De La Seguridad Social Research Articles

The Role of EU Law in Challenging the Unjustified Differential Treatment of Domestic Workers: An Analysis of the Court of Justice Decision in CJ v Tesorería General de la Seguridad Social (TGSS) (C-389/20)

The Role of EU Law in Challenging the Unjustified Differential Treatment of Domestic Workers: An Analysis of the Court of Justice Decision in CJ v Tesorería General de la Seguridad Social (TGSS) (C-389/20)

Relation between cumulative damage in systemic lupus erythematosus and recognised disability by the National Social Security Institute of Spain (INSS)

IntroductionSystemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disease that particularly affects young women during their second and third decades. Events attributed to SLE itself and others related to the disease may impact negatively on the quality of life, employment and disability. However, there are not many studies focused on the impact that the disease may have on patients regarding those aspects. In Spain, the evaluation of disability and the assignation of a pension is given by the National Social Security Institute of Spain, INSS (“Instituto Nacional de la Seguridad Social”). ObjectiveTo assess the relationship between cumulative damage regarding the affected organ and the percentage of disability recognised by the National Social Security Institute of Spain (INSS) in SLE patients. MethodsCross-sectional prospective study of SLE patients according to the SLICC-2012 criteria, from the Rheumatology Service of two Spanish hospitals. We collected clinical and demographic data through personal interview and the SLICC/ACR questionnaire, and classified patients regarding a recognised disability or not. Results142 patients were evaluated; 30% had some percentage of official disability. We found a positive correlation between percentage of recognised disability and the SLICC/ACR index score. Musculoskeletal system is the most affected system, without differences between both groups; but we found a higher proportion of damage in nervous system, renal and vasculitis in patients with a recognised disability. ConclusionThere is a positive correlation between percentage of recognised disability in Spain and the cumulative damage in SLE.

Mortality analysis of persons with disabilities in Argentina by age, sex and duration of benefit, 2015–16

AbstractThis article describes the differential mortality of Argentina’s disability pension beneficiaries during the 2015–16 period, based on National Social Security Administration (Administración Nacional de la Seguridad Social – ANSES) payment records. It compares data for those with an assessed disability with overall population data, as well as with available international data (from Canada, Chile, Mexico, and the United States of America). In addition to breaking down mortality rates for people with disabilities by age and sex, it also factors in duration of benefit, establishing an inverse correlation between benefit duration and mortality.

Relation between cumulative damage in systemic lupus erythematosus and recognised disability by the National Social Security Institute of Spain (INSS).

Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disease that particularly affects young women during their second and third decades. Events attributed to SLE itself and others related to the disease may impact negatively on the quality of life, employment and disability. However, there are not many studies focused on the impact that the disease may have on patients regarding those aspects. In Spain, the evaluation of disability and the assignation of a pension is given by the National Social Security Institute of Spain, INSS ("Instituto Nacional de la Seguridad Social"). To assess the relationship between cumulative damage regarding the affected organ and the percentage of disability recognised by the National Social Security Institute of Spain (INSS) in SLE patients. Cross-sectional prospective study of SLE patients according to the SLICC-2012 criteria, from the Rheumatology Service of two Spanish hospitals. We collected clinical and demographic data through personal interview and the SLICC/ACR questionnaire, and classified patients regarding a recognised disability or not. 142 patients were evaluated; 30% had some percentage of official disability. We found a positive correlation between percentage of recognised disability and the SLICC/ACR index score. Musculoskeletal system is the most affected system, without differences between both groups; but we found a higher proportion of damage in nervous system, renal and vasculitis in patients with a recognised disability. There is a positive correlation between percentage of recognised disability in Spain and the cumulative damage in SLE.

PMD65 - Cost-Effectiveness of Transcathether Aortic Valve Implantation with the New Repositionable Self-Expandable Evolut R Versus Corevalve System in Inoperable Patients with Severe Aortic Stenosis in Mexico

To assess the cost-effectiveness of the transcathether aortic valve implantation with the new repositionable self-expandable Evolut R versus CoreValve system, for patients with severe aortic stenosis and high surgical risk in Mexico After a systematic review on MEDLINE, EMBASE, The Cochrane Library, Health Technology Assessment (HTA), Database of Abstracts of Reviews of Effects (DARE) and NHS Economic Evaluation Database (EED), a single paper was identified as the main input. We developed a cost-effectiveness evaluation, through a decision tree model, from the public-sector perspective. A post-surgery time horizon (in- hospital days after surgery) was considered. Health effect was measured based on the probability of in-hospital survival; with a scenario sensitivity analysis (SSA) at 30 and 365 days. We estimated direct medical costs (intervention and adverse events) from official sources (diagnosis-related group and unit costs from "Instituto Mexicano de la Seguridad Social"). Deterministic sensitivity analysis (DSA) and probabilistic sensitivity analysis (PSA) was performed to evaluate uncertainty levels. Our model show Evolut ™ R as a dominant option vs CoreValve ™, with an incremental effectiveness of 0.023 extra survival probability (ESP) and cost savings of $3,653.00 USD ($ 68,712.98 MXN) for the post-surgery scenario; in SSA at 30 and 365 days ESP were 0.062 and 0.061 respectively. The most influential variables in the incremental cost effectiveness ratio (ICER) at DSA are the price of Evolut ™ R and the moderate or severe paravalvular leak. PSA through 1000 iterations illustrate that in 90% of them, Evolut ™ R remains as a cost-effective option. In a Life-threatening disease, as an inoperable patient with severe aortic stenosis, E Evolut ™ R provided meaningful clinical benefits and cost savings, compared with CoreValve, with incremental costs considered within acceptable threshold by Mexico authorities.

Clusterin: a key player in cancer chemoresistance and its inhibition

Clusterin is a heterodimeric disulfide-linked glycoprotein (449 amino acids) isolated in the rat prostate after castration. It is widely distributed in different tissues and highly conserved in species. There are two isoforms (1 and 2) with antagonistic actions regarding apoptosis. Clusterin is implicated in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement cascade, representing a truly multifunctional protein. Isoform 2 is overexpressed under cellular stress conditions and protects cells from apoptosis by impeding Bax actions on the mitochondrial membrane and exerts other protumor activities, like phosphatidylinositol 3-kinase/protein kinase B pathway activation, modulation of extracellular signal-regulated kinase 1/2 signaling and matrix metallopeptidase-9 expression, increased angiogenesis, modulation of the nuclear factor kappa B pathway, among others. Its overexpression should be considered as a nonspecific cellular response to a wide variety of tissue insults like cytotoxic chemotherapy, radiation, excess of free oxygen radicals, androgen or estrogen deprivation, etc. A review of the recent literature strongly suggests potential roles for custirsen in particular, and proapoptosis treatments in general, as novel modalities in cancer management. Inhibition of clusterin is known to increase the cytotoxic effects of chemotherapeutic agents, and custirsen, a second-generation antisense oligonucleotide that blocks clusterin, is being tested in a Phase III clinical trial after successful results were achieved in Phase II studies. A major issue in cancer evolution that remains unanswered is whether clusterin represents a driving force of tumorigenesis or a late phenomenon after chemotherapy. This review presents preclinical data that encourages trials in various types of cancer other than advanced castration-resistance prostate cancer and discusses briefly the appropriate timing for clusterin inhibition in the clinical context.

The Incidence of Veno-Occlusive Disease Following Allogeneic Hematopoietic Stem Cell Transplantation Has Diminished and the Outcome Improved over the Last Decade

The evolution of the incidence, morbidity, and mortality of veno-occlusive disease (VOD) was analyzed in 845 allogeneic hematopoietic stem cell transplantations (allo-HSCTs) performed over 24 years. A total of 117 patients and 73 patients developed VOD following the Seattle and the Baltimore diagnostic criteria, respectively (cumulative incidence 13.8% and 8.8%). The cumulative incidence was significantly higher in the period 1985 to 1996 than in 1997 to 2008 (11.5% vs 6.5%; P= .01). This decline was because of the low incidence of VOD among reduced-intensity conditioning-HSCT (RIC-HSCT) (2.1%) and the reduction among those receiving myeloablative-HSCT from unrelated donors (32.7% vs 10.5%, P = .001). A total of 35 patients had severe VOD (26 with multiorgan failure [MOF]), and 20 died by VOD (cumulative mortality rate 17.3%, Seattle, or 22.5%, Baltimore). The mortality declined since 1997 (from 22% to 9%; P = .06, Seattle, and from 36% to 14%; P= .04, Baltimore), with the introduction of defibrotide being the only relevant change in the management of patients. This occurred even though the severity of VOD was similar in both periods. Among those with MOF, only 2 of 8 (25%) receiving defibrotide died versus 14 of 18 (78%) receiving other treatments (P = .007). Myeloablative conditioning, previous liver disease, poor performance status, and alternative donors were the variables with higher impact on VOD development. In summary, although VOD remains a dreaded early complication of HSCT, technical and therapeutic progress in recent decades have notably reduced its incidence and improved the outcome.

The extension of healthcare coverage and protection in relation to the labour market: Problems and policies in Latin America

Abstract In the past 25 years almost all 20 countries of Latin America have reformed their healthcare systems, but coverage by social insurance averages 53 per cent of the total population (less than the ILO minimum standard), ranges from 7 to 26 per cent in ten countries and has stagnated or decreased in at least eight, and access is insufficient. This article (1) analyses the transformation of the labour market and its impact on social insurance coverage; describes legal coverage of various groups; estimates statistical coverage/access and its trends in the three typical sectors (public, social insurance and private); documents the differences in coverage by income, geographical area and ethnic group; examines the difficulties in the incorporation of the informal economy, the rural population, indigenous peoples and the poor, as well as the causes of low coverage, and touches problems of access;(2) summarizes recommendations from international organizations on coverage and access; suggests specific policies to expand protection in general and to vulnerable groups, and identifies themes that require more statistics and research; and (3) summarizes findings and recommendations. A preliminary version of this article was presented at the ISSA Regional Conference for the Americas held in Belize City, 28‐31 May 2006. Based on the author's book Las Reformas de Saluden América Latina y el Caribe: Su Impacto en los Principios de la Seguridad Social (Santiago, ECLAC/GTZ, 2006), the article summarizes and restructures all pertinent sections of that book, with numerous changes and new data. Useful comments were provided by two anonymous referees.

Increased intracranial pressure in myelomeningocele (MMC) patients never shunted: results of a prospective preliminary study.

In some young adults non-shunted myelomeningocele (MMC) patients without symptoms or with unspecific clinical findings, moderate or severe stabilised ventriculomegaly are observed in control CT scans. Physicians are then faced with the so-called 'Arrested Hydrocephalus' (AH) syndrome. The present study is part of a prospective protocol in which patients with hydrocephalus associated with MMC and long-term clinical diagnosis of AH were included. To evaluate myelomeningocele patients never shunted with clinical and/or CT scan criteria compatible with AH. Multidisciplinary Spina Bifida Unit in a tertiary university hospital in Barcelona, Spain. Fourteen MMC patients were selected, in all of them, continuous intracranial pressure (ICP) monitoring was performed. Analysis of the ICP records was done using the method described by Borgesen in mmHg. All patients were also studied by intelligence quotient (IQ) testing before and after shunting. The CT in all the study cases showed an Evans ratio </=0.30. The majority of patients (11/14) presented continuous high or intermittently raised ICP (active or unstable compensated hydrocephalus group) and in three (3/14) cases we confirmed the diagnosis of arrested hydrocephalus. There were no complications associated with ICP monitoring. In view of our results, we believe that in all non-shunted cases with clinical and/or CT scan criteria compatible with AH, the use of an objective method, such as continuous ICP monitoring, is necessary to diagnose arrested hydrocephalus, and a more comprehensive method that includes extensive neuropsychological valoration should be developed for the diagnosis and treatment of arrested hydrocephalus. Supported in part by Grant number 97-0923 from the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISS).

La valoración médica de la incapacidad para el trabajo (elaboración del listado de enfermedades con la colaboración de las sociedades científicas)

Amongst the financial benefits given by the Social Security Service, that of disability benefit is one of the most important. To determine the right to obtain this and the amount due, it is necessary to have administrative certification of the existence of this disability, the cause of it and the degree (partial, total, absolute or great disability). Therefore medical assessment is essential. The medical assessors of the Disability Tribunals of the Instituto Nacional de la Seguridad Social are responsible for medical assessment. It is necessary for these doctors to understand all types of disorders and useful for them to have methodology at their disposal for each of the different disorders. Also, lack of official criteria for evaluation, due to the variety of situations which may arise, make unification difficult. We aim to devise criteria for evaluation of the diagnosis, by means of the tests and investigations necessary, their evaluation and the symptoms of each disorder which may cause problems (deficiencies) in the individual person, when carrying out his work (determining which tests and investigations allow this to be shown). Neurology is one of the specialities which offers the greatest difficulty to nonspecialists. This is due to the evaluation of complementary tests used and the subjectivity of some defects. In this paper, we aim to report these difficulties in order to promote collaboration between medical assessors and Neurology specialists.

Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant.

Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant.

Emergence of multiple drug-resistant Vibrio cholerae 01 in San Pedro Sula, Honduras

We investigated the occurrence of drug-resistant Vibrio cholerae among patients in the Hospital Regional de la Seguridad Social in San Pedro, Sula, Honduras. 11 patients were studied; five children and six adults. Stool samples were collected in sterile containers and processed for V cholerae isolation. Colonies presumptively identified as V cholerae were tested for antibiotic resistance with standardised disk diffusion. All suspect V cholerae isolates were sent to the INCIENSA Reference Laboratory for Cholera (Tres Rios, Costa Rica) for confirmation and serotyping. They reported that all strains were V cholerae O1, biotype El Tor, serotype Ogawa. Results of antibiograms indicated that 27% (3/11) of the patients were infected with multidrug-resistant strains. These strains were resistant to tetracycline, trimethoprim-sulfamethoxazole, kanamycin, gentamicin, chloramphenicol, ampicillin, cephalothin, and doxycycline. Isolates were sensitive to all other antibiotics tested (table). All patients recovered after administration of intravenous rehydration fluid and antibiotic treatment consisting of either tetracycline, trimethoprim-sulfamethoxazole, or erythromycin. Patients infected with multidrug-resistant strains were treated with nalidixic acid. Antimicrobial-resistant strains of V cholerae have been previously documented from cholera endemic areas. Latin America, however, has not been host to endemic cholera for over a century. Honduras witnessed its first case of cholera from the new pandemic on Oct 13, 1991. The rapid appearance of multidrug-resistant strains in Latin America may be due to overuse of antibiotics in this area of the world or may indicate that strains of multidrug-resistant cholera are becoming more prevalent as the dominant infecting form of the organism. A report from Guatemala indicated that 47% (7/15) of cholera isolates obtained from patients in Guatemala City were resistant to furazolidone, sulfisoxazole, and streptomycin. Guatemalan and Honduran isolates differ from the Latin American epidemic strain, which has been generally susceptible to antibiotics. Two of the drugs against which the cholera strains developed resistance in our study, tetracycline and trimethoprim, are the two first-line drugs used in Honduras and many other developing countries because they are relatively inexpensive. The development of resistance to

Chemotherapeutic study of chromones from Spanish Cneoraceae.

We thank the Department of Botany, University of La Laguna, for advice and in whose herbarium voucher samples have been deposited, Drs. B. M. Fraga and A. G. Ravelo for their collaboration on the chemical aspects and Miss E. Bayo for her efficient technical work in the determination of the cytostatic activity. This research was financed by a grant from the Comision Administradora del Fondo de Investigaciones Sanitarias de la Seguridad Social (411/81).

PRESENT DEVELOPMENT AND FUTURE PLANS OF THE GUATEMALA SOCIAL SECURITY SCHEME1

International Social Security ReviewVolume 29, Issue 2 p. 167-181 PRESENT DEVELOPMENT AND FUTURE PLANS OF THE GUATEMALA SOCIAL SECURITY SCHEME1 Jorge E. Barascout, Jorge E. Barascout Chairman of the Technical Board of the Social Security Institute of GuatemalaSearch for more papers by this author Jorge E. Barascout, Jorge E. Barascout Chairman of the Technical Board of the Social Security Institute of GuatemalaSearch for more papers by this author First published: April 1976 https://doi.org/10.1111/j.1468-246X.1976.tb00949.x 1 This article appeared in Estudios de la Seguridad Social (No. 15, 1975), a Spanish-language publication of the General Secretariat of the ISSA. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume29, Issue2April 1976Pages 167-181 RelatedInformation

Differential diagnosis of tumors of the salivary glands with radioactive isotopes.

International AbstractsDifferential Diagnosis of Tumors of the Salivary Glands with Radioactive IsotopesRafael Rioboo GarciaRafael Rioboo Garcia(Clin. Puerta de Hieno de la Seguridad Social, Madrid, Spain).Search for more papers by this authorPublished Online:23 Jan 2015https://doi.org/10.1259/dmfr.1975.0022SectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail About"Differential Diagnosis of Tumors of the Salivary Glands with Radioactive Isotopes." Dentomaxillofacial Radiology, 4(1), p. 61 Previous article Next article FiguresReferencesRelatedDetails Volume 4, Issue 1January 1975Pages: 2-71 © 1975 The Authors. Published by the British Institute of Radiology History Published onlineJanuary 23,2015 Metrics Download PDF