Decline In Hearing Sensitivity Research Articles

Sex differences and the effect of female sex hormones on auditory function: a systematic review.

First, to discuss sex differences in auditory function between women and men, and whether cyclic fluctuations in levels of female sex hormones (i.e., estradiol and progesterone) affect auditory function in pre-menopausal and post-menopausal women. Second, to systematically review the literature concerning the discussed patterns in order to give an overview of the methodologies used in research. Last, to identify the gap in knowledge and to make recommendations for future work. Population, Exposure, Control, Outcome and Study design (PECOS) criteria were used in developing the review questions. The review protocol follows the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and was pre-registered in the Prospective Register of Systematic Reviews (PROSPERO; CRD42020201480). Data Sources: EMBASE, PubMed, MEDLINE (Ovid), PsycINFO, ComDisDome, CINAHL, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) via Cochrane Library, and scanning reference lists of relevant studies, and internet resources (i.e., Mendeley) were used. Only studies published between 1999 and 2022, in English, or in English translation, were included. The quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS). Sex differences: Women had more sensitive hearing (measured at the level of peripheral and central auditory system) than men. Cyclic fluctuations: Auditory function in women fluctuated during the menstrual cycle, while no such fluctuations in men over the same time period were reported. Hearing sensitivity improved in women during the late follicular phase, and decrease during the luteal phase, implying an effect of female sex hormones, although the specific effects of estradiol and progesterone fluctuations on the central auditory system remain unclear. Hearing sensitivity in women declined rapidly at the onset of menopause. The review has shown the following. Consistent sex differences exist in auditory function across the auditory pathway with pre-menopausal women often showing better function than age-matched men. Moreover, pre-menopausal women show fluctuations in hearing function across the menstrual cycle with a better function during the peak of estradiol or when the ratio of estradiol to progesterone is high. Third, menopause marks the onset of hearing loss in women, characterized by a rapid decline in hearing sensitivity and a more pronounced loss than in age-matched men. Finally, the systematic review highlights the need for well-designed and -controlled studies to evaluate the influence of estradiol and progesterone on hearing by consistently including control groups (e.g., age-matched man), using objective tests to measure hormonal levels (e.g., in saliva or blood), and by testing participants at different points across the menstrual cycle. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020201480, identifier CRD42020201480.

Effect of amplitude fluctuations on the loudness of low-frequency sounds

The loudness of two-tone complexes (TTCs) with center frequencies (fc ) of 40, 63, 80, and 1000 Hz was matched with that of unmodulated tones (UTs). Frequency differences between the TTC components, corresponding to beat frequencies, fb , were 1, 2, 5, and 12 Hz. To compensate for the steep decline in hearing sensitivity below 100 Hz, prior to the loudness match, subjects adjusted the relative levels (ΔL) of the TTC components to give maximum beat perception. Twenty-four normal-hearing subjects were tested. The values of ΔL giving best beats were well predicted from the transfer function of the middle ear and the estimated shapes of the auditory filters, assuming that the auditory filter whose output dominated the beat percept was centered somewhat above fc . At the same root-mean-square level and independent of fc , TTCs were perceived as louder than UTs for fb ≤ 2 Hz, had roughly equal loudness to UTs for fb = 5 Hz, and were less loud than UTs for fb = 12 Hz. The similar pattern observed across fc suggests that the dependence of loudness on amplitude-fluctuation rate is determined by processes occurring at higher stages of the auditory system than the cochlea.The loudness of two-tone complexes (TTCs) with center frequencies (fc ) of 40, 63, 80, and 1000 Hz was matched with that of unmodulated tones (UTs). Frequency differences between the TTC components, corresponding to beat frequencies, fb , were 1, 2, 5, and 12 Hz. To compensate for the steep decline in hearing sensitivity below 100 Hz, prior to the loudness match, subjects adjusted the relative levels (ΔL) of the TTC components to give maximum beat perception. Twenty-four normal-hearing subjects were tested. The values of ΔL giving best beats were well predicted from the transfer function of the middle ear and the estimated shapes of the auditory filters, assuming that the auditory filter whose output dominated the beat percept was centered somewhat above fc . At the same root-mean-square level and independent of fc , TTCs were perceived as louder than UTs for fb ≤ 2 Hz, had roughly equal loudness to UTs for fb = 5 Hz, and were less loud than UTs for fb = 12 Hz. The similar pattern observed across fc s...

Associations of Hearing Sensitivity, Higher-Order Auditory Processing, and Cognition Over Time in Middle-Aged Adults.

Age-related hearing loss (impairment in hearing sensitivity and/or higher-order auditory processing) and cognitive decline are common co-occurring impairments in elderly adults. Their relation in the process of aging remains insufficiently understood. We aim to assess the temporal relations of decline in hearing sensitivity, higher-order auditory processing, and cognition in middle-aged adults. This study included 1,274 Beaver Dam Offspring Study participants who participated in three examinations (baseline, 5-year, and 10-year follow-up). We assessed hearing sensitivity through pure-tone audiometry (PTA, averaged thresholds of 0.5, 1, 2, 4 kHz of the better ear), higher-order auditory processing as word recognition in competing message (WRCM) using the Northwestern University 6 word list in the better ear, and cognition through trail-making test performance (TMT). Linear mixed-effects models and linear regression models were used to determine associations over time and to what extent these measures influence each other over time. The longitudinal decline between all functions was associated with the strongest relationships between PTA and WRCM. The effect of baseline PTA on WRCM 10 years later (standardized ß = -.30) was almost twice as big as the effect of baseline WRCM on PTA 10 years later (standardized ß = -.18). The effect of baseline WRCM on TMT 10 years later and vice versa were small (standardized ß = -.05). No directional relationship between PTA and TMT was identified (standardized ß ≤ .02). While hearing sensitivity might affect higher-order auditory processing, associations between hearing and cognition appear bidirectional and weak in midlife. We need to be cautious before inferring causal effects of hearing on cognition.

On the loudness of low-frequency sounds with fluctuating amplitudes.

Some environmental sounds have strong amplitude fluctuations that may affect their perceived loudness and annoyance. This study assessed the effect of beat rate (fb) and center frequency (fc) on the loudness of low-frequency beating tones. The loudness of two-tone complexes (TTCs) with fc = 40, 63, 80, and 1000 Hz was matched with that of unmodulated tones (UTs). Frequency differences between the TTC components, corresponding to fb = 1, 2, 5, and 12 Hz, were used. To compensate for the steep decline in hearing sensitivity below 100 Hz, prior to the loudness match, subjects adjusted the relative levels (ΔL) of the TTC components to give maximum beat perception. Twenty-four normal-hearing subjects were tested. The values of ΔL giving best beats were well predicted from the transfer function of the middle ear and the estimated shapes of the auditory filters, assuming that the auditory filter whose output dominated the beat percept was centered somewhat above fc. At the same root-mean-square level and independent of fc, TTCs were perceived as louder than UTs for fb ≤ 2 Hz, had roughly equal loudness to UTs for fb = 5 Hz, and were less loud than UTs for fb = 12 Hz.

Stimulus bandwidth impact on auditory evoked potential thresholds and estimated upper-frequency limits of hearing in dolphins.

The frequency range of hearing is important for assessing the potential impact of anthropogenic noise on marine mammals. Auditory evoked potentials (AEPs) are commonly used to assess toothed whale hearing, but measurement methods vary across researchers and laboratories. In particular, estimates of the upper-frequency limit of hearing (UFL) can vary due to interactions between the unintended spread of spectral energy to frequencies below the desired test frequency and a sharp decline in hearing sensitivity at frequencies near the UFL. To assess the impact of stimulus bandwidth on UFL measurement, AEP hearing tests were conducted in four bottlenose dolphins (Tursiops truncatus) with normal and impaired hearing ranges. Dolphins were tested at frequencies near the UFL and at a frequency 1/2-octave below the UFL, where hearing sensitivity was better (i.e., threshold was lower). Thresholds were measured using sinusoidal amplitude modulated (SAM) tones and tone-bursts of varying bandwidth. Measured thresholds varied inversely as a function of stimulus bandwidth near the UFL with narrow-band tone-bursts approximating thresholds measured using SAM tones. Bandwidth did not impact measured thresholds where hearing was more sensitive, highlighting how stimulus bandwidth and the rate of decline of hearing sensitivity interact to affect measured threshold near the UFL.

Large cross-sectional study of presbycusis reveals rapid progressive decline in auditory temporal acuity

The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18–98 years) were shown to decline at a minimum rate of 1.05 ms (15%) per decade. Age was a significant predictor of TGDT when controlling for audibility (partial correlation) and when restricting analyses to persons with normal-hearing sensitivity (n = 434). The TGDTs were significantly better for males (3.5 ms; 51%) than females when averaged across the life span. These results highlight the need for indices of temporal processing in diagnostics, as treatment targets, and as factors in models of aging.

Hearing Loss in Patients Who Received Cranial Radiation Therapy for Childhood Cancer.

Patients treated with cranial radiation therapy (RT) are at risk for sensorineural hearing loss (SNHL). Although SNHL is often characterized as a delayed consequence of anticancer therapy, longitudinal reports of SNHL in childhood cancer survivors treated with contemporary RT are limited. We report the incidence, onset, severity, and long-term trajectory of SNHL among children receiving RT. Potential risk factors for SNHL were also identified. Serial audiologic testing was conducted on 235 pediatric patients who were treated with conformal or intensity-modulated RT as part of an institutional phase II trial for localized primary brain tumors, including craniopharyngioma, ependymoma, and juvenile pilocytic astrocytoma. All but one patient had measurable cochlear radiation dose (CRD) greater than 0 Gy. The median follow-up from RT initiation to latest audiogram was 9 years with a median of 11 post-RT audiograms per patient. Audiograms were classified by the Chang Ototoxicity Grading Scale. Progression was defined by an increase in Chang grade from SNHL onset to the most recent evaluation. At last evaluation, SNHL was prevalent in 14% of patients: 2.1% had mild and 11.9% had significant SNHL requiring hearing aids. Median time from RT to SNHL onset was 3.6 years (range, 0.4 to 13.2 years). Among 29 patients with follow-up evaluations after SNHL onset, 65.5% experienced continued decline in hearing sensitivity in either ear and 34.5% had no change. Younger age at RT initiation (hazard ratio [HR], 2.32; 95% CI, 1.21 to 4.46), higher CRD (HR, 1.07; 95% CI, 1.03 to 1.11), and cerebrospinal fluid shunting (HR, 2.02; 95% CI, 1.07 to 3.78) were associated with SNHL. SNHL is a late effect of RT that likely worsens over time. Long-term audiologic follow-up for a minimum of 10 years post-RT is recommended.

Musicians experience less age-related decline in central auditory processing.

Age-related decline in auditory perception reflects changes in the peripheral and central auditory systems. These age-related changes include a reduced ability to detect minute spectral and temporal details in an auditory signal, which contributes to a decreased ability to understand speech in noisy environments. Given that musical training in young adults has been shown to improve these auditory abilities, we investigated the possibility that musicians experience less age-related decline in auditory perception. To test this hypothesis we measured auditory processing abilities in lifelong musicians (N = 74) and nonmusicians (N = 89), aged between 18 and 91. Musicians demonstrated less age-related decline in some auditory tasks (i.e., gap detection and speech in noise), and had a lifelong advantage in others (i.e., mistuned harmonic detection). Importantly, the rate of age-related decline in hearing sensitivity, as measured by pure-tone thresholds, was similar between both groups, demonstrating that musicians experience less age-related decline in central auditory processing.

Study finds higher cardiovascular fitness associated with greater hearing acuity

Initial signs of auditory aging start long before age 65.Johnson and Hawkins reported evidence of nerve degen-eration in the cochlea secondary to hair cell degenerationby 5early adolescence. Numerous studies have reporteddeterioration of hearing levels with middle age and then anotable acceleration above 70 years.

Tutorial on the potential deterioration in hearing due to hearing aid usage.

This manuscript examines the issue of potential decline in hearing sensitivity due to hearing aid usage through an analysis of data obtained from the temporary threshold shift (TTS) paradigm. Following a critique of the traditional measures of TTS, the concept of integrated TTS (ITTS) is reviewed and data on hearing-aid-induced ITTS are presented. In addition, a series of equations relating permanent threshold shift (PTS) to a recently developed measure of noise dose (Dn) is derived and predictions for hearing-aid-induced PTS are made. Recommended gain settings established to protect the hearing of a person wearing a hearing aid from further decline following various durations of hearing aid usage are also provided.