use, coverage of essential interventions is increasing and exceptionally high with limited sociodemographic inequities. By 2030, improved case management of premature babies will save the most neonatal lives. Interpretation: The Kyrgyz Republic has reduced NMR considerably, with the potential for further reduction given its remarkably high coverage and low inequities of preventative maternal and newborn health interventions. A particular focus is needed on scaling-up packages of interventions to care for small and sick babies, assuring quality of care in all healthcare facilities, and creating a linked national registry system for mothers and newborns. Funding Statement: US Fund for UNICEF under the Countdown to 2015 and UNICEF Kyrgyzstan Declaration of Interests: All authors declare no competing interests.

Association of Temporal Changes in Gestational Age With Perinatal Mortality in the United States, 2007-2015

Whether the changing gestational age distribution in the United States since 2005 has affected perinatal mortality remains unknown. To examine changes in gestational age distribution and gestational age-specific perinatal mortality. This retrospective cohort study examined trends in US perinatal mortality by linking live birth and infant death data among more than 35 million singleton births from January 1, 2007, through December 31, 2015. Year of birth and changes in gestational age distribution. Changes in the proportion of births at gestational ages 20 to 27, 28 to 31, 32 to 33, 34 to 36, 37 to 38, 39 to 40, 41, and 42 to 44 weeks; changes in perinatal mortality (stillbirth at ≥20 weeks, and neonatal deaths at <28 days) rates; and contribution of gestational age changes to perinatal mortality. Trends were estimated from log-linear regression models adjusted for confounders. Among the 34 236 577 singleton live births during the study period, the proportion of births at all gestational ages declined, except at 39 to 40 weeks, which increased (54.5% in 2007 to 60.2% in 2015). Overall perinatal mortality declined from 9.0 to 8.6 per 1000 births (P < .001). Stillbirths declined from 5.7 to 5.6 per 1000 births (P < .001), and neonatal mortality declined from 3.3 to 3.0 per 1000 births (P < .001). Although the proportion of births at gestational ages 34 to 36, 37 to 38, and 42 to 44 weeks declined, perinatal mortality rates at these gestational ages showed annual adjusted relative increases of 1.0% (95% CI, 0.6%-1.4%), 2.3% (95% CI, 1.9%-2.8%), and 4.2% (95% CI, 1.5%-7.0%), respectively. Neonatal mortality rates at gestational ages 34 to 36 and 37 to 38 weeks showed a relative adjusted annual increase of 0.9% (95% CI, 0.2%-1.6%) and 3.1% (95% CI, 2.1%-4.1%), respectively. Although the proportion of births at gestational age 39 to 40 weeks increased, perinatal mortality showed an annual relative adjusted decline of -1.3% (95% CI, -1.8% to -0.9%). The decline in neonatal mortality rate was largely attributable to changes in the gestational age distribution than to gestational age-specific mortality. Although the proportion of births at gestational age 39 to 40 weeks increased, perinatal mortality at this gestational age declined. This finding may be owing to pregnancies delivered at 39 to 40 weeks that previously would have been unnecessarily delivered earlier, leaving fetuses at higher risk for mortality at other gestational ages.

Neonatal Mortality in the Eastern Mediterranean Region: Socio-Demographic, Economic and Perinatal Factors, 1990 - 2013

Background: The neonatal mortality rate (NMR) is considered amongst the most important socioeconomic and health indicators of a community development. Globally, it has been reported that the daily mortality rate during the neonatal period is much higher (30-fold) than the post-neonatal period. In the Eastern Mediterranean Region, about 40% of the under-5 mortality occurs in the neonatal period. This study aimed to explore the association between the socio-economic, demographic and perinatal care related factors, and the neonatal mortality in the Eastern Mediterranean Region. Methods: The secondary data for the 1990 to 2013 on neonatal mortality rates, socio-demographic, socio-economic and health factors were extracted from official websites, including united nations children’s fund (UNICEF), world health organization (WHO), and united nations educational, scientific and cultural organization (UNESCO). Data were collected using the following keywords: ‘neonatal mortality’, ‘perinatal deaths’, ‘child health, education’, ‘expenditure on health’, ‘safe water’, ‘sanitation’ and ‘health indicators’. We used secondary data analysis to explore the relationship between the possible explanatory variables and neonatal mortality using correlation coefficient analysis. Results: There was a noticeable decline in neonatal mortality rates (NMR) among the Eastern Mediterranean countries from 1990 to 2013. The neonatal mortality rate had a negative and significant association with literacy status of both sexes, annual growth rates, antenatal care coverage, birth attendance by skilled health personnel, Gross National Income (GNI), total health expenditure per capita, safe drinking water and adequate sanitation facilities. However, the neonatal mortality rate had significant and positive relationships with maternal mortality ratio, total fertility rate, population size, total births and low birth weight. Conclusion: Despite the fall in the neonatal mortality rate, it remains high in the Eastern Mediterranean countries. Socioeconomic and other related factors appear to play a major role in determining neonatal mortality and there is an inverse relationship between socioeconomic status and the neonatal mortality rate. Neonatal health in Eastern Mediterranean countries needs a more effective and innovative approach to sustain the rapid progress in the overall reduction of child mortality.

Improvements in Essential Newborn Care and Newborn Resuscitation Services Following a Capacity Building and Quality Improvement Program in Three Districts of Uttar Pradesh, India.

Background:Neonatal death remains a global challenge contributing to 45% of underfive deaths. With rising institutional delivery, to accelerate decline in neonatal mortality rate (NMR) improvement in the quality of perinatal care requires attention.Objectives:This implementation research targeted improving service delivery readiness for quality of newborn care at public health facilities in three districts of Uttar Pradesh, India, with high NMR.Materials and Methods:This before-after study assessed the facility readiness and quality of newborn services at 42 health facilities. The changes in 26 signal functions for routine and emergency obstetric and newborn care were tracked.Results:There was marked improvement in newborn service availability: skilled birth attendants (51%), resuscitation (30%), and kangaroo mother care (27%) at these facilities. A multifold rise in newborn resuscitation efforts and documentation (n = 4431 vs. n = 144 in preintervention period) with high success rate (98.6%) was observed. There was also improvement in obstetric care services including partograph use (31%) and active management of third stage of labor (46%). However, several infrastructural indicators (electricity, water supply, toilets, and sanitation) remained unchanged.Conclusion:Overall improvements were observed in the majority of the signal functions for perinatal care and newborn resuscitation efforts. There was a limited impact on the infrastructural and supervision components.

State of newborn health in India.

About 0.75 million neonates die every year in India, the highest for any country in the world. The neonatal mortality rate (NMR) declined from 52 per 1000 live births in 1990 to 28 per 1000 live births in 2013, but the rate of decline has been slow and lags behind that of infant and under-five child mortality rates. The slower decline has led to increasing contribution of neonatal mortality to infant and under-five mortality. Among neonatal deaths, the rate of decline in early neonatal mortality rate (ENMR) is much lower than that of late NMR. The high level and slow decline in early NMR are also reflected in a high and stagnant perinatal mortality rate. The rate of decline in NMR, and to an extent ENMR, has accelerated with the introduction of National Rural Health Mission in mid-2005. Almost all states have witnessed this phenomenon, but there is still a huge disparity in NMR between and even within the states. The disparity is further compounded by rural–urban, poor–rich and gender differentials. There is an interplay of different demographic, educational, socioeconomic, biological and care-seeking factors, which are responsible for the differentials and the high burden of neonatal mortality. Addressing inequity in India is an important cross-cutting action that will reduce newborn mortality.

Newborn care practices: A case study of tribal women, Gujarat

Plateaued rate of decline in neonatal mortality rate is one of the major obstacles in achieving Millennium Development Goal 4 especially in developing countries. Even in India, nationwide interventions targeting safe mother and newborn care have not yielded the desired impact, indicating the necessity to combat neonatal mortality rate at population specific level. The objective of this study is to identify the newborn care practices and beliefs, analyze their harmful or beneficial characteristics, describe the deviations from the essential newborn care practices during hospital/home delivery, explain barriers to care seeking and identify areas of potential resistance for behavior change; and utilize study findings to tailor-make cost-effective essential newborn care package. The study uses qualitative data from in-depth interview of mothers who had experienced neonatal death and key-informant interviews with healthcare personnel and birth attendants. 33 cases were randomly selected from the registered neonatal deaths across Bharuch district of Gujarat, India. Key finding of this study is less prevalent practice of essential newborn care among all cases irrespective of place of delivery and the health-care personnel facilitating delivery. Habitual traditional/tribal newborn care methods challenge the practice of prescribed essential newborn care. Clustering of deaths in few households added significantly to the existing burden of neonatal deaths, attributed to superstition “Ratewa” by tribal. Study has concluded that the introduction and implementation of essential newborn care at hospital and community/ household level are the need of the hour. Quality home based neonatal care through cost effective interventions is deemed necessary where accessing institutional care is not possible in the immediate term. Community health workers can contribute to the eradication of harmful newborn care practices and the sustenance of essential practices through community education and behavior change communication.

Analysis of under 5 years old children mortality and the leading death cause in China from 1996 to 2000

To study the trend of under 5 years old children mortality and the leading cause of the deaths in China from 1996 to 2000. The data presented in this report were obtained from the national child mortality surveillance network, including 116 counties (cities) throughout China. The target population was all children under 5 years old in the monitored areas whose mothers or fathers had resided in the area for at least one year. The data were collected and reported by health workers at the three-level network. The neonatal mortality rate (NMR), infant mortality rate (IMR) and under 5 years old mortality rate (U(5)MR) in China dropped to 22.8, 32.2, 39.7 per 1,000 live births in 2000, respectively (they were 24.0, 36.0, 45.0 respectively in 1996), which declined 5.0%, 10.6%, 11.8% from 1996 to 2000, respectively. In urban areas, NMR, IMR and U(5)MR dropped to 9.5, 11.8, 13.8 per 1,000 live births in 2000, respectively (they were 12.2, 14.8, 16.9 respectively in 1996), which declined 22.1%, 20.3%, 18.3% from 1996 to 2000, respectively. In rural areas, NMR, IMR and U(5)MR dropped to 25.8, 37.0, 45.7 per 1,000 live births in 2000, respectively (they were 26.7, 40.9, 51.4 respectively in 1996), which declined 3.4%, 9.5%, 11.1% from 1996 to 2000, respectively. There was a steady decline in the U(5)MR due to diarrhea, pneumonia, neural tube defects and drowning in China. In urban/rural areas, the overall decline in NMR, IMR and U(5)MR from 1996 to 2000 was spectacular. Especially the U(5)MR due to avoidable deaths such as pneumonia and diarrhea was dropped markedly in rural areas.

Neonatal audit in the United Arab Emirates: a country with a rapidly developing economy

We aimed to determine whether birth-weight-specific mortality rates and causes of neonatal death could identify interventions needed to reduce neonatal mortality rates. Data were collected from three hospitals responsible for 99% of births in Al-Ain Medical District. There were 8083 live births weighing > or = 500 g, of which 54 (0.67%) died. The mortality rate among very low-birth-weight infants was higher in this district than from centres with more advanced neonatal technology and resources. Problems of preterm births, lethal malformations and asphyxia accounted for 95% of deaths and half of the malformations were autosomal recessive syndromes. Improved management of lower-birth-weight infants, asphyxia and genetic counselling could lead to a further decline in neonatal mortality rates.

Neonatology in developing countries: problems, practices and prospects.

A recent review of perinatal and neonatal care in developed countries found that a decline in neonatal mortality rates due to improved neonatal care has played a major role in the decline of infant mortality over the past 3 decades. However efforts to reduce high infant mortality rates (IMR) in most developing countries have focused mainly upon post-neonatal mortality while neonatal mortality (NND) has been almost ignored. A recent World Health Organization focus upon the health of newborn infants and the contribution of NND to IMR has called attention to the need to improve perinatal and neonatal care facilities and resources in order to realize any significant reduction in the high IMR observed in developing countries. One important step toward improving neonatal care and reducing neonatal mortality in developing countries is to carefully examine government health funding neonatal health care resources and the major determinants of neonatal mortality. Economic and health indicators of IMR neonatal vital statistics and causes of death and the major neonatal problems of low birth weight birth asphyxia infections and severe jaundice are discussed followed by a summary of problems and future prospects.

The postponement of neonatal deaths into the postneonatal period: evidence from Massachusetts.

Part of the slow decline in the postneonatal mortality rate and the rapid decline in the neonatal mortality rate during the 1970s may have been due to a postponement of some neonatal deaths into the postneonatal period. The authors hypothesized that any such postponement should be accompanied by a lack of decline, or even an increase, in late neonatal and postneonatal mortality rates among low birth weight babies and babies dying of conditions originating in the perinatal period. To examine this theory, the authors used vital records data to compare infant mortality rates in Massachusetts during 1970-1972 with rates during 1978-1980. Log-linear hazard models were used to calculate death rates, while controlling for changes in maternal age, race, education, and prior reproductive history. The authors found that babies of birth weight under 1,500 g had no decline in late neonatal mortality rates and babies of birth weight under 2,500 g had no decline in postneonatal mortality rates. Babies of birth weight 500-999 g had an increased postneonatal mortality rate (rate ratio = 2.4; 95% confidence limits = 1.0-5.4). These unimproved or increased death rates were due in part to conditions originating in the perinatal period. The authors conclude that, although infant mortality rates have declined, this postponement was real, and that efforts to monitor infant mortality will benefit from its routine quantification.