Present Day Research Articles

The History of US Menstrual Health, School Nurses, and the Future of Menstrual Health Equity.

In the United States, adolescents suffer from inadequate menstrual health, meaning that adolescents are unprepared for menarche, lack the practical resources they need to comfortably and confidently manage menstruation, and receive inadequate health education and care for menstrual pain and disorders. In this article, we provide a historical analysis of the role of school nurses in addressing menstruation from the early 20th century up to the present day. We contextualize the current realities of school nursing and menstrual health education and clinical support. We argue that the decentralized US school system, a cultural aversion to open discussion about menstruation, and the outsized influence of commercial menstrual product manufacturers have hampered the ability of school nurses to deliver menstrual health education along with menstrual health support. Finally, we discuss implications for today's schooling experiences as well as recommendations for how to support school nurses in aligning our national approach to menstrual health toward the public health perspective of menstrual equity. (Am J Public Health. 2024;114(9):903-908. https://doi.org/10.2105/AJPH.2024.307705).

Role of Indian Medicinal Plants for Immunity Booster Against SARS-CoV-2 Infection: An Updated Review

Abstract: The coronavirus disease (COVID-19) came to be an epidemic that has occurred at the expense of the health of people. This disease reveals it can be lethal. Aged people and people with other medical occurrences may be more susceptible and become remarkably ill. The existing pandemic situation mandates scientific vigilance, hence we exploration to medicinal plants like Curcuma longa, Azadirachta indica, Ocimum sanctum, Tinospora cordifolia, Triphala, Phyllanthus emblica, Aloe barbadensis, Syzygium aromaticum, Cinnamomum verum, Allium cepa, Zingiber officinale, Piper nigrum, Allium sativum. The holistic Indian therapeutic system prescription is acknowledged as “Ayurveda”. Natural herbal remedies show more effectiveness which is moving towards the present day with the help of traditional medicine. The factual of the Immunity booster is to determine components of natural lineage have an antiviral outcome. This booster helps to prevent humans from infection caused by SARS-CoV-2. The molecular docking technique is used to disclose the interaction between molecules which is already researched, and the protein. In conclusion, the identified natural compounds from medicinal plants act as an herbal booster for increasing immunity in contradiction to SARS-CoV-2 contagion in patients.

Redefining ITT cortisol thresholds on Abbott platforms to prevent misdiagnosis of adrenal insufficiency.

Adrenal insufficiency (AI) is a life-threatening condition which requires long term glucocorticoid replacement. The insulin tolerance test (ITT) is the current gold standard test for diagnosis of secondary AI, but the widely accepted cut-off value of a peak cortisol of less than 500 nmol/L assumes that anyone who does not reach this value has AI and thus requires full replacement. The cut-off used to diagnose AI is also founded on outdated assays. Use of this cut-off in an era of more specific immunoassays therefore risks misdiagnosis, subsequent unnecessary glucocorticoid exposure and associated adverse effects with increased mortality risk. This retrospective analysis assessed 300 ITT cortisol responses using the Abbott Architect and Alinity analyser platforms in patients with suspected AI over a period of 12 years (August 2010 to January 2022), at a tertiary centre. Patients were classified as having AI or not, based on a comprehensive clinical review of electronic patient records from the point of test to the present day by a panel of pituitary and adrenal specialists. Using the current institutional cut-off value of 500 nmol/L, receiver operating characteristic analysis identified a 100.0% sensitivity and 43.6% specificity (area under the curve 0.979). Using a lower cortisol threshold value of 416 nmol/L on the Abbott analyser platform maintained a sensitivity of 100.0% and improved the specificity to 86.7%. This data supports lowering the Abbott analyser ITT peak cortisol threshold to 416 nmol/L. Use of this improved cut-off avoids unnecessary glucocorticoid replacement therapy in 104 (34.7%) of individuals in this study. All patients remained well with at least 1 year longitudinal follow up of glucocorticoid replacement.

Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review).

Acyl‑coenzyme A thioesterases (ACOTs) are crucial in mediating lipid metabolic functions, including energy expenditure, hepatic gluconeogenesis and neuronal function. The two distinct types are type I and II ACOTs, the latter of which are 'hotdog' fold superfamily members. Type II ACOTs include carboxyl‑terminal modulator protein 1 (CTMP1), also termed thioesterase superfamily member 4 (THEM4), and CTMP2, also termed THEM5. Due to their similar structural features and distinct sequence homology, CTMP1 and CTMP2 stand out from other type II ACOTs. CTMP1 was initially known as a protein kinase B (PKB) inhibitor that attenuates PKB phosphorylation. PKB is the central regulator of various cellular functions, including survival, proliferation, growth and metabolism. Therefore, by inhibiting PKB, CTMP1 can affect various cellular processes. Various other functions of CTMP1 have been revealed, including functions in cancer, brain injury, mitochondrial function and lipid metabolism. CTMP2 is a paralog of CTMP1 and was first identified as a cardiolipin remodeling factor involved in the development of fatty liver. As the functions of CTMP1 and CTMP2 were discovered separately, a review to summarize and connect these findings is essential. The current review delineates the intricate complexity of CTMP regulation across different metabolic pathways and encapsulates the principal discoveries concerning CTMP until the present day.

Effectiveness and Feasibility of Home-Based Palliative Care Interventions for Geriatric Oncology Patients: A Systematic Review Using Narrative Synthesis.

Due to an urgent need to develop palliative care services for geriatric patients with advanced cancer, an overview of available information regarding home-based palliative care interventions would be valuable. To summarize current literature for interventions targeted to homebound, older patients with incurable cancer, and investigate whether these patients can be benefited from home-based palliative care and achieve improved outcomes. A search strategy consisting of terms related to home care, palliation, oncology, and geriatrics was employed. A protocol following PRISMA guidelines was prospectively uploaded at PROSPERO (ID = CRD42023404675). Pubmed (MEDLINE), Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Epistemonikos.org databases were searched from inception until the present day. Eligibility criteria were selected based on the research question, the population of interest, and the research design. The Risk of Bias Assessment Tool version 2 (RoB-2) was used to appraise study quality. A total of 10 articles including 871 patients (out of 1236 titles and 141 fully-reviewed texts) were selected. Four studies assessed exercise interventions, two evaluated multi-component home-care models, two focused on supervision services, and two had nutrition and activity components. Eight studies reported improved outcomes in either specified or mixed cancer geriatric populations. There is a scarcity of clinical trials regarding home-based palliative care for geriatric oncology patients, resulting in poor information and a lack of evidence. At-home interventions seem feasible and have a positive effect on pain management and functional status, but more high-quality studies are required.

Эволюция публичной присяги служащих как меры укрепления государственности: от сословности к бессословности

This article examines the evolution of the oath of office over an extended period, beginning in the XVI century and continuing to the present day. The author traces the origins of this legal phenomenon, suggesting that it initially emerged as a vow, applied more in private legal and procedural relations than in public-legal contexts. Since the oath was traditionally accompanied by the kissing of the cross, it was referred to as the “kissing of the cross” oath. During the period of the estate-representative monarchy, the oath of allegiance to the monarch held significant importance in the public sphere. Along with the crowning of the kingdom, it played a crucial role in legitimizing and strengthening public power. During the imperial period, the oath of office became widely practiced, with the military oath being the most typical example analyzed. This example demonstrates both continuity and innovation in legal practice. In Tsarist Russia, the oath was characterized by its estate-based nature, as it served as an instrument of estate policy and was administered separately to officers of noble birth and the rank and file, who were recruited from commoners. In the early Soviet period, the military oath was initially taken only by individuals from the working class, and its name was changed to the “solemn promise”. After 1939, the military oath was administered to all servicemen. The military oath played a vital role in establishing discipline, strengthening the morale, and enhancing the combat readiness of the army, thereby contributing to the consolidation of state power. At present, the military oath is not a thing of the past with the liquidation of Soviet power, but it requires improvement. Based on the analysis, the author attempts to formulate proposals for improving not only the military oath but also the civil service oath, as well as the procedure for its implementation.

Contrast in Secondary Organic Aerosols between the Present Day and the Preindustrial Period: The Importance of Nontraditional Sources and the Changed Atmospheric Oxidation Capability

Contrast in Secondary Organic Aerosols between the Present Day and the Preindustrial Period: The Importance of Nontraditional Sources and the Changed Atmospheric Oxidation Capability

Performance analysis of fire protective clothing: a review

Firefighters in such serious environments (i.e., hazardous flames and radiant heat, high air temperatures, hot chemicals and liquids) must wear fire protective clothing during fire extinguishing and rescue operations. Many studies in the field of fire protective clothing have been conducted to evaluate the protective, mechanical and comfort performance of fire protective clothing. A comprehensive review of the literature has been undertaken to provide a better understanding of single-layer and multilayer fire protective clothing with protective, mechanical and comfort performance. Factors affecting the durability of protective clothing in the light of their expected retirement age and a number of significant standards for laboratory and manikin testing are discussed. The comfort of wearing clothing is another aspect that needs special consideration when designing a multilayered fire protective suit. A number of emerging technologies have been outlined to address the various challenges of the present day.

Analysis of Key Events to Economic Growth in Thailand's History

In recent decades, Thailand has made a lot of efforts to achieve a rapid economy increase, and completed the transition from agricultural production to industrialization. Thailands economic journey has seen significant reforms, challenges, and changes, closely intertwined with global economic changes and domestic policies. This article examines Thailand's economic trajectory from the 1960s to the present day, focusing on pivotal events such as the economic reforms of the 1960s, the Asian financial crisis in 1997, and the growth of the tourism sector since the 1980s. By examining these key historical moments, it aims to uncover the fundamental principles and trends that have influenced Thailand's economic development trajectory. Through an analysis of their impacts on economic growth, this study identifies lessons gleaned from both successes and setbacks. It highlights the significance of adaptive economic policies, resilience in the face of external shocks, and the role of sectoral diversification in fostering sustainable growth.

A Review on Ancient Cryptographic, Modern Cryptographic and Quantum Cryptographic Techniques

Cryptography has a long and fascinating history, evolving from ancient techniques to modern methods and now exploring the potential of quantum mechanics. This review paper provides a comprehensive overview of cryptographic techniques from past to present. We begin by examining ancient cryptographic techniques, tracing their origins back to 2000 B.C. when the ancient Egyptians used "secret" hieroglyphics. We also discuss evidence from ancient Greece and Rome, such as secret writings and the famous Caesar cipher [1]. These early methods laid the foundation for the field of cryptography. Next, we delve into modern cryptographic techniques that have become increasingly complex and diverse in their applications. We explore how cryptography now makes extensive use of mathematical concepts from fields like information theory, computational complexity, statistics, combinatorics, abstract algebra, number theory, and finite mathematics. We also discuss how the development of digital computers and electronics has revolutionized cryptography, allowing for the encryption of any kind of binary data and the design of much more intricate ciphers [2]. Finally, we examine the emerging field of quantum cryptography, which aims to harness the principles of quantum mechanics to achieve new cryptographic functionalities beyond classical information alone. We survey some of the most remarkable theoretical uses of quantum information for cryptography, as well as the limitations and challenges faced by cryptographers in this new paradigm [3]. By tracing the evolution of cryptography from ancient times to the present day and beyond, this review paper provides valuable insights into the rich history and promising future of this critical field of study.

Citrus tristeza virus: A century‐long challenge for the world's citrus industries

AbstractCitrus tristeza virus (CTV) is a causal agent of diseases that have challenged the global citrus production for more than a century. The disease named ‘tristeza’, which means ‘sadness’ in Portuguese and Spanish, has spread by aphids and vegetative propagation, resulting in costly pandemics that reshaped the world citrus production by forcing the adaption of disease‐tolerant rootstocks. Furthermore, management of the second major CTV‐induced disease, stem pitting, became a unique example of the use of cross‐protection on a large nationwide scale, allowing many citrus growing regions to control the disease that could not be managed through horticultural practices. The information gathered in this review commemorates a hundred years of research on the virus and the respective diseases, which began with classical horticultural approaches and advanced toward the cutting‐edge molecular biology studies. In this regard, it is proper to mention that CTV research greatly benefited from close international collaboration between research institutions and scientists from the affected and nonaffected citrus areas. Moreover, despite the considerable initial losses caused by tristeza, the world's fresh fruit and juice concentrate citrus industries reemerged as highly productive following the research advancements, a situation that changed throughout Florida and Brazil in the past two decades or so with the outbreak of the devastating citrus greening (Huanglongbing) bacterial disease. This review encompasses past and recent advances in the CTV research positioning the citrus‐CTV pathosystem as a pivotal model system for investigating virus interactions with perennial woody hosts. The review will also serve as an updated version of the respective section on CTV in the Description of Plant Viruses that the Association of Applied Biologists manages. We dedicated this review to the 85th Birthday celebration of Prof. Moshe Bar‐Joseph, a world‐renowned plant pathologist whose half‐a‐century‐long career devoted to citrus diseases yielded many important, pioneering discoveries on CTV and other closteroviruses. Many of those are highlighted in this review. Prof. Bar‐Joseph retired from the Volcani Center, Agricultural Research Organization in Israel several years ago, yet he continues to be actively engaged in research and provides his expertise to citrus pathologists around the world in the present days.

Short-term air pollution prediction using graph convolutional neural networks

Pollution is a major concern in the present day, causing multiple illnesses and deaths, specifically in developing countries in Asia and Africa. While it has drawn worldwide attention as governments try to issue laws to meet certain criteria for air pollution levels, pollution concentration forecasting has become a major challenge. Particularly, short term forecasting will help to gain information regarding concentrations of harmful pollutants for the upcoming hours and enable better decision-making with regards to controlling air pollution. In this paper, we investigate spatio-temporal graph-based models to determine the best methods for spatial and temporal analysis of data. The models have the additional capacity to perform multi-variate predictions of correlated data, i.e., predicting multiple pollutant concentrations simultaneously, thus requiring lower computational efforts. A real-world pollution dataset measured over Delhi, India, is used to comparing the proposed models with baselines, which shows the Spatio-Temporal Graph Convolution Neural Network (STGCN) models to be performing better than others. For a better understanding of model architectures with the most effective strategies for spatial and temporal data analysis, three models, namely STGCN-A, STGCN-B, STGCN-C have been developed. The models have been compared with 6 other baselines over multiple forecasting horizons of 1 h, 24 h, and 48 h timesteps using various metrics such as mean absolute error (MAE), root mean square error (RMSE), mean absolute percent error (MAPE). On the PM2.5 dataset of Delhi, STGCN-B achieves a performance of 10.53 MAE, 6.92 RMSE and 25.25 MAPE for a 1 h forecast, while STGCN-C achieves 20.18 MAE, 14.73 RMSE and 55.45 MAPE for a 24 h forecast. In general, both structures achieve similar results, with STGCN-C being better in many cases. They are further analysed through observation-prediction graphs and Taylor diagrams, which give an insight into our findings. The models are additionally validated on a benchmark real-world dataset from California, USA for better understanding of the spatio-temporal relations and model performances on a more stable dataset, where STGCN-C performs best for PM2.5 with 4.30 RMSE, 1.98 MAE, 25.96 MAPE for 1 h predictions for univariate data and 3.63 RMSE, 1.88 MAE and 25.91 MAPE in multivariate forecasting. The developed spatio-temporal graph-based models hold promising applications in urban air quality management, aiding policymakers in implementing targeted interventions to mitigate pollution-related health risks. Furthermore, these models can support public health agencies by providing timely and accurate forecasts of pollutant concentrations, enabling proactive measures to safeguard community well-being. Our study showcases the efficacy of spatio-temporal graph-based models in accurately forecasting air pollutant concentrations, with particular emphasis on short-term predictions. By leveraging multi-variate capabilities, our proposed models demonstrate superior performance compared to baseline approaches across various forecasting horizons.

The Impact of Fermentation on the Antioxidant Activity of Food Products.

From ancient times to the present day, fermentation has been utilized not only for food preservation but also for enhancing the nutritional and functional properties of foods. This process is influenced by numerous factors, including the type of microorganisms used, substrate composition, pH, time, and temperature, all of which can significantly alter the characteristics of the final product. Depending on the parameters, fermentation enhances the bioactive content of the products and imparts the necessary properties, such as antioxidant characteristics, for the products to be considered functional. The enhancement of these properties, particularly antioxidant activity, enriches foods with bioactive compounds and functional attributes, contributing to improved health benefits. Through a review of recent research, this study elucidates how different fermentation processes can enhance the bioavailability and efficacy of antioxidants, thereby improving the nutritional and functional qualities of foods. This study investigated the multifaceted effects of fermentation on antioxidant properties by exploring various types and conditions of fermentation. It highlights specific examples from dairy products and other food categories as well as the valorization of food waste and byproducts. The findings underscore the potential of fermentation as a sustainable method to produce health-promoting foods with elevated antioxidant activities, offering new perspectives for food science and technology.

Overview of ASDEX upgrade results in view of ITER and DEMO

Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98(p,y) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q-profile) were established on AUG and characterised concerning their plasma performance.

Where Are the Women in Spine Surgery? A Demographic Study of the Range of Gender Disparity in Academic Spine Hospitals in the United States

There is a paucity of women in the field of academic spine surgery. In 2022, 20% of orthopaedic surgery residents and 24% of neurosurgery residents were women, the lowest and third lowest of all medical specialties respectively. There exists a significant discrepancy in the number of women employed as adult spine surgeons at academic hospitals. To quantify the number of female attending spine surgeons at academic hospitals and identify institutions that based on faculty diversity are demonstrating inequity Study Design: Descriptive Methods: Demographic data was collected utilizing the 2023-2024 NASS Fellowship Directory in combination with publicly available information on faculty profiles from January 1, 2024 - January 30, 2024. Data collected included gender and training institutions (medical school, residency, and fellowship). Adult spine fellowship-trained orthopaedic surgeons and neurosurgeons who perform adult spine surgery were included. There are 943 neurosurgical and orthopaedic adult spine surgeons employed at 73 academic hospitals. The breakdown of orthopaedic spine surgeons versus neurosurgeons is roughly equivalent, at 453 and 490, respectively. Among orthopaedic spine surgeons, 19 out of 453 (4%) are female. Among neurosurgeons, 44 out of 490 (9%) are female. The number of female academic spine surgeons who are neurosurgeons is more than double that of orthopaedic surgeons. 12 out of the 19 (63%) female orthopaedic spine surgeons, and 16 out of the 44 (36%) female neurosurgeons are employed at the program where they trained. Out of 45 larger academic spine hospitals with >10 faculty members, there were 15 without any female faculty. There is one academic hospital with ≥ 20 spine faculty, and zero women. The number of women pursuing academic spine careers continues to lag behind present day demographics of training programs. These continued trends should prompt both individuals and institutions to support progress in gender disparity research. V.

Risk factors for long COVID syndrome in postmenopausal women with previously reported diagnosis of COVID-19

PurposeLong COVID-19 syndrome occurs in 10–20 % of people after a confirmed/probable SARS-COV-2 infection; new symptoms begin within three months of COVID-19 diagnosis and last > 8 weeks. Little is known about risk factors for long COVID, particularly in older people who are at greater risk of COVID complications. MethodsData are from Women’s Health Initiative (WHI) postmenopausal women who completed COVID surveys that included questions on whether they had ever been diagnosed with COVID and length and nature of symptoms. Long COVID was classified using standard consensus criteria. Using WHI demographic and health data collected at study enrollment (1993–98) through the present day, machine learning identified the top 20 risk factors for long COVID. These variables were tested in logistic regression models. ResultsOf n = 37,280 survey respondents, 1237 (mean age = 83 years) reported a positive COVID-19 test and 425 (30 %) reported long COVID. Symptoms included an array of neurological, cardio-pulmonary, musculoskeletal, and general fatigue, and malaise symptoms. Long COVID risk factors included weight loss, physical and mobility limitations, and specific heath conditions (e.g., history of heart valve procedure, rheumatoid arthritis). ConclusionsKnowledge of risk factors for long COVID may be the first step in understanding the etiology of this complex disease.

An updated reconstruction of Campi Flegrei caldera (southern Italy) ground deformation history and its interaction with the human sphere since Roman time

Since the 19th century, many scientists have tried to reconstruct the ground motions that occurred in the Campi Flegrei caldera, one of the most dangerous volcanos in the Mediterranean area. This study aims to assess the joint effects of vertical ground movements and anthropic forcing along the coasts of this volcanic area. A huge dataset of hundreds of archeo-stratigraphic boreholes was coupled with direct and indirect surveys of the main underwater archaeological sites scattered along the whole coastal sector and with the reinterpretation of bibliographic sources. Clear evidence of a differential volcano-tectonic behaviour (highlighted for the first time in this study) led us to divide the study area into three coastal stretches with homogeneous vertical ground movements. In each sector, a new relative sea-level (RSL) curve was reconstructed, by interpreting our stratigraphic and archaeological data in terms of SL markers covering a wider timespan compared to the previous studies, from the first Roman urbanization to the present day. The comparison between RSL curves and GIA models allowed estimating vertical ground movements (See Supplementary material 2) that occurred along the coast with decimetres accuracy. For each of the 5 recognized phase of uplift or subsidence, we also studied the subsequent effects in terms of coastal geomorphological change, and advantages or negative impacts on ancient human activities. We measured an overall subsiding trend that brought the RSL from −12 ± 1 m (4th century BC) to 7 ± 0.2 m during three different episodes between 5th and 15th centuries (1450–450 y BP), which was interrupted by short-lived falls (less of 100 years) of RSL. During the phases of RSL fall and/or volcano-tectonic stability, detected for the first time in the eastern and western part of the caldera (1st-2nd century AD and 3rd-4th century AD), a basinward shift of the coastline created newly emerged land even at the base of the local sea cliffs, where shore platforms emerged, favouring intense phases of urbanization on them along the Baia – Miseno sector and at the footslope of Rione Terra. This trend also favoured the closure of the Lucrino lagoon with an extended spit bar during the 2nd century BC, allowing the establishment of a large oyster farming system belonging to Sergio Orata. On the contrary, the subsiding phases resulted in the flooding of coastal areas and anthropic structures such as villas, nymphaea and ports inducing the construction of coastal protection structures. In the extreme case of Portus Julius, subsidence led to the abandonment of the military port and its move to nearby Miseno.

The writing on the wall: Identity, placemaking and territoriality in Karachi's graffiti culture

This article explores the spatiality of political graffiti and urban murals and the role they play in placemaking, territoriality and identity building amongst Karachi's migrant communities. From Independence in 1947 to the present day, the city has been the site of several waves of in-migration, both domestic and international, resulting in a migrant megacity. Through shared migration experiences and cultural heritage, political patronage and spatial clustering, communities have consolidated and reimagined ethnic identities into political ones. These ethno-political entities demarcate territories of dominance and spaces of tension using political graffiti. This tool for placemaking and territory marking is an urban declaration of power on the walls of the city. More recently, political graffiti has been deliberately replaced by civil society actors in the form of murals changing the provocative ethno-political sloganeering to a nationalistic counter narrative. With multiple actors – political and apolitical - sentiments and stories now vying for space through their occupation of the city's walls, these surfaces become spaces of declaration, dialogue and at times, erasure. Through a process of diachronic documentation, this article shows that the walls of the city are a palimpsest of political opinion and identity; each subsequent layer in dialogue with the layer that precedes it. The authors of each layer through a process of placemaking, construct, deconstruct and reconstruct narratives of identity, ownership and belonging.

Impact of Long-Term Pyriproxyfen Exposure on the Genetic Structure and Diversity of Aedes aegypti and Aedes albopictus in Manaus, Amazonas, Brazil.

Aedes aegypti and Aedes albopictus are responsible for transmitting major human arboviruses such as Dengue, Zika, and Chikungunya, posing a global threat to public health. The lack of etiological treatments and efficient vaccines makes vector control strategies essential for reducing vector population density and interrupting the pathogen transmission cycle. This study evaluated the impact of long-term pyriproxyfen exposure on the genetic structure and diversity of Ae. aegypti and Ae. albopictus mosquito populations. The study was conducted in Manaus, Amazonas, Brazil, where pyriproxyfen dissemination stations have been monitored since 2014 up to the present day. Double digest restriction-site associated DNA sequencing was performed, revealing that despite significant local population reductions by dissemination stations with pyriproxyfen in various locations in Brazil, focal intervention has no significant impact on the population stratification of these vectors in urban scenarios. The genetic structuring level of Ae. aegypti suggests it is more stratified and directly affected by pyriproxyfen intervention, while for Ae. albopictus exhibits a more homogeneous and less structured population. The results suggest that although slight differences are observed among mosquito subpopulations, intervention focused on neighborhoods in a capital city is not efficient in terms of genetic structuring, indicating that larger-scale pyriproxyfen interventions should be considered for more effective urban mosquito control.

Gorkhas’ Recruitment into British Army: A Historical Overview

This article presents a historical overview and analysis of the Gorkhas’ recruitment into the British Army over more than 200 years. The study examines the evolution of the recruitment process, highlighting key periods and changes: the era of the East India Company before 1886, the World War periods, and the present day. The research investigates how the bravery, dedication, and loyalty of Nepalese youths during the Anglo-Nepal Wars (1814-16) led to British authorities encouraging Gorkhali youths to join the British Army, aiming to leverage their skills for future wars and imperial expansion. Despite their valor, Gorkhas faced numerous challenges, and significant improvements in recruitment conditions did not occur until after 1886. Even then, parental consent was a significant barrier. It was not until the 1970s that Gorkha youths openly expressed a desire to join, but by then, the selection process had become much tougher due to decreased demand for their services. Employing a qualitative research approach, the article utilizes a variety of sources including books on Britain-Nepal military relations, journal articles, periodicals, and war history books from Nepal, Britain, and other relevant regions to provide a comprehensive analysis. The study’s findings indicate that the recruitment process was particularly challenging before 1886 and during the World Wars, despite a high demand for Gorkha soldiers. In the present day, while the recruitment process is more transparent, opportunities for Gorkhas have significantly diminished due to a reduced demand for their services.