Review Of Database Research Articles

Treatment-induced ripple effect: a systematic review exploring the abscopal phenomenon in Glioblastoma multiforme.

This systematic review aimed to collate and synthesize the available literature on the abscopal effect in Glioblastoma multiforme (GBM) neoplasms, focusing on the reported biochemical mechanisms driving the abscopal effect. A systematic search was conducted in PubMed, Cochrane Database of Systematic Reviews, and Epistemonikos from inception to May 1, 2023. Studies exploring the abscopal effect in GBM were included. The Clinical Relevance Assessment of Animal Preclinical research (RAA) tool was used to assess methodological quality of preclinical studies. Data on preclinical models, biochemical mechanisms, and outcomes were extracted and synthesized systrmatically. Out of a total of 7 studies, five preclinical studies met the inclusion criteria. The studies utilized various in vivo mouse models, including bilateral tumor models and immunohumanized mice. Key biochemical mechanisms identified included immunogenic cell death, danger-associated molecular pattern release, macrophage activation, and enhanced T cell responses. Combinatorial approaches involving oncolytic virotherapy, nanoparticle-based treatments, radiation therapy, and immune checkpoint inhibitors showed promise in inducing abscopal effects. Significant tumor growth inhibition and improved survival were reported in treated animals. However, the RAA analysis highlighted concerns regarding research transparency and internal validity across studies. This systematic review highlighted the potential of the abscopal effect in GBM, demonstrating its ability to enhance anti-tumor immune responses both locally and systemically. The synergistic effects of combinatorial approaches showed promise for improving outcomes. However, the low methodological quality of existing studies underscored the need for more rigorous preclinical research. Future studies should focus on improving research transparency, exploring the abscopal effect in other primary CNS neoplasms, and translating these findings into clinical trials to assess safety and efficacy in humans.

Airway management and ventilation strategy among obese adult patients: a comprehensive review and analysis

Background: Difficulties with mask ventilation and intubation are more prevalent in obese patients. Hence, health care practitioners engaged in airway management of obese individuals must exercise particular vigilance and care. Ventilation strategies can potentially have a detrimental impact on postoperative pulmonary function, prolong hospital stays, and increase costs. As a result, the aim of this review was to investigate airway management technique and ventilation strategies in obese adult patients. Methods: The PubMed, HINARI, Google Scholar, and Cochrane Review databases were searched using appropriate keywords and search engines for adequate evidence from studies meeting the inclusion criteria to reveal the endpoint, which was ventilation strategy and airway management in adult obese patients. Duplicate entries were eliminated through EndNote software. Screening of literature was conducted with proper appraisal checklist. This review was reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 statement. Results: The included literature covers a wide range of topics, including preoxygenation, making the patient in a 25° head-up position, use of 10–12cmH2O of positive end-expiratory pressure (PEEP) and continuous positive airway pressure (CPAP) during induction, placing the patient in a ramping posture during intubation, high-flow oxygenation (15 L/min) through the nasopharyngeal airway or nasal cannula during laryngoscopy, using low tidal volume during surgery, a 1:1/1.5:1 I:E ratio, PEEP of 10–20 cmH2O, Fio2 reduced to make SpO2 > 90, pressure-controlled (PC)/volume-controlled (VC) ventilation mode, and recruitment maneuver (RM). Following surgery, it was essential to provide oxygen therapy to maintain preoperative levels, provide CPAP/non-invasive positive pressure ventilation, place patients in semi-sitting positions, and provide thorough postanesthesia care unit monitoring in order to enhance patient outcomes with regard to morbidity and mortality among obese patients. To safely manage and overcome airway challenges in severely obese patients with a suspected difficult airway, awake fiberoptic intubation is recommended. Conclusions: Positioning the patient in a head-up position (semi-sitting), utilizing CPAP during preoxygenation, and administering oxygen via nasal cannula during intubation to prolong apnoea time and awake fibrotic for suspected difficult airway. Additionally, selecting appropriate ventilation modes (PC/VC), PEEP + RM, and positions during the intraoperative phase is crucial to improving outcomes in obese surgical patients.

Risk factors for complications of Mycoplasma pneumoniae pneumonia in hospitalized children in China: a systematic review and meta-analysis

BackgroundMycoplasma pneumoniae pneumonia (MPP) is a common respiratory disease in children. Some patients may develop long-term respiratory issues such as chronic cough and wheezing due to complications. These complications increase the health burden for children with MPP, highlighting the need to understand their risk factors in order to improve disease prognosis. This study aims to assess the risk factors for complications in hospitalized children with MPP in China.MethodsA comprehensive review of Chinese and English databases was conducted up to April 2024 to retrieve studies focusing on complications in hospitalized children with MPP. Pooled effect sizes were calculated using random-effects or fixed-effects models. Statistical analyses were performed using R software and RevMan 5.3.ResultsThis meta-analysis encompassed a total of 17 studies. We analyzed multiple risk factors associated with complications, including prolonged fever (OR: 3.79, aOR: 1.64), pleural effusion (OR: 3.71, aOR: 6.70), extensive lung infiltration (OR: 5.52, aOR: 3.57), ≥ 2/3 consolidation in a single lung lobe (OR: 4.29, aOR: 4.52), right upper lung lesion (OR: 4.84, aOR: 3.57), extrapulmonary manifestations (OR: 3.20, aOR: 1.89), hypoxemia (OR: 7.58, aOR: 12.43), delayed administration of glucocorticoids (OR: 7.93, aOR: 6.67), and delayed administration of macrolides (OR: 2.75, aOR: 3.84).ConclusionHospitalized children with SMPP and RMPP may have a higher risk of complications, and it is important to identify risk factors early and provide appropriate treatment to minimize complications. The current level of evidence is relatively low and may not accurately reflect the actual clinical situation in China. Further high-quality studies are needed to validate and clarify these findings.Trial registrationOur protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (registration number: CRD42024534397).

Effects of Peer Support Work in Psychiatry: A Systematic Literature Review of Reviews

The current systematic review summarizes reviews on effects of formalized peer support work in clinical psychiatric settings in order to obtain an up-to-date picture of the current state of evidence. Search in five electronic databases for relevant literature reviews regarding effects of peer support work in psychiatric settings. Database searches were complemented by a hand search. 16 reviews were found. They evaluate effects of peer support on clinical or psychosocial outcomes. No consistent effects are found for clinical outcomes. Small positive tendencies occur for psychosocial outcomes. The authors of the reviews consistently mentioned the low quality of the primary studies. Therefore, the present results can rather be interpreted as a preliminary tendency. Further studies are necessary for evaluation of peer support in a more differentiated way.

Glucocorticoid dosing and implications for vaccination: Evolution of global definitions.

Despite widespread adoption of "high-dose" glucocorticoid definitions across international immunisation guidelines (i.e., prednisone-equivalent dosing >20 mg/day, or >2 mg/kg/day in children), the rationale remains unclear. Literature searches were performed through academic databases for this narrative review to identify relevant evidence regarding glucocorticoid dosing on vaccine responses and safety. In people receiving prednisone <7 mg/day, vaccine responses are maintained. In people on 'high-dose' glucocorticoids (>20 mg/day), antibody titres and seropositivity are reduced, whereas the impact of low- to medium-dose glucocorticoids (7 to 20 mg/day) on vaccine efficacy remains inconclusive. Due to inconsistent paediatric dosing regimens, data is insufficient to support a unified "high-dose" glucocorticoid threshold. Non-live vaccines are well tolerated in patients receiving glucocorticoids with rheumatic/inflammatory disorders, but enhanced reactogenicity after live vaccination may occur in those with severe immunodeficiencies. Clinicians should consider individual risk-benefit profiles, rather than following strict dosing thresholds, when curating immunisation programs for patients prescribed glucocorticoids.

An Integrative Review of Specialised Nursing Career Frameworks to Develop a Nursing Career Framework for Registered Nurses Working in Aged Care.

The aim of this study is to synthesise literature on specialised nursing career frameworks to inform the development of an aged care nursing career framework. An integrative review was conducted. The review followed Whittemore and Knafl's five-step integrative review method. To appraise the quality of the studies, the Quality Appraisal for Diverse Studies tool for peer-reviewed articles and the ACCODS (Authority, Accuracy, Coverage, Objectivity, Date, and Significance) checklist for grey literature were used. Data were extracted and synthesised using the constant comparison method. The electronic databases of CINAHL, Medline, PsycINFO and Google Scholar were searched to identify peer-reviewed articles and grey literature reporting on specialised nursing career frameworks for registered nurses. Eight studies were reviewed, and the findings were presented corresponding to each of the three research questions of the review. First, the research methods adopted to develop specialised nursing career frameworks were described based on the research design, stakeholder involvement and data collection methods. Second, the key elements of specialised nursing career frameworks were identified as career pathways, nursing competencies and roles and progression between the career levels. Third, the findings suggested that the key purposes for developing specialised nursing career frameworks are to improve professional development, recruitment and retention and to promote consistency and quality in nursing practice. The study highlights a significant gap in the evidence base of career frameworks for registered nurses in aged care, emphasising the need for future research. This review answered three research questions: methods for developing specialised nursing career frameworks, their key components and main purposes, providing insights to guide healthcare organisations and researchers. The findings indicate that career frameworks are primarily intended to promote knowledge and skills development and may also to bolster recruitment and retention rates, and support nurses' career advancement, but there is limited evidence on implementation, evaluation and sustainability. The findings will guide healthcare organisations and future researchers with methods and techniques to develop specialised nursing career frameworks. Implementing a specialised nursing career framework in aged care could enhance continuous professional development, recruitment, retention and career progression among nurses. Nursing career frameworks have been widely applied to address professional development and retention objectives. However, there is limited evidence available to formulate a career framework for registered nurses working in aged care. The review identified the research methods adopted to develop specialised nursing career frameworks along with the key elements of specialised nursing career frameworks. These findings will guide employers and future researchers in developing evidence-based aged-care nursing career frameworks. Additionally, the findings will guide registered nurses in using career frameworks as a tool to facilitate career advancement and competency development. Furthermore, the review recognised the key purposes for developing specialised nursing career frameworks, suggesting that the meaningful adoption of career frameworks could be utilised as a strategic approach for enhancing retention and workforce development of the aged care workforce. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was used for reporting. No patient or public contribution. The integrative review protocol was registered in the PROSPERO international prospective register of systematic reviews database (registration no: CRD42022354728).

Adaptive evaluation of gross total resection rates for endoscopic endonasal approach based on preoperative MRI morphological features of pituitary adenomas

ObjectiveThis study aims to define a set of related anatomical landmarks based on preoperative Magnetic Resonance Imaging (MRI) of patients with pituitary adenomas (PAs). It explores the impact of the dynamic relationships between different anatomical landmarks and the tumor on the resection rate and tumor progression/recurrence during the endoscopic endonasal approach (EEA).MethodsA single-center institutional database review was conducted, identifying patients with PAs treated with EEA from December 2018 to January 2023. Clinical data were reviewed, and anatomical landmarks were categorized into two regions: the suprasellar region and the cavernous sinus region. Following basic statistical and univariate logistic regression analyses, patients were randomly divided into training and validation sets. A nomogram was then established through the integration of least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression analysis. The clinical prediction model was evaluated using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis. Kaplan-Meier curves were plotted for survival analysis.ResultsA total of 626 patients with PAs were included in the study, with gross total resection (GTR) achieved in 570 cases (91.05%). Significant differences were observed in the distribution of age, Knosp grade, and tumor size between the GTR and near total resection (NTR) groups. LASSO regression identified 8 key anatomical landmarks. The resulting model demonstrated an AUC of 0.96 in both the training and validation sets. Calibration curves indicated a strong agreement between the nomogram model and actual observations. Survival analysis revealed that the extent of resection (EOR), age, Knosp grade, tumor size, and PAs extending beyond several anatomical landmarks identified were significantly associated with the progression or recurrence of PAs.ConclusionThis study proposes a model for adaptively assessing the resection rate of PAs by delineating relevant anatomical landmarks. The model comprehensively considers instrument manipulation angles, surgical accessibility during EEA procedures, anatomical variations, and the displacement of related anatomical structures in pathological states. This approach can assist neurosurgeons in preoperative planning and developing personalized surgical strategies.

Synthesis of existing literature on the colorectal surgery patients’ challenges during hospital-to-home transitions: a scoping review protocol

IntroductionDespite advances in innovation to improve patients’ transition experiences, it is unclear—in the context of colorectal surgery—what elements of patient education and care could provide the greatest benefit to patient...

Single-dose activated charcoal: evaluation of effectiveness and safety in the intoxicated patient

Introduction: Activated charcoal has been widely used in the management of acute poisoning due to its ability to adsorb a wide variety of toxins. Currently, the use of single-dose activated charcoal has emerged as a simplified alternative, promising efficacy with a simpler and potentially less invasive regimen. Objectives: To evaluate the efficacy and safety of the use of single-dose activated charcoal in the treatment of acute poisoning, by reviewing the literature, in order to determine its viability as a simplified alternative in the management of toxicological emergencies. Materials and methods: A structured search was performed in the PUBMED/MEDLINE database for works related to the use of single-dose activated charcoal in acute poisoning between the years 2005 and 2024 using the following terms and keywords in English that will be found in the title or abstract: “(single dose) and (activated charcoal) and (poisoned patient)”. In turn, articles from the author's personal database were included, being deliberately selected. Results: Twelve articles that met the selection criteria were selected and 2 additional articles were included after review of the authors' database. Conclusions: Single-dose activated charcoal administration shows comparable efficacy in various acute poisonings. The reviewed data indicate that this modality is safe and can significantly simplify the management of toxicological emergencies. However, further large-scale clinical studies are required to confirm these findings.

Proposal of a predictive score for the occurrence of postoperative cerebral vasospasm: analysis of a large single institution retrospective series and literature review.

Despite being uncommon, postoperative vasospasm (PoVS) present notably high morbidity and mortality rates. Our aim was to identify prognostic factors associated with this condition and introduce a scoring system to improve subsequent clinical and radiological surveillance strategies. We conducted a retrospective analysis of our institutional database covering patients aged over 18 who underwent craniotomic or transsphenoidal surgery for elective tumor removal at the Neurosurgical Unit of our institution between January 2016 and August 2023. A comprehensive search was conducted using the Cochrane Database of Systematic Reviews and PubMed database to identify the most correlated risk factors. Literature review included a final group of 32 studies (52 patients) and identified SAH, vessel encasement or vessel manipulation, hypothalamic disfunction, meningitis, younger age, tumor size > 3 cm, and long operative time as predictive factors for PoVS. Our cohort included 2132 patients, with only 13 individuals (0.61%) presenting PoVS. To predict the occurrence of PoVS, we developed a logistic multivariate regression model that identified thick (defined as Fisher grade ≥ 3) subarachnoid hemorrhage (coeff. 6.7, p < 0.001), intraparenchymal hemorrhage (coeff. 3.44, p < 0.001), lesion located in the parasellar region (coeff. 2.1, p = 0.064), and lesion size ≥ 4 cm (coeff. 2.0, p = 0.069) as potential independent predictors of PoVS. Based on statistical model for these variables was assigned a score: thick SAH 7 points, intraparenchymal hemorrhage 3 points, parasellar lesion site 2 points, and lesion size ≥ 4 cm 2 points. The cumulative scores ranged from 0 to 14. PoVS is a rare complication but its association with significant morbidity and mortality underscores the importance of early identification and treatment. In our study we proposed a stratified risk score to identify high risk patients. However, due to rarity of this condition, our score proposal should be considered as a training set a to be validated in future studies with a multicenter setting.

Brief Assessment Tools for Obsessive Compulsive Disorders in Children: A Systematic Review.

Children and adolescents with suspected obsessive-compulsive disorder (OCD). To estimate the comparative performance of brief diagnostic assessment tools. PubMed, the Cochrane Register of Clinical Trials, the Cochrane Database of Systematic Reviews, Embase, CINAHL, PsycINFO, and ERIC, and for unpublished studies with reported results in ClinicalTrials.gov through May 15, 2024. Studies of children (up to age 21) with a clinical suspicion of OCD that evaluated the accuracy (predictive validity) of brief assessment tools for OCD, compared to a reference standard. We extracted participant characteristics, scale and reference standard information, results, and risk of bias assessment. We performed random-effects diagnostic meta-analysis where feasible. We assessed strength of evidence for each scale. There is moderate strength of evidence that the 8-question version of the Child Behavior Checklist-Obsessive Compulsive subscale is sufficiently sensitive and specific (summary area under the curve of 0.84, 95% CI 0.74 to 0.91) to prompt specialist referral for additional diagnostic assessment. Other tools may perform as well or better, but the current evidence is insufficient to justify broad conclusions about their performance. Few studies per scale, case-control studies, and homogenous White populations may preclude generalizability of tool performance. Based on the current evidence the CBCL-OCS probably is sufficiently accurate to indicate which youth should be further evaluated for OCD, but further research is needed to establish that the 8-question subscale can function as a stand-alone measure. The available evidence is insufficient for other brief assessment tools.

External Ventricular Drain Misadministration Events: Systematic Literature Review and Report of a Case.

External ventricular drain (EVD) is a common neurosurgical procedure with potential complications, including catheter misplacement, infection, mechanical obstruction, and inadvertent catheter pull-out. A less discussed but critical complication is the misadministration of medications into EVD. This project aimed to review the literature on EVD misadministration and discuss preventative measures, emphasizing the new International Organization for Standardization (ISO) standard for neuraxial connectors. A systematic review of PubMed, Embase, and SCOPUS databases was conducted to identify studies reporting misadministration in EVD systems. We also present a case of misadministration of a blood product into an EVD. Factors contributing to these events were researched, relevant guidelines from professional organizations were reviewed, and preventive strategies, including the novel NRFit® connector designed to prevent such errors, were discussed. The literature review identified 7 reports of 8 cases of misadministration involving substances such as gadolinium-based contrast agents, anesthetic agents, and antiepileptic drugs. In addition, we report a case of an 87-year-old man with multiple traumatic brain injuries, where a blood transfusion line was mistakenly connected to the EVD. This incident is the first reported case of blood misadministration through EVD. Despite immediate drainage and flushing of the EVD system with saline, the patient's condition did not improve, and he eventually died. Contributing factors included unfamiliarity with the EVD system, similarity to IV connectors, and poor visibility during procedures. Importantly, the novel ISO 80369 standard for all neuraxial connectors, including NRFit® connectors that have a 20% smaller nozzle outside diameter than traditional Luer connectors, has been recommended to prevent misconnection errors and mitigate associated risks. Misadministration to EVD connectors is a preventable event that highlights the need for enhanced safety solutions. Adoption of ISO standard neuraxial connectors, thorough training, and the use of distinctly marked equipment are critical steps in minimizing risks.

Pandemic-Proofing: Intercepting Zoonotic Spillover Events

Zoonotic spillover events pose a significant and growing threat to global health. By focusing on preventing these cross-species transmissions, we can significantly mitigate pandemic risks. This review aims to analyze the mechanisms of zoonotic spillover events, identify key risk factors, and propose evidence-based prevention strategies to reduce future pandemic threats. Through a comprehensive literature review and analysis of major databases including PubMed, Web of Science, and Scopus from 1960–2024, we examined documented spillover events, their outcomes, and intervention strategies. This article emphasizes that targeting the root cause—the spillover event itself—is key to averting future pandemics. By analyzing historical and contemporary outbreaks, we extract crucial insights into the dynamics of zoonotic transmission. Factors underlying these events include increased human–animal contact due to habitat encroachment, agricultural intensification, and wildlife trade. Climate change, global travel, and inadequate healthcare infrastructure exacerbate risks. The diversity of potential viral reservoirs and rapid viral evolution present major challenges for prediction and prevention. Solutions include enhancing surveillance of wildlife populations, improving biosecurity measures, investing in diagnostic capabilities, and promoting sustainable wildlife management. A “One Health” approach integrating human, animal, and environmental health is crucial. Predictive modelling, international cooperation, and public education are key strategies. Developing pre-exposure prophylactics and post-exposure treatments is essential for mitigating outbreaks. While obstacles remain, advances in genomics and ecological modelling offer hope. A proactive, comprehensive approach addressing the root causes of spillover events is vital for safeguarding global health against future pandemics.

Barriers and Facilitators of Physical Activity in Pregnancy and Postpartum Among Iranian Women: A Scoping Review

Inactivity during pregnancy and postpartum is largely a result of women’s attitudes and misunderstandings of physical activity, especially in Iran. This scoping review critically assesses the barriers and facilitators influencing physical activity among pregnant and postpartum Iranian women to provide the basis for future physical activity interventions. Ten databases and platforms were searched up to 1 June 2024: Medline, SportDISCUS, PsycINFO, EMBASE, CINAHL, Cochrane Review Database, Clinical Trial, SID, ISC, and Web of Science. Grey literature sources were included to retrieve original publications on barriers and facilitators during pregnancy and postpartum among Iranian women. The search resulted in 2470 identified studies screened for inclusion criteria. After screening both abstracts and full texts, 33 of the studies were included, and data were extracted and charted. Findings were summarized in alignment with the objectives. The results show that the basic physical activity barriers are intrapersonal, interpersonal, and environmental factors. Facilitating factors include using E-learning resources and combined interventions to educate women and provide awareness of the existence of exercise classes. Social and emotional support by family members and other women in the same situation can be effective. Overall, the study of obstacles to and enablers of physical activity during pregnancy and postpartum is ongoing. In addition to highlighting the present situation in Iran, this study identifies further opportunities for future research on the development of appropriate interventions to reduce the barriers and strengthen the facilitators for physical activity among pregnant and postpartum Iranian women with trained groups, including skilled healthcare providers.

Hybrid intraperitoneal onlay mesh repair for incisional hernias: a systematic review and meta-analysis.

Laparoscopic IPOM is technically challenging, especially regarding fascial closure. Hybrid repair has been proposed as a simpler approach. We aimed to compare hybrid and laparoscopic intraperitoneal onlay mesh repair (IPOM) in patients undergoing ventral hernia repair (VHR). We performed a systematic review of Cochrane, Scopus, and MEDLINE databases to identify studies comparing hybrid versus laparoscopic IPOM VHR reporting the outcomes of recurrence, mortality, seroma, postoperative complications, reoperation, surgical site infection, and operative time. Statistical analysis was performed using RStudio 4.1.2 using a random-effects model. We screened 2,896 articles and fully reviewed 22 of them. A total of five studies, encompassing 664 patients were included. Among them, 337 (50.8%) underwent laparoscopic IPOM. All patients had incisional hernias, with a mean diameter varying from 3 to 12.7cm, 60% were women, with a mean BMI varying from 29.5 to 38. The hybrid approach had a lower rate of seroma when compared to the laparoscopic (OR 0.22; 95% CI 0.05 to 0.92; p = 0.038; I²=78%). We found no difference in recurrence, mortality, postoperative complications, reoperation, surgical site infection, and operative time between groups. Hybrid IPOM is a safe and effective method for incisional hernia repair. Moreover, it facilitates fascial defect closure and decreases postoperative seromas.

Malnutrition and risks of atrial fibrillation recurrence after catheter ablation

AbstractBackgroundRecent data showed an association between malnutrition and increased all‐cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.MethodsWe conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. Relative Risk (RR) or hazard ratio (HR) and 95% CIs were retrieved from each study and combined using the generic inverse variance method.ResultsWe included 3 cohort studies with 1697 participants undergoing AF ablation (10.9%) who had malnutrition indicated by GNRI score below 98. Patients with malnutrition had a higher risk of AF recurrence following catheter ablation for AF compared to those without malnutrition (Pooled RR = 2.74, 95% CI 1.36–5.51, I2 = 67%, p = .005).ConclusionsOur pooled analysis indicates that malnourished patients undergoing catheter ablation for AF have an increased risk of AF recurrence compared to non‐malnourished patients.

In Patients With Painful Hip Osteoarthritis, Is It More Beneficial to Offer Them an Ultrasound-Guided or a Fluoroscopic-Guided Intra-Articular Corticosteroid Injection to Relieve Their Symptoms? A Systematic Review and Network Meta-Analysis.

Hip osteoarthritis (OA) is a common disabling musculoskeletal condition. Clinical guidelines recommend intra-articular corticosteroid injections (IACSI) as a pharmacological adjunct to help manage pain. IACSI are typically image-guided either by ultrasound guidance (USG) or fluoroscopic guidance (FG) with no clear evidence towards the more efficacious guidance technique. This study aims to systematically review the scientific literature to determine the clinical effectiveness of USG compared with FG-IACSIs for people with pain-related hip OA. A systematic review of major bibliographic databases from inception to 24 August 2023 was conducted. Randomised controlled trials of USG- and FG-IACSIs for patients with hip OA were included. The primary outcome measure was pain. Hedges' g calculated effect size and meta-analysis using the random-effects model-estimated pooled effect sizes. τ2, I2 and Cochran's Q calculated heterogeneity. Network meta-analysis was completed to indirectly compare effect sizes. Quality was assessed using the Cochrane risk-of-bias tool (RoB2). A total of 1464 citations were identified; eight studies were included in the review. No studies directly compared imaging modalities. Two network meta-analyses indirectly comparing USG- to FG-IACSI via an image-guided comparator hip injection ([any comparator], [local anaesthetic or saline]) established effect sizes (g) of 2.61 and 2.46, respectively, both in favour of FG-IACSI. Heterogeneity was low in the USG studies and high in the FG studies. Evidence suggests that both USG and FG-IACSI are effective at reducing pain at 1 month in patients with painful hip OA. Although network meta-analyses favoured FG-IACSI, further high-quality trials are needed to determine the preferred guidance technique.

Review of sociological databases on consumption

The article suggests a typology of sociological sample surveys on consumption. A detailed classification of 106 databases is given according to their geography, time frame, institutional affiliation, access to data, sampling and data collection methodology, and thematic content. Among databases reviewed, six main types of surveys were distinguished: 1) Household Economic Survey; 2) Marketing consumer surveys; 3) Consumer sentiment indices; 4) Surveys of household time budgets; 5) Single studies in the field of consumption; 6) Repositories of quantitative and qualitative data in the field of consumption. The identified types are described by the following characteristics: topics covered by the surveys, institutional affiliation, type of sampling and data collection, mode of access, possibilities for enrichment with other types of data, advantages and disadvantages when used by academic researchers. The online appendix offers a complete navigator table for the surveys included in the review.

Projecting the world. The mediated geography of the projection lantern in Belgium c.1900-c.1920

This article studies the virtual world(s) that Belgian audiences encountered through the multimodal mass medium of the projection lantern in the early twentieth century. In contrast to previous work, we move from studying the visual representation of a single place in a small number of projection slides to examining the virtual world(s) that the lantern medium enabled. To achieve this overview, we produce and analyze a database of announcements and reviews of 5673 unique lectures lantern lectures published in Antwerp and Brussels newspapers in three sample periods (1902–1904, 1914–1918, and 1922–1924). Oscillating between distant reading the database and close reading individual announcements, we chart the virtual world(s) of this multimodal mass medium in Belgium: the parts of the globe that became visible – be it in a positive or negative projection light – and the parts that remained underexposed. We show that in this virtual world, the Belgian colony of Congo was relatively close, while it was almost impossible to visit South America. While previous research has underlined the representation of far-away and exotic places, our research demonstrates that audiences most prominently used the projection lantern to take trips in their own country. By analyzing the virtual geography on multiple scales —continents, countries, and cities— we show how Belgian audiences experienced the world through the lens of a particular medium, uncovering the complex interplay between technology, media, and geographical imagination.

A review of health equity considerations in Cochrane reviews of lifestyle interventions for cardiovascular health in adults

ObjectiveCardiovascular disease (CVD) is the leading cause of global disease burden and rising healthcare costs. Systematic reviews (SRs) rigorously evaluate evidence on health interventions' effects and guide personal, clinical, and policy decision-making. Health equity is the absence of avoidable and unfair differences in health between groups within a population. Assessing equity in lifestyle interventions for cardiovascular health is important due to persisting health inequities in CVD burden and access to interventions. We aim to explore how health equity considerations are addressed in Cochrane SRs of lifestyle interventions for cardiovascular health. Study Design and SettingThis is a methodological review of Cochrane SRs of lifestyle interventions for cardiovascular health using the PROGRESS-Plus framework. PROGRESS-Plus stands for Place of residence, Race/ethnicity/culture/language, Occupation, Gender/sex, Religion, Education, Socioeconomic status, and Social capital, while “Plus” stands for additional factors associated with discrimination and exclusion such as age, disability, and comorbidity. Using predefined selection criteria, two authors independently screened all Cochrane reviews published in the Cochrane Database of Systematic Reviews between August 2017 and December 2022. PROGRESS-Plus factors in the SRs were sought in the Summary of Findings (SoF) table, Methods/Inclusion criteria, Methods/Subgroup analyses, Results/Included studies, Results/Subgroup analyses, and Discussion/Overall completeness and applicability of evidence. ResultsWe included 36 SRs published by 10 Cochrane groups, addressing 11 health conditions with mostly dietary and exercise interventions. The most common PROGRESS-Plus factors assessed were gender/sex, age, and comorbidity. PROGRESS-Plus factors were most addressed in the inclusion criteria (64%), the discussion (75%), and the included studies (92%) sections of the SRs. Only 33% of SoF tables referenced PROGRESS-Plus. Sixty-nine percent of the included SRs planned for subgroup analyses across one or more PROGRESS-Plus factors, but only 43% of SRs conducted subgroup analyses, suggesting limited reporting of PROGRESS-Plus factors in primary studies. ConclusionsEquity factors are not sufficiently addressed in Cochrane reviews of lifestyle interventions for cardiovascular health. Low reporting of PROGRESS-Plus factors in implications for practice and research sections of Cochrane SRs limit equity focused guidance for current clinical practice, public health interventions and future research.