The objective of this research is to analyse the extent and manner of the kind of fatigue among shift workers in Tamil Nadu, India. As for shift workers, they often have disturbed night’s sleep. Shift work is distinguished by its irregular and unique work hours, unlike the regular day-time Schedule. It is combined with circadian alteration, which affects most of the bodily activities. They have diverse sorts of health problems, such as physical and mental fatigue. A Cross-sectional Analysis was done among airport workers. 200 participants were randomly selected for the study aged 35-45 years and conducted for a duration of 6 months in the Airport, Tamilnadu. Sleep quality and cognition were assessed using a validated questionnaire. The muscle fatigue was evaluated using Mosso’s ergograph. R-statistical Software (version 4.0.2) was used for Data Analysis. The Primary analyses of data set’s normality were done by Kolmogorov - Smirnov Z test. Significant negative correlation exists between global PSQI score and both cognition score (r= -0.315, P<0.001) and Work done by Mosso (r= -0.405, P<0.001) There is also negative correlation exists between work done and the cognition score (r= - 0.565, P<0.001) which is statistically significant. Decreased Sleep Quality, more fatigue and lowering of cognition levels not only affects physical health but also the quality of life. It has been noted that sleep disturbance leads to physical and mental exhaustion among Tamil Nadu shift workers. The outcomes underscore the need for targeted interventions to improve sleep-related behaviours as well as the treatment of fatigue in this population. Reducing the disturbances of shift work effects on produce, growth as well as health may be authorized by way of implementing organized work shifts and also promoting sleep promotion.