De Luxembourg Research Articles

Editorial introductions.

Editorial introductions.

First systematic inventory of the jumping plant lice of Luxembourg (Hemiptera, Sternorrhyncha, Psylloidea).

Psyllids (superfamily Psylloidea), also known as jumping plant lice, are a group of plant-sap sucking Hemiptera having significant pest status for crops, forest trees and ornamental plants. Only seven species of psyllids have been recorded in Luxembourg so far. An additional group of seven species has been recorded exclusively, based on the findings of their galls or specific plant deformations; but no mention exists in literature on the actual collection of the inducing insect in Luxembourg. To fill this knowledge gap, field collections were carried out during the years 2019-2020. In addition, samples from 1999-2000 stored in the wet collection of the Musée National d'Histoire Naturelle de Luxembourg were studied. This research, in combination with information coming from literature, allowed us to list 48 species of the families Aphalaridae (5 species), Liviidae (5), Psyllidae (24) and Triozidae (14), though the presence of one species within the last family (Triozarhamni) needs to be confirmed. Brief information on geographical distribution, biology and (if available) illustrations of diagnostic characters are provided on the psyllid species detected in Luxembourg so far.

Care pathway for Covid-19 patients in a hospital in Luxembourg

The current care pathway for COVID-19 patients was set up at the Centre Hospitalier de Luxembourg following the experiences of the first wave. The role of the nurse in this pathway is fundamental: she coordinates care and themultidisciplinary team as well as the families, in addition to monitoring and treating the patients. Her tool is clinical reasoning, which is the guarantee of care adapted to the needs and expectations of the patients.

Incidence of and Risk Factors for Colorectal Strictures in Ulcerative Colitis: A Multicenter Study

Ulcerative colitis (UC) is increasingly recognized as a progressive disease and patients with long-standing disease can develop colorectal stricture. Few data about its incidence in UC are available, while risk factors for colorectal strictures in UC remain to be determined. We assessed the incidence of and risk factors for developing colorectal strictures in a large UC population. All adult patients followed at Nancy University hospital and at the centre hospitalier de Luxembourg for UC, between January 2004 and July 2019, were eligible for inclusion in this multicenter retrospective cohort study. A total of 439 patients with UC were included. Median follow-up duration was 9.6 years. Incidence of colorectal stricture was 3.6%. The cumulative probability of developing this complication was 1% at 5 years and 2.3% at 10 years. Median age at stricture diagnosis was 47.9 years (41.0; 63.0), and median time from UC diagnosis to onset of stricture was 11.5 years (5; 15.3). Montreal A3 classification (age > 40 years) (P = .008) and steroids use (HR = 4.1; 95% CI, 1.1-16.1) were independent risk factors for stricture, whereas mesalamine-treated patients carried a lower risk (HR = 0.3; 95% CI, 0.1-0.9). Dysplasia was found in 6 patients with strictures (42.9%) and among them 5 developed a colorectal cancer (33.3%). Patients with Montreal A3 classification and those exposed to steroids have a higher risk for strictures, while use of mesalamine lowers this risk. These factors should be assessed in daily clinical practice to prevent stricture occurrence in these patients.

Editorial introductions.

Editorial introductions.

Editorial introductions

Editorial introductions

Tribute to Linda Joanna DE MEIRLEIR

Tribute to Linda Joanna DE MEIRLEIR

BLS Teenage Providers on Bicycle at the ING Night Marathon in Luxembourg

2018 marked the 13th edition of the ING Night Marathon in Luxembourg. In collaboration with the Luxembourg Resuscitation Council LRC up to 20 students of the First Aid team of the ‘Athénée de Luxembourg’ (1) were called upon over the last three years as first responders and BLS providers in addition to the professional medical support of the race.

Procès politiques au temps de Louis XI: Armagnac et Bourgogne, ed. Joel Blanchard

This volume is a further instalment in Joel Blanchard’s project to present unpublished documents relating to the political trials launched against some twenty of Louis XI’s most highly placed opponents between 1465 and 1483. The previous volume, which appeared in 2012, dealt in great depth with the trial of Jacques d’Armagnac, Duke of Nemours in 1477, while that of Louis de Luxembourg, Constable of Saint-Pol appeared in 2008. With this volume we have two corpora of documents, the first relating to Nemours’ cousin Jean V Count of Armagnac, the second to the posthumous trial of Charles the Bold, Duke of Burgundy in 1478. Neither case represents a ‘treason trial’ of a living person but serves to demonstrate the development of royal ideology and illustrate the impact of competing jurisdictions, understandings of the idea of sovereignty and obligation within the political class of late medieval France. As Blanchard points out in his introduction, such documents do not answer all the questions one would wish to ask and present formidable problems in disentangling the complexities of networks of allies and clients in a rapidly changing political environment. The overall context is, of course, the Guerre du Bien public of 1465 and the dangerous series of conspiracies in 1472–4. Both generated an intense discourse on bad government which was attractive and powerful, and which Louis XI in his turn was careful to counter by pointing out in his letters and declarations the contradiction between demands for good government and abuses of power on the part of those who made them. In turn, the king was careful to observe at least the forms of judicial procedure and to carry a consensus. He was concerned to ‘de-legitimise’ rebellion by demonstrating judicially the ‘lack of faith’ on the part of opponents who had received his letters of grace and forgiveness and yet continued to attack him. The Nemours trial documents are an unusual survival of a complete dossier, in effect to ‘declare’ the guilt of the accused before eliminating him. The documents in the cases under review here largely follow the aftermath of such elimination. Armagnac was notoriously murdered after his surrender of Lectoure to a royal army in March 1473, having been stripped of his lands twice before (in 1443 and 1455). Banished in 1460, rehabilitated in 1461, he dabbled in the Bien public and other conspiracies in the late 1460s. Mandrot and Samaran published some documents on his case, such as the arrêt de Parlement of May 1460 declaring him guilty of treason, as well as the arrêt of September 1470 and the depositions of witnesses to events at Lectoure. This publication concentrates on, firstly, the memorandum for Charles d’Armagnac, Jean V’s brother, for rehabilitation and the return of his property in 1490. This interestingly gives the Armagnac case for Louis XI’s arbitrary rule and the procedural errors in his trials; secondly, the response of the procureur-général du roi. Finally, we have the depositions of the Cadet d’Albret, kinsman and ally of Jean V, who was tried and executed after the siege of Lectoure. His evidence covers a broad range of matters related to the end of Jean V’s life, including accusations of witchcraft, the count’s notoriously colourful family life (he had sired three children by his sister) and the siege itself. As for the post-mortem ‘trial’ of Charles the Bold for lèse-majesté, much revolved around the question of the constraint applied to the king at Péronne in 1468. In fact, no original of Burgundy’s safe-conduct has survived and, indeed, the surviving copies differ from each other. Blanchard suggests that it was not beyond the king to manufacture such a document which was crucial to his case of ‘notorious’ treason before the Parlement. The first document published here is a copy of a legal opinion on whether the king was placed under constraint by Burgundy at Péronne. The argument is advanced that the treaty was nullified by the mortal fear applied by the Duke. In the second draft opinion published, that of Pierre d’Oriole, a broader argument is developed which sought to question all the major treaties with Burgundy: Arras (1435), Conflans (1465) and Péronne (1468). Of all these, Péronne was singled out as illegitimate. Other documents published concern essentially the king’s position in 1478 on the course of his relations with Burgundy. The case was not followed to a conclusion but the effect of declaring Burgundy guilty of notorious lèse-majesté was enough to serve the king’s purposes at the time. As Blanchard concludes, the purpose of all these cases was a pragmatic development of the doctrine of lèse-majesté from doctrines already in existence but powerfully applied by the Crown in new circumstances. All documents are scrupulously edited with full notes and helpful indexes which permit navigation through the text.

Cherrey (1399-1410). L’exceptionnelle fondation d’un monastère hiéronymite en France par le cardinal Louis de Bar

Until now, historiography has not mentioned any medieval foundation of the order of Saint Jerome in the kingdom of France. The cathedral chapter of Langres, however, relates that in 1399 the administrator of the diocese, Cardinal Louis de Bar, endowed a Hieronomite monastery at Cherrey, near Langres. Other acts confirm that the brothers actually lived there. A canon at Reims chose to be buried here in 1401 and in 1410 the cardinal combines the priory of Cherrey, then occupied by four Hieronymites, with an Augustinian chapter presided over by the provost of Groenendael in the diocese of Cambrai. A foundation that is so intriguing and ephemeral in the kingdom of France calls for explanations. It must be situated in the context of the Great Schism and in the life of Louis de Bar, cousin of the king. This little known cardinal created by the Aragonese Pope Benedict XIII is also the brother of Yolande, queen of Aragon, who founded a Hieronymite monastery near Barcelona in 1393. What motivated Louis de Bar’s unusual desire to summon Aragonese monks, when there were Celestines and Carthusians in France ? Was he influenced by his cousin, the Cardinal Pierre de Luxembourg, who died young and in the odor of sanctity, probably a victim of his own asceticism ? A few unpublished archival sources oblige us to reconsider the beginnings of the religious order of Saint Jerome, while taking care to reconstitute the networks of each individual, from canon to cardinal.

REVIVING THE ART OF SOCIABILITY: Madame de Genlis’s Post-Revolutionary Salon at the Arsenal

Madame de Genlis is famous as a critic of the philosophes thanks largely to her society dialogue of the 1820s, Les dîners du baron d’Holbach (1822). Her portrait of positive sociability, Les soupers chez la maréchale de Luxembourg (1828), is far less famous. The soupers establish Genlis’s ideal of courtly sociability as superior to what she saw as perverse Enlightenment sociability and the incivility of the Revolutionary period. Yet these stylized dialogues are far from straightforward-ly historical representations of high society conversations. Instead, they are practical models for conversation, calculated to serve as a moral tonic for a divided society. Issuing from her experi-ence as a salonnière at the Bibliothèque de l’Arsenal, Genlis’s fictionalized dialogues of the 1820s reinvent the idea of eighteenth-century sociability to suit the tastes of the leaders of the nine-teenth century.

Preventing Ventilator-Associated Lung Injury at the Bedside*

Service des Soins Intensifs Polyvalents, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg *See also p. 527. Dr. Max has served as lecturer for Gambro and Heinen+Loewenstein and is a board member for the Scientific Council (WissenschaftlicherBeirat) and KCI.

The rapid evolution of knee osteotomies

For many years, osteotomies were ranked among the most important surgical procedures in the treatment of unicompartmental osteoarthritis of the knee. Following the success of knee arthroplasty, they have lost a major part of their initial impact. Recent data from the national knee arthroplasty register in Sweden have shown that the preferred treatment for young osteoarthritic patients is total knee arthroplasty [10]. The rate of osteotomies in this population has declined rapidly over the last decade, and the authors of this study pointed out that there is a real risk to see this treatment alternative eventually abandoned by surgeons. In several other European countries, an increasing interest in osteotomies has been noted over the past decade [3–6, 8, 9]. This revival started with the development of new osteotomy techniques and fixation methods. Modern osteotomy concepts include precise planning, safe and reproducible surgical techniques and a high primary stability of the implants used for fixation. They are supposed to induce few changes in the bony anatomy and do not bear the need of supplemental procedures such as fibular osteotomies. In standard conditions, their complication rates are nowadays below the acceptable 5 % range in lowvolume as well as in high-volume surgeons. Patients have a good early outcome and some can even resume sports activities. Indications have evolved as well. In the early times, osteotomies were mainly limited to patients with grade 4 osteoarthritis. In the middle of the past decade, ISAKOS summarized the inclusion criteria as well as contraindications of osteotomies [7]. Now we see these criteria evolve in the hands of the most experienced surgeons. Osteotomies are increasingly performed in patients under the age of 40, and increasing experience is gained in overweight patients. They are progressively used on a routine basis either as a stand-alone or a combined surgical option in patients with early osteoarthritis or compartment overload, in patients with knee instabilities or as an additive procedure in patients where a biological reconstructive procedure, for example, cartilage surgery and meniscus transplantation, is considered. Indications, operative technique, fixation methods and results of the currently available techniques are different from those of the initial methods. In general, new surgical procedures have to undergo four different phases until they will be globally accepted. In the initial pioneering phase, the procedure is developed and the initial investigators’ early results are presented. In the standardization phase, the technique is used successfully by other surgeons and it is simultaneously refined in the developers’ hands. General strategies are developed to prevent and manage the remaining complications. In the phase of outcome R. Seil (&) Centre de l’Appareil Locomoteur, de Medecine du Sport et de Prevention, Centre Hospitalier de Luxembourg, 78, rue d’Eich, 1460 Luxembourg, Luxembourg e-mail: rseil@yahoo.com

The National Library of Luxembourg

The origins of the National Library of Luxembourg (Bibliothèque nationale de Luxembourg, BnL) date back to 1798. This article provides an historical overview, outlines the core missions and describes the collections. Because several languages are spoken in Luxembourg, the BnL offers interface menus to the catalogues in French, German and English. The BnL coordinates the national network bibnet.lu of Luxembourgish libraries and is maintaining their integrated library information systems. It cooperates with the library of the University of Luxembourg and the documentation centres of three research centres as a member and coordinator of the Consortium Luxembourg for the acquisition and management of electronic publications. A programme to digitize the country's printed heritage has begun with historic newspapers. The BnL contributes to the Europeana digital library.

Editorial introductions

Editorial introductions

Commynes et les procès politiques de Louis XI: du nouveau sur la lèse-majesté by Joël Blanchard

1150 Reviews for, the range of items discovered and recorded. I have found only two missing items: (i) Philippe Menard, 'LTllustration d'un manuscrit de fabliau francais du xme siecle', in La cultura delVltalia padana e la presenza francese nei secoli XIII-XIV (Alessandria: Edizioni dell'Orso, 2001), pp. 255-79; (h) 'Fabliaux', in Gretchen Mieszkowski, Medieval Go-Betweens and Chaucer s Pandarus (New York: Palgrave Macmillan, 2006), pp. 38-55. The index of medieval texts and authors is a major research tool in that it provides references to the fabliaux individually. The subject index will also be invaluable for the study of broader issues: audiences and patrons, comedy, courtliness, folklore, parody, performance, psychoanalytical interpretations, women, etc. Moreover, read from cover to cover, rather than just used as a work of reference, the present volume provides a splendid guide to the genre of the fabliaux. University of Liverpool Glyn S. Burgess Commynes et les proces politiques de Louis XI: du nouveau sur la lese-majeste. By Joel Blanchard. Paris: Picard. 2008. 183 pp. 32. ISBN 978-2-7084-0834-0. On 19 December 1477 Louis de Luxembourg, Count of Saint-Pol and Constable of France, was executed after a trial by the Parlement of Paris on charges including lese-majeste. The fall of one of his most powerful contemporaries attracted the attention of Philippe de Commynes, who devoted three of the eight books of his Memoires to the trial. The present volume is an edition of Bibliotheque nationale de France MS 3869, the complete, official text of the trial, by the recent editor of the Memoires (Textes litteraires francais, 585, 2 vols (Geneva: Droz, 2007)). In place of a detailed exposition of the contents and context of the trial, the editor has included an essay entitled 'La lese majeste: entre categorie penale et sentiments', inwhich he reflects on different themes which, he believes, connect the trial to thework and career of Commynes. JoelBlanchard briefly touches on historical and judicial interpretations of the term lese-majeste. The rare application of the term, and the difficultyof interpreting itwhen it is used, have caused prob lems for jurists and historians. Blanchard notes two different applications of the term.One described violations of public order, such as an attack on representatives of theking, or an attack on his powers (such as forgery), tantamount to an attack on the public' body of the king. The second was more subtle, less juridical, and arose from the rupture of fidelitybetween a great nobleman and the king, which could be interpreted as an attack' on the king's private rather than public body. Itwas the second that Louis XI honed to his political purposes, although its application depended on theking's ability to impose his will on his great princes at a particular point in time. The term could be brought into proceedings late in the day, raising the stakes for those on trial. The king was in regular contact with commissioners whom he appointed to serve alongside the counsellors of the Parlement, and intervened constantly, and when he met resistance, even threatened to purge the Parlement. The trial of Saint-Pol, of his contemporary Jacques d'Armagnac, Duke MLR, 105.4, 2010 1151 ofNemours, and Louis XI's attempt to indict Charles the Bold, Duke of Burgundy with a posthumous charge of lese-majeste, are less important as examples of the development of judicial process during the reign than as illustrations of thatkings ability to adapt a judicial process for 'repressive and arbitrary purposes' (pp. 46-47). Commynes himself had a long and generally rancorous experience of judicial processes, partly because of his own intransigence in clinging on to confiscated rights and property. He himself dabbled in conspiracy during the minority of Charles VIII, and was lucky to escape the full rigour of lese-majeste. Blanchard con siders that these experiences made him more alert than other contemporary writers to theways inwhich Louis XI used lese-majeste to justify extraordinary measures. Blanchard raises many interesting ideas born out of his extensive knowledge ofCommynes and his context. The edition itself is clear and valuable, embellished by its user-friendly font and layout. It is accompanied by illuminating notes...

Cor Triatriatum Dexter Mimicking Ebstein Disease

A 4-month-old girl was referred for cyanosis and echocardiographic suspicion of Ebstein anomaly. Medical history had been uneventful thus far. At clinical examination, she was restless and cyanosed but did not show respiratory distress, cardiac failure, or failure to thrive. Cardiac and lung auscultation were normal except for tachycardia (150 to 180 bpm). Femoral pulses were present. Oxygen saturation on pulse oximetry oscillated between 55% and 70%. ECG showed abnormal right atrial hypertrophy (Figure 1). Chest x-ray showed no cardiomegaly but reduced pulmonary blood flow (Figure 2). Repeat echocardiography showed normal situs and connections. There was a large patent foramen ovale with mainly right to left shunt. The tricuspid valve annulus size was normal (13.1 mm; Z score=+0.2). First images suggested a restrictive opening of the tricuspid valve, which appeared shifted toward the apex, as seen in Ebstein disease (Figure 3). There was, however, hardly any tricuspid valve regurgitation. Close analysis showed normal insertions of the leaflets, precluding the diagnosis of Ebstein disease. Slow-motion analysis showed during diastole a very large and thick membrane arising from the right atrium, protruding toward the right …

Body image in obese candidates for bariatric surgery

Event Abstract Back to Event Body image in obese candidates for bariatric surgery Gloria Aguayo1*, M. Dammé1, C. Arendt2, S. Bachim2, M. Larcelet1, M. Vaillant1 and Charles Pull1, 2 1 Centre de Recherche Public de la Santé, Luxembourg 2 Centre Hospitalier de Luxembourg, Luxembourg Obese patients present a high body dissatisfaction. There exist little studies exploring the relation between obesity and body image. Aims of the current study were to assess a possible relation between body image problems and degree of obesity, depression, quality of life, self-esteem and body dissatisfaction. Conference: Annual CyberTherapy and CyberPsychology 2009 conference, Villa Caramora, Italy, 21 Jun - 23 Jun, 2009. Presentation Type: Poster Presentation Topic: Abstracts Citation: Aguayo G, Dammé M, Arendt C, Bachim S, Larcelet M, Vaillant M and Pull C (2009). Body image in obese candidates for bariatric surgery. Front. Neuroeng. Conference Abstract: Annual CyberTherapy and CyberPsychology 2009 conference. doi: 10.3389/conf.neuro.14.2009.06.001 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Mar 2009; Published Online: 18 Mar 2009. * Correspondence: Gloria Aguayo, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg, gloria.aguayo@crp-sante.lu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gloria Aguayo M. Dammé C. Arendt S. Bachim M. Larcelet M. Vaillant Charles Pull Google Gloria Aguayo M. Dammé C. Arendt S. Bachim M. Larcelet M. Vaillant Charles Pull Google Scholar Gloria Aguayo M. Dammé C. Arendt S. Bachim M. Larcelet M. Vaillant Charles Pull PubMed Gloria Aguayo M. Dammé C. Arendt S. Bachim M. Larcelet M. Vaillant Charles Pull Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

A Randomized Controlled Study of Virtual Reality Exposure Therapy and Cognitive-Behaviour Therapy in Panic Disorder with Agoraphobia

Event Abstract Back to Event A Randomized Controlled Study of Virtual Reality Exposure Therapy and Cognitive-Behaviour Therapy in Panic Disorder with Agoraphobia Charles Pull1*, A. Pelissolo2, M. Zaoui3, M. C. Pull-Erpelding1, L. Wouters1, Gloria Aguayo1, M. Larcelet1, V. Genouilhac4, A. Duinat4, F. Znaid2, C. De Mey Guillard4, P. Panagiotaki3, F. Fanget4, E. Mollard4, S. Gaillard5, F. Gueyffier6, S. Roche6, R. Ecochrad6, A. Berthoz3, R. Jouvent2 and J. Cottraux4 1 Centre Hospitalier de Luxembourg et Centre de Recherche Public Santé, Luxembourg 2 CHU Pitié Salpetrière, French Guiana 3 Collège de France, France 4 Unité de Traitement de l’Anxiété, France 5 CIC, Hôpital Cardiologique, France 6 Université Claude Bernard, France 92 patients presenting with Panic disorder with Agoraphobia were included in a randomized controlled trial comparing classical Cognitive Behavioral Therapy (CBT) to Virtual Reality Exposure Therapy (VRET) and a waiting list. There was no significant difference in outcome between VRET and CBT neither immediately after treatment nor at follow-up after 3, 6 and 12 months. Conference: Annual CyberTherapy and CyberPsychology 2009 conference, Villa Caramora, Italy, 21 Jun - 23 Jun, 2009. Presentation Type: Oral Presentation Topic: Oral Presentations Citation: Pull C, Pelissolo A, Zaoui M, Pull-Erpelding MC, Wouters L, Aguayo G, Larcelet M, Genouilhac V, Duinat A, Znaid F, De Mey Guillard C, Panagiotaki P, Fanget F, Mollard E, Gaillard S, Gueyffier F, Roche S, Ecochrad R, Berthoz A, Jouvent R and Cottraux J (2009). A Randomized Controlled Study of Virtual Reality Exposure Therapy and Cognitive-Behaviour Therapy in Panic Disorder with Agoraphobia. Front. Neuroeng. Conference Abstract: Annual CyberTherapy and CyberPsychology 2009 conference. doi: 10.3389/conf.neuro.14.2009.06.082 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Mar 2009; Published Online: 20 Mar 2009. * Correspondence: Charles Pull, Centre Hospitalier de Luxembourg et Centre de Recherche Public Santé, Luxembourg, Luxembourg, pull.charles@chl.lu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Charles Pull A. Pelissolo M. Zaoui M. C Pull-Erpelding L. Wouters Gloria Aguayo M. Larcelet V. Genouilhac A. Duinat F. Znaid C. De Mey Guillard P. Panagiotaki F. Fanget E. Mollard S. Gaillard F. Gueyffier S. Roche R. Ecochrad A. Berthoz R. Jouvent J. Cottraux Google Charles Pull A. Pelissolo M. Zaoui M. C Pull-Erpelding L. Wouters Gloria Aguayo M. Larcelet V. Genouilhac A. Duinat F. Znaid C. De Mey Guillard P. Panagiotaki F. Fanget E. Mollard S. Gaillard F. Gueyffier S. Roche R. Ecochrad A. Berthoz R. Jouvent J. Cottraux Google Scholar Charles Pull A. Pelissolo M. Zaoui M. C Pull-Erpelding L. Wouters Gloria Aguayo M. Larcelet V. Genouilhac A. Duinat F. Znaid C. De Mey Guillard P. Panagiotaki F. Fanget E. Mollard S. Gaillard F. Gueyffier S. Roche R. Ecochrad A. Berthoz R. Jouvent J. Cottraux PubMed Charles Pull A. Pelissolo M. Zaoui M. C Pull-Erpelding L. Wouters Gloria Aguayo M. Larcelet V. Genouilhac A. Duinat F. Znaid C. De Mey Guillard P. Panagiotaki F. Fanget E. Mollard S. Gaillard F. Gueyffier S. Roche R. Ecochrad A. Berthoz R. Jouvent J. Cottraux Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

A study of seven rule-based algorithms for the interpretation of HIV-1 genotypic resistance data in Thailand

Since the free therapy program was started by the Thai government , the number of patients infected by HIV-1 with access to antiretroviral drugs has increased. The selection of effective interpretation algorithms for antiretroviral drug resistance has become even more important for clinical management. In this retrospective study, the level of agreement was evaluated in 721 antiretroviral-therapy failing HIV-1 subjects. Regarding genetic diversity, about 89% was recognized as non-B variants (CRF01_AE). The level of complete concordant interpretation score in all seven algorithms was recognized in non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) (67%), but not in nucleoside reverse transcriptase inhibitors (NRTIs) (52%). Over 10% of the major discordance score with TRUGENE was revealed in didanosine (Agence Nationale de Recherches sur le SIDA[ANRS]; Detroit Medical Centre [DMC]), abacavir (ANRS; Centre Hospitalier de Luxembourg [CHL]), and also with delavirdine, indinavir and amprenavir (Grupo de Aconselhamento Virológico [GAV]). A good to excellent agreement range of kappa scores was detected for most antiretroviral drugs. However, poor agreement with the TRUGENE system ( k < 0.40) was seen in the ANRS system with didanosine, abacavir and lopinavir; GAV system in indinavir and amprenavir; and DMC system in ritonavir. These might be an option for resource limited countries when selecting the use of a low cost or free algorithm interpretation, which has excellent agreement as the U.S. Food and Drug Administration (FDA)-approved TRUGENE commercial system.